chemotherapy-induced — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T1790	Fosaprepitant dimeglumine	L785298,MK-0517,Fosaprepitant dimeglumine salt	Neurokinin receptor
	Fosaprepitant dimeglumine (MK-0517) is the dimeglumine salt form of fosaprepitant, the water-soluble, N-phosphorylated prodrug of aprepitant, with antiemetic activity. Upon intravenous administration and rapid conversion...		Neurokinin receptor
T68068L	(R)-CJ 11974		Neurokinin receptor
	(R)-CJ 11974 is a novel non-peptide neurokinin NK1 substance P receptor antagonist with potential analgesic activity that can be used to study chemotherapy-induced vomiting.		Neurokinin receptor
T1156	Palonosetron hydrochloride	RS 25259 197,Palonosetron HCl,RS 25259	5-HT Receptor
	Palonosetron hydrochloride (RS 25259) is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.		5-HT Receptor
T10244	ACY-1083		HDAC
	ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor (IC50: 3 nM) and effectively reverses chemotherapy-induced peripheral neuropathy.		HDAC
T3716	Rolapitant	SCH619734	Neurokinin receptor
	Rolapitant (SCH619734) Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. ...		Neurokinin receptor
T0776	Phenothiazine	ENT 38	Dopamine Receptor , Antibacterial , Antibiotic , Antifungal
	Phenothiazine (ENT 38) is a class of agents exhibiting antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Phenothiazines antagonize the dopamine D2-receptor in the chemoreceptor trigger zone (CTZ)...		Dopamine Receptor , Antibacterial , Antibiotic , Antifungal
T39024	PrNMI		Cannabinoid Receptor
	PrNMI is a highly effective and orally active agonist targeting the peripherally restricted cannabinoid 1 receptor (CB1R). It exhibits pronounced analgesic properties, efficiently suppressing both chemotherapy-induced pe...		Cannabinoid Receptor
T1285	Anethole trithione	Anetholtrithion	Others , AChR
	Anethole trithione (Anetholtrithion) is a bile secretion-stimulating drug that restores salivation and relieves the discomfort of dry mouth in chemotherapy-induced xerostomia.		Others , AChR
T2589	Dolasetron Mesylate hydrate	Dalasetron Mesylate Hydrate	5-HT Receptor
	Dolasetron Mesylate hydrate (Dalasetron Mesylate Hydrate) , a selective serotonin receptor antagonist, competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radioth...		5-HT Receptor
T9955	EX-A5758		NOS
	EX-A5758 is a novel putative small molecule nNOS-NOS1AP inhibitor, suppressing inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with paclitaxel to reduce tumor cell viability.		NOS
T2563	Acetyl-L-carnitine hydrochloride	Acetyl L-carnitine hydrochloride,O-Acetylcarnitine,O-acetyl-L-carnitine,O-Acetyl-L-carnitine hydrochloride	Others , Endogenous Metabolite
	Acetyl-L-carnitine hydrochloride (Acetyl L-carnitine hydrochloride) is a nutritional supplement composed of the hydrochloride salt form of the acetylated form of the endogenously produced L-carnitine, with potential neur...		Others , Endogenous Metabolite
T22393	Palonosetron	RS25259,RS 25259 197	5-HT Receptor
	Palonosetron, a 5-HT3 antagonist with Ki of 0.17 nM, is used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).		5-HT Receptor
T38692	Fabesetron	FK1052 free base
	Fabesetron (FK1052) is an orally active compound that acts as a dual antagonist, targeting both the 5-HT3 and 5-HT4 receptors. It exhibits efficacy in studying emesis induced by cancer chemotherapy, showing potential for...
T68371	Rolapitant hydrochloride hydrate
	Rolapitant, also known as SCH-619734, is an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant compe...
T81424	Polysaccharidase	Tremella polysaccharide
	Polysaccharidase (Tremella polysaccharide), a fungal polysaccharide, exhibits immunoenhancing properties and holds potential for research in mitigating chemotherapy and radiotherapy-induced leukopenia [1] [2].
T82475	Emfilermin
	Emfilermin, a recombinant human leukemia inhibitory factor (LIF), is utilized in the research of chemotherapy-induced peripheral neuropathy [1].
T79303	IACS-52825
	IACS-52825 is a potent, selective DLK inhibitor, exhibiting a dissociation constant (Kd) of 1.3 nM, and is valuable for researching chemotherapy-induced peripheral neuropathy (CIPN) [1].
T72820	(R)-Casopitant	(R)-GW679769
	(R)-Casopitant ((R)-GW679769), an isomer of Casopitant, functions as an NK(1)-receptor antagonist. It has applications in the study of chemotherapy-induced nausea and vomiting [1] [2].
T72184	Ac-Tyr-Val-Lys-Asp-aldehyde
	Ac-Tyr-Val-Lys-Asp-aldehyde is a caspase-1 inhibitor applicable in research related to diverse anemias, including those associated with chronic diseases, chemotherapy-induced anemia, and Diamond-Blackfan anemia.
T60305	ZLc-002
	ZLc-002 is a selective small-molecule inhibitor of nNOS-Capon coupling. ZLc-002 suppresses inflammatory nociception and chemotherapy-induced neuropathic pain. ZLc-002 can be used in anxiety disorder and inflammation rese...