aβ42 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9641	Aβ42-IN-2		Gamma-secretase
	Aβ42-IN-2 is a γ-secretase modulator. Aβ42-IN-2 has an IC 50 of 6.5 nM for Αβ 42. Aβ42-IN-2 can be used for the Alzheimer's disease research[1].		Gamma-secretase
T10211	Aβ42-IN-1		Others
	Aβ42-IN-1, compound 1v, is a novel, potent and orally active γ-secretase modulator (GSM). Aβ42-IN-1 potently reduced Aβ42 levels with an IC 50 value of 0.091 μM in cultured cells without inhibiting CYP3A4. Aβ42-IN-1 show...		Others
T10443	Aβ42-IN-1 free base		Others
	Aβ42-IN-1 free base (compound 1v), an orally active γ-secretase modulator with high brain exposure, effectively lowers Aβ42 levels, exhibiting an IC 50 of 0.091 μM, and significantly diminishes brain Aβ42 levels in mice....		Others
T1686	Hematoxylin	Hydroxybrazilin,Natural Black 1,Haematoxylin	Beta Amyloid , Others
	Hematoxylin (Natural Black 1) is a dye obtained from the heartwood of logwood (Haematoxylon campechianum Linn., Leguminosae) used as a stain in microscopy and in the manufacture of ink.		Beta Amyloid , Others
T0883	Tramiprosate	Homotaurine,3-Amino-1-propanesulfonic acid,Alzhemed	Beta Amyloid , GABA Receptor
	Tramiprosate (Alzhemed) is an orally active, blood-brain-barrier-crossing, naturally occurring amino acid found in a variety of red seaweeds that binds soluble Aβ and maintains it in a non-protofibrillar form.It is a GAB...		Beta Amyloid , GABA Receptor
T22678	3,5-Bis(4-nitrophenoxy)benzoic acid	Compound W	Gamma-secretase
	3,5-Bis(4-nitrophenoxy)benzoic acid (Compound W) is an inhibitor of γ-secretase. It also causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25).		Gamma-secretase
T10532	BI-1408		Others , Gamma-secretase
	BI-1408 is a modulator potent of γ secretase (IC50: 0.04 μM for Aβ42).		Others , Gamma-secretase
T2262	Itanapraced	CHF5074,CSP-1103	Beta Amyloid , Gamma-secretase
	Itanapraced (CHF5074), a γ-secretase modulator, reduces Aβ42/40 secretion (IC50: 3.6/18.4 μM).		Beta Amyloid , Gamma-secretase
T6125	Semagacestat	LY450139	Beta Amyloid , Gamma-secretase
	Semagacestat (LY450139) (LY450139) is a γ-secretase blocker for Aβ42/Aβ40/Aβ38 (IC50: 10.9/12.1/12.0 nM) and also inhibits Notch signaling (IC50: 14.1 nM).		Beta Amyloid , Gamma-secretase
T6249	Avagacestat	BMS-708163	Gamma-secretase
	Avagacestat (BMS-708163) (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2.		Gamma-secretase
T6202	DAPT	LY-374973,GSI-IX	Apoptosis , Beta Amyloid , Gamma-secretase , Autophagy
	DAPT (LY-374973) is a γ-secretase inhibitor that inhibits total Aβ and Aβ42 (IC50=115/200 nM) and is orally active. DAPT is also a Notch inhibitor. DAPT induces cell differentiation, autophagy and apoptosis.		Apoptosis , Beta Amyloid , Gamma-secretase , Autophagy
T7857	DO1	Disperse Orange 1	Others
	DO1 (Disperse Orange 1) is an anti-amyloid agent which potently delays both seeded and non-seeded Aβ42 polymerization at substoichiometric concentrations		Others
T63208	Aβ-IN-1		Gamma-secretase
	Aβ-IN-1 is a novel, potent and orally active γ-secretase modulator (GSM). Aβ-IN-1 potently reduced Aβ42 levels with an IC 50 value of 0.091 μM in cultured cells without inhibiting CYP3A4. Aβ-IN-1 shows a sustained pharma...		Gamma-secretase
TN7246	3-Sulfopropanoic acid	3-SPA	Drug Metabolite
	3-Sulfopropanoic acid, a major metabolite of treprostinil and its prodrug ALZ-801, is an endogenous molecule present in the cerebrospinal fluid (CSF) of AD patients that inhibits the formation of Aβ42 oligomers.		Drug Metabolite
T62263	γ-Secretase modulator 13		Gamma-secretase
	γ-Secretase modulator 13 is a γ-secretase modulator (GSMs) that inhibits the production of amyloid β-peptide Aβ42 and can be used to study Alzheimer's disease and tumors.		Gamma-secretase
T10782	CGP52411	DAPH	EGFR , Beta Amyloid
	CGP52411 is an orally active, and ATP-competitive inhibitor of EGFR (IC50: 0.3 μM). CGP52411 blocks the toxic influx of Ca2+ ions into neuronal cells and dramatically inhibits and reverses the formation of β-amyloid Aβ42...		EGFR , Beta Amyloid
T16773	Ro 90-7501	RO-90-7501	Apoptosis , Phosphatase , ATM/ATR , Gamma-secretase
	Ro 90-7501 is an amyloid β42 (Aβ42) protofibrillar and TPR-dependent PP5 inhibitor, a novel radiosensitiser for cervical cancer cells, which inhibits ATM phosphorylation, promotes apoptosis, and induces cell-cycle arrest...		Apoptosis , Phosphatase , ATM/ATR , Gamma-secretase
T6478	Donepezil Hydrochloride	Aricept,BNAG,E2020,Donepezil HCl	AChR , AChE
	Donepezil HCl(Aricept) is a selective and effective AChE inhibitor for bAChE and hAChE (IC50: 8.12/11.6 nM).		AChR , AChE
T4S0350	Licochalcone B		Beta Amyloid , Others
	1. Licochalcone B (LCB) inhibits the proliferation of human malignant bladder cancer cell lines (T24 and EJ) in vitro and antitumor activity in vivo in MB49 (murine bladder cancer cell line) tumor model. 2. LCB and Licoc...		Beta Amyloid , Others
T6708	Tolcapone	Tasmar,Ro 40-7592	Apoptosis , Beta Amyloid , Transferase
	Tolcapone (Ro 40-7592) is a catechol-O-methyltransferase inhibitor used in the therapy of Parkinson disease as adjunctive therapy in combination with levodopa and carbidopa.		Apoptosis , Beta Amyloid , Transferase