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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T15141 | DM4 | Ravtansine | Others , Microtubule Associated |
DM4 (Ravtansine) can be used in the preparation of antibody drug conjugate and it is an antitubulin agent. It can inhibit cell division. | |||
T38682 | Lys-Nε-SPDB-DM4 | Lys-Nε-SPDB-DM4 | |
Lys-Nε-SPDB-DM4 is a drug-linker conjugate that combines the tubulin inhibitor DM4 with the linker Lys-Nε-SPDB, facilitating the creation of an antibody-drug conjugate (ADC). | |||
T13766 | Maytansinoid DM4 | Others | |
Maytansinoid DM4, a thiol-containing maytansine derivative, is a highly potent cytotoxic moiety utilized in ADC applications. | |||
T18701 | SPDB-DM4 | Others | |
SPDB-DM4 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications, employing the maytansine-based payload DM4 (a tubulin inhibitor) connected through a SPDB linker. This compound demonstrates si... | |||
T18702 | DBA-DM4 | Others | |
DBA-DM4 is a drug-linker conjugate for antibody-drug conjugate (ADC) synthesis, combining the tubulin inhibitor DM1 with the SPDP linker[1]. | |||
T11059 | DM4-SMe | Others | |
DM4-SMe is a cytotoxic part of antibody-drug conjugates (ADCs) and a metabolite of antibody-maytansin conjugates (AMCs) and tubulin inhibitors, which can also be stabilized by disulfide bonds or thioether The bond binds ... | |||
T17833 | DM4-SMCC | Others | |
DM4-SMCC, a non-cleavable drug-linker conjugate for antibody-drug conjugates (ADC), leverages the antitumor efficacy of DM4 (an antitubulin agent) through attachment with the SMCC linker, exhibiting antitumor activity[1]... | |||
T17834 | DM4-SPDP | Others | |
DM4-SPDP, a drug-linker conjugate, integrates the antitubulin agent DM4 with the linker SMCC, facilitating the creation of antibody drug conjugates[1]. Additionally, SPDP serves as a short-chain crosslinker enabling amin... | |||
T18731 | Sulfo-PDBA-DM4 | Others | |
Sulfo-PDBA-DM4 is a drug-linker conjugate for antibody-drug conjugate (ADC) applications, combining the potent tubulin inhibitor DM4 with the gluthatione-cleavable linker Sulfo-PDBA. This configuration harnesses DM4's cy... | |||
T18730 | Sulfo-SPDB-DM4 | Others | |
Sulfo-SPDB-DM4 is a drug-linker conjugate designed for antibody-drug conjugates (ADCs) that employs the maytansine-based payload (DM4, an antitubulin agent) connected through the sulfo-SPDB linker. | |||
T77872 | S-Me-DM4 | ||
S-Me-DM4 is an intracellular enzyme S-methylated metabolite of DM4, a maytansinoid with microtubule-depolymerizing properties and potent cytotoxicity, employed as an Antibody-Drug Conjugate (ADC) cytotoxin [1]. | |||
T77907 | Tusamitamab ravtansine | HuMAb2-3-SPDB-DM4,SAR-408701 | |
Tusamitamab ravtansine (SAR-408701) is a DM4-linked anti-CEACAM5 antibody-drug conjugate (ADC) comprising a humanized monoclonal antibody targeting carcinoembryonic antigen-related cell adhesion molecule-5 (CEACAM5) conj... | |||
T60654 | KDM4C-IN-1 | Histone Demethylase | |
KDM4C-IN-1 is a selective and potent KDM4C inhibitor (IC50: 8 nM) with potential anticancer activity.KDM4C-IN-1 inhibits the growth of HepG2 and A549 cells, and can be used for the study of leukaemia. | |||
T4214 | KDM4D-IN-1 | Histone Demethylase | |
KDM4D-IN-1 is a KDM4D inhibitor (IC50: 0.41±0.03 μM). | |||
T25142 | BDM44768 | BDM 44768,BDM-44768 | |
BDM44768 is an insulin-degrading enzyme (IDE) inhibitor that acts by inducing glucose intolerance. | |||
T11749 | KDM4-IN-2 | Glucokinase | |
KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively. | |||
T60354 | KDM4-IN-4 | ||
KDM4-IN-4 (compound 47) is a potent inhibitor of histone lysine demethylase 4 (KDM4), demonstrating modest affinity with a binding constant of approximately 80 μM for the KDM4A-Tudor domain. It effectively inhibits the b... | |||
T60593 | KDM4-IN-3 | ||
KDM4-IN-3 is a KDM4 inhibitor that is cell-permeable and kills prostate cancer cells at low micromolar concentrations. | |||
T27721 | KDM4C-IN-35 | KDM4C IN 35,KDM4CIN35 | |
KDM4C-IN-35 is a novel and selective KDM4C inhibitor. | |||
T27722 | KDM4-IN-I | ||
KDM4-IN-I is a novel inhibitor of KDM4. |