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Search Results for " a431 "

Targets

27

Compounds

2

Natural Products

4

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T7506 Yoda 1 Piezo Channel
Yoda1 is a Piezo1 ion channel agonist (EC50s = 17.1 and 26.6 μM for murine and human Piezo1-transfected HEK293T cells, respectively)
T8151 Mobocertinib tak788 EGFR
Mobocertinib (tak788) is a potent inhibitor of epidermal growth factor receptor (EGFR) and an antineoplastic agent
T2325 Neratinib HKI-272 EGFR , HER
Neratinib (HKI-272) (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor for HER2 and EGFR (IC50: 59/92 nM), respectively.
T6928 Pantoprazole SKF96022,BY1023 Apoptosis , Proton pump , Autophagy
Pantoprazole (BY1023) is a proton pump inhibitor used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.
T2586 Cabozantinib XL184,BMS-907351 Apoptosis , VEGFR , FLT , c-Met/HGFR , c-RET , TAM Receptor , c-Kit
Cabozantinib (XL184) is a multi-targeted tyrosine kinase receptor inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM). Cabozantinib exhibits both antitumor and antiangiogenic activity...
T21312 Afatinib Afatinib free base,BIBW 2992 EGFR , Autophagy
Afatinib (BIBW 2992) is an irreversible inhibitor of EGFR family (EGFR-wt, EGFR-L858R, EGFR-L858R/T790M and HER2 with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM , respectively).
T0161 Pantoprazole Sodium Hydrate SKF96022 sodium hydrate,BY1023 (sodium hydrate),SKF96022 (sodium hydrate) Apoptosis , Potassium Channel , Proton pump , Autophagy
Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.
T5164 Cabozantinib hydrochloride XL184,Cabozantinib hydrochloride (849217-68-1(free base)),BMS-907351 VEGFR , FLT , c-Met/HGFR , TAM Receptor , c-Kit , ROR
Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6 nM).
T6929 Pantoprazole sodium Pantecta,SKF96022 sodium,SKF96022 (sodium),BY1023 (sodium),BY-1023 sodium,Pantoloc Apoptosis , Others , Proton pump , HIF , Autophagy
Pantoprazole sodium (Pantecta) is the sodium salt form of a substituted benzimidazole with proton pump inhibitor activity. Pantoprazole sodium is a lipophilic, weak base that crosses the parietal cell membrane and enters...
T1773 Afatinib Dimaleate BIBW2992,Afatinib,BIBW 2992MA2,Afatinib (BIBW2992) Dimaleate EGFR , HER , Autophagy
Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the receptor tyrosine kinase (RTK) epidermal growth factor receptor (ErbB; EGFR) family, with antineoplastic act...
T77718 FAK-IN-10 FAK
FAK-IN-10 is an inhibitor of FAK (IC50:76.3 μM).FAK-IN-10 z MCF-7 and A431 cell lines showed antitumor activity with IC50 of 4.23 and 0.78 μM, respectively.
T5155 (E)-AG 99 (E)-Tyrphostin AG 99,(E)-Tyrphostin 46,AG 99,Tyrphostin 46 EGFR
(E)-AG 99 ((E)-Tyrphostin AG 99) is an inhibitor of EGFR kinase (IC50: 10 μM in the human epidermoid carcinoma cell line A431).
T64124 Sunvozertinib DZD9008,DZD 9008,DZD-9008 EGFR , BTK
Sunvozertinib (DZD9008) is a potent ErbBs and BTK inhibitor and has inhibitory effects on EGFR, Her2 and mutant epidermal growth factor. Sunvozertinib showed inhibition of EGFR exon 20 NPH insertion, EGFR exon 20 ASV ins...
T8525 EGFR-IN-16 AG473 EGFR , FGFR
EGFR-IN-16 (AG473) is an inhibitor of EGFR in human A431 cells.
T73101 EGFR-IN-25
EGFR-IN-25, an efficacious EGFR inhibitor, demonstrates IC50 values of 9 nM for BaF3 cells (EGFR DEL19/T790M/C797S) and 60 nM for A431 cells (WT), respectively.
T60314 Anticancer agent 38
Anticancer agent 38 (compound 19) is an aryl-urea compound, and is a potent anticancer agent. Anticancer agent 38 inhibits A431 cell growth with an IC 50 of 5.2 μg/mL [1].
T9905 Cetuximab Cetuximab (anti-EGFR),C225 EGFR
Cetuximab (C225) is a monoclonal antibody that is an inhibitor of human epidermal growth factor receptor (EGFR) (Kd=0.201 nM). Cetuximab has antitumor activity, inhibiting tumor cell proliferation and inducing apoptosis.
T61827 RJ-34
RJ-34, an aristolactam analogue, demonstrates strong antitumor effects across a wide range of cancer cell lines, with subnanomolar GI 50 values (GI 50 <0.1 nM) observed for A431, MES-SA, MES-SA/DX5, HCT-15, and HCT-15/CL...
T61602 Anticancer agent 35
Anticancer agent 35 (compound 10), a sulfonylurea derivative, is a potent anticancer agent. Anticancer agent 35 inhibits A549, A431, PACA2 cell growth with IC 50 s of 18.1 μg/mL, 4.0 μg/mL, 18.9 μg/mL, respectively [1].
T79888 EGFR-IN-87 EGFR
EGFR-IN-87 is an EGFR tyrosine kinase inhibitor with potent inhibitory activity, exhibiting IC50 values of 3.1 nM, 1.3 nM, and 7.1 nM against EGFR_d746-750, EGFR_L858R/T790M, and EGFR_WT, respectively, in A431 cells. It ...
T69438 MT477
MT477 is PKC-α inhibitor. MT477 interfered with PKC activity as well as phosphorylation of Ras and ERK1/2 in H226 human lung carcinoma cells. It also induced poly-caspase-dependent apoptosis. MT477 had a dose-dependent (...
T63769 EGFR-IN-60
EGFR-IN-60 is an effective, orally active, safe antitumor agent. EGFR-IN-60 significantly inhibits EGFRWT (IC50: 83 nM), EGFRT790M (IC50: 26 nM), EGFRL858R (IC50: 53 nM) and JAK3 (IC50: 69 nM). IN-60 inhibited H1975 cell...
T37586 DMHAPC-Chol
DMHAPC-Chol is a cationic cholesterol. Liposomes containing DMHAPC-chol have been used for DNA plasmid delivery in vitro and in vivo in a B16-F10 mouse xenograft model. Liposomes containing DMHAPC-chol are cytotoxic to B...
T35671 Salazinic Acid
Salazinic acid is a depsidone lichen metabolite that has been found in P. sulcata.1 It is active against B. cereus, B. subtilis, S. aureus, P. aeruginosa, S. typhimurium, C. albicans, and A. niger in vitro (MICs = 3.9-30...
T36907 1-Oleoyl Lysophosphatidic Acid Oleoyl-sn-3-Glycerophosphate,1-Oleoyl LPA,1-Oleoyl Lysophosphatidic Acid
1-Oleoyl lysophosphatidic acid is a species of lysophosphatidic acid (LPA) containing oleic acid at the sn-1 position. Phosphatidic acid is produced either directly through the action of phospholipase D (PLD) or through ...
T36844 Inostamycin A
Inostamycin A is a bacterial metabolite that has been found inStreptomycesand has anticancer activity.1It is an inhibitor of CDP-diacylglycerol:inositol 3-phosphatidyltransferase (IC50= 0.02 μg/ml in A431 cell membranes)...
T35897 ASK120067
ASK120067 is a potent and orally active inhibitor of EGFRT790M (IC50:0.3 nM) with selectivity over EGFRWT (IC50:6.0 nM). ASK120067 is a third-generation EGFR-TKI for the research of non-small cell lung cancer (NSCLC)[1]...

Compounds

Yoda 1
T7506
Synonym:
Target: Piezo Channel
Mobocertinib
T8151
Synonym: tak788
Target: EGFR
Neratinib
T2325
Synonym: HKI-272
Target: EGFR, HER
Pantoprazole
T6928
Synonym: SKF96022,BY1023
Target: Apoptosis, Proton pump, Autophagy
Cabozantinib
T2586
Synonym: XL184,BMS-907351
Target: Apoptosis, VEGFR, FLT, c-Met/HGFR, c-RET, TAM Receptor, c-Kit
Afatinib
T21312
Synonym: Afatinib free base,BIBW 2992
Target: EGFR, Autophagy
Pantoprazole Sodium Hydrate
T0161
Synonym: SKF96022 sodium hydrate,BY1023 (sodium hydrate),SKF96022 (sodium hydrate)
Target: Apoptosis, Potassium Channel, Proton pump, Autophagy
Cabozantinib hydrochloride
T5164
Synonym: XL184,Cabozantinib hydrochloride (849217-68-1(free base)),BMS-907351
Target: VEGFR, FLT, c-Met/HGFR, TAM Receptor, c-Kit, ROR
Pantoprazole sodium
T6929
Synonym: Pantecta,SKF96022 sodium,SKF96022 (sodium),BY1023 (sodium),BY-1023 sodium,Pantoloc
Target: Apoptosis, Others, Proton pump, HIF, Autophagy
Afatinib Dimaleate
T1773
Synonym: BIBW2992,Afatinib,BIBW 2992MA2,Afatinib (BIBW2992) Dimaleate
Target: EGFR, HER, Autophagy
FAK-IN-10
T77718
Synonym:
Target: FAK
(E)-AG 99
T5155
Synonym: (E)-Tyrphostin AG 99,(E)-Tyrphostin 46,AG 99,Tyrphostin 46
Target: EGFR
Sunvozertinib
T64124
Synonym: DZD9008,DZD 9008,DZD-9008
Target: EGFR, BTK
EGFR-IN-16
T8525
Synonym: AG473
Target: EGFR, FGFR
EGFR-IN-25
T73101
Synonym:
Target:
Anticancer agent 38
T60314
Synonym:
Target:
Cetuximab
T9905
Synonym: Cetuximab (anti-EGFR),C225
Target: EGFR
RJ-34
T61827
Synonym:
Target:
Anticancer agent 35
T61602
Synonym:
Target:
EGFR-IN-87
T79888
Synonym:
Target: EGFR
MT477
T69438
Synonym:
Target:
EGFR-IN-60
T63769
Synonym:
Target:
DMHAPC-Chol
T37586
Synonym:
Target:
Salazinic Acid
T35671
Synonym:
Target:
1-Oleoyl Lysophosphatidic Acid
T36907
Synonym: Oleoyl-sn-3-Glycerophosphate,1-Oleoyl LPA,1-Oleoyl Lysophosphatidic Acid
Target:
Inostamycin A
T36844
Synonym:
Target:
ASK120067
T35897
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T2S0961 Chalcone benzylideneacetophenone,phenyl styryl ketone,Cinnamophenone,benzalacetophenone,β-phenylacrylophenone EGFR , Antibacterial
Chalcone (Cinnamophenone) is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones.
TN6569 Cis-Moschamine
cis-Moschamine exerts antitumour effects on HeLa, MCF7 and A431 cells.

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-00978 Progranulin Protein, Human, Recombinant (His) Human HEK293
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The precursor protein, progranulin, ...
TMPY-02169 Epiregulin Protein, Human, Recombinant (hFc) Human HEK293
Epiregulin (EREG) is a member of the epidermal growth factor family. Epiregulin (EREG) can function as a ligand of EGFR (epidermal growth factor receptor), as well as a ligand of most members of the ERBB (v-erb-b2 oncoge...
TMPY-02166 Epiregulin Protein, Mouse, Recombinant (hFc) Mouse HEK293
Epiregulin (EREG) is a member of the epidermal growth factor family. Epiregulin (EREG) can function as a ligand of EGFR (epidermal growth factor receptor), as well as a ligand of most members of the ERBB (v-erb-b2 oncoge...
TMPY-01435 Progranulin Protein, Mouse, Recombinant (His) Mouse HEK293
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The precursor protein, progranulin, ...
TargetMol