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Search Results for " threonine proteases "

Targets

26

Compounds

2

Natural Products

Cat No. Product Name Synonyms Targets
T7017 WNK463 Serine/threonin kinase
WNK463 is a pan-WNK-kinase inhibitor. It effectively inhibits the in vitro kinase activity of all four WNK family members (WNK1/2/3/4).
TP1277 Bradykinin Endogenous Metabolite , Bradykinin Receptor
Bradykinin is an inflammatory mediator. It is a peptide that causes blood vessels to dilate (enlarge) via the release of prostacyclin, nitric oxide, and Endothelium-Derived Hyperpolarizing Factor. Bradykinin is a physiol...
T11666 IPR-803 Serine/threonin kinase
IPR-803 is an effective inhibitor of the uPAR·uPA protein-protein interaction (PPI) with anti-tumor activity. IPR-803 binds directly to uPAR with a Ki of 0.2 μM.
T9920 Evolocumab Others
Evolocumab is a human IgG2 monoclonal antibody that binds to human PCSK9 Proprotein Convertase Subtilisin Kexin Type 9).
T10547 BioE-1115 Serine/threonin kinase , Casein Kinase
BioE-1115 is a selective and potent inhibitor of serine-threonine protein kinase (PASK, IC50 = 4 nM). BioE-1115 is a potent inhibitor of CK2α (IC50 = 10 μM).
T4058 R-IMPP Others , Serine/threonin kinase
R-IMPP is an inhibitor of PCSK9 translation. R-IMPP stimulates uptake of LDL-C in hepatoma cells by increasing LDL-R levels, without altering levels of secreted transferrin.
T11885 LSP-249 Others
LSP-249 is a plasma kallikrein inhibitor under the study for angioedema, with an EC50 less than 100 nM in cell.
T13257 Upamostat PAI-1 , Serine/threonin kinase , Serine Protease
Upamostat is an inhibitor of a serine protease and is a urokinase plasminogen activator (uPA) inhibitor.
T8350 TPCK Proteasome
TPCK is an irreversible inhibitor of chymotrypsin-like proteases that affect cell proliferation, apoptosis, and tumorigenesis
T4524 SBC-110736 SBC110736 Others , Serine/threonin kinase
SBC-110736 is a proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor
T8676 FOY 251 Others , Serine/threonin kinase , SARS-CoV
FOY 251 is a proteinase inhibitor, and is an anti-proteolytic active metabolite camostate.
T9276 SBC-115337 Others , Serine/threonin kinase
SBC-115337 is a PCSK9 inhibitor.
T14358 Avoralstat BCX4161 Others
Avoralstat (BCX4161) is an oral plasma kallikrein (PKK) inhibitor. Which is used for the treatment of hereditary angioedema.
T8362 Benzamidine hydrochloride Benzamidine HCl Serine/threonin kinase , Serine Protease
Benzamidine hydrochloride (Benzamidine HCl) is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Ki of 35, 350, and 220 μM, respectively).
T5456 WNK-IN-11 Allosteric WNK Kinase Inhibitor Serine/threonin kinase
WNK-IN-11 (Allosteric WNK Kinase Inhibitor) is an allosteric With-No-Lysine (WNK) kinase inhibitor,WNK1(IC50 : 4 nM)
T8645 PF-06446846 Others
PF 06446846 is a potent and selective PCSK9 inhibitor
T2626 SBC-115076 SBC115076 Others , Serine/threonin kinase
SBC-115076 is a potent extracellular proprotein convertase subtilisin kexin type 9 (PCSK9) antagonist.
T6370 AEBSF hydrochloride AEBSF HCl,Pefabloc SC Thrombin , Serine Protease , Influenza Virus
AEBSF hydrochloride (Pefabloc SC) is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, thrombin, plasmin, and trypsin.
T13408 ZK824190 Others , Serine Protease
ZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA) as a potential treatment for multiple sclerosis(IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively).
T3359 Aprotinin Bovine Pancreatic Trypsin Inhibitor,Traskolan,Antilysin Others , Serine Protease , Influenza Virus , Proteasome
Aprotinin (Traskolan) a broad-spectrum serine protease inhibitor, inhibiting the activity of a number of different esterases and proteases, including trypsin, chymotrypsin, kallikrein, plasmin, tissue plasminogen activat...
T2392 Nafamostat mesylate FUT-175 Apoptosis , Serine/threonin kinase , SARS-CoV , Serine Protease
Nafamostat mesylate (FUT-175), a synthetic serine protease inhibitor, has been used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis.
T31206 Darexaban YM 150,Darexaban, Tanexaban,YM150 Factor Xa
Darexaban (Tanexaban, YM-150) is a direct inhibitor of Factor Xa.Darexaban and Darexaban glucuronide selectively and competitively inhibit FXA and inhibit prothrombin activity at the site of blood clot (thrombus) formati...
T19763 Cetraxate hydrochloride DV-1006,DV 1006,Cetraxate HCl,DV1006 Serine/threonin kinase
Cetraxate hydrochloride (DV10062) is an oral gastrointestinal medication. It has a cytoprotective effect.
T8936 Proteinase K proteinase K for tritirachium album,Protease K Others
Proteinase K (proteinase K for tritirachium album) is a nonspecific serine protease that is useful for general digestion of proteins. It is active in the presence of SDS or urea and over a wide range of pH (4-12), salt c...
T2391 Camostat mesylate FOY-S980,FOY305,Camostat mesilate Serine/threonin kinase , SARS-CoV , Sodium Channel
Camostat mesylate (FOY-S980) is a trypsin-like protease inhibitor and inhibits airway epithelial sodium channel (ENaC) function.
T80094 Dansyl-Glu-Gly-Arg-Chloromethylketone
Dansyl-Glu-Gly-Arg-Chloromethylketone is a protease inhibitor that specifically impedes serine/threonine proteases and has been shown to inhibit activated porcine factor IX [1].

Compounds

WNK463
T7017
Synonym:
Target: Serine/threonin kinase
Bradykinin
TP1277
Synonym:
Target: Endogenous Metabolite, Bradykinin Receptor
IPR-803
T11666
Synonym:
Target: Serine/threonin kinase
Evolocumab
T9920
Synonym:
Target: Others
BioE-1115
T10547
Synonym:
Target: Serine/threonin kinase, Casein Kinase
R-IMPP
T4058
Synonym:
Target: Others, Serine/threonin kinase
LSP-249
T11885
Synonym:
Target: Others
Upamostat
T13257
Synonym:
Target: PAI-1, Serine/threonin kinase, Serine Protease
TPCK
T8350
Synonym:
Target: Proteasome
SBC-110736
T4524
Synonym: SBC110736
Target: Others, Serine/threonin kinase
FOY 251
T8676
Synonym:
Target: Others, Serine/threonin kinase, SARS-CoV
SBC-115337
T9276
Synonym:
Target: Others, Serine/threonin kinase
Avoralstat
T14358
Synonym: BCX4161
Target: Others
Benzamidine hydrochloride
T8362
Synonym: Benzamidine HCl
Target: Serine/threonin kinase, Serine Protease
WNK-IN-11
T5456
Synonym: Allosteric WNK Kinase Inhibitor
Target: Serine/threonin kinase
PF-06446846
T8645
Synonym:
Target: Others
SBC-115076
T2626
Synonym: SBC115076
Target: Others, Serine/threonin kinase
AEBSF hydrochloride
T6370
Synonym: AEBSF HCl,Pefabloc SC
Target: Thrombin, Serine Protease, Influenza Virus
ZK824190
T13408
Synonym:
Target: Others, Serine Protease
Aprotinin
T3359
Synonym: Bovine Pancreatic Trypsin Inhibitor,Traskolan,Antilysin
Target: Others, Serine Protease, Influenza Virus, Proteasome
Nafamostat mesylate
T2392
Synonym: FUT-175
Target: Apoptosis, Serine/threonin kinase, SARS-CoV, Serine Protease
Darexaban
T31206
Synonym: YM 150,Darexaban, Tanexaban,YM150
Target: Factor Xa
Cetraxate hydrochloride
T19763
Synonym: DV-1006,DV 1006,Cetraxate HCl,DV1006
Target: Serine/threonin kinase
Proteinase K
T8936
Synonym: proteinase K for tritirachium album,Protease K
Target: Others
Camostat mesylate
T2391
Synonym: FOY-S980,FOY305,Camostat mesilate
Target: Serine/threonin kinase, SARS-CoV, Sodium Channel
Dansyl-Glu-Gly-Arg-Chloromethylketone
T80094
Synonym:
Target:
Cat No. Product Name Synonyms Targets
TN2082 Pinostrobin Beta Amyloid , IL Receptor , Serine/threonin kinase , TNF
Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα²(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative damage and calcium overload, as well as suppress...
T5S0689 Demethylwedelolactone Serine Protease
Demethylwedelolactone is a natural product isolated from Eclipta alba, has trypsin inhibitory effect an IC50 of 3.0 μM. it exerts anti-invasive growth effect on breast cancer cells.
TargetMol