bronchial asthma

Fevipiprant (NVP-QAW039) is a selective, potent, reversible competitive CRTh2 antagonist.

Cromoglicic acid prevents the release of inflammatory chemicals such as histamine from mast cells.

Parogrelil Free Base (NM-702 Free Base) is a selective phosphodiesterase 3 inhibitor with bronchodilatory and anti-inflammatory effects, inhibits leukotriene (LT)D(4) and histamine-induced constriction of isolated guinea pig tracheal strips, and can be used in the study of bronchial asthma.

Fluticasone propionate (CCI-187881), derived from fluticasone used to remedy asthma and allergic rhinitis, is a high affinity, selective GR (glucocorticoid receptor) agonist.

Betahistine mesylate (Extovyl) is a histamine analog and H1 receptor agonist that serves as a vasodilator. It is used in MENIERE DISEASE and in vascular headaches but may exacerbate bronchial asthma and peptic ulcers.

Zileuton (A 64077) is a synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the formation of leukotrienes from arachidonic acid; causes bronchodilation; decreases bronchial mucous secretion and edema; and may prevent or decrease the symptoms of asthma.

Diphylline (Diprophylline) is a xanthine derivative. Diphylline exerts bronchodilator effects and to a lesser extent vasodilator and diuretic properties. Diphylline probably acts as a competitive inhibitor of phosphodiesterase which leads to an increase in intracellular cAMP. This results in relaxation of bronchial smooth muscle and other smooth muscles. Diphylline may also antagonize adenosinereceptors. Diphylline is used in the treatment of acute bronchial asthma, chronic bronchitis and emphysema.

Methacholine Chloride (Acetyl-β-methylcholine chloride) is a quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma.

Trans-Tranilast is an antiallergic drug developed by Kissei Pharmaceuticals. It was approved in 1982 for use in Japan and South Korea for bronchial asthma. Indications for keloid and hypertrophic scar were added in 1993. It has been used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis.

Metaproterenol hemisulfate (Orciprenaline sulfate) is a beta-2 adrenergic agonist used in the treatment of ASTHMA and BRONCHIAL SPASM.

1,1-Diphenyl-4-(pyrrolidin-1-yl)but-2-yn-1-ol is an anticholinergic agent with potential for bronchial asthma research [1].

Histamine glutarimide is a novel small molecule agent functioning as an inhibitor of glutaminyl-peptide cyclotransferase (QPCT), which targets key inflammatory processes including eosinophilic migration and mast cell degranulation, Histamine glutarimide has demonstrated significant anti-asthmatic effects in various preclinical animal models of allergic asthma.

Quinetolate, a quinolone derivative, is utilized in the treatment of bronchial asthma.

ADORA2A PDE4D-IN-1 (Compound 9) is a dual inhibitor of the adenosine A2a receptor (ADORA2A) and phosphodiesterase 4D (PDE4D). This compound is applicable for research in bronchial asthma.

Tulobuterol is mainly used for the prevention and treatment of bronchial asthma, asthmatic bronchitis and chronic bronchitis. Research shows that it could inhibit rhinovirus infection in primary cultures of human tracheal epithelial cells.

Isoprenaline (Norisodrine) is a non-selective and orally active β-adrenoceptor agonist.Isoproterenol is a potent peripheral vasodilator and bronchodilator.Isoproterenol can be used in the study of bradycardia and bronchial asthma for the treatment of heart block, bradycardia.

APC 366 is a selective tryptase inhibitor (Ki = 7.1 μM). Tryptase is a serine protease released during mast cell degranulation, which reduces acute airway responses to allergens and can be used for asthma allergy treatment.

Tranilast Sodium has been used for the treatment of bronchial asthma. Tranilast is also used to autoimmune diseases, atopic and fibrotic pat.

Andolast, also known as CR-2039, an anti-allergic agent for the treatment of bronchial asthma, chronic obstructive pulmonary disease (COPD). Andolast acts at different cellular levels to inhibit immunoglobulin E synthesis. Andolast proved to be significan

S-5751, a prostanoid DP (DP1) antagonist, is used potentially for the treatment of bronchial asthma.

Arpenal is a ganglionic blocking agent which may be useful in the treatment of bronchial asthma.

Arpenal HCl is a ganglionic blocking agent which may be useful in the treatment of bronchial asthma.

Betahistine (Vasomotal) is a histamine analog and H1 receptor agonist that serves as a vasodilator. It is used in MENIERE DISEASE and in vascular headaches but may exacerbate bronchial asthma and peptic ulcers. Betahistine dihydrochloride is an anti-vertigo drug. It is commonly prescribed for balance disorders or to alleviate vertigo symptoms associated with Ménière's disease.

Pemirolast is an orally active antiallergic agent that attenuates paclitaxel hypersensitivity reactions by inhibiting the release of sensory neuropeptides, and can be used for bronchial asthma and conjunctivitis research [1] - [5].