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Complement System

The complement system, also known as complement cascade, is a part of the immune system that enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promote inflammation, and attack the pathogen's cell membrane. It is part of the innate immune system, which is not adaptable and does not change during an individual's lifetime. The complement system can, however, be recruited and brought into action by antibodies generated by the adaptive immune system.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T7497 C3a (70-77) 63555-63-5
C3a (70-77)
C3a (70-77) is an octapeptide corresponding to the COOH terminus of C3a.
T78191 NH2-C6-ARC186 98%
NH2-C6-ARC186
NH2-C6-ARC186 is a derivative of the aptamer ARC186, featuring an NH2-C6 moiety that enables coupling to various peptides or molecules. As a potent complement in...
T80083 Zilucoplan TFA 98%
Zilucoplan TFA
Zilucoplan TFA (RA101495), a 15-amino acid macrocyclic peptide, serves as a potent inhibitor of complement component 5 (C5). It has applications in the study of ...
T80131 C5a Anaphylatoxin (human) 1816940-05-2 98%
C5a Anaphylatoxin (human)
C5a Anaphylatoxin (human) is a pro-inflammatory peptide that functions as a leukocyte chemoattractant, utilized in researching inflammation and immune responses,...
T80265 C5a Receptor agonist, mouse, human 144555-06-6 98%
C5a Receptor agonist, mouse, human
C5a Receptor Agonist (mouse, human) is a bioactive peptide derived from the C-terminus of the complement fragment 5 anaphylatoxin (C5a), functioning as an agonis...
T13379 (Z)-Leukadherin-1 2055362-72-4 98%
(Z)-Leukadherin-1
(Z)-Leukadherin-1 (ADH-503 free base) is an allosteric agonist of CD11b.
T9695L POT-4 acetate 98%
POT-4 acetate
POT-4 acetate inhibits Complement C3 activation. POT-4 acetate can be used for studies about age-related macular degeneration.
T76831 Tesidolumab 1531594-08-7 SDS-PAGE:95% SEC-HPLC:99.72%
Tesidolumab
Tesidolumab (LFG316) is a fully human IgG1/λ anti-C5 monoclonal antibody. Tesidolumab (LFG316) has an inhibitory effect on crovalimab and C5, blocking the cuttin...
T76702 Sutimlimab 2049079-64-1 SDS-PAGE:95% SEC-HPLC:95%
Sutimlimab
Sutimlimab is a novel monoclonal antibody targeting complement protein C1. Sutimlimab is commonly used as a C1 inhibitor to treat cold agglutina-associated hemol...
T76867 Ravulizumab 1803171-55-2 SDS-PAGE:95% SEC-HPLC:95%
Ravulizumab
Ravulizumab (ALXN1210) is a humanized monoclonal antibody targeting complement factor 5 that specifically binds to human complement protein C5 with high affinity...
T0945 Cyclosporin A 59865-13-3 99.99%
Cyclosporin A
Cyclosporin A is a naturally occurring cyclic polypeptide that is the active metabolite of a fungus. Cyclosporin A is an immunosuppressant that binds to procycli...
TP1305L LEP(116-130)(mouse)TFA(258276-95-8 free base) 99.93%
LEP(116-130)(mouse)TFA(258276-95-8 free base)
LEP(116-130)(mouse) is a synthetic leptin peptide fragment.
TP2334 PMX 53 acetate(219639-75-5 free base) 852629-88-0 99.91%
PMX 53 acetate(219639-75-5 free base)
PMX-53 is a potent and orally active CD88 (C5aR) antagonist (IC50: 20 nM) and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 va...
T8223 Avacopan 1346623-17-3 99.9%
Avacopan
Avacopan (CCX168) is an orally administered small-molecule C5aR ( IC50 : 0.1 nM.)antagonist that blocks the effects of C5a and prevents the development of GN ind...
T8509 Danicopan 1903768-17-1 99.88%
Danicopan
Danicopan (ACH-4471) (ACH-4471) is a selective, orally active small molecule factor D inhibitor with high binding affinity to human factor D, with a Kd value of ...
T60161 CP-289 1349637-14-4 99.85%
CP-289
CP-289 is a potent C5a receptor antagonist with IC50 of 1 μM.
T9189 Iptacopan hydrochloride 1646321-63-2 99.84%
Iptacopan hydrochloride
Iptacopan hydrochloride (LNP023 hydrochloride) is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM. Iptacopan ...
T1076 Dexamethasone 50-02-2 99.77%
Dexamethasone
Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist and an IL receptor modulator. Dexamethasone has anti-inflammatory and immunosuppressive activit...
T60151 CP-447697 1092847-21-6 99.62%
CP-447697
CP-447697, a lipophilic C5a receptor antagonist, exhibits an IC50 of 31 nM. It is utilized in inflammation research.
T11154L EG01377 2HCl 2749438-61-5 99.56%
EG01377 2HCl
EG01377 2HCl is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1) with a Kd value of 1.32 μM and an IC50 value of 609 nM for both EG01377 2HC...
C3a (70-77)
T7497
C3a (70-77) is an octapeptide corresponding to the COOH terminus of C3a.
NH2-C6-ARC186
T78191
NH2-C6-ARC186 is a derivative of the aptamer ARC186, featuring an NH2-C6 moiety that enables coupling to various peptides or molecules. As a potent complement in...
Zilucoplan TFA
T80083
Zilucoplan TFA (RA101495), a 15-amino acid macrocyclic peptide, serves as a potent inhibitor of complement component 5 (C5). It has applications in the study of ...
C5a Anaphylatoxin (human)
T80131
C5a Anaphylatoxin (human) is a pro-inflammatory peptide that functions as a leukocyte chemoattractant, utilized in researching inflammation and immune responses,...
C5a Receptor agonist, mouse, human
T80265
C5a Receptor Agonist (mouse, human) is a bioactive peptide derived from the C-terminus of the complement fragment 5 anaphylatoxin (C5a), functioning as an agonis...
(Z)-Leukadherin-1
T13379
(Z)-Leukadherin-1 (ADH-503 free base) is an allosteric agonist of CD11b.
POT-4 acetate
T9695L
POT-4 acetate inhibits Complement C3 activation. POT-4 acetate can be used for studies about age-related macular degeneration.
Tesidolumab
T76831
Tesidolumab (LFG316) is a fully human IgG1/λ anti-C5 monoclonal antibody. Tesidolumab (LFG316) has an inhibitory effect on crovalimab and C5, blocking the cuttin...
Sutimlimab
T76702
Sutimlimab is a novel monoclonal antibody targeting complement protein C1. Sutimlimab is commonly used as a C1 inhibitor to treat cold agglutina-associated hemol...
Ravulizumab
T76867
Ravulizumab (ALXN1210) is a humanized monoclonal antibody targeting complement factor 5 that specifically binds to human complement protein C5 with high affinity...
Cyclosporin A
T0945
Cyclosporin A is a naturally occurring cyclic polypeptide that is the active metabolite of a fungus. Cyclosporin A is an immunosuppressant that binds to procycli...
LEP(116-130)(mouse)TFA(258276-95-8 free base)
TP1305L
LEP(116-130)(mouse) is a synthetic leptin peptide fragment.
PMX 53 acetate(219639-75-5 free base)
TP2334
PMX-53 is a potent and orally active CD88 (C5aR) antagonist (IC50: 20 nM) and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 va...
Avacopan
T8223
Avacopan (CCX168) is an orally administered small-molecule C5aR ( IC50 : 0.1 nM.)antagonist that blocks the effects of C5a and prevents the development of GN ind...
Danicopan
T8509
Danicopan (ACH-4471) (ACH-4471) is a selective, orally active small molecule factor D inhibitor with high binding affinity to human factor D, with a Kd value of ...
CP-289
T60161
CP-289 is a potent C5a receptor antagonist with IC50 of 1 μM.
Iptacopan hydrochloride
T9189
Iptacopan hydrochloride (LNP023 hydrochloride) is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM. Iptacopan ...
Dexamethasone
T1076
Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist and an IL receptor modulator. Dexamethasone has anti-inflammatory and immunosuppressive activit...
CP-447697
T60151
CP-447697, a lipophilic C5a receptor antagonist, exhibits an IC50 of 31 nM. It is utilized in inflammation research.
EG01377 2HCl
T11154L
EG01377 2HCl is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1) with a Kd value of 1.32 μM and an IC50 value of 609 nM for both EG01377 2HC...
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TargetMol