Home Tools
Log in
Cart

Search Result

Search Results for " tnbc "

55

Compounds

4

Natural Products

8

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T39815 Anti-TNBC agent-1
anti-TNBC agent-1 is a highly effective compound specifically designed to target and combat triple-negative breast cancer (TNBC). It demonstrates remarkable potency against various breast cancer cell types, with IC50 val...
T79699 Anti-TNBC agent-2 Apoptosis
Anti-TNBC agent-2 (3j), a purine derivative, acts as an anti-triple negative breast cancer (TNBC) therapeutic. It promotes apoptosis in MDA-MB-231 cells, while also inhibiting their migration and angiogenesis. Moreover, ...
T79410 Anti-TNBC agent-3
Anti-TNBC agent-3 (compound 3g) is a compound that induces apoptosis and possesses anti-cancer cell proliferation properties. It effectively inhibits tumor growth and metastasis in xenograft models of triple-negative bre...
T9407 Rasarfin Others , Ras
Rasarfin inhibits Ras and ARF6.
T10268 AGX51 Others
AGX51 is an antagonist of inhibitor of DNA binding (ID) proteins. AGX51 treatment lead to pan-Id degradation, cell cycle arrest, and cell death.
T9468 FR054 Others
FR054 is an inhibitor of the Hexosamine Biosynthetic Pathway (HBP) enzyme PGM3, with a remarkable anti-breast cancer effect. FR054 induces in different breast cancer cells a dramatic decrease in cell proliferation and su...
T2436 GSK2801 Apoptosis , Epigenetic Reader Domain
GSK2801 is an effective, specific and cell active acetyl-lysine competitive inhibitor of BAZ2A(Kd: 136 nM) and BAZ2B(Kd: 257 nM) bromodomains.
T8850 Sbp-7455 Autophagy
SBP-7455 potently inhibited ULK1/2 enzymatic activity in vitro and in cells, reduced the viability of TNBC cells and had oral bioavailability in mice.
T13780 MS1943 Apoptosis , Histone Methyltransferase
MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM).
T4325 COTI-2 COTI 2,COTI2 Apoptosis , p53
COTI-2, an orally available thiosemicarbazone, is an activator of mutant forms of the p53 protein with potential antineoplastic activity.
T6797 Telaglenastat CB 839,CB839,CB-839 transporter , Glutaminase , Autophagy
Telaglenastat (CB 839) (IC50 of 24 nM), an effective, specific, and oral inhibitor, which is bioavailable glutaminase, for recombinant human GAC.
T16961 Supinoxin RX-5902 Apoptosis , DNA/RNA Synthesis
Supinoxin (RX-5902) is an orally active inhibitor of phosphorylated-p68 RNA helicase and a potent first-in-class anti-cancer agent. Supinoxin induces cell apoptosis and inhibits the growth of TNBC cancer cell lines (IC50...
T9320 YK-3-237 B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid Sirtuin
YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferative effects toward triple-negative breast cancer (TNBC) cells ca...
T8934 (6R)-FR054 FR054 Apoptosis , Others
(6R)-FR054 is an inhibitor of the Hexosamine Biosynthetic Pathway (HBP) enzyme PGM3, with a remarkable anti-breast cancer effect.
T8808L LYN-1604 dihydrochloride LYN-1604 2HCl(2216753-86-3 free base) Apoptosis , Autophagy
LYN-1604 is a novel ULK1 activator.It inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.
T4123 LYN-1604 LYN1604 Apoptosis , Autophagy
LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.
T13044 Mevociclib SY-1365 CDK
Mevociclib (SY-1365) is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors.
T35528 TD52 Apoptosis , Phosphatase , Akt
TD52 is an orally active inhibitor of cancerous inhibitor of PP2A (CIP2A). TD52 is an Erlotinib derivative and indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter.
T70353 JG-231 HSP
JG-231 is a JG-98 analog with anticancer activity.JG-231 inhibits the MDA-MB-231 xenograft tumor model of triple-negative breast cancer (TNBC).JG-231 inhibits the interaction of Hsp70-BAG3.JG-231 inhibits the MDA-MB-231 ...
T74178 Glembatumumab vedotin CR011-vcMMAE,CR 011 ADC,CDX-011 Microtubule Associated
Glembatumumab vedotin (CDX-011) is an antibody-activated small molecule coupling, Glembatumumab vedotin has potent anticancer effects and can be used in the study of triple negative breast cancer (TNBC).
T14685 BMS-986158 Epigenetic Reader Domain
BMS-986158 is a potent BET inhibitor with IC50s of 6.6 and 5 nM in NCI-H211 small cell lung cancer (SCLC) cells and MDA-MB231 triple negative breast cancer (TNBC) cells, respectively.
T5351L PU-WS13 hydrobromide PU-WS13 hydrobromide (1454619-14-7 Free base) GPR
PU-WS13 hydrobromide is a GRP94 inhibitor with anti-inflammatory activity and inhibits the proliferation of M2-like macrophages in mouse TNBC tumors.
T77759 GPX4-IN-6 GPX
GPX4-IN-6 is a small molecule covalent GPX4 inhibitor (IC50: 0.12 μM) with antitumour activity.GPX4-IN-6 induces iron death and is used for the treatment= and prevention of triple negative breast cancer (TNBC).
T6224 Iniparib NSC-746045,IND-71677,BSI-201 PARP , Influenza Virus
Iniparib (BSI-201) (BSI-201) , a PARP1 inhibitor, exhibits potency in triple-negative breast Y (TNBC).
T77755 GPX4-IN-5 GPX
GPX4-IN-5 is a small molecule covalent GPX4 inhibitor (IC50: 0.12 μM) with antitumour activity.GPX4-IN-5 induces iron death and can be used for the prevention and treatment of triple-negative breast cancer (TNBC).
T7296 THZ2 CDK7-IN-1 CDK
THZ2 (CDK7-IN-1), an analog of THZ1, is a potent and selective CDK7 inhibitor(IC50:13.9 nM),with the potential to treat Triple-negative breast cancer (TNBC).
T8325 SR-4835 Apoptosis , CDK
SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13(CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM), which disables triple-negative breast cancer (TNBC) cells
T35528L TD52 dihydrochloride TD52 dihydrochloride(1798328-24-1 Free base),TD52 2HCl Others
TD52 dihydrochloride (TD52 2HCl), a derivative of Erlotinib, is a potent and orally active inhibitor of protein phosphatase 2A (CIP2A). It exhibits strong anti-cancer properties by regulating the CIP2A/PP2A/p-Akt signali...
T31539 DK-1-150 DK-1150,DK 1-150,DK1-150,DK 1 150
DK-1-150 is an inducer of apoptotic cell death in TNBC cell lines without causing cytotoxicity in the normal mammary epithelial cell line.
T79405 PARP1-IN-15 PARP
PARP1-IN-15 (Compound 6) is a PARP1 inhibitor that also inhibits tankyrase (TNKS) and promotes DNA double-strand breaks, leading to tumor cell apoptosis. It exhibits anti-cancer activity in triple-negative breast cancer ...
T31540 DK-1-166 DK1-166,DK 1-166,DK-1166
DK-1-166 is a inducer of apoptotic cell death in TNBC cell lines without causing cytotoxicity in the normal mammary epithelial cell line.
T39687 LYN-1604 hydrochloride
LYN-1604 hydrochloride, a powerful activator of UNC-51-like kinase 1 (ULK1) with an EC50 value of 18.94 nM, has significant implications in the study of triple-negative breast cancer (TNBC).
T78787 PARP-1/2-IN-2 PARP
PARP-1/2-IN-2-IN-1 (Compound 12e) effectively inhibits PARP1/2 and CDK12 with IC 50 values of 34 nM, 30 nM, and 285 nM respectively, impairing DNA damage repair and inducing cell cycle arrest and apoptosis. This compound...
T74802 FAK-IN-9
FAK-IN-9 (Compound 8f) is a potent and orally active FAK inhibitor with an IC 50 of 27.44 nM. FAK-IN-9 induces triple-negative breast cancer (TNBC) cell apoptosis [1] .
T74675 MS8815
MS8815 is a selective enhancer of zeste homolog 2 (EZH2) PROTAC degrader. MS8815 has inhibition activity for EZH2 with an IC 50 value of 8.6 nM. MS8815 can be used for the research of triple-negative breast cancer (TNBC)...
T72836 SHP2/CDK4-IN-1
SHP2/CDK4-IN-1 (compound 10) is a dual inhibitor targeting SHP2 and CDK4, exhibiting oral activity and high potency with IC50 values of 4.3 nM for SHP2 and 18.2 nM for CDK4. It effectively induces G0/G1 arrest, inhibitin...
T82758 CDK9-Cyclin T1 PPI-IN-1 CDK
CDK9-Cyclin T1 PPI-IN-1 (Compound B19) is a selective inhibitor of the CDK9-Cyclin T1 protein-protein interaction (PPI), suppressing cell proliferation in TNBC MDA-MB-231 cells with an IC50 of 0.044 μM and inducing apopt...
T13889 SLLN-15 Others
SLLN-15 is an oral active, selective and potent enhancer of autophagy. SLLN-15 activates cytostatic macroautophagy/autophagy in triple-negative breast cancer (TNBC) [1].
T74359 PP-C8
PP-C8 is a potent and selective PROTAC CDK12-Cyclin K degrader. PP-C8 induces CDK12-Cyclin K degradation with DC 50 s of 416 and 412 nM for CDK12 and Cyclin K, respectively. PP-C8 demonstrates profound synergistic antipr...
T72946 G4/HDAC-IN-1
G4/HDAC-IN-1 is a G4/HDAC dual-targeting compound. G4/HDAC-IN-1 inhibits intracellular HDAC activity with an IC 50 value of 1.1 μM, and induces G4 formation. G4/HDAC-IN-1 inhibits TNBC proliferation and tumor growth in ...
T79776 ZZM-1220 Histone Methyltransferase
ZZM-1220, a covalent inhibitor of histone lysine methyltransferase G9a/GLP, exhibits IC50 values of 458 nM for G9a and 924 nM for GLP. It effectively inhibits H3K9me2 in cells, induces apoptosis in triple-negative breast...
T80217 BT1718 MMP
BT1718 is a bicyclic peptide conjugate that targets MT1-MMP, a protease overexpressed in various advanced solid tumors such as triple-negative breast cancer (TNBC) and non-small cell lung cancer [1] [2]. By exploiting MT...
T74784 LL-K8-22
LL-K8-22 is a potent, selective and durable CDK8-cyclin C dual degrader, with DC 50 values of 2.52 and 2.64 μM, respectively. LL-K8-22 also suppresses STAT1 Ser 727 phosphorylation. LL-K8-22 inhibits E2F- and MYC-driven ...
T79369 ZMF-23 PAK
ZMF-23, a PAK1/HDAC6 dual inhibitor, suppresses PAK1 and HDAC6-mediated aerobic glycolysis and cellular migration while inducing TNF-α-regulated necroptosis and augmenting apoptosis. The compound effectively hampers the ...
T78753 Aurora Kinases-IN-4 Aurora Kinase
Aurora Kinases-IN-4 (Compound 11c) is a covalent, ATP-competitive inhibitor of aurora kinase A with an IC50 value of 1.7 nM. It demonstrates cell proliferation inhibition in SJSA-1, MDA-MB-231, A549, and HeLa cell lines ...
T79780 IHMT-EZH2-426 Histone Methyltransferase
IHMT-EZH2-426 (compound 38) is a potent, covalent degrader of EZH2, demonstrating IC50 values of 1.3 nM for EZH2 wild-type, 1.2 nM for EZH2-A687V, and 1.7-3.5 nM for EZH2-Y641F/Y641N/Y641S mutants. The compound effective...
T61582 Anticancer agent 57
Anticancer agent 57 (compound 14) demonstrates potent inhibition of MDA-MB-231, MDA-MB-468, and MCF-7 cell lines, with IC 50 values ranging from 6.43 to 8.00 μM. Additionally, this agent induces cell cycle arrest and pro...
T63991 BRD4/CK2-IN-1
BRD4/CK2-IN-1 is the first potent, orally active dual-target inhibitor of BRD4/CK2 (bromodomain-containing protein 4/casein kinase 2), acting on both BRD4 (IC50: 180 nM) and CK2 (IC50: 230 nM). In triple-negative breast ...
T29172 YD277 YD 277,YD-277
YD277 is a small molecule derived from ML264, a KLF5 inhibitor that elicits cytotoxic effects in colon cancer cell lines. YD277 significantly induced G1 cell cycle arrest and apoptosis in MDA-MB-231 and MDA-MB-468 TNBC c...
T70344 BJ-2302
BJ-2302 is a SRC inhibitor. BJ-2302 effectively suppressed MDA-MB-231 cell invasion (Matrigel invasion assay) and metastasis (chorioallantoic membrane assay xenografted with MDA-MB-231-luc2-tdTomato cancer cells). Additi...

Compounds

anti-TNBC agent-1
T39815
Synonym:
Target:
anti-TNBC agent-2
T79699
Synonym:
Target: Apoptosis
anti-TNBC agent-3
T79410
Synonym:
Target:
Rasarfin
T9407
Synonym:
Target: Others, Ras
AGX51
T10268
Synonym:
Target: Others
FR054
T9468
Synonym:
Target: Others
GSK2801
T2436
Synonym:
Target: Apoptosis, Epigenetic Reader Domain
sbp-7455
T8850
Synonym:
Target: Autophagy
MS1943
T13780
Synonym:
Target: Apoptosis, Histone Methyltransferase
COTI-2
T4325
Synonym: COTI 2,COTI2
Target: Apoptosis, p53
Telaglenastat
T6797
Synonym: CB 839,CB839,CB-839
Target: transporter, Glutaminase, Autophagy
Supinoxin
T16961
Synonym: RX-5902
Target: Apoptosis, DNA/RNA Synthesis
YK-3-237
T9320
Synonym: B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid
Target: Sirtuin
(6R)-FR054
T8934
Synonym: FR054
Target: Apoptosis, Others
LYN-1604 dihydrochloride
T8808L
Synonym: LYN-1604 2HCl(2216753-86-3 free base)
Target: Apoptosis, Autophagy
LYN-1604
T4123
Synonym: LYN1604
Target: Apoptosis, Autophagy
Mevociclib
T13044
Synonym: SY-1365
Target: CDK
TD52
T35528
Synonym:
Target: Apoptosis, Phosphatase, Akt
JG-231
T70353
Synonym:
Target: HSP
Glembatumumab vedotin
T74178
Synonym: CR011-vcMMAE,CR 011 ADC,CDX-011
Target: Microtubule Associated
BMS-986158
T14685
Synonym:
Target: Epigenetic Reader Domain
PU-WS13 hydrobromide
T5351L
Synonym: PU-WS13 hydrobromide (1454619-14-7 Free base)
Target: GPR
GPX4-IN-6
T77759
Synonym:
Target: GPX
Iniparib
T6224
Synonym: NSC-746045,IND-71677,BSI-201
Target: PARP, Influenza Virus
GPX4-IN-5
T77755
Synonym:
Target: GPX
THZ2
T7296
Synonym: CDK7-IN-1
Target: CDK
SR-4835
T8325
Synonym:
Target: Apoptosis, CDK
TD52 dihydrochloride
T35528L
Synonym: TD52 dihydrochloride(1798328-24-1 Free base),TD52 2HCl
Target: Others
DK-1-150
T31539
Synonym: DK-1150,DK 1-150,DK1-150,DK 1 150
Target:
PARP1-IN-15
T79405
Synonym:
Target: PARP
DK-1-166
T31540
Synonym: DK1-166,DK 1-166,DK-1166
Target:
LYN-1604 hydrochloride
T39687
Synonym:
Target:
PARP-1/2-IN-2
T78787
Synonym:
Target: PARP
FAK-IN-9
T74802
Synonym:
Target:
MS8815
T74675
Synonym:
Target:
SHP2/CDK4-IN-1
T72836
Synonym:
Target:
CDK9-Cyclin T1 PPI-IN-1
T82758
Synonym:
Target: CDK
SLLN-15
T13889
Synonym:
Target: Others
PP-C8
T74359
Synonym:
Target:
G4/HDAC-IN-1
T72946
Synonym:
Target:
ZZM-1220
T79776
Synonym:
Target: Histone Methyltransferase
BT1718
T80217
Synonym:
Target: MMP
LL-K8-22
T74784
Synonym:
Target:
ZMF-23
T79369
Synonym:
Target: PAK
Aurora Kinases-IN-4
T78753
Synonym:
Target: Aurora Kinase
IHMT-EZH2-426
T79780
Synonym:
Target: Histone Methyltransferase
Anticancer agent 57
T61582
Synonym:
Target:
BRD4/CK2-IN-1
T63991
Synonym:
Target:
YD277
T29172
Synonym: YD 277,YD-277
Target:
BJ-2302
T70344
Synonym:
Target:
1 2
Cat No. Product Name Synonyms Targets
T7979 2-Hydroxychalcone 2-(2-Hydroxybenzal)Acetophenone Apoptosis , BCL , Others , NF-κB
2-Hydroxychalcone (2-(2-Hydroxybenzal)Acetophenone) can be used as antiparasitic hit compounds when Methoxylated.It can inhibit invasion of triple negative breast cancer cells.
T4S1383 Escin IA Aescin IA,Escin IA;Aescin IA,Escin IA HIV Protease
Escin IA (Escin IA;Aescin IA) is a triterpene saponin isolated from horse chestnut, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved ...
TN1493 Chrysosplenol D IL Receptor , NF-κB , JNK
Chrysosplenol D, an efflux pump inhibitor that can potentiate the activity of commercially important antibiotics and antimalarials.
TN2691 2',3'-Dehydrosalannol BCL , Akt , Caspase
2',3'-Dehydrosalannol possesses antifeedant activity against Spodptera litura. It shows anticancer effects on triple-negative breast cancer(TNBC), it inhibits cathepsin-mediated pro-survival signaling which resulted in g...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPK-00785 ANXA2 Protein, Mouse, Recombinant (His) Mouse E. coli
ANXA2, highly expressed in invasive breast cancer cells, is closely related with poor prognosis, and acts as a molecular switch to EGFR activation. ANXA2 expression is inversely correlated with cell sensitivity to gefiti...
TMPY-04203 RAB1B Protein, Human, Recombinant (hFc) Human HEK293
RAB1B, a member of the RAS oncogene family, was significantly down-regulated in highly metastatic breast cancer cells. Moreover, down-regulation of RAB1B was also found to promote the proliferation and migration of TNBC ...
TMPK-00941 TFF1 Protein, Mouse, Recombinant (hFc) Mouse HEK293
Breast cancer (BC) is the most common cancer in women and the second leading cause of their cancer death. Establishing an accurate BC prognosis is very difficult because of its heterogeneity. Elevated TFF1 levels in seru...
TMPK-00007 TFF1 Protein, Human, Recombinant (hFc) Human HEK293
Breast cancer (BC) is the most common cancer in women and the second leading cause of their cancer death. Establishing an accurate BC prognosis is very difficult because of its heterogeneity. Elevated TFF1 levels in seru...
TMPY-04817 Syntenin Protein, Human, Recombinant (His) Human E. coli
Syntenin1/SDCBP (syndecan binding protein), also known as melanoma differentiation associated gene-9 (MDA-9), is a PDZ domain-containing molecule, which was initially identified as a key oncogene in melanoma. IL-6 promot...
TMPK-00784 ANXA2 Protein, Human, Recombinant (His) Human E. coli
ANXA2, highly expressed in invasive breast cancer cells, is closely related with poor prognosis, and acts as a molecular switch to EGFR activation. ANXA2 expression is inversely correlated with cell sensitivity to gefiti...
TMPY-06249 CCK4/PTK7 Protein, Human, Recombinant (His) Human HEK293
Protein tyrosine kinase 7 (PTK7) is a highly conserved but catalytically inactive receptor tyrosine kinase in the Wnt signaling pathway. PTK7 regulates various processes in embryonic development and tissue homeostasis. O...
TMPY-06250 CCK4/PTK7 Protein, Cynomolgus, Rhesus, Recombinant (His) Cynomolgus,Rhesus HEK293
Protein tyrosine kinase 7 (PTK7) is a highly conserved but catalytically inactive receptor tyrosine kinase in the Wnt signaling pathway. PTK7 regulates various processes in embryonic development and tissue homeostasis. O...
TargetMol