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Cat No. | Product Name | Synonyms | Targets |
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T7506 | Yoda 1 | Piezo Channel | |
Yoda1 is a Piezo1 ion channel agonist (EC50s = 17.1 and 26.6 μM for murine and human Piezo1-transfected HEK293T cells, respectively) | |||
T8151 | Mobocertinib | tak788 | EGFR |
Mobocertinib (tak788) is a potent inhibitor of epidermal growth factor receptor (EGFR) and an antineoplastic agent | |||
T2325 | Neratinib | HKI-272 | EGFR , HER |
Neratinib (HKI-272) (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor for HER2 and EGFR (IC50: 59/92 nM), respectively. | |||
T6928 | Pantoprazole | SKF96022,BY1023 | Apoptosis , Proton pump , Autophagy |
Pantoprazole (BY1023) is a proton pump inhibitor used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. | |||
T2586 | Cabozantinib | XL184,BMS-907351 | Apoptosis , VEGFR , FLT , c-Met/HGFR , c-RET , TAM Receptor , c-Kit |
Cabozantinib (XL184) is a multi-targeted tyrosine kinase receptor inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM). Cabozantinib exhibits both antitumor and antiangiogenic activity... | |||
T21312 | Afatinib | Afatinib free base,BIBW 2992 | EGFR , Autophagy |
Afatinib (BIBW 2992) is an irreversible inhibitor of EGFR family (EGFR-wt, EGFR-L858R, EGFR-L858R/T790M and HER2 with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM , respectively). | |||
T0161 | Pantoprazole Sodium Hydrate | SKF96022 sodium hydrate,BY1023 (sodium hydrate),SKF96022 (sodium hydrate) | Apoptosis , Potassium Channel , Proton pump , Autophagy |
Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. | |||
T5164 | Cabozantinib hydrochloride | XL184,Cabozantinib hydrochloride (849217-68-1(free base)),BMS-907351 | VEGFR , FLT , c-Met/HGFR , TAM Receptor , c-Kit , ROR |
Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6 nM). | |||
T6929 | Pantoprazole sodium | Pantecta,SKF96022 sodium,SKF96022 (sodium),BY1023 (sodium),BY-1023 sodium,Pantoloc | Apoptosis , Others , Proton pump , HIF , Autophagy |
Pantoprazole sodium (Pantecta) is the sodium salt form of a substituted benzimidazole with proton pump inhibitor activity. Pantoprazole sodium is a lipophilic, weak base that crosses the parietal cell membrane and enters... | |||
T1773 | Afatinib Dimaleate | BIBW2992,Afatinib,BIBW 2992MA2,Afatinib (BIBW2992) Dimaleate | EGFR , HER , Autophagy |
Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the receptor tyrosine kinase (RTK) epidermal growth factor receptor (ErbB; EGFR) family, with antineoplastic act... | |||
T77718 | FAK-IN-10 | FAK | |
FAK-IN-10 is an inhibitor of FAK (IC50:76.3 μM).FAK-IN-10 z MCF-7 and A431 cell lines showed antitumor activity with IC50 of 4.23 and 0.78 μM, respectively. | |||
T5155 | (E)-AG 99 | (E)-Tyrphostin AG 99,(E)-Tyrphostin 46,AG 99,Tyrphostin 46 | EGFR |
(E)-AG 99 ((E)-Tyrphostin AG 99) is an inhibitor of EGFR kinase (IC50: 10 μM in the human epidermoid carcinoma cell line A431). | |||
T64124 | Sunvozertinib | DZD9008,DZD 9008,DZD-9008 | EGFR , BTK |
Sunvozertinib (DZD9008) is a potent ErbBs and BTK inhibitor and has inhibitory effects on EGFR, Her2 and mutant epidermal growth factor. Sunvozertinib showed inhibition of EGFR exon 20 NPH insertion, EGFR exon 20 ASV ins... | |||
T8525 | EGFR-IN-16 | AG473 | EGFR , FGFR |
EGFR-IN-16 (AG473) is an inhibitor of EGFR in human A431 cells. | |||
T73101 | EGFR-IN-25 | ||
EGFR-IN-25, an efficacious EGFR inhibitor, demonstrates IC50 values of 9 nM for BaF3 cells (EGFR DEL19/T790M/C797S) and 60 nM for A431 cells (WT), respectively. | |||
T60314 | Anticancer agent 38 | ||
Anticancer agent 38 (compound 19) is an aryl-urea compound, and is a potent anticancer agent. Anticancer agent 38 inhibits A431 cell growth with an IC 50 of 5.2 μg/mL [1]. | |||
T9905 | Cetuximab | Cetuximab (anti-EGFR),C225 | EGFR |
Cetuximab (C225) is a monoclonal antibody that is an inhibitor of human epidermal growth factor receptor (EGFR) (Kd=0.201 nM). Cetuximab has antitumor activity, inhibiting tumor cell proliferation and inducing apoptosis. | |||
T61827 | RJ-34 | ||
RJ-34, an aristolactam analogue, demonstrates strong antitumor effects across a wide range of cancer cell lines, with subnanomolar GI 50 values (GI 50 <0.1 nM) observed for A431, MES-SA, MES-SA/DX5, HCT-15, and HCT-15/CL... | |||
T61602 | Anticancer agent 35 | ||
Anticancer agent 35 (compound 10), a sulfonylurea derivative, is a potent anticancer agent. Anticancer agent 35 inhibits A549, A431, PACA2 cell growth with IC 50 s of 18.1 μg/mL, 4.0 μg/mL, 18.9 μg/mL, respectively [1]. | |||
T79888 | EGFR-IN-87 | EGFR | |
EGFR-IN-87 is an EGFR tyrosine kinase inhibitor with potent inhibitory activity, exhibiting IC50 values of 3.1 nM, 1.3 nM, and 7.1 nM against EGFR_d746-750, EGFR_L858R/T790M, and EGFR_WT, respectively, in A431 cells. It ... | |||
T69438 | MT477 | ||
MT477 is PKC-α inhibitor. MT477 interfered with PKC activity as well as phosphorylation of Ras and ERK1/2 in H226 human lung carcinoma cells. It also induced poly-caspase-dependent apoptosis. MT477 had a dose-dependent (... | |||
T63769 | EGFR-IN-60 | ||
EGFR-IN-60 is an effective, orally active, safe antitumor agent. EGFR-IN-60 significantly inhibits EGFRWT (IC50: 83 nM), EGFRT790M (IC50: 26 nM), EGFRL858R (IC50: 53 nM) and JAK3 (IC50: 69 nM). IN-60 inhibited H1975 cell... | |||
T37586 | DMHAPC-Chol | ||
DMHAPC-Chol is a cationic cholesterol. Liposomes containing DMHAPC-chol have been used for DNA plasmid delivery in vitro and in vivo in a B16-F10 mouse xenograft model. Liposomes containing DMHAPC-chol are cytotoxic to B... | |||
T35671 | Salazinic Acid | ||
Salazinic acid is a depsidone lichen metabolite that has been found in P. sulcata.1 It is active against B. cereus, B. subtilis, S. aureus, P. aeruginosa, S. typhimurium, C. albicans, and A. niger in vitro (MICs = 3.9-30... | |||
T36907 | 1-Oleoyl Lysophosphatidic Acid | Oleoyl-sn-3-Glycerophosphate,1-Oleoyl LPA,1-Oleoyl Lysophosphatidic Acid | |
1-Oleoyl lysophosphatidic acid is a species of lysophosphatidic acid (LPA) containing oleic acid at the sn-1 position. Phosphatidic acid is produced either directly through the action of phospholipase D (PLD) or through ... | |||
T36844 | Inostamycin A | ||
Inostamycin A is a bacterial metabolite that has been found inStreptomycesand has anticancer activity.1It is an inhibitor of CDP-diacylglycerol:inositol 3-phosphatidyltransferase (IC50= 0.02 μg/ml in A431 cell membranes)... | |||
T35897 | ASK120067 | ||
ASK120067 is a potent and orally active inhibitor of EGFRT790M (IC50:0.3 nM) with selectivity over EGFRWT (IC50:6.0 nM). ASK120067 is a third-generation EGFR-TKI for the research of non-small cell lung cancer (NSCLC)[1]... |
Cat No. | Product Name | Synonyms | Targets |
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T2S0961 | Chalcone | benzylideneacetophenone,phenyl styryl ketone,Cinnamophenone,benzalacetophenone,β-phenylacrylophenone | EGFR , Antibacterial |
Chalcone (Cinnamophenone) is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones. | |||
TN6569 | Cis-Moschamine | ||
cis-Moschamine exerts antitumour effects on HeLa, MCF7 and A431 cells. |
Cat No. | Product Name | Species | Expression System |
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TMPY-00978 | Progranulin Protein, Human, Recombinant (His) | Human | HEK293 |
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The precursor protein, progranulin, ... | |||
TMPY-02169 | Epiregulin Protein, Human, Recombinant (hFc) | Human | HEK293 |
Epiregulin (EREG) is a member of the epidermal growth factor family. Epiregulin (EREG) can function as a ligand of EGFR (epidermal growth factor receptor), as well as a ligand of most members of the ERBB (v-erb-b2 oncoge... | |||
TMPY-02166 | Epiregulin Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Epiregulin (EREG) is a member of the epidermal growth factor family. Epiregulin (EREG) can function as a ligand of EGFR (epidermal growth factor receptor), as well as a ligand of most members of the ERBB (v-erb-b2 oncoge... | |||
TMPY-01435 | Progranulin Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The precursor protein, progranulin, ... |