contractility — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7538	Tetraethylammonium chloride		Potassium Channel
	Tetraethylammonium chloride is a quaternary ammonium compound. It is a non-selective potassium channel blocker. It is a good substrate for organic cation transporter proteins and has antitumor properties.		Potassium Channel
T23516	VU590		Potassium Channel
	VU590 is a potent and moderately selective inhibitor of extrarenal medullary potassium ROMK (Kir1.1).VU590 inhibits Kir7.1 and modulates uterine myometrial contractility and melanocortin signalling.		Potassium Channel
T4S1422	Praeruptorin E		Others , Calcium Channel
	1. Praeruptorin C and E can relax swine coronary artery and decrease contractility in guinea-pig left atria, these effects are similar in many respects to those displayed by drugs that have calcium entry blocking activit...		Others , Calcium Channel
T4S1518	Pseudoginsenoside RT1		Others
	Pseudoginsenoside RT1, isolated from the fruit of Randia siamensis, exhibits acute ichthyotoxic activity. Pseudoginsenoside RT1 can cause a decrease in blood pressure, an increase in heart rate and an increase in spontan...		Others
T3465L	Vesnarinone HCl	Synonym 2,OPC-8212 HCl,Vesnarinone HCl(81840-15-5 Free base)	Potassium Channel , Calcium Channel , PDE
	Vesnarinone HCl (OPC-8212 HCl) is an orally active phosphodiesterase 3 (PDE3) inhibitor.Vesnarinone HCl modulates calcium and potassium ions, increasing calcium flux and decreasing potassium flux.Vesnarinone HCl is a new...		Potassium Channel , Calcium Channel , PDE
T2530	Levosimendan	OR1259,OR1855	Potassium Channel , PDE , Carbonic Anhydrase , Autophagy
	Levosimendan (OR1259) is a calcium sensitizer used in the management of acutely decompensated congestive heart failure. It increases the sensitivity of the heart to calcium, thus increasing cardiac contractility without ...		Potassium Channel , PDE , Carbonic Anhydrase , Autophagy
T1146	Nifedipine	BAY-a-1040,Procardia XL,Procardia,Adalat	CaMK , Potassium Channel , Calcium Channel , Autophagy
	Nifedipine (Procardia) is a dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation ...		CaMK , Potassium Channel , Calcium Channel , Autophagy
TP2158	TRV-120027 TFA	TRV-120027 TFA (1234510-46-3 free base)	RAAS , Arrestin
	TRV120027 TFA is a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R) and engages ß-arrestins while blocking G-protein signaling.		RAAS , Arrestin
T1083L	Theophylline monohydrate	Quibron	HDAC , PDE , Adenosine Receptor
	Theophylline monohydrate (Quibron) appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize adenosine. Theophylline monohydrate is a ...		HDAC , PDE , Adenosine Receptor
T28778	Silperisone HCl	RGH5002,SILA336,RGH-5002,Silperisone hydrochloride,SILA-336
	Silperisone HCl (RGH-5002) blocks sodium and calcium channels in cells, decreases excitability and contractility of muscle cells, reduces peripheral tone, and acts as a muscle relaxant and peripheral vasodilator. Silperi...
T30197	ATI-22-107	ATI22-107
	ATI-22-107 is a positive cardiac inotropic agent which may affect myocyte calcium cycling and contractility.
T15425	GSK1702934A		Others
	GSK1702934A is a selective TRPC3 agonist. It modulates cardiac contractility and f arrhythmogenesis by activation of TRPC3.		Others
T16769	Ro 363		Adrenergic Receptor
	RO 363 is an effective inotropic stimulant and is a cardiovascular modulator that decreases diastolic blood pressure and pronounces increases in myocardial contractility. Ro 363 is an effective and highly selective β1-ad...		Adrenergic Receptor
T13806	OR-1855		Others
	OR-1855 is an active Levosimendan metabolite, has effect on human myometrial contractility.		Others
T76629	(Phe2,Orn8)-Oxytocin
	(Phe2,Orn8)-Oxytocin, a selective V1 vasopressin agonist, exhibits sustained contractility in rabbit epididymis, achieving an EC50 value of 280 nM [1].
T28268	ORM-3819
	ORM-3819 is a potent and selective PDE III inhibitor. ORM-3819 promotes cardiac contractility through Ca(2+) sensitization.
T28321	PD 122860	PD-122860,PD122860
	PD 122860 is a dihydropyridine with calcium channel blocking and sodium channel stimulating properties. In the rat heart, PD 122860 increased left ventricular contractility, decreased coronary resistance and altered the ...
T83454	13-Hydroxylupanine hydrochloride	Hydroxylupanine hydrochloride
	13-Hydroxylupanine, a characteristic alkaloid of sweet lupins, inhibits ganglionic transmission, reduces cardiac contractility, and induces contraction of uterine smooth muscle [1].
T24690	Pyrromecaine HCl	Bumecaine hydrochloride,Pyrromecaine
	Pyrromecaine is a local anesthetic used for surface anesthesia. Pyromecaine has a wide spectrum of antiarrhythmic action, exerts a favorable effect on the contractility of the left ventricle, and on the myocardial blood ...
T62986	CCG-271423
	CCG-271423 is a potent and selective inhibitor of GRK5, acting on both GRK5 (IC50: 0.0021 μM) and GRK2 (IC50: 44 μM). CCG-271423 reduces Ca2+ transients and inhibits cardiomyocyte contractility.