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Search Results for " dm4 "

20

Compounds

Cat No. Product Name Synonyms Targets
T15141 DM4 Ravtansine Others , Microtubule Associated
DM4 (Ravtansine) can be used in the preparation of antibody drug conjugate and it is an antitubulin agent. It can inhibit cell division.
T38682 Lys-Nε-SPDB-DM4 Lys-Nε-SPDB-DM4
Lys-Nε-SPDB-DM4 is a drug-linker conjugate that combines the tubulin inhibitor DM4 with the linker Lys-Nε-SPDB, facilitating the creation of an antibody-drug conjugate (ADC).
T13766 Maytansinoid DM4 Others
Maytansinoid DM4, a thiol-containing maytansine derivative, is a highly potent cytotoxic moiety utilized in ADC applications.
T18701 SPDB-DM4 Others
SPDB-DM4 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications, employing the maytansine-based payload DM4 (a tubulin inhibitor) connected through a SPDB linker. This compound demonstrates si...
T18702 DBA-DM4 Others
DBA-DM4 is a drug-linker conjugate for antibody-drug conjugate (ADC) synthesis, combining the tubulin inhibitor DM1 with the SPDP linker[1].
T11059 DM4-SMe Others
DM4-SMe is a cytotoxic part of antibody-drug conjugates (ADCs) and a metabolite of antibody-maytansin conjugates (AMCs) and tubulin inhibitors, which can also be stabilized by disulfide bonds or thioether The bond binds ...
T17833 DM4-SMCC Others
DM4-SMCC, a non-cleavable drug-linker conjugate for antibody-drug conjugates (ADC), leverages the antitumor efficacy of DM4 (an antitubulin agent) through attachment with the SMCC linker, exhibiting antitumor activity[1]...
T17834 DM4-SPDP Others
DM4-SPDP, a drug-linker conjugate, integrates the antitubulin agent DM4 with the linker SMCC, facilitating the creation of antibody drug conjugates[1]. Additionally, SPDP serves as a short-chain crosslinker enabling amin...
T18731 Sulfo-PDBA-DM4 Others
Sulfo-PDBA-DM4 is a drug-linker conjugate for antibody-drug conjugate (ADC) applications, combining the potent tubulin inhibitor DM4 with the gluthatione-cleavable linker Sulfo-PDBA. This configuration harnesses DM4's cy...
T18730 Sulfo-SPDB-DM4 Others
Sulfo-SPDB-DM4 is a drug-linker conjugate designed for antibody-drug conjugates (ADCs) that employs the maytansine-based payload (DM4, an antitubulin agent) connected through the sulfo-SPDB linker.
T77872 S-Me-DM4
S-Me-DM4 is an intracellular enzyme S-methylated metabolite of DM4, a maytansinoid with microtubule-depolymerizing properties and potent cytotoxicity, employed as an Antibody-Drug Conjugate (ADC) cytotoxin [1].
T77907 Tusamitamab ravtansine HuMAb2-3-SPDB-DM4,SAR-408701
Tusamitamab ravtansine (SAR-408701) is a DM4-linked anti-CEACAM5 antibody-drug conjugate (ADC) comprising a humanized monoclonal antibody targeting carcinoembryonic antigen-related cell adhesion molecule-5 (CEACAM5) conj...
T60654 KDM4C-IN-1 Histone Demethylase
KDM4C-IN-1 is a selective and potent KDM4C inhibitor (IC50: 8 nM) with potential anticancer activity.KDM4C-IN-1 inhibits the growth of HepG2 and A549 cells, and can be used for the study of leukaemia.
T4214 KDM4D-IN-1 Histone Demethylase
KDM4D-IN-1 is a KDM4D inhibitor (IC50: 0.41±0.03 μM).
T25142 BDM44768 BDM 44768,BDM-44768
BDM44768 is an insulin-degrading enzyme (IDE) inhibitor that acts by inducing glucose intolerance.
T11749 KDM4-IN-2 Glucokinase
KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively.
T60354 KDM4-IN-4
KDM4-IN-4 (compound 47) is a potent inhibitor of histone lysine demethylase 4 (KDM4), demonstrating modest affinity with a binding constant of approximately 80 μM for the KDM4A-Tudor domain. It effectively inhibits the b...
T60593 KDM4-IN-3
KDM4-IN-3 is a KDM4 inhibitor that is cell-permeable and kills prostate cancer cells at low micromolar concentrations.
T27721 KDM4C-IN-35 KDM4C IN 35,KDM4CIN35
KDM4C-IN-35 is a novel and selective KDM4C inhibitor.
T27722 KDM4-IN-I
KDM4-IN-I is a novel inhibitor of KDM4.
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