a-ctx

ω-Hexatoxin-Hv1a, a neurotoxin extracted from the venom of the spider Hadronyche versuta, inhibits voltage-gated calcium channels [1] [2].

alpha-Conotoxin imi is a nicotinic acetylcholine receptor ligand.

Temozolomide (TMZ) is a DNA alkylating agent with blood-brain barrier permeability and oral activity. Temozolomide has antitumor activity and antiangiogenic activity, and also induces apoptosis and autophagy. Temozolomide is stable under acidic conditions and hydrolyzes under neutral or slightly alkaline conditions.

Avibactam free acid is a potent β-lactamase inhibitor exhibiting covalent and reversible properties, capable of inhibiting TEM-1, P99, and CTX-M-15 at nanomolar concentrations. Avibactam free acid and Ceftazidime may be combined for treating urinary tract infections.

CCR4 antagonist 2 (Compound 31) is a novel, potent, orally bioavailable small molecule antagonist of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues. CCR4 antagonist 2 (Compound 31) exhibits IC50 values of Ca2+ flux and [chemotaxis] CTX at 40 nM and 70 nM, respectively.

CTX-0294885, a novel bisanilino pyrimidine, exhibits inhibitory activity against a broad range of kinases in vitro and is further developed into a Sepharose-supported kinase capture reagent.

Doxazosin impurity 12 acts as an inhibitor of CTX-M β-lactamase (Beta-lactamase) with a Ki value of 0.7 mM against CTX-M.

5β-Cholestane-3α,7α,12α,25-tetrol is a type of bile acid alcohol that activates the G protein-coupled bile acid receptor 1 (GPBAR1), also known as TGR5, in HEK293 cells that express the human receptor, at concentrations between 0.1 to 10 µM. In individuals with cerebrotendinous xanthomatosis (CTX), a progressive metabolic leukodystrophy, levels of this compound are elevated in the blood, feces, and bile.

FPI-1523, a derivative of Avibactam, is a potent inhibitor of β-lactamase enzymes with Kd values of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. It also inhibits PBP2 with an IC50 of 3.2 μM and demonstrates significant antimicrobial activity.

FPI-1523 sodium, a derivative of avibactam, is a potent β-lactamase inhibitor with Kd values of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. It inhibited PBP2 with an IC50 of 3.2 μM and has a high level of antibacterial and considerable antimicrobial activity.

CCR4 antagonist 3 is an orally active, potent and selective CCR4 antagonist. CCR4 antagonist 3, featuring a novel piperidinyl-azetidine motif, has IC 50 s of 22 nM and 50 nM in the calcium flux and CTX assay. CCR4 antagonist 3 has antitumor activity.

CCR4 antagonist 3 hydrochloride is an orally active, potent and selective CCR4 antagonist. CCR4 antagonist 3, featuring a novel piperidinyl-azetidine motif, has IC 50 s of 22 nM and 50 nM in the calcium flux and CTX assay. CCR4 antagonist 3 has antitumor activity.

Avibactam sodium hydrate (NXL-104 hydrate) is a highly effective β-lactamase inhibitor that inhibits β-lactamases TEM-1 and CTX-M-15, as well as the carbapenemase produced by Klebsiella pneumoniae and carbapenem-resistant Enterobacteriaceae.

Avibactam sodium (NXL-104) dihydrate inhibits CTX-M-15 and β-lactamase TEM-1 with IC50 values of 5 nM and 8 nM, respectively, and is a reversible covalent inhibitor of non-β-lactam β-lactamase [1].

FPI-1465 is a dual inhibitor of serine-β-Lactamases and Penicillin-binding proteins (PBPs), demonstrating inhibition of PBP2 with an IC50 of 1.0 μg/mL. Additionally, it exhibits activity against β-lactamase CTX-M-15 and OXA-48, with dissociation constants (Kd) of 0.011 μM and 5.3 μM, respectively [1].

CTX-712 is a potent inhibitor of cdc2-like kinase (CLK), effectively reducing cancer cell growth and survival.

CTX-0124143 is a histone acetyltransferase inhibitor with an IC50 value of 1.0 μM for KAT6A.CTX-0124143 can be used to study cellular senescence.

CTX-0294885 hydrochloride is a broad-spectrum kinase inhibitor capable of capturing 235 kinases from MDA-MB-231 cells, including all members of the AKT family. This compound serves as a potent tool for analyzing kinome signaling networks and holds potential for research into diseases such as inflammation, diabetes, and cancer.

Desacetylcefotaxime, an in vivo metabolite of Cefotaxime (CTX), exhibits noteworthy in vitro antimicrobial efficacy, akin to its parent compound, against a broad spectrum of aerobic and anaerobic bacteria [1].

CTX-471 is a fully humanized monoclonal antibody targeting CD137, exhibiting agonistic activity and binding affinity (Kd=50/61/748 nM) to recombinant human, cynomolgus monkey, and mouse CD137. It enhances T cell and natural killer cell activation, making it suitable for studying immunomodulation and cancer.

CTX-2026, a fully human antibody, targets and binds to CD277, demonstrating an anti-tumor effect in ovarian tumor models, and is utilized in cancer research [1].

PF-9363 (CTX-3648) is a potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer.

Cardiotoxin Analog (CTX) IV (6-12) TFA, a partial peptide of Cardiotoxin Analog IV, is derived from the venom of the Taiwan Cobra, showcasing the unique properties of snake venom cardiotoxin.

Cardiotoxin Analog (CTX) IV (6-12) is a peptide fragment of Cardiotoxin Analog (CTX) IV, isolated from the venom of the Taiwan Cobra (Naja atra).