Complement System

The complement system, also known as complement cascade, is a part of the immune system that enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promote inflammation, and attack the pathogen's cell membrane. It is part of the innate immune system, which is not adaptable and does not change during an individual's lifetime. The complement system can, however, be recruited and brought into action by antibodies generated by the adaptive immune system.

Cat. No.	Product name	CAS No.	Purity
T7497	C3a (70-77)	63555-63-5
T7497	C3a (70-77) is an octapeptide corresponding to the COOH terminus of C3a.
T78191	NH2-C6-ARC186		98%
T78191	NH2-C6-ARC186 is a derivative of the aptamer ARC186, featuring an NH2-C6 moiety that enables coupling to various peptides or molecules. As a potent complement in...
T80083	Zilucoplan TFA		98%
T80083	Zilucoplan TFA (RA101495), a 15-amino acid macrocyclic peptide, serves as a potent inhibitor of complement component 5 (C5). It has applications in the study of ...
T80131	C5a Anaphylatoxin (human)	1816940-05-2	98%
T80131	C5a Anaphylatoxin (human) is a pro-inflammatory peptide that functions as a leukocyte chemoattractant, utilized in researching inflammation and immune responses,...
T80265	C5a Receptor agonist, mouse, human	144555-06-6	98%
T80265	C5a Receptor Agonist (mouse, human) is a bioactive peptide derived from the C-terminus of the complement fragment 5 anaphylatoxin (C5a), functioning as an agonis...
T13379	(Z)-Leukadherin-1	2055362-72-4	98%
T13379	(Z)-Leukadherin-1 (ADH-503 free base) is an allosteric agonist of CD11b.
T9695L	POT-4 acetate		98%
T9695L	POT-4 acetate inhibits Complement C3 activation. POT-4 acetate can be used for studies about age-related macular degeneration.
TP1305L	LEP(116-130)(mouse)TFA(258276-95-8 free base)	TP1305L	99.93%
TP1305L	LEP(116-130)(mouse) is a synthetic leptin peptide fragment.
TP2334	PMX 53 acetate(219639-75-5 free base)	852629-88-0	99.91%
TP2334	PMX-53 is a potent and orally active CD88 (C5aR) antagonist (IC50: 20 nM) and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 va...
T8223	Avacopan	1346623-17-3	99.9%
T8223	Avacopan (CCX168) is an orally administered small-molecule C5aR ( IC50 : 0.1 nM.)antagonist that blocks the effects of C5a and prevents the development of GN ind...
T8509	Danicopan	1903768-17-1	99.88%
T8509	Danicopan (ACH-4471) (ACH-4471) is a selective, orally active small molecule factor D inhibitor with high binding affinity to human factor D, with a Kd value of ...
T60161	CP-289	1349637-14-4	99.85%
T60161	CP-289 is a potent C5a receptor antagonist with IC50 of 1 μM.
T9189	Iptacopan hydrochloride	1646321-63-2	99.84%
T9189	Iptacopan hydrochloride (LNP023 hydrochloride) is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM. Iptacopan ...
T1076	Dexamethasone	50-02-2	99.77%
T1076	Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist and an IL receptor modulator. Dexamethasone has anti-inflammatory and immunosuppressive activit...
T60151	CP-447697	1092847-21-6	99.62%
T60151	CP-447697, a lipophilic C5a receptor antagonist, exhibits an IC50 of 31 nM. It is utilized in inflammation research.
T11154L	EG01377 2HCl	2749438-61-5	99.56%
T11154L	EG01377 2HCl is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1) with a Kd value of 1.32 μM and an IC50 value of 609 nM for both EG01377 2HC...
T12506L1	PMX 205 acetate(514814-49-4 free base)	T12506L1	99.4%
T12506L1	PMX 205 acetate is an antagonist of complement C5a receptor (C5aR; CD88).
T10863	Complement C5-IN-1	2365402-67-9	99.2%
T10863	Complement C5-IN-1 is a small-molecule inhibitor of complement component 5 protein (C5).
T12851	SB290157 trifluoroacetate	1140525-25-2	98.93%
T12851	SB290157 trifluoroacetate is a potent and selective antagonist of C3a receptor(IC50 of 200 nM).
T13568L	BCX 1470 hydrochloride		98.76%
T13568L	BCX 1470 hydrochloride is a potent serine protease inhibitor with anti-inflammatory activity that inhibits the ester hydrolysis and haemolytic activity of factor...