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Search Result

Search Results for " arthritic "

Targets

p38 MAPK TNF

14

Compounds

9

Natural Products

4

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T2367 SKF-86002 SKF86002 p38 MAPK , TNF
SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM).
T10839 Clozic Clobuzarit,ICI 55897 Others
Clozic (ICI 55897) exhibits reversible anti-proliferative effects and can be used in studies about serving as a potential anti-arthritic agent.
T4561 Tiaprofenic acid Tiaprofensaeure,Acido tiaprofenico,Surgam Others , COX
Tiaprofenic acid (Acido tiaprofenico) is a non-steroidal anti-inflammatory drug used to treat pain, especially arthritic pain.
T6687 Suprofen Maldocil,Suprol,TN-762,Profenal COX , PGE Synthase
Suprofen (Suprol) is an IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic.
T23681 AHR-15010 AHR 15010
AHR-15010 is a novel anti-arthritic agent.
T41059 Resolvin D3 RvD3
Resolvin D3 (RvD3) is a dysregulated mediator originating from docosahexaenoic acid (DHA). It plays a crucial role in reducing arthritic inflammation.
TP2153 RC-3095 acetate Others
RC-3095 acetate is an antagonist of bombesin/gastrin-releasing peptide receptor (GRPR). It exerts protective effects by reducing gastric oxidative injury in the arthritic mice.
T72655 3'-Sialyllactose 3'-SL
3'-Sialyllactose (3'-SL), a prebiotic with anti-inflammatory and anti-arthritic properties, plays a role in maintaining immune homeostasis. As a common carbohydrate with the lowest toxicity level, it is utilized in infla...
T63315 IRAK4-IN-19
IRAK4-IN-19 is a potent inhibitor of interleukin 1 receptor-associated kinase 4 (IRAK4) (IC50: 4.3 nM).IRAK4-IN-19 inhibits LPS-induced IL23 production in THP and DC cells and suppresses the development of arthritis in a...
T38327 Cryogenine
Cryogenine is an alkaloid originally isolated from H. salicifolia that has anti-inflammatory activity.1 It inhibits prostaglandin synthetase (IC50 = 424 μM). Cryogenine (100 mg/kg per day, p.o.) reduces paw edema and the...
T68266 BMS-751324
BMS-751324, a p38α MAPK inhibitor, features a carbamyl-methyl linkage precursor with esters and phosphate functional groups from hydroxyphenylacetic acid (HPA). It effectively reduces foot swelling and suppresses LPS-ind...
T62950 IRAK4-IN-18
IRAK4-IN-18 is a potent inhibitor of interleukin 1 receptor-associated kinase 4 (IRAK4) (IC50: 15 nM). IRAK4-IN-18 inhibits LPS-induced IL23 production in THP and DC cells and blocks the development of arthritis in rats,...
T62969 PDE4-IN-6
PDE4-IN-6 is a safe, potent and moderately selective inhibitor of PDE4, acting on PDE4B (IC50: 0.125 μM) and PDE4D (IC50: 0.43 μM). PDE4-IN-6 is able to down-regulate TNF-α and IL-6 expression levels, exhibits anti-infla...
T36679 Rp-cAMPS sodium salt
Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 μM and 4.5 μM, respectively) antagonist. Rp-cAMPS sodium salt is resistant to hydrolysis b...
Cat No. Product Name Synonyms Targets
TJS2216 Aurantiamide acetate Asperglaucide Cysteine Protease
Aurantiamide acetate (Asperglaucide) was isolated from the fermentation broth of Aspergillus penicilloides for the first time. Aurantiamide acetate is a selective and orally active cathepsin inhibitor. Aurantiamide aceta...
T5S2059 Glaucine Calcium Channel , Dopamine Receptor , Influenza Virus , Adrenergic Receptor , PDE
Glaucine has antitussive, antioxidative potential and antiviral activities, it may be an anti-arthritic agent, it can enhance LPS and zymosan-induced IL-10 production. Glaucine can inhibit the migration and invasion of h...
TN1438 Beta-Amyrin acetate Antioxidant , HMG-CoA Reductase , Epoxide Hydrolase , Antifungal
beta-Amyrin acetate inhibits HMG-CoA Reductase (HMGCR) and sEH activity with IC50 of 3.4 μM. beta-Amyrin acetate has anti-inflammatory, antifungal, antioxidant, and anti-hyperlipidemic activities.
T2895 Lupeol Fagarasterol,Monogynol B,Clerodol,(3β,13ξ)-Lup-20(29)-en-3-ol,Farganasterol Apoptosis , Androgen Receptor , Akt
Lupeol (Monogynol B) is a novel androgen receptor inhibitor with anti-inflammatory and antioxidant activity.
TN1877 Lonicerin Apoptosis , Antibacterial
Lonicerin has antioxidant, anti-arthritic and antifungal activities, it can result in a combination therapy for the treatment of fungal arthritis due to C. albicans infection.
TN1507 Clematichinenoside AR TNF , Autophagy
Clematichinenoside AR exerts anti-inflammatory and immunosuppressive properties, it has anti-arthritic effects on PI3K/Akt signaling pathway and TNF-α± associated with collagen-induced arthritis.
T4S1050 Pristimerin Celastrol methyl ester NF-κB , Antibacterial
1. Pristimerin (Celastrol methyl ester) has anticancer activity , treatment with Pristimerin may be a potential strategy for the suppression of hypoxia-induced metastasis through the reversal of hypoxia-induced stem cell...
T4S1943 Kirenol Kirel Wnt/beta-catenin
1. Kirenol (Kirel) has anti-oxidant, anti-inflammatory, anti-allergic, and anti-arthritic activities. 2. Kirenol is effective against gram-positive bacteria. 3. Kirenol possesses antitumor action on human chronic myeloid...
T11895 Luteolin-7-rutinoside Others
Luteolin-7-rutinoside has both antifungal activities and anti-arthritic, can result in a combination therapy for the treatment of fungal arthritis due to C. albicans infection.

Natural Products

Aurantiamide acetate
TJS2216
Synonym: Asperglaucide
Target: Cysteine Protease
Glaucine
T5S2059
Synonym:
Target: Calcium Channel, Dopamine Receptor, Influenza Virus, Adrenergic Receptor, PDE
beta-Amyrin acetate
TN1438
Synonym:
Target: Antioxidant, HMG-CoA Reductase, Epoxide Hydrolase, Antifungal
Lupeol
T2895
Synonym: Fagarasterol,Monogynol B,Clerodol,(3β,13ξ)-Lup-20(29)-en-3-ol,Farganasterol
Target: Apoptosis, Androgen Receptor, Akt
Lonicerin
TN1877
Synonym:
Target: Apoptosis, Antibacterial
Clematichinenoside AR
TN1507
Synonym:
Target: TNF, Autophagy
Pristimerin
T4S1050
Synonym: Celastrol methyl ester
Target: NF-κB, Antibacterial
Kirenol
T4S1943
Synonym: Kirel
Target: Wnt/beta-catenin
Luteolin-7-rutinoside
T11895
Synonym:
Target: Others

Recombinant Proteins

Species：
Human (2)
Mouse (2)
Expression System：
HEK293 (3)
E. coli (1)
Tag：
His (3)
N-terminal GST-tagged (1)
Cat No. Product Name Species Expression System
TMPH-00867 ADAMTS4 Protein, Human, Recombinant (GST) Human E. coli
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neu...
TMPY-01933 CHI3L2 Protein, Human, Recombinant (His) Human HEK293
Chondrocyte protein 39 (YKL-39), also known as Chitinase 3-like 2 (CHI3L2), is a secretory protein of articular chondrocytes belonging to the glycosyl hydrolase 18 family. Its highest expression is in chondrocytes, follo...
TMPY-02163 PGLYRP1 Protein, Mouse, Recombinant (His) Mouse HEK293
Peptidoglycan recognition protein 1, also known as Peptidoglycan recognition protein short, PGRP-S, PGLYRP1, PGLYRP, PGRP and TNFSF3L, is a secreted protein that belongs to the N-acetylmuramoyl-L-alanine amidase 2 family...
TMPY-01852 CHST3 Protein, Mouse, Recombinant (His) Mouse HEK293
Carbohydrate sulfotransferase 3, also known as Chondroitin 6-O-sulfotransferase 1, Chondroitin 6-sulfotransferase and CHST3, is a single-pass type II membrane protein which belongs to thesulfotransferase 1 family and ...
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