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Complement System

The complement system, also known as complement cascade, is a part of the immune system that enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promote inflammation, and attack the pathogen's cell membrane. It is part of the innate immune system, which is not adaptable and does not change during an individual's lifetime. The complement system can, however, be recruited and brought into action by antibodies generated by the adaptive immune system.

Iptacopan hydrochloride
T91891646321-63-2In house
Iptacopan hydrochloride (LNP023 hydrochloride) is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM. Iptacopan hydrochloride shows direct, reversible, and high-affinity binding to human factor B with a KD of 7.9 nM.
  • $155
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Dexamethasone
T107650-02-2
Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist and IL receptor modulator with anti-inflammatory and immunosuppressive properties that induces autophagy and inhibits LPS-induced inflammatory responses in macrophages.
  • $29
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JR14a
T93162411440-41-8
JR14a (5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride) is a potent antagonist of human complement C3a receptor.
  • $84
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SB290157 trifluoroacetate
T128511140525-25-2
SB290157 trifluoroacetate is a potent and selective antagonist of the C3a receptor, with an IC50 of 200 nM.
  • $43
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ADH-503
T77762055362-74-6
ADH-503 (GB1275) is an orally available, allosteric CD11b small molecule agonist that can lead to repolarization of tumor-associated macrophages, reduction in the number of tumor-infiltrating immunosuppressive myeloid cells, and enhancement of dendritic cell responses.
  • $48
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Lipoteichoic acid
T4064656411-57-5
Lipoteichoic acid, a polymer of Staphylococcus aureus cell wall, activates the complement system by inducing C3 and inhibiting CD55, and reduces fat deposition via the IGF-1 pathway.
  • $196
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Compstatin
TP1304206645-99-0
Compstatin is a cyclic peptide consisting of 13 amino acid residues and is a potent inhibitor of complement system C3. Compstatin is species-specific and has inhibitory effects only on the complement system of primates. Studies have shown that it can bind to baboon C3 and is resistant to proteolytic cleavage in baboon blood. Its IC50 values for the classical pathway and alternative pathway are 63 μM and 12 μM, respectively.
  • $73
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EG01377 2HCl
T11154L2749438-61-5In house
EG01377 2HCl is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1) with a Kd value of 1.32 μM and an IC50 value of 609 nM for both EG01377 2HCl against NRP1-a1 and NRP1-b1.EG01377 exhibits anti-angiogenic, antimigratory and antitumor activities.
  • $148
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Danicopan
T85091903768-17-1
Danicopan (ACH-4471) (ACH-4471) is a selective, orally active small molecule factor D inhibitor with high binding affinity to human factor D, with a Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits the activity of the complement replacement pathway (APC) and may block the complement replacement pathway in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS).
  • $97
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Eculizumab
T9915219685-50-4
Eculizumab is a recombinant humanized monoclonal antibody against the complement protein C5
  • $179
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BCX 1470 hydrochloride
T13568L In house
BCX 1470 hydrochloride is a potent serine protease inhibitor with anti-inflammatory activity that inhibits the ester hydrolysis and haemolytic activity of factor D and C1s, and can be used to study oedema.
  • $139
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Avacopan
T82231346623-17-3
Avacopan (CCX168) is a C5aR antagonist (IC50=0.1 nM) with selective and oral activity. Avacopan blocks the action of C5a and prevents the development of GN induced by anti-myeloperoxidase antibodies in a mouse model of AAV. Avacopan can be used to treat anti-neutrophil cytoplasmic antibody (ANCA)-related vasculitis.
  • $33
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C3a Receptor Agonist
T38287944997-60-8
C3a Receptor Agonist (C3a receptor agonist 1) binds the G protein-coupled C3a receptors (C3aRs) in the immune system complement pathway. Activation of C3aR prevents neutrophils from being mobilized in a model of intestinal ischemia-reperfusion injury. C3aRs are expressed on neural progenitor cells and immature neurons in adult mice. C3a stimulates differentiation of neural progenitor cells in vitro.
  • $89
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Sutimlimab
T767022049079-64-1
Sutimlimab is a novel monoclonal antibody targeting complement protein C1. Sutimlimab is commonly used as a C1 inhibitor to treat cold agglutina-associated hemolysis.
  • $208
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W-54011
T17250405098-33-1
W-54011 is a potent non-peptide C5a receptor antagonist. W-54011 inhibits the binding of 125I-labeled C5a to human neutrophils (Ki: 2.2 nM). W-54011 inhibits C5a-induced intracellular Ca2+ mobilization, chemotaxis, and generation of ROS in human neutrophi
  • $77
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PMX 205 acetate(514814-49-4 free base)
T12506L1
PMX 205 acetate is an antagonist of complement C5a receptor (C5aR; CD88).
  • $113
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Complement factor D-IN-2
T383321903742-34-6
Complement factor D-IN-2 is an inhibitor that reduces the excessive activation of Complement factor D.
  • $189
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Complement C5-IN-1
T108632365402-67-9In house
Complement C5-IN-1 is a small-molecule inhibitor of complement component 5 protein (C5).
  • $155
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CP-289
T601611349637-14-4
CP-289 is a potent C5a receptor antagonist with IC50 of 1 μM.
  • $117
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Leukadherin-1
T3638344897-95-6
Leukadherin-1 is an allosteric activator of CD11b CD18. Increasing CD11b CD18-dependent cell adhesion to fibrinogen, Decreasing leukocyte motility and transendothelial migration; reduces inflammation.
  • $39
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PMX 53 acetate(219639-75-5 free base)
TP2334852629-88-0
PMX-53 is a potent and orally active CD88 (C5aR) antagonist (IC50: 20 nM) and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 values of 22 nM and 75 nM, respectively. PMX-53 is also an agonist of Mas-related gene 2 (MrgX2).
  • $113
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CP-447697
T601511092847-21-6
CP-447697, a lipophilic C5a receptor antagonist, exhibits an IC50 of 31 nM. It is utilized in inflammation research.
  • $45
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NDT 9513727
T24524439571-48-9
NDT 9513727 is a potent, selective, and competitive C5aR1 inverse agonist used in the study of inflammatory and immune disorders.
  • $31
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Compstatin control peptide acetate
TP2180L301544-78-5
Compstatin control peptide acetate is an inhibitor of complement protein C3 by binding and inhibiting the cleavage of complement C3.
  • $189
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TLQP 21 acetate
TP2296L
TLQP 21 acetate is a potent agonist of G-protein-coupled receptor complement-3a receptor 1 (C3aR1). The EC50 values are 10.3 μM for mouse and 68.8 μM for human. TLQP 21 acetate is a VGF-derived peptide with endocrine and extraendocrine properties.
  • $185 TargetMol
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LEP(116-130)(mouse)TFA(258276-95-8 free base)
TP1305L
LEP(116-130)(mouse) is a synthetic leptin peptide fragment.
  • $47
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C3a 70-77 2TFA(63555-63-5(free base))
T7497L
C3a 70-77 2TFA(63555-63-5(free base)) (Complement 3a (70-77)) is an octapeptide corresponding to the COOH terminus of C3a.
  • $48
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3-Phenoxybenzaldehyde
T6438839515-51-0
3-Phenoxybenzaldehyde is a complement (classical pathway) inhibitor with IC50 of 1388μM.
  • $29
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Vilobelimab
T769582250440-41-4
Vilobelimab (CaCP-29) is a human-mouse chimeric IgG antibody targeting human complement component 5a, a C5a inhibitor that inhibits neutrophil activation, and can be used for the study of systemic inflammation caused by SARS-CoV-2 infection.
  • $197
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Vesencumab
T768791205533-60-3
Vesencumab (MNRP-1685A) is an IG1 antibody targeting NRP-1 with anti-angiogenic and anti-tumor activity that reduces the number of globules formed by the SUM159 and Hs578T cell lines. Vesencumab inhibits EGFR and PDGFRα activation and can be used to study solid tumors.
  • $317
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(Rel)-Factor B-IN-5
T626892760789-22-6In house
(Rel)-Factor B-IN-5 is a complement factor B inhibitor that can be used to study diseases associated with activation of the alternative complement pathway.
  • $2,140
1-2 weeks
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C5a Anaphylatoxin (human)
T801311816940-05-2
C5a Anaphylatoxin (human) is a pro-inflammatory peptide that acts as a leukocyte chemoattractant and is used in research on inflammation and immune responses, including allergic asthma [1] [2].
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Tesidolumab
T768311531594-08-7
Tesidolumab (LFG316) is a fully human IgG1 λ anti-C5 monoclonal antibody. Tesidolumab (LFG316) has an inhibitory effect on crovalimab and C5, blocking the cutting of C5 and preventing the subsequent formation of membrane attack complex, which can be used to study extravascular hemolysis.
  • $198
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POT-4 acetate
T9695L
POT-4 acetate inhibits Complement C3 activation. POT-4 acetate can be used for studies about age-related macular degeneration.
  • $187
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C1q Protein (Mouse)
T200280
C1qProtein (Mouse) is a subunit of the complement system. It recognizes a variety of ligands and plays roles in maintaining immune system balance, promoting tissue repair, and defending against pathogens.
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Zilucoplan TFA
T80083
Zilucoplan TFA (RA101495), a 15-amino acid macrocyclic peptide, is a potent inhibitor of complement component 5 (C5) with applications in studying immune-mediated necrotising myopathy (IMNM) [1] [2].
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Ravulizumab
T768671803171-55-2
Ravulizumab (ALXN1210) is a humanized monoclonal antibody that specifically binds to human complement protein C5 with high affinity, targeting complement factor 5 to block complement activation. It can be used for the prevention and treatment of paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, and myasthenia gravis.
  • $247
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C5a Receptor agonist, mouse, human
T80265144555-06-6
C5a Receptor Agonist (mouse, human) is a bioactive peptide derived from the C-terminus of the complement fragment 5 anaphylatoxin (C5a), functioning as an agonist for the C5a receptor. This peptide plays a role in mediating inflammatory responses by promoting chemotaxis, leukocyte degranulation, enhanced vascular permeability, and cytokine production. Its agonistic activity is critically dependent on the presence of cyclohexylalanine at position 5 and the d-isomer of Arg at the terminal position.
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C3a (70-77)
T749763555-63-5
C3a (70-77) is an octapeptide that corresponds to the COOH terminus of C3a.
  • $82
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NH2-C6-ARC186
T78191
NH2-C6-ARC186 is a derivative of the aptamer ARC186, featuring an NH2-C6 moiety that enables coupling to various peptides or molecules. As a potent complement inhibitor, it operates by inhibiting convertase-mediated C5 activation [1].
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(Z)-Leukadherin-1
T133792055362-72-4
(Z)-Leukadherin-1 (ADH-503 free base) is an allosteric agonist of CD11b.
  • $30
5 days
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