b-ngf

Anti-NGF/bNGF Antibody is a humanized monoclonal antibody that binds specifically to β-NGF (bNGF) with high affinity, blocking its interaction with TrkA and p75NTR receptors and inhibiting downstream signaling. It serves as an important pharmacological tool for researching chronic pain, inflammatory pain, and neurogenic inflammation.

Anti-NGF/bNGF Antibody (AS2886401-00) is a human monoclonal antibody (mAb) targeting NGF/bNGF. It inhibits intracellular calcium (Ca2+) influx and provides sustained analgesic effects during movement in an osteoarthritis (OA) rat model. This antibody is applicable for research in osteoarthritis.

Rasagiline-13C3 (mesylate) is intended for use as an internal standard for the quantification of rasagiline by GC- or LC-MS. Rasagiline (mesylate) (T6962) is an inhibitor of monoamine oxidase B (MAO-B; IC50= 4.43 nM for the rat brain enzyme).1It is selective for MAO-B over MAO-A (IC50= 412 nM for the rat brain enzyme). It inhibits serum and NGF withdrawal-induced apoptosis of PC12 cells when used at concentrations ranging from 0.01 to 100 μM.2Rasagiline inhibits rat brain MAO-Bin vivo (ED50= 0.1 mg/kg).1It reduces cerebral edema in a mouse model of traumatic brain injury.2Rasagiline (0.1 mg/kg) reduces cortical and hippocampal levels of full-length and soluble amyloid precursor protein (APP) in rats and mice. It also reduces α-synuclein-induced substantia nigral neuron loss and improves motor dysfunction in a mouse model of Parkinson's disease.3Formulations containing rasagiline have been used in the treatment of Parkinson's disease.

Methyl Ganoderic acid B, a triterpenoid isolated from Ganoderma lucidum, exhibits neuronal survival-promoting effects similar to nerve growth factor (NGF-like) [1].

B355252 protects against cell death caused by glutamate-evoked oxidative stress. B355252 shows neuroprotective effect, potentiating nerve growth factor (NGF)-induced neurite outgrowth.

Indocarbazostatin B inhibits NGF-induced neurite outgrowth in rat pheochromocytoma PC12 cells at a minimum effective concentration of 24 nM.

Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±-synuclein, it may have potential therapeutic effects on Parkinson disease, Alzheimer disease and Huntington disease.

Gentiside B is a potent inducer of neurite outgrowth on PC12 cells, it shows a significant neuritogenic activity at 30 microM against PC12 cells that is comparable to that seen for the best nerve growth factor (NGF) concentration of 40 ng/mL.

Erinacin B, an active product extracted from the mycelia of Hericium erinaceum, exhibits potent stimulation of nerve growth factor (NGF) synthesis [1].