Anti-infection

Pyrolin has a strong antifungal activity and exerts a potent impact on the ultrastructure of M.fructicola.

Vincetoxicoside B, isolated from Polygonum paleaceum Wall. Vincetoxicoside B , quercetin, kaempferol , and (-)-epicatechin show synergistic antifungal activities with the FICI values <0.5.

Terpineol possesses antifungal activity against Trichophyton mentagrophytes, it also exhibits strong antimicrobial activity against periodontopathic and cariogenic bacteria. α-Terpineol (Terpineol) shows anticonvulsant, and anti-inflammatory activities, it inhibits the gene expression of the IL-6 receptor.

2-Furoic acid (Furan-2-carboxylic acid) 2-Furoic acid can reduce serum cholesterol and triglyceride levels and has anti-lipidemic effects.

Octacosanoic acid has antiplatelet and antithrombotic effects.

Monocaprin is a 1-monoglyceride of capric acid that has antimicrobial activity against enveloped viruses, certain bacteria, and the yeast Candida albicans.

5-Geranoxy-7-methoxycoumarin shows antifungal activity.

Isoforsythiaside has antioxidant, and antibacterial activities.

N-(Hydroxymethyl)nicotinamide (Bilamid) is an antimicrobial agent.

Delamanid (OPC-67683) is an anti-tuberculosis agent derived from the nitro-dihydro-imidazooxazole class of compounds that inhibits mycolic acid synthesis of bacterial cell wall.

Pimpinellin is a natural product that acts as antagonist of proteins with GABA receptor activity.

4-Acetamidobenzenesulfonamide used in proteomics research and is an anti-infective agent

Eriodictyol chalcone has anti-plasmodial effects on P. falciparum growth.

8-Epidiosbulbin E acetate exhibits broad-spectrum plasmid-curing activity against multidrug-resistant (MDR) bacteria, including vancomycin-resistant enterococci.

3,4,5-Trimethoxybenzaldehyde shows anti-Candida efficacy and inhibits adhesion and biofilms.

Sulfabrom (Sulfabromomethazine) is a long-acting sulfonamide medicine for the treatment of coccidiosis and various bacterial infections in poultry, pigs, and cattle.

Fuziline is a diterpene alkaloid found in Aconitum kusnezoffii and Aconitum carmichaelii.It is functionally related to an aconitane.

2-Desoxy-4-epi-pulchellin has potent in vitro cytotoxicities against the K562, MCF-7, Hela, DU145, U937, H1975, SGC-7901, A549, MOLT-4, and HL60 cell lines with IC50 values ranging from 0.10 to 46.7uM, while it shows significant antiviral (H1N1 and H3N2) activities, it also displays significant antimycobacterial activity (IC50=7.6 uM).

2'-Hydroxy-4'-methylacetophenone, a phenolic compound isolated from Angelicae koreana roots possesses acaricidal property. 2'-Hydroxy-4'-methylacetophenone has acaricidal activity, it could be used in the preparation of 4'-methyl-2'-[(p-tolylsulfonyl) oxy] acetophenone.

Secoxyloganin possesses a hepato-protective effect. Secoxyloganin possesses antibacterial activity. Secoxyloganin has cytotoxic activity against UACC-62 cell line.Secoxyloganin possesses the perfect protective effect on PRRSV infected cell and with the minimum protection concentration of 6. 25 μg/mL.

Febrifugine is an effective coccidiostat, possesses schizonticide props; it and its derivatives shows high degree of antimalarial activity but use limited by toxicity .

Viridicatol, with potent antibacterial activity against Staphylococcus aureus(MIC: 15.6 μg/mL), is isolated from the fermentation of an endophytic fungus Penicillium sp. R22 in Nerium indicum.

Antibacterial agent 27 has potent anti-Candida activity.

Heraclenin has anticoagulant, and anti-inflammatory activities, it also has mutagenicity in Chlamydomonas reinhardii. Heraclenin can induce apoptosis in Jurkat leukemia cells, it has a strong clastogenic effect . (+)-Heraclenin displays significant levels

Robinetin (3,3',4',5',7-Pentahydroxyflavone) has antioxidant and antiradical activities, inhibits EYPC membrane lipid peroxidation and HbA glycosylation with high efficiency.

Pyromeconic acid (3-hydroxy-4H-pyran-4-one) and derivatives thereof are potent inhibitors of endonuclease

Paulownin, a furofuran lignan from Paulownia tomentosa,has the action of anti-inflammation,analgesia,immunity,hypoglycemia and has little toxicity.

Ceftezole sodium (Falomesin) is a broad-spectrum cephalosporin antibiotic active gram-negative and gram-positive bacteria except for Proteus vulgaris, Pseudomonas aeruginosa, and Serratia marcescens. It has the inhibition of cell wall synthesis via affinity for penicillin-binding proteins. It also inhibits alpha-glucosidase.

Baicalin methyl ester shows inhibitory effects on the Avian Myeloblastosis Virus reverse transcriptase (AMV-RT).

Kaempferol 3-O-sophoroside (Kaempferol 3-O-beta-sophoroside) has antibacterial and antiviral activities.

Rubiadin-1-methyl ether (Rubiadin 1-methyl ether) is a natural product.It inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nuclear translocation of p65.

Sulfadimethoxine is a antimicrobial agent, treatment of respiratory, urinary tract, enteric, and soft tissue infections

Octahydrocurcumin has antioxidant and and anti-inflammatory activities, it can inhibit the lipopolysaccharide (LPS)-induced inflammatory response via the mechanism of inhibiting NF-kB translocation to the nucleus. Octahydrocurcumin exhibits potent cytotoxic effect (IC50 =19.46 ug mL) and shows high antimicrobial activity.

Dictamine (Dectamine) shows anticholinesterase, anti-inflammatory, mutagenic, and has antimicrobial activity against bacteria and fungi. It has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma cells.

Methyl rosmarinate is a noncompetitive tyrosinase inhibitor which is isolated from Rabdosia serra, with an IC50 of 0.28 mM for mushroom tyrosinase.Methyl rosmarinate shows antioxidative, and antifungal activities. It has inhibitory activities against tyrosinase, α±-glucosidase, and matrix metalloproteinase-1 (MMP-1).

Evocarpine shows antimycobacterial, and vasorelaxant effects, it can inhibit Ca2+ influx through voltage-dependent calcium channels.

Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L. donovani and acts as a non-competitive inhibitor interacting with both subunits of the enzyme. Niranthin also exhibits anti-hepatitis B virus, antiinflammatory and antiallodynic actions.

Bacopasaponin C may have antioxidant activity, it also shows anti-leishmanial property.

(+)-Aromadendrene is a natural product that has significant antibacterial activity against the Gram-positive and Gram-negative bacteria.

1,3,5,8-Tetrahydroxyxanthone (Desmethylbellidifolin) is a natural xanthone extracted from Gentianella acuta. 1,3,5,8-Tetrahydroxyxanthone has antispasmodic effect and anti-inflammatory activity. Dimethylbellidifolin shows mutagenicity in Salmonella typhimurium TA100, TA98, TA97, and TA2637 by the preincubation method; it also exhibits at the dose of 200 ug disk a significant inhibition of the growth of Staphylococcus aureus.

Piperlonguminine is an alkaloid amide isolated from the Piper species. Piperlonguminine shows anti-inflammatory, antitumor, neuroprotective, anti-platelet, anti-melanogenic, antifungal and antibacterial activities.Piperlonguminine is an inhibitor of Akt/mTOR signalling. It acts by promoting autophagy and mediating cancer cell death.

7-Hydroxyflavanone shows antimicrobial activity against Streptococcus pneumoniae clinical isolates.

Sorbic acid is a natural product that inhibits various bacteria, including sporeformers,

Dihydropinosylvinin is an phytoalexin, it shows antifungal activity against Cladosporium cladosporioides, Botryodiplodia theobromae, Aspergillus niger and Penicillium schlerotgenum, it also exhibits strong antibacterial activity against Bacillus cereus, S

Quercimeritrin (Quercetin-7-O-beta-D-glucopyranoside) has antibacterial activity, it shows promising activity against Staphylococcus aureus.

5,7-DIMETHOXYFLAVONE possessed remarkable leishmanicidal potential.

13,21-Dihydroeurycomanone (Pasakbumin C) is a natural product isolated from the root of Eurycoma longifolia with antiparasitic activity such as Plasmodium falciparum and Toxoplasma gondii.

Vasicine is oxytocic and abortifacient agents.Vasicine, a potential natural cholinesterase inhibitor, has been in development for treatment of Alzheimer's disease. Vasicine can regulate the inflammatory reaction, have great potentials to develop safe medi

Aspoxicillin, a broad-spectrum antimicrobial agent, demonstrates efficacy against 68 isolates of Actinobacillus pleuropneumoniae, with a minimum inhibitory concentration (MIC90) of <= 0.05 μg/ml. It exhibits a prolonged half-life of 55 minutes in mouse serum.

2,5-Dihydroxybenzaldehyde (Gentisaldehyde) has antioxidant activity against Mycobacterium avium subsp. Paratuberculosis. 2,5-Dihydroxybenzaldehyde also inhibits S. aureus strains(MIC50: 500 mg/L).