c-Fms

Colony stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR), and CD115 (Cluster of Differentiation 115), is a cell-surface protein encoded, in humans, by the CSF1R gene (known also as c-FMS). It is a receptor for a cytokine called colony stimulating factor 1.

Cat. No.	Product name	CAS No.	Purity
T61589	C-Fms-IN-13	885704-58-5	98%
T61589	c-Fms-IN-13 (compound 14) is a potent FMS kinase inhibitor (IC50= 17 nM). c-Fms-IN-13 is an anti-inflammatory agent.
T10648	C-Fms-IN-9	1628574-50-4	98%
T10648	c-Fms-IN-9 is a c-FMS inhibitor extracted from patent WO2014145023A1 (Example 7). It inhibits unphosphorylated c-FMS kinase (uFMS) and uKIT (IC50s: <0.01 μM and ...
T11734	K-80003	1292821-90-9	98%
T11734	K-80003 is a potent inhibitor of cancer cell growth and tRXRα-dependent Akt activation.
T1925	PLX647	873786-09-5	98%
T1925	PLX647 is a highly selective dual FMS/KIT kinase inhibitor (IC50: 28/16 nM).
T12505	PLX5622 hemifumarate	T12505	98%
T12505	PLX5622 hemifumarate is a highly selective brain penetrant and orally active CSF1R inhibitor with an IC 50 of 0.016 μM and Ki of 5.9 nM. PLX5622 hemifumarate all...
T10645	C-Fms-IN-6	1628574-81-1	98%
T10645	c-Fms-IN-6 is a potent inhibitor of c-FMS (IC50 ≤10 nM for unphosphorylated c-FMS) and also weakly inhibits unphosphorylated c-KIT and PDGFR (IC50: > 1 μM).
T10649	C-Fms-IN-3	885704-21-2	98%
T10649	c-Fms-IN-3 is a novel inhibitor of the c-FMS and can be used in studies about antirheumatic and anti-inflammatory diseases.
T2609	Masitinib	790299-79-5	98%
T2609	Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 2008 it has ...
T10643	C-Fms-IN-1	885703-64-0	98%
T10643	c-Fms-IN-1 is an inhibitor of c-FMS kinase (IC50 = 0.8 nM).
T5586	CFMS Receptor Inhibitor II	959860-85-6	98%
T5586	cFMS Receptor Inhibitor II is a CSF1R kinase inhibitor
T5172	AZ304	942507-42-8	98%
T5172	AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and wild type CRAF (IC50s: 79/38/68 nM).
T2624	OSI-930	728033-96-3	98%
T2624	OSI-930, an orally active inhibitor of c-Kit and the vascular endothelial growth factor receptor-2 (VEGFR-2), targets cancer cell proliferation and blood vessel ...
T60087	CFMS Receptor Inhibitor IV	959626-45-0	98%
T60087	cFMS Receptor Inhibitor IV is an inhibitor of c-Fms tyrosine kinase.
TQ0015	PRN1371	1802929-43-6	98%
TQ0015	PRN1371 is a specific and potent FGFR1-4 and CSF1R inhibitor (IC50s: 0.6/1.3/4.1/19.3/8.1 nM for FGFR1/2/3/4 and CSF1R).
T13194	CSF1R-IN-2	2271119-26-5	98%
T13194	CSF1R-IN-2 is an oral-active SRC, MET and c-FMS inhibitor (IC50s: 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively).
T2659	GW2580	870483-87-7	98%
T2659	GW2580 is a specific, oral-bioavailable CSF-1R inhibitor for c-FMS.
T3351	Onatasertib	1228013-30-6	98%
T3351	CC-223 is an orally available mTOR inhibitor with potential antitumor activity. CC-223 inhibits the activity of mTOR, which may result in the induction of tumor ...
T7100	PLX5622	1303420-67-8	98%
T7100	PLX-5622 is a highly selective brain penetrant and oral active CSF1R inhibitor.
T4376	Nampt-IN-1	1698878-14-6	98%
T4376	Nampt-IN-1 (LSN3154567) is a potent and selective NAMPT inhibitor. Nampt-IN-1 inhibits purified NAMPT with an IC50 of 3.1 nM.
T4315	Ki20227	623142-96-1	98%
T4315	Ki-20227 is a specific c-Fms tyrosine kinase(CSF1R) inhibitor (IC50: 2 nM). It also has certain inhibitory against VEGFR2(IC50: 12 nM) and c-Kit/PDGFRβ(IC50: 451...