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c-Fms

Colony stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR), and CD115 (Cluster of Differentiation 115), is a cell-surface protein encoded, in humans, by the CSF1R gene (known also as c-FMS). It is a receptor for a cytokine called colony stimulating factor 1.
Cat. No. Product name CAS No. Purity Chemical Structure
T10645 C-Fms-IN-6 1628574-81-1 98%
c-Fms-IN-6 is a potent inhibitor of c-FMS (IC50 ≤10 nM for unphosphorylated c-FMS) and also weakly inhibits unphosphorylated c-KIT and PDGFR (IC50: > 1 μM).
T1925 PLX647 873786-09-5 98%
PLX647 is a highly selective dual FMS/KIT kinase inhibitor (IC50: 28/16 nM).
T11734 K-80003 1292821-90-9 98%
K-80003 is a potent inhibitor of cancer cell growth and tRXRα-dependent Akt activation.
T12505 PLX5622 hemifumarate T12505 98%
PLX5622 hemifumarate is a highly selective brain penetrant and orally active CSF1R inhibitor ( IC 50 =0.016 μM; K i =5.9 nM). PLX5622 hemifumarate allows for ext...
T10648 C-Fms-IN-9 1628574-50-4 98%
c-Fms-IN-9 is a c-FMS inhibitor extracted from patent WO2014145023A1 (Example 7). It inhibits unphosphorylated c-FMS kinase (uFMS) and uKIT (IC50s: <0.01 μM and ...
T6104 Cerdulatinib hydrochloride 1369761-01-2 98%
Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and S...
T35570 Chiauranib 1256349-48-0 96.25%
Chiauranib is a multi-target inhibitor against tumor angiogenesis and exhibits potent anticancer effects. Chiauranib potently inhibits the angiogenesis-related k...
T10775 C-Fms-IN-2 791587-67-2 97.34%
c-Fms-IN-2 is an inhibitor of c-FMS kinase (IC50 = 24 nM).
T2116 AEE788 497839-62-0 98%
AEE788 has been used in trials studying the treatment of Cancer, Glioblastoma Multiforme, and Brain and Central Nervous System Tumors.
T6028 PF 477736 952021-60-2 98.34%
PF-477736 is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CSF1R), Ret and Yes.
T10894 CSF1R-IN-1 2095849-04-8 98.57%
CSF1R-IN-1 is a CSF1R inhibitor with IC50 of 0.5 nM.
T10652 Vimseltinib 1628606-05-2 98.98%
DCC-3014 is a c-FMS (CSF-IR) and c-Kit dual inhibitor (IC50s: <0.01 μM and 0.1-1 μM) extracted from the patent WO2014145025A2 (Example 10).
T2514 Linifanib 796967-16-3 99.29%
Linifanib (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) and PDGFRβ (IC50: ...
T4315 Ki20227 623142-96-1 99.37%
Ki-20227 is a specific c-Fms tyrosine kinase(CSF1R) inhibitor (IC50: 2 nM). It also has certain inhibitory against VEGFR2(IC50: 12 nM) and c-Kit/PDGFRβ(IC50: 451...
T4376 Nampt-IN-1 1698878-14-6 99.4%
Nampt-IN-1 (LSN3154567) is a potent and selective NAMPT inhibitor. Nampt-IN-1 inhibits purified NAMPT with an IC50 of 3.1 nM.
T2659 GW2580 870483-87-7 99.48%
GW2580 is a specific, oral-bioavailable CSF-1R inhibitor for c-FMS.
T2115 Pexidartinib 1029044-16-3 99.66%
Pexidartinib is a capsule formulation containing a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic a...
T6930 Pazopanib Hydrochloride 635702-64-6 99.69%
Pazopanib HCl (GW786034 HCl) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 7...
T15199 Edicotinib 1142363-52-7 99.69%
Edicotinib is a brain penetrant and orally active inhibitor of the colony-stimulating factor-1 receptor (IC50: 3.2 nM). It shows less inhibitory effects on KIT a...
T13194 CSF1R-IN-2 2271119-26-5 99.71%
CSF1R-IN-2 is an oral-active SRC, MET and c-FMS inhibitor (IC50s: 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively).
c-Fms-IN-6
T10645
c-Fms-IN-6 is a potent inhibitor of c-FMS (IC50 ≤10 nM for unphosphorylated c-FMS) and also weakly inhibits unphosphorylated c-KIT and PDGFR (IC50: > 1 μM).
PLX647
T1925
PLX647 is a highly selective dual FMS/KIT kinase inhibitor (IC50: 28/16 nM).
K-80003
T11734
K-80003 is a potent inhibitor of cancer cell growth and tRXRα-dependent Akt activation.
PLX5622 hemifumarate
T12505
PLX5622 hemifumarate is a highly selective brain penetrant and orally active CSF1R inhibitor ( IC 50 =0.016 μM; K i =5.9 nM). PLX5622 hemifumarate allows for ext...
c-Fms-IN-9
T10648
c-Fms-IN-9 is a c-FMS inhibitor extracted from patent WO2014145023A1 (Example 7). It inhibits unphosphorylated c-FMS kinase (uFMS) and uKIT (IC50s: <0.01 μM and ...
Cerdulatinib hydrochloride
T6104
Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and S...
Chiauranib
T35570
Chiauranib is a multi-target inhibitor against tumor angiogenesis and exhibits potent anticancer effects. Chiauranib potently inhibits the angiogenesis-related k...
c-Fms-IN-2
T10775
c-Fms-IN-2 is an inhibitor of c-FMS kinase (IC50 = 24 nM).
AEE788
T2116
AEE788 has been used in trials studying the treatment of Cancer, Glioblastoma Multiforme, and Brain and Central Nervous System Tumors.
PF 477736
T6028
PF-477736 is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CSF1R), Ret and Yes.
CSF1R-IN-1
T10894
CSF1R-IN-1 is a CSF1R inhibitor with IC50 of 0.5 nM.
Vimseltinib
T10652
DCC-3014 is a c-FMS (CSF-IR) and c-Kit dual inhibitor (IC50s: <0.01 μM and 0.1-1 μM) extracted from the patent WO2014145025A2 (Example 10).
Linifanib
T2514
Linifanib (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) and PDGFRβ (IC50: ...
Ki20227
T4315
Ki-20227 is a specific c-Fms tyrosine kinase(CSF1R) inhibitor (IC50: 2 nM). It also has certain inhibitory against VEGFR2(IC50: 12 nM) and c-Kit/PDGFRβ(IC50: 451...
Nampt-IN-1
T4376
Nampt-IN-1 (LSN3154567) is a potent and selective NAMPT inhibitor. Nampt-IN-1 inhibits purified NAMPT with an IC50 of 3.1 nM.
GW2580
T2659
GW2580 is a specific, oral-bioavailable CSF-1R inhibitor for c-FMS.
Pexidartinib
T2115
Pexidartinib is a capsule formulation containing a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic a...
Pazopanib Hydrochloride
T6930
Pazopanib HCl (GW786034 HCl) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 7...
Edicotinib
T15199
Edicotinib is a brain penetrant and orally active inhibitor of the colony-stimulating factor-1 receptor (IC50: 3.2 nM). It shows less inhibitory effects on KIT a...
CSF1R-IN-2
T13194
CSF1R-IN-2 is an oral-active SRC, MET and c-FMS inhibitor (IC50s: 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively).
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