DSS

Dextran sulfate sodium salt (MW 36,000–50,000) is a medium molecular weight polyanionic dextran derivative with strong intestinal epithelial permeability. It is the most commonly used agent for inducing inflammatory bowel disease (IBD) models, effectively inducing both acute and chronic colitis. Its mechanism may involve macrophage dysfunction and gut microbiota dysbiosis. Due to its colonic epithelial toxicity, long-term use can also induce colorectal cancer models.

Dextran sulfate sodium salt (MW 4500-5500) is a polymer of dehydrated glucose and an inhibitor of complement and coagulation pathways. Dextran sulfate sodium salt (MW 4500-5500) can be used as an anticoagulant, antiviral agent and antilipidemic agent. Dextran sulfate sodium salt (MW 4500-5500) can prevent the HIV-1 virus from adsorbing onto host cells. Dextran sulfate sodium salt (MW 4500-5500) can inhibit NK cell-mediated cytotoxicity. Dextran sulfate sodium salt (MW 4500-5500) can inhibit the immediate blood-mediated inflammatory response (IBMIR).

1. Norisoboldine ((+)-Laurelliptine) might be a potential therapeutic agent for rheumatoid arthritis, and it functions through protecting joint destruction as well as regulating the abnormal immune responses. 2. Norisoboldine inhibits the macrophage activation and the resultant production of pro-inflammatory cytokines via down-regulating the activation of MAPKs signaling pathways rather than NF-κB.

DSS-D4 Deuterated Crosslinker is[Succinimidyl] 2,2,7,7-suberate-D4 is a membrane permeable crosslinker with four deuterium atoms.

DSS30 is a P25/CDK5 inhibitor.DSS30 acts by inhibiting the phosphorylation of amyloid precursor protein cleaving enzyme 1 (BACEl), which reduces the secretion of β-amyloid (Aβ).DSS30 can be used for the prevention and treatment of neurodegenerative diseases such as Alzheimer's disease.

DSS Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It is a homobifunctional crosslinker that is cell membrane permeable, with amine-reactive NHS esters at both ends of an 8-atom [11.4 angstrom] spacer arm for conjugating proteins, including intracellular proteins.

(Asp-Ser-Ser)6 ((DSS)6) is a synthetically engineered bone-targeting peptide. It serves as a ligand to modify apoptotic cell-derived extracellular vesicles (ApoEVs), enhancing their bone-targeting ability and efficacy in osteoporosis treatment. (Asp-Ser-Ser)6 is applicable in osteoporosis research.

Dextran sulfate sodium salt (DSS) (MW 450000-550000) is a polymer of anhydroglucose with a molecular weight ranging from 450000 to 550000. Various molecular weights of dextran sulfate sodium salt exhibit different biological activities. DSS (MW 450000-550000) inhibits the replication of HIV-1 and influenza A virus. Additionally, dextran sulfate sodium salt (DXS) can be formulated into nanoparticles, showing antibacterial properties, and is useful in the preparation of functional materials.

Dextran sulfate sodium salt (MW 9000-20000) (DSS (MW 9000-20000)) is a negatively charged sulfated polysaccharide. It exhibits antiviral, antibacterial, anti-inflammatory, antifibrotic, and wound healing properties. Dextran sulfate sodium salt can be used as an additive in cell culture media to prevent cell aggregation and also serves as a gel-forming agent in cosmetics.

Dextran sulfate sodium salt (MW 6500-10000) (DSS (MW 6500-10000)) is a negatively charged sulfated polysaccharide. It possesses antiviral, antibacterial, anti-inflammatory, antifibrotic, and wound-healing properties. Additionally, it can be used as an additive in cell culture media to prevent cell aggregation and as a gel-forming agent in cosmetics.

Dextran sulfate sodium salt (MW>500000) (DSS (MW>500000)) is a negatively charged sulfated polysaccharide. It exhibits antiviral, antibacterial, anti-inflammatory, antifibrotic, and wound-healing properties. Additionally, Dextran sulfate sodium salt can be utilized as an additive in cell culture media to prevent cell clumping and as a gel-forming agent in cosmetic products.

DSSeb Crosslinker (Disuccinimidyl sebacate) is a dual N-hydroxyethyl ketone ester and cell-membrane-permeable amine-reactive crosslinker, suitable for protein crosslinking and investigating protein-protein interactions.

PTDSS1-IN-1 is an active molecule that can be used in life science related research. The CAS number of PTDSS1-IN-1 is 2488609-21-6.

SDSSD is a peptide that targets osteoblasts by selectively binding to them through periostin. Nanomaterials modified with SDSSD can be utilized in the study of osteoblast-induced bone diseases.

Emedastine Difumarate is a selective histamine H1 receptor antagonist with anti-allergic activity, prescribed for allergic conjunctivitis. Upon ocular administration, emedastine causes a dose-dependent inhibition of histamine-stimulated vascular permeabil

Grepafloxacin Hydrochloride is an antimicrobial agent, oral broad-spectrum fluoroquinolone. It is used to treat bacterial infections.

N, N'-Ethylenediamine disuccinic acid, as an aminopolycarboxylic acid, can be used as a biodegradable chelating agent similar to EDTA and used on a large scale in numerous applications.

Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.

1. Palmatine (Burasaine) is an inhibitor of dopamine generation. 2. Palmatine could potentially be developed for the treatment of flavivirus infections. 3. Palmatine has been used in the treatment of jaundice, dysentery, hypertension, inflammation, and liver-related diseases.

RS-246204 is an R-spondin-1 substitute compound capable of initiating and sustaining intestinal organoids in R-spondin-1-deficient media, activating R-spondin-dependent pathways in DSS-induced colitis models, and promoting regeneration of damaged intestinal epithelium.

NLRP3-IN-48 is an inhibitor of NLRP3. It suppresses the activation of the NLRP3 inflammasome by targeting the NLRP3 protein, thereby interfering with the assembly of the NLRP3 inflammasome. Additionally, NLRP3-IN-48 exhibits anti-inflammatory activity in a DSS-induced acute colitis model in mice.

FKK6 is a selective agonist of the pregnane X receptor (PXR) with an EC50 of 1.2 µM. It demonstrates strong affinity for plasma proteins and exhibits favorable metabolic characteristics in human microsomes. FKK6 inhibits the PXR-related NF-κB signaling pathway, reducing the expression of inflammatory factors and showing anti-inflammatory activity in a mouse model of DSS-induced colitis.

CB2 receptor agonist 9 (Compound 33) is an orally active agonist of cannabinoid receptor 2 (CB2 receptor) with an EC50 of 16.2 nM. It inhibits the expression of TNF-α, IL-1β, and IL-6, demonstrating anti-inflammatory activity in a DSS-induced acute colitis model in mice.

RIPK2/3 inhibitor 29 (compound 29) is a dual inhibitor of RIPK2 (IC50=12 nM) and RIPK3 (IC50=18 nM), which can directly bind to RIPK2 and RIPK3, effectively inhibiting NOD induced cytokine production and cell necrosis. Compound 29 has shown significant therapeutic effects in DSS induced colitis mouse models and has broad potential for dual inhibition of RIPK2/RIPK3 in the treatment of IBD.