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c-Fms

Colony stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR), and CD115 (Cluster of Differentiation 115), is a cell-surface protein encoded, in humans, by the CSF1R gene (known also as c-FMS). It is a receptor for a cytokine called colony stimulating factor 1.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T1925 PLX647 873786-09-5
PLX647
PLX647 is a highly selective dual FMS/KIT kinase inhibitor (IC50: 28/16 nM).
T78603 Sotuletinib dihydrochloride 2222138-40-9 98%
Sotuletinib dihydrochloride
Sotuletinib (BLZ945) dihydrochloride is an orally administered, blood-brain barrier-permeable inhibitor specifically targeting CSF1-R with an IC50 of 1 nM. It pr...
T79472 CSF1R-IN-17 98%
CSF1R-IN-17
CSF1R-IN-17 (compound 9) is a potent, selective antagonist of CSF1R, exhibiting an inhibition concentration half-maximum (IC50) of 0.2 nM. It is capable of inhib...
T79815 C-Fms-IN-14 1898210-99-5 98%
c-Fms-IN-14
c-Fms-IN-14 (Example 76) is a potent inhibitor of the c-Fms kinase with an IC50 of 4 nM, utilized in cancer and autoimmune disease research [1].
T80585 Anti-Mouse GM-CSF Antibody (MP1-22E9) 98%
Anti-Mouse GM-CSF Antibody (MP1-22E9)
Anti-Mouse GM-CSF Antibody is a rat-derived IgG2a isotype inhibitor that targets mouse granulocyte-macrophage colony-stimulating factor (GM-CSF).
T10648 C-Fms-IN-9 1628574-50-4 98%
c-Fms-IN-9
c-Fms-IN-9 is a c-FMS inhibitor. It inhibits unphosphorylated c-FMS kinase (uFMS) and uKIT (IC50s: <0.01 μM and 0.1-1 μM).
T69759 IACS-9439 2231259-57-5 98%
IACS-9439
IACS-9439 is a potent, selective, and orally active inhibitor of CSF1R, exhibiting a K(i) of 1 nM. It is applicable in the research of advanced solid tumors [1]....
T12505 PLX5622 hemifumarate 98%
PLX5622 hemifumarate
PLX5622 hemifumarate is a highly selective brain penetrant and orally active CSF1R inhibitor with an IC 50 of 0.016 μM and Ki of 5.9 nM. PLX5622 hemifumarate all...
T10645 C-Fms-IN-6 1628574-81-1 98%
c-Fms-IN-6
c-Fms-IN-6 is a potent inhibitor of c-FMS (IC50 ≤10 nM for unphosphorylated c-FMS) and also weakly inhibits unphosphorylated c-KIT and PDGFR (IC50: > 1 μM).
T10649 C-Fms-IN-3 885704-21-2 99.92%
c-Fms-IN-3
c-Fms-IN-3 is a novel inhibitor of the c-FMS and can be used in studies about antirheumatic and anti-inflammatory diseases.
T2609 Masitinib 790299-79-5 99.91%
Masitinib
Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 200...
T10643 C-Fms-IN-1 885703-64-0 99.88%
c-Fms-IN-1
c-Fms-IN-1 is an inhibitor of c-FMS kinase (IC50 = 0.8 nM).
T5586 CFMS Receptor Inhibitor II 959860-85-6 99.86%
cFMS Receptor Inhibitor II
cFMS Receptor Inhibitor II is a CSF1R kinase inhibitor
T61589 C-Fms-IN-13 885704-58-5 99.83%
c-Fms-IN-13
c-Fms-IN-13 (compound 14) is a potent FMS kinase inhibitor (IC50= 17 nM). c-Fms-IN-13 is an anti-inflammatory agent.
T79157 Pimicotinib 2253123-16-7 99.8%
Pimicotinib
Pimicotinib (ABSK021) is a potent CSF1R inhibitor with antitumor activity and can be used to study advanced solid tumors.
T2624 OSI-930 728033-96-3 99.76%
OSI-930
OSI-930, an orally active inhibitor of c-Kit and the vascular endothelial growth factor receptor-2 (VEGFR-2), targets cancer cell proliferation and blood vessel ...
T7100 PLX5622 1303420-67-8 99.76%
PLX5622
PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor.
T60087 CFMS Receptor Inhibitor IV 959626-45-0 99.73%
cFMS Receptor Inhibitor IV
cFMS Receptor Inhibitor IV is an inhibitor of c-Fms tyrosine kinase.
TQ0015 PRN1371 1802929-43-6 99.72%
PRN1371
PRN1371 is a specific and potent FGFR1-4 and CSF1R inhibitor (IC50s: 0.6/1.3/4.1/19.3/8.1 nM for FGFR1/2/3/4 and CSF1R).
T13194 CSF1R-IN-2 2271119-26-5 99.71%
CSF1R-IN-2
CSF1R-IN-2 is an oral-active SRC, MET and c-FMS inhibitor (IC50s: 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively).
PLX647
T1925
PLX647 is a highly selective dual FMS/KIT kinase inhibitor (IC50: 28/16 nM).
Sotuletinib dihydrochloride
T78603
Sotuletinib (BLZ945) dihydrochloride is an orally administered, blood-brain barrier-permeable inhibitor specifically targeting CSF1-R with an IC50 of 1 nM. It pr...
CSF1R-IN-17
T79472
CSF1R-IN-17 (compound 9) is a potent, selective antagonist of CSF1R, exhibiting an inhibition concentration half-maximum (IC50) of 0.2 nM. It is capable of inhib...
c-Fms-IN-14
T79815
c-Fms-IN-14 (Example 76) is a potent inhibitor of the c-Fms kinase with an IC50 of 4 nM, utilized in cancer and autoimmune disease research [1].
Anti-Mouse GM-CSF Antibody (MP1-22E9)
T80585
Anti-Mouse GM-CSF Antibody is a rat-derived IgG2a isotype inhibitor that targets mouse granulocyte-macrophage colony-stimulating factor (GM-CSF).
c-Fms-IN-9
T10648
c-Fms-IN-9 is a c-FMS inhibitor. It inhibits unphosphorylated c-FMS kinase (uFMS) and uKIT (IC50s: <0.01 μM and 0.1-1 μM).
IACS-9439
T69759
IACS-9439 is a potent, selective, and orally active inhibitor of CSF1R, exhibiting a K(i) of 1 nM. It is applicable in the research of advanced solid tumors [1]....
PLX5622 hemifumarate
T12505
PLX5622 hemifumarate is a highly selective brain penetrant and orally active CSF1R inhibitor with an IC 50 of 0.016 μM and Ki of 5.9 nM. PLX5622 hemifumarate all...
c-Fms-IN-6
T10645
c-Fms-IN-6 is a potent inhibitor of c-FMS (IC50 ≤10 nM for unphosphorylated c-FMS) and also weakly inhibits unphosphorylated c-KIT and PDGFR (IC50: > 1 μM).
c-Fms-IN-3
T10649
c-Fms-IN-3 is a novel inhibitor of the c-FMS and can be used in studies about antirheumatic and anti-inflammatory diseases.
Masitinib
T2609
Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 200...
c-Fms-IN-1
T10643
c-Fms-IN-1 is an inhibitor of c-FMS kinase (IC50 = 0.8 nM).
cFMS Receptor Inhibitor II
T5586
cFMS Receptor Inhibitor II is a CSF1R kinase inhibitor
c-Fms-IN-13
T61589
c-Fms-IN-13 (compound 14) is a potent FMS kinase inhibitor (IC50= 17 nM). c-Fms-IN-13 is an anti-inflammatory agent.
Pimicotinib
T79157
Pimicotinib (ABSK021) is a potent CSF1R inhibitor with antitumor activity and can be used to study advanced solid tumors.
OSI-930
T2624
OSI-930, an orally active inhibitor of c-Kit and the vascular endothelial growth factor receptor-2 (VEGFR-2), targets cancer cell proliferation and blood vessel ...
PLX5622
T7100
PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor.
cFMS Receptor Inhibitor IV
T60087
cFMS Receptor Inhibitor IV is an inhibitor of c-Fms tyrosine kinase.
PRN1371
TQ0015
PRN1371 is a specific and potent FGFR1-4 and CSF1R inhibitor (IC50s: 0.6/1.3/4.1/19.3/8.1 nM for FGFR1/2/3/4 and CSF1R).
CSF1R-IN-2
T13194
CSF1R-IN-2 is an oral-active SRC, MET and c-FMS inhibitor (IC50s: 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively).
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