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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8312 | Derenofylline | Adenosine Receptor | |
Derenofylline is a selective and potent adenosine A(1) antagonist in vitro (Ki=1 nM) | |||
T9258 | Aficamten | Others | |
Aficamten is a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy. | |||
TN6490 | Regaloside C | Others | |
Regaloside C is a glycerol glucoside isolated from Lilium genus with anti-inflammatory properties. | |||
T7298 | FT011 | Others | |
FT011, a direct anti-fibrotic agent,attenuates cardiac remodelling and dysfunction in experimental diabetic cardiomyopathy. | |||
T32155 | Indecainide | Ricainide,Ricainid,Decabid,Indecainidum,Indecainida | Others |
Indecainide (Ricainid) is a novel antiarrhythmic compound that is carcinogenic and can be used to study chronic stable ventricular arrhythmias secondary to coronary artery disease or cardiomyopathy. | |||
T71961 | TUN-92046 | DM-α-KG,T71961,Dimethyl 2-ketoglutarate,Dimethyl 2-oxoglutarate | Others |
TUN-92046 (Dimethyl 2-oxoglutarate) is a membrane-permeable alpha-ketoglutarate analogue that inhibits maladaptive autophagy in pressure overloading induced cardiomyopathy. | |||
T72023 | JB002 | Myosin | |
JB002, a myosin II inhibitor, exhibits potent activity with an IC50 of ≤10 μM. It holds potential for research applications in muscle spasticity, chronic musculoskeletal pain, and hypertrophic cardiomyopathy. | |||
T8198 | Visnagin | Others | |
Visnagin has acute hypotensive, anti-inflammatory, and neuroprotective effects, it protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase. | |||
T67952 | JB062 | Myosin | |
JB062 is a chemical compound acting as a nonmuscle myosin inhibitor, exhibiting IC50 values of 1.6, 5.4, and >100 μM against skeletal muscle myosin, cardiac muscle myosin, and smooth muscle myosin II, respectively. It se... | |||
T63067 | Emprumapimod | ||
Emprumapimod is a selective, orally active inhibitor of p38α MAPK. emprumapimod acts on RPMI-8226 cells and directly inhibits LPS-induced IL-6 production with an IC50 value of 100 pM. emprumapimod can be used to study di... | |||
T36230 | C2 Ceramide (d14:1/2:0) | C2 Ceramide (d14:1/2:0) | |
C2 Ceramide (d14:1/2:0) is a bioactive sphingolipid. Dietary administration of C2 ceramide (d14:1/2:0) (100 μM) induces lipotoxic cardiomyopathy via increasing diastolic and systolic diameter as well as reducing fraction... | |||
T10666 | Calhex 231 hydrochloride | CaSR | |
Calhex 231 hydrochloride is a CaSR inhibitor with the potential for diabetic cardiomyopathy treatment. It blocks Ca2+-induced accumulation of [3H]inositol phosphate (IC50: 0.39 μM in HEK293 cells). | |||
T61344 | VO-OHPic | ||
VO-OHPic is a reversible, noncompetitive, and selective inhibitor of PTEN with an IC50 of 46 nM. It effectively attenuates apoptosis, adverse cardiac remodeling, and the presence of pro-inflammatory M1 macrophages in mod... | |||
T63640 | CCG-273463 | ||
CCG-273463 is a potent, covalent, selective inhibitor of GRK5 (IC50: 9 nM). CCG-273463 can be used to study heart failure, hypertrophic cardiomyopathy and cancer. | |||
T80876 | Vasomera | ||
Vasomera, a stable, long-acting vasoactive intestinal peptide (VIP) agonist, targets G-protein-coupled VPAC2 receptors and is employed in the study of cardiomyopathy associated with dystrophinopathies [1]. | |||
TN1951 | Moracin O | HIF | |
Moracin O shows significant neuroprotective, and analgesic activities, it also has a strong protective influence against doxorubicin-induced cardiomyopathy in H9c2 cells with the EC50 value of 4.5 ± 1.3 μM. Moracin O exh... | |||
T62924 | Ifetroban sodium | ||
Ifetroban (BMS-180291) sodium is an orally active thromboxane A2 (TXA2) or prostaglandin H2 (PGH2) receptor antagonist. It is used to study myocardial ischaemia, stroke, hypertension, thrombosis and cardiomyopathy. | |||
T60428 | Cibenzoline | ||
Cibenzoline is an antiarrhythmic agent that inhibits the KATP channel by directly affecting the pore-forming Kir6.2 subunit rather than the SUR1 subunit. Cibenzoline shows little anticholinergic activity. Cibenzoline mar... |