free radical scavenger

Compound 8, a free radical scavenger, exhibits an IC50 value of 43.39 μg ml in neutralizing the DPPH radical [1].

Edaravone (MCI-186) is a potent new free radical scavenger used for the therapy of patients with acute brain infarction.

4-Chloro-4'-hydroxybenzophenone inhibits tyrosinase and also acts as a free radical scavenger or antioxidant, reducing lipid and protein oxidation.

(+)-Catechin Hydrate is an antioxidant flavonoid of plant origin; a free radical scavenger, preventing free radical-mediated damage in a variety of biological systems.

Naringenin (NSC-11855) is a flavanone that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, antiinflammatory, carbohydrate metabolism promoter, immunity system modulater. This substance has also been shown to repair DNA.

Tempone is an aminooxyalkane that acts as a free radical scavenger and reacts with reactive oxygen species (ROS). Intravenous Tempone reduces mean arterial pressure in spontaneously hypertensive rats.

Sinapinic Acid (Synapoic acid) protects the rat liver from CCl4-induced inflammation, most likely by acting as a free radical scavenger and modulator of NF-κB p65 activation and proinflammatory cytokine expression. Sinapic acid with antioxidant role protects cardiac cells and its functions from I/R induced oxidative stress. Sinapic acid is a potentially useful agent for the protection against liver fibrosis and cirrhosis. Sinapic acid prevents the alterations in the levels of lipids and lipoproteins by virtue of its anti-lipidaemic effect in isoproterenol induced myocardial infarcted rats. Sinapic acid ameliorates hyperglycemia through PLC-PKC signals to enhance the glucose utilization in diabetic rats.

Fullerene-C60 is a potent free radical scavenger with a wide range of bioactivities that can attenuate liver injury and hepatotoxicity, and improve intestinal flora structure and lipid homeostasis.

Tempo (2,2,6,6-Tetramethylpiperidinooxy) has a wide range of applications including use as a free radical scavenger, a reagent in organic synthesis and as a structural probe in electron spin resonance spectroscopy.

Sodium 2-oxopropanoate (Sodium pyruvate) is a antioxidant potentially used to treatment of chronic obstructive pulmonary disease.

Edaravone, a novel and potent free radical scavenger, effectively prevents MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator. Its deuterium-labeled variant, Edaravone D5, retains the original compound's attributes while offering isotopic labeling benefits.

Compound 3, known as 5-LOX MAOs-IN-1, acts as an inhibitor of 5-LOX MAOs and is an effective free radical scavenger, displaying antioxidant characteristics. It has demonstrated neuroprotective effects in cell models damaged by oxidative stress and is capable of activating the neurogenesis microenvironment in adult mouse neural stem cells. This compound is utilized in research focused on neurodegenerative diseases.

Carazostatin is an antioxidant, free radical scavenger, and potent lipid peroxidation inhibitor.

Phenazoviridin is a newly discovered microbial free radical scavenger isolated from the culture medium of Streptomyces HR04. It is an anti-hypoxic compound with strong inhibitory activity against lipid peroxidation in rat brain homogenates and anti-hypoxic activity in mice.

MAO-IN-M30 dihydrochloride is a highly potent non-selective inhibitor of MAO-A and MAO-B (IC50 < 0.1 μM). MAO-IN-M30 dihydrochloride is orally active and can cross the blood-brain barrier. It is an effective iron chelator and free radical scavenger. MAO-IN-M30 dihydrochloride has neuroprotective activity in in vitro and in vivo models of Parkinson's disease (PD). It increases brain dopamine, serotonin and norepinephrine and can serve as a lead drug for the development of multifunctional drugs to treat various neurodegenerative diseases.

(-)-Taxifolin, the less active enantiomer of Taxifolin, demonstrates vital anti-tyrosinase activity and notable inhibition against collagenase [IC50 = 193.3 μM], and is valued as an essential natural compound with antifibrotic potential, acting as a capable free radical scavenger with antioxidant capacity.

(±)-Taxifolin ((±)-Dihydroquercetin) is the racemate of Taxifolin, a flavonoid with anti-tyrosinase and anti-fibrotic activity, commonly found in onion, silymarin, French maritime pine bark, and Douglas fir bark. It inhibits collagenase with an IC50 value of 193.3 μM and acts as a free radical scavenger with antioxidant capacity.

Nelonemdaz potassium (also known as Salfaprodil) is a potent NR2B-selective and uncompetitive antagonist of N-methyl-D-aspartate (NMDA). This compound exhibits remarkable neuroprotection against cell death induced by both NMDA and free radicals, in addition to its role as a free radical scavenger.

Arjunic acid is a strong antioxidant and a free radical scavenger. Arjunic acid shows activity against Gram-positive and Gram-negative bacteria with MIC values ranging between 1.9 and 15.6 microg mL.

Isobellidifolin, a xanthone compound, serves as a free radical scavenger and antioxidant. It exhibits a potent antifungal effect.

Cirsiliol 4′-glucoside, a compound extracted from Ruellia tuberosa L., acts as a free radical scavenger and demonstrates potential anti-diabetic activity [1].

Epicaptopril (SQ 14534) is a derivative of Captopril and serves as an inhibitor of angiotensin-converting enzyme (ACE). It enhances vasodilation dependent on endothelium-derived relaxing factor (EDRF) and acts as a free radical scavenger. This makes it useful in studies related to oxidative stress and cardiovascular diseases caused by free radical damage.

NecroX-7 (LC-280126) is a potent free radical scavenger and HMGB1 (high-mobility group box 1) inhibitor. It serves as an antidote to acetaminophen toxicity and exerts a protective effect by preventing HMGB1 release in ischemia reperfusion injury. Additionally, NecroX-7 inhibits HMGB1-induced release of TNF and IL-6 and the expression of TLR-4 and receptor for advanced glycation end products. This compound may be used for graft-versus-host disease (GVHD) research [1].

Naringenin-d4 is a deuterium-labeled Naringenin for isotopic tracing.Naringenin (NSC-11855) acts as an antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator.