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ire 1

" in TargetMol Product Catalog
  • Inhibitors & Agonists
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IRE1 Protein, Human, Recombinant (aa 465-977)
IRE1P, IRE1a, IRE1, hIRE1p, endoplasmic reticulum to nucleus signaling 1
TMPY-04753
IRE1 Protein, Human, Recombinant (aa 465-977) is expressed in Baculovirus insect cells. The predicted molecular weight is 58.3 kDa and the accession number is O75460-1.
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7-10 days
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IRE1 Protein, Human, Recombinant (aa 465-977, His & GST)
IRE1P, IRE1a, IRE1, hIRE1p, endoplasmic reticulum to nucleus signaling 1
TMPY-04413
IRE1 Protein, Human, Recombinant (aa 465-977, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 86 kDa and the accession number is O75460-1.
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7-10 days
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HAO1 Protein, Human, Recombinant (His)
hydroxyacid oxidase (glycolate oxidase) 1, HAOX1, GOX1, GOX
TMPY-01770
Hydroxyacid oxidase 1, also known as Glycolate oxidase, HAO1, and GOX1, is a member of the FMN-dependent alpha-hydroxy acid dehydrogenase family. HAO1 GOX1 has 2-hydroxyacid oxidase activity. It is most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate. HAO1 GOX1 is a liver-specific peroxisomal enzyme that oxidizes glycolate to glyoxylate with the concomitant production of H2O2. In Hao1 messenger RNA (mRNA), an iron-responsive element (IRE) homologous to the sequence recognized by iron regulatory proteins (IRP), key regulators of iron homeostasis, is present. Mammalian HAO1 GOX1 is a peroxisomal protein and that the C-terminal sequence SKI acts as the targeting signal. Down-regulation of HAO1 GOX1 expression during oxidative stress may provide a mechanism to prevent excessive H2O2 formation in liver peroxisomes and may represent the prototype of a poorly recognized but potentially relevant response to an oxidative injury involving down-regulation of ROS-producing enzymes.
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7-10 days
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