dbco-acid

DBCO-acid is utilized in the synthesis of ADC linker DBCO-NHS ester and drug-linker conjugates DBCO-PEG-MMAE[1].

DBCO acid 2 is a Click Chemistry intermidate used for antibody-drug conjugates.

DBCO-C6-acid is a non-cleavable linker used in the synthesis of antibody-drug conjugates (ADCs) and carmaphycin analogues[1].

DBCO-Amide-PEG5-acid is a non-cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs)[1].

DBCO-PEG4-C2-acid is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-NHCO-PEG13-acid is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-NHCO-PEG3-acid, a PEG-based linker for PROTACs, joins two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

DBCO-NHCO-PEG7-acid is a PEG-based linker for PROTACs, connecting two essential ligands vital for forming PROTAC molecules and enabling selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

DBCO-NHS ester 3 (Compound 12) is a cleavable linker utilized in the synthesis of antibody-drug conjugate (ADC). It is a derivative of Dibenzylcyclooctyne (DBCO) resulting from the activation of N-hydroxysuccinimide by the carboxylic acid moiety of both methyl-oxanorbornadiene (MeOND) and dibenzoazacyclooctyne (DIBAC)[1][2].

DBCO-PEG1-acid is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-PEG12-acid is a PEG-based linker for PROTACs that connects two essential ligands, enabling selective protein degradation through the ubiquitin-proteasome system within cells.

DBCO-PEG2-acid is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands necessary for PROTAC molecule formation, and enables selective protein degradation via the ubiquitin-proteasome system within cells.

DBCO-PEG8-acid, a PEG-based linker for PROTACs, joins two essential ligands critical for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

N-DBCO-N-bis(PEG2-C2-acid) is a polyethylene glycol (PEG) linker commonly employed in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

DBCO-PEG3-C1-acid serves as a linker for antibody-drug conjugates (ADCs), facilitating the strain-promoted azide-alkyne click reaction as a reaction handle.

Azido-PEG13-acid is a PEG-based PROTAC linker useful in the synthesis of PROTAC molecules. It acts as a click chemistry reagent containing an azide group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAC) with molecules featuring alkyne groups. Additionally, it can engage in strain-promoted azide-alkyne cycloaddition reaction (SPAAC) with molecules that have DBCO or BCN groups.

Azido-PEG7-acid is a PROTAC linker belonging to the PEG class, used in the synthesis of PROTAC molecules. It functions as a click chemistry reagent, incorporating an Azide group that facilitates copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing Alkyne groups. Additionally, it can engage in strain-promoted azide-alkyne cycloaddition reactions (SPAAC) with molecules that possess DBCO or BCN groups.

3-Azidopropionic Acid Sulfo-NHS Ester is a water-soluble compound containing an azide group and an NHS ester. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The NHS ester can be used to label the p

DBCO-PEG4-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-PEG4-acetic-Val-Cit-PAB is a cleavable tetraethylene glycol-based linker for antibody-drug conjugate (ADC) synthesis, featuring a dibenzocyclooctyne group, an acetic acid moiety, a valine-citrulline dipeptide, and a p-aminobenzyl alcohol end.

11-Azidoundecanoic acid, a click chemistry reagent with an azide group, serves as a hydrophobic bioconjugation linker amenable to further modification via Staudinger ligation or Click chemistry. This compound is recognized as a substrate by lipoic acid ligase (LpIA) for labeling purposes [1] [2]. Additionally, 11-Azidoundecanoic acid can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-bearing molecules and engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules featuring DBCO or BCN groups.

15-Azido-pentadecanoic acid, also known as Azido Palmitic Acid, serves as a click chemistry reagent due to its azide group. This compound is instrumental in the identification and characterization of post-translationally palmitylated proteins through a straightforward two-step labeling and detection methodology [1]. It can partake in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-bearing molecules and also engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules featuring DBCO or BCN groups, showcasing its versatility in biochemical applications.

DBCO-S-S-acid, a cleavable ADC linker for synthesizing antibody-drug conjugates (ADCs) [1], is a click chemistry reagent that features a DBCO group capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with Azide-containing molecules.

N3-PEG4-amido-Lys(Fmoc)-acid is a 4 unit PEG ADC linker utilized in the production of antibody-drug conjugates (ADCs) [1]. This compound, functioning as a click chemistry reagent, is equipped with an Azide group that enables it to partake in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with Alkyne group-bearing molecules. Additionally, it is capable of engaging in strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.