deoxyuridine

2'-Azido-2'-deoxyuridine (N3dUrd) is a ribonucleotide reductase inhibitor exhibiting anti-cancer activity.

3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II and strongly competes with UTP incorporation into RNA, with a Ki value of 2.0 μM[1].

'3'-Deoxyuridine-5'-triphosphate trisodium (3'-dUTP trisodium) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II by competitively blocking UTP incorporation into RNA with a dissociation constant (Ki) of 2.0 μM[1].

2'-Deoxyuridine (2-deoxyuridine). An antimetabolite that is converted to deoxyuridine triphosphate during DNA synthesis. Laboratory suppression of deoxyuridine is used to diagnose megaloblastic anemias due to vitamin B12 and folate deficiencies.

5-Ethynyl-2'-deoxyuridine (EdU) is a nucleoside analog of thymidine used to monitor de novo DNA synthesis through click chemistry and serves as an alkyl chain-based PROTAC linker for synthesizing PROTACs.

5-Chloro-2'-deoxyuridine (5-Chlorodeoxyuridine) is a thymine analog. It can be used to study the potential of hypochlorous acid damage to DNA and DNA precursors.

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine (5'-O-DMT-dU) is a competitive inhibitor of dUTP nucleotidohydrolase (dUTPase) in E. coli with a Ki greater than 1 mM. 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine can be used in machine-assisted DNA synthesis.

2'-Deoxyuridine 5'-monophosphate disodium (2'-dUMP⋅2Na) salt is utilized by the enzyme thymidylate synthetase (TS) for the de novo synthesis of dTMP and serves as the reference substrate in studies of dUMP analogues for potential chemotherapy applications.

2′,2′-Difluorodeoxyuridine (dFdU), the major metabolite of Gemcitabine, exhibits anticancer and antitumor activities, shows radiosensitization under hypoxic conditions, and can be used to study pancreatic cancer.

dUTP trisodium (Deoxyuridine triphosphate) is a deoxyuridine phosphate having a triphosphate group at the 5'-position and can be used for PCR.

Idoxuridine (Dendrid) is an analog of DEOXYURIDINE that inhibits viral DNA synthesis. The drug is used as an antiviral agent.

Doxifluridine (AMC 0101) is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to circumvent the rapid degradation of 5-FU by dihydropyrimidine dehydrogenase in the gut wall, is converted into 5-FU in the presence of pyrimidine nucleoside phosphorylase. 5-FU interferes with DNA synthesis and subsequent cell division by reducing normal thymidine production and interferes with RNA transcription by competing with uridine triphosphate for incorporation into the RNA strand.

Zebularine (4-Deoxyuridine) is a DNA methylation inhibitor. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. It also inhibits cytidine deaminase (Ki: 2 μM, in a cell-free assay).

5-BrdU (Broxuridine) is a nucleoside analogue. 5-BrdU is used to detect proliferating cells and compete with thymidine for incorporation into DNA.

5-BrdUTP sodium salt is a TdT substrate used for labeling DNA double-strand breaks.

dUTP (Deoxyuridine triphosphate) is a deoxyuridine phosphate featuring a triphosphate group at the 5' position. It can be utilized in PCR reactions.

3′-Deoxyuridine, a potential anticancer and antiviral agent, inhibits the production of bovine diarrhoea virus (BVDV) [1].

3'-Beta-C-Ethynyl-4-deoxyuridine is a purine nucleoside analog known for its broad antitumor activity targeting indolent lymphoid malignancies. Its anticancer mechanisms primarily involve the inhibition of DNA synthesis and induction of apoptosis, among other processes [1].

5-(2-Hydroxyethyl)-2',3'-di-O-toluoyl-2'-deoxyuridine, a purine nucleoside analog, exhibits widespread antitumor activity specifically against indolent lymphoid malignancies. Its anticancer effects are primarily through the inhibition of DNA synthesis and the induction of apoptosis, among other mechanisms [1].

Rp-2'-Deoxyuridine-5'-O-(1-thiotriphosphate) (Rp-dUTP-α-S), a sulfur-containing nucleotide isomer and purinergic P2Y2 receptor agonist, preferentially promotes inositol phosphate accumulation in 1321N1 astrocytoma cells with P2Y2 receptors (EC50 = 12.5 µM) compared to those expressing P2Y4 receptors at a concentration of 10 µM.

2'-Chloro-2'-deoxyuridine is a Halo-nucleoside.

3'-Amino-3'-deoxyuridine is a Nucleoside Derivative - Amino-nucleoside, 3'-Modified nucleoside.

3'-N-Acetyl-3'-amino-3'-deoxyuridine is a Nucleoside Derivative - 3'-Modified nucleoside; Amino nucleoside.

5-Bromo-2'-fluoro-2'-deoxyuridine is a Nucleoside, fluoro-modified nucleoside, halo-nucleoside.