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Galectin

Galectins are a class of proteins that bind specifically to β-galactoside sugars, such as N-acetyllactosamine (Galβ1-3GlcNAc or Galβ1-4GlcNAc), which can be bound to proteins by either N-linked or O-linked glycosylation. They are also termed S-type lectins due to their dependency on disulphide bonds for stability and carbohydrate binding. There have been about 15 galectins discovered in mammals, encoded by the LGALS genes, which are numbered in a consecutive manner. Only galectin-1, -2, -3, -4, -7, -7B, -8, -9, -9B, 9C, -10, -12, -13, -14, and -16 have been identified in humans. Galectin-5 and -6 are found in rodents, whereas galectin-11 and -15 are uniquely found in sheep and goats. Members of the galectin family have also been discovered in other mammals, birds, amphibians, fish, nematodes, sponges, and some fungi. Unlike the majority of lectins they are not membrane bound, but soluble proteins with both intra- and extracellular functions. They have distinct but overlapping distributions[2] but found primarily in the cytosol, nucleus, extracellular matrix or in circulation. Although many galectins must be secreted, they do not have a typical signal peptide required for classical secretion. The mechanism and reason for this non-classical secretion pathway is unknown.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T79380 Galectin-3/galectin-8-IN-1 98%
Galectin-3/galectin-8-IN-1
Galectin-3/galectin-8-IN-1 (Compound 53) serves as a dual inhibitor of the Galectin-3 and galectin-8 C-terminal domains, exhibiting dissociation constants (Kd) o...
T79381 Galectin-3/galectin-8-IN-2 98%
Galectin-3/galectin-8-IN-2
Galectin-3/galectin-8-IN-2 (Compound 57) is a dual inhibitor targeting the C-terminal domains of Galectin-3 and galectin-8, exhibiting dissociation constants (Kd...
T82605 DB21, Galectin-1 Antagonist 1623027-80-4 98%
DB21, Galectin-1 Antagonist
DB21, Galectin-1 Antagonist, is a peptidomimetic conjugated with dibenzofuran, serving as an allosteric inhibitor of galectin-1 (GAL1) interactions with glycans ...
T74538 Galectin-3 antagonist 2 2921603-02-1 98%
Galectin-3 antagonist 2
Galectin-3, a β-galactoside-specific carbohydrate recognition protein (lectin), facilitates the migration of B-cell precursor acute lymphoblastic leukemia (BCP-A...
T38074 Thiodigalactoside 51555-87-4 99.74%
Thiodigalactoside
Thiodigalactoside (TDG), a non-metabolizable disaccharide, serves as an orally active, potent galectin (GAL) inhibitor, exhibiting Kd values of 24 μM and 49 μM f...
T5121 TD139 1450824-22-2 99.05%
TD139
TD139 is an inhaled galectin-3 inhibitor (Kd: 14 nM).
T16413 OTX008 286936-40-1 98.77%
OTX008
OTX008 (PTX008) is a selective galectin-1 inhibitor.
T15372 GB1107 1978336-61-6 98.33%
GB1107
GB1107 is an effective and selective Galectin-3 inhibitor with a Kd of 37 nM.
T11346L G3-C12 acetate(848301-94-0 free base) 95.09%
G3-C12 acetate(848301-94-0 free base)
G3-C12 acetate shows anticancer activity. is a galectin-3 binding peptide, with Kd of 88 nM.
Galectin-3/galectin-8-IN-1
T79380
Galectin-3/galectin-8-IN-1 (Compound 53) serves as a dual inhibitor of the Galectin-3 and galectin-8 C-terminal domains, exhibiting dissociation constants (Kd) o...
Galectin-3/galectin-8-IN-2
T79381
Galectin-3/galectin-8-IN-2 (Compound 57) is a dual inhibitor targeting the C-terminal domains of Galectin-3 and galectin-8, exhibiting dissociation constants (Kd...
DB21, Galectin-1 Antagonist
T82605
DB21, Galectin-1 Antagonist, is a peptidomimetic conjugated with dibenzofuran, serving as an allosteric inhibitor of galectin-1 (GAL1) interactions with glycans ...
Galectin-3 antagonist 2
T74538
Galectin-3, a β-galactoside-specific carbohydrate recognition protein (lectin), facilitates the migration of B-cell precursor acute lymphoblastic leukemia (BCP-A...
Thiodigalactoside
T38074
Thiodigalactoside (TDG), a non-metabolizable disaccharide, serves as an orally active, potent galectin (GAL) inhibitor, exhibiting Kd values of 24 μM and 49 μM f...
TD139
T5121
TD139 is an inhaled galectin-3 inhibitor (Kd: 14 nM).
OTX008
T16413
OTX008 (PTX008) is a selective galectin-1 inhibitor.
GB1107
T15372
GB1107 is an effective and selective Galectin-3 inhibitor with a Kd of 37 nM.
G3-C12 acetate(848301-94-0 free base)
T11346L
G3-C12 acetate shows anticancer activity. is a galectin-3 binding peptide, with Kd of 88 nM.
TargetMol