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c-Fms

Colony stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR), and CD115 (Cluster of Differentiation 115), is a cell-surface protein encoded, in humans, by the CSF1R gene (known also as c-FMS). It is a receptor for a cytokine called colony stimulating factor 1.
Cat. No. Product name CAS No. Purity Chemical Structure
T61589 C-Fms-IN-13 885704-58-5 98%
c-Fms-IN-13 (compound 14) is a potent FMS kinase inhibitor (IC50= 17 nM). c-Fms-IN-13 is an anti-inflammatory agent.
T10648 C-Fms-IN-9 1628574-50-4 98%
c-Fms-IN-9 is a c-FMS inhibitor extracted from patent WO2014145023A1 (Example 7). It inhibits unphosphorylated c-FMS kinase (uFMS) and uKIT (IC50s: <0.01 μM and ...
T11734 K-80003 1292821-90-9 98%
K-80003 is a potent inhibitor of cancer cell growth and tRXRα-dependent Akt activation.
T1925 PLX647 873786-09-5 98%
PLX647 is a highly selective dual FMS/KIT kinase inhibitor (IC50: 28/16 nM).
T12505 PLX5622 hemifumarate T12505 98%
PLX5622 hemifumarate is a highly selective brain penetrant and orally active CSF1R inhibitor with an IC 50 of 0.016 μM and Ki of 5.9 nM. PLX5622 hemifumarate all...
T10645 C-Fms-IN-6 1628574-81-1 98%
c-Fms-IN-6 is a potent inhibitor of c-FMS (IC50 ≤10 nM for unphosphorylated c-FMS) and also weakly inhibits unphosphorylated c-KIT and PDGFR (IC50: > 1 μM).
T10649 C-Fms-IN-3 885704-21-2 98%
c-Fms-IN-3 is a novel inhibitor of the c-FMS and can be used in studies about antirheumatic and anti-inflammatory diseases.
T2609 Masitinib 790299-79-5 98%
Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 2008 it has ...
T10643 C-Fms-IN-1 885703-64-0 98%
c-Fms-IN-1 is an inhibitor of c-FMS kinase (IC50 = 0.8 nM).
T5586 CFMS Receptor Inhibitor II 959860-85-6 98%
cFMS Receptor Inhibitor II is a CSF1R kinase inhibitor
T5172 AZ304 942507-42-8 98%
AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and wild type CRAF (IC50s: 79/38/68 nM).
T2624 OSI-930 728033-96-3 98%
OSI-930, an orally active inhibitor of c-Kit and the vascular endothelial growth factor receptor-2 (VEGFR-2), targets cancer cell proliferation and blood vessel ...
T60087 CFMS Receptor Inhibitor IV 959626-45-0 98%
cFMS Receptor Inhibitor IV is an inhibitor of c-Fms tyrosine kinase.
TQ0015 PRN1371 1802929-43-6 98%
PRN1371 is a specific and potent FGFR1-4 and CSF1R inhibitor (IC50s: 0.6/1.3/4.1/19.3/8.1 nM for FGFR1/2/3/4 and CSF1R).
T13194 CSF1R-IN-2 2271119-26-5 98%
CSF1R-IN-2 is an oral-active SRC, MET and c-FMS inhibitor (IC50s: 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively).
T2659 GW2580 870483-87-7 98%
GW2580 is a specific, oral-bioavailable CSF-1R inhibitor for c-FMS.
T3351 Onatasertib 1228013-30-6 98%
CC-223 is an orally available mTOR inhibitor with potential antitumor activity. CC-223 inhibits the activity of mTOR, which may result in the induction of tumor ...
T7100 PLX5622 1303420-67-8 98%
PLX-5622 is a highly selective brain penetrant and oral active CSF1R inhibitor.
T4376 Nampt-IN-1 1698878-14-6 98%
Nampt-IN-1 (LSN3154567) is a potent and selective NAMPT inhibitor. Nampt-IN-1 inhibits purified NAMPT with an IC50 of 3.1 nM.
T4315 Ki20227 623142-96-1 98%
Ki-20227 is a specific c-Fms tyrosine kinase(CSF1R) inhibitor (IC50: 2 nM). It also has certain inhibitory against VEGFR2(IC50: 12 nM) and c-Kit/PDGFRβ(IC50: 451...
c-Fms-IN-13
T61589
c-Fms-IN-13 (compound 14) is a potent FMS kinase inhibitor (IC50= 17 nM). c-Fms-IN-13 is an anti-inflammatory agent.
c-Fms-IN-9
T10648
c-Fms-IN-9 is a c-FMS inhibitor extracted from patent WO2014145023A1 (Example 7). It inhibits unphosphorylated c-FMS kinase (uFMS) and uKIT (IC50s: <0.01 μM and ...
K-80003
T11734
K-80003 is a potent inhibitor of cancer cell growth and tRXRα-dependent Akt activation.
PLX647
T1925
PLX647 is a highly selective dual FMS/KIT kinase inhibitor (IC50: 28/16 nM).
PLX5622 hemifumarate
T12505
PLX5622 hemifumarate is a highly selective brain penetrant and orally active CSF1R inhibitor with an IC 50 of 0.016 μM and Ki of 5.9 nM. PLX5622 hemifumarate all...
c-Fms-IN-6
T10645
c-Fms-IN-6 is a potent inhibitor of c-FMS (IC50 ≤10 nM for unphosphorylated c-FMS) and also weakly inhibits unphosphorylated c-KIT and PDGFR (IC50: > 1 μM).
c-Fms-IN-3
T10649
c-Fms-IN-3 is a novel inhibitor of the c-FMS and can be used in studies about antirheumatic and anti-inflammatory diseases.
Masitinib
T2609
Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 2008 it has ...
c-Fms-IN-1
T10643
c-Fms-IN-1 is an inhibitor of c-FMS kinase (IC50 = 0.8 nM).
cFMS Receptor Inhibitor II
T5586
cFMS Receptor Inhibitor II is a CSF1R kinase inhibitor
AZ304
T5172
AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and wild type CRAF (IC50s: 79/38/68 nM).
OSI-930
T2624
OSI-930, an orally active inhibitor of c-Kit and the vascular endothelial growth factor receptor-2 (VEGFR-2), targets cancer cell proliferation and blood vessel ...
cFMS Receptor Inhibitor IV
T60087
cFMS Receptor Inhibitor IV is an inhibitor of c-Fms tyrosine kinase.
PRN1371
TQ0015
PRN1371 is a specific and potent FGFR1-4 and CSF1R inhibitor (IC50s: 0.6/1.3/4.1/19.3/8.1 nM for FGFR1/2/3/4 and CSF1R).
CSF1R-IN-2
T13194
CSF1R-IN-2 is an oral-active SRC, MET and c-FMS inhibitor (IC50s: 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively).
GW2580
T2659
GW2580 is a specific, oral-bioavailable CSF-1R inhibitor for c-FMS.
Onatasertib
T3351
CC-223 is an orally available mTOR inhibitor with potential antitumor activity. CC-223 inhibits the activity of mTOR, which may result in the induction of tumor ...
PLX5622
T7100
PLX-5622 is a highly selective brain penetrant and oral active CSF1R inhibitor.
Nampt-IN-1
T4376
Nampt-IN-1 (LSN3154567) is a potent and selective NAMPT inhibitor. Nampt-IN-1 inhibits purified NAMPT with an IC50 of 3.1 nM.
Ki20227
T4315
Ki-20227 is a specific c-Fms tyrosine kinase(CSF1R) inhibitor (IC50: 2 nM). It also has certain inhibitory against VEGFR2(IC50: 12 nM) and c-Kit/PDGFRβ(IC50: 451...
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