tri-1

TRi-1 is irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1), with an IC50 of 12 nM. TRi-1 has little mitochondrial toxicity for anticancer therapy

1,2,3-Tri-10(Z)-undecenoyl glycerol is a triglyceride composed of 10-undecenoic acid esterified at the sn-1, sn-2, and sn-3 positions.

1,2,3-Tri-13(E)-docosenoyl glycerol, a triacylglycerol featuring 13(E)-docosenoic acid at the \(sn-1\), \(sn-2\), and \(sn-3\) positions, transiently elevates heart triglyceride levels in weanling rats when administered as 15% of a calcium-deficient diet, with levels returning to baseline after 28 days.

1,2,3-Tri-11(Z)-eicosenoyl glycerol, a triacylglycerol with 11(Z)-eicosenoic acid at the sn-1,sn-2, and sn-3 positions, serves as an internal standard for quantifying triacylglycerols in seed and olive oils.

RMC-6291 is an orally active, covalent inhibitor of KRAS G12C (ON) that forms a tri-complex within tumor cells between KRAS G12C (ON) and cyclophilin A (CypA), thereby preventing KRAS G12C (ON) from signaling via steric blockade of RAS effector binding and eliciting deep and durable suppression of RAS pathway activity in KRAS G12C tumor models [1].

b-Casomorphin (1-3) Acetate is a tri-peptide with an opioid effect.

Amino-Tri-(carboxyethoxymethyl)-methane, an ADC linker and PROTAC linker, is a cleavable PEG compound utilized for the synthesis of antibody-drug conjugates (ADCs)[1] and PEG-based PROTACs[2].

Azido-PEG4-amido-tri-(carboxyethoxymethyl)-methane is a PEG-based linker compound used in the synthesis of PROTACs [1].

Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane, a PEG-derived PROTAC linker, is used for PROTAC synthesis[1].

Maleimido-tri(ethylene glycol)-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) for the preparation of neolymphostin-based ADC precursors, specifically for site-specific cysteine mutant trastuzumab-A114C conjugation[1].

Tri(Amino-PEG5-amide)-amine is a polyethylene glycol (PEG) derivative used as a PEG-based proteolysis targeting chimera (PROTAC) linker to aid in the synthesis of PROTACs[1].

Tri(t-butoxycarbonylethoxymethyl) ethanol, an alkyl/ether-based PROTAC linker, is suitable for synthesizing PROTACs[1].

Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine, a cleavable PEG ADC linker, is employed in the synthesis of antibody-drug conjugates (ADCs). It is also a PEG-based PROTAC linker, specifically Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane, widely used in the synthesis of PROTACs [1].

Amino-Tri-(m-PEG4-ethoxymethyl)-methane, a PEG-based PROTAC linker, is a crucial element for synthesizing PROTACs[1].

m-C-tri(CH2-PEG1-NHS ester) is a non-cleavable one-unit polyethylene glycol (PEG) linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Tri(Amino-PEG3-amide)-amine, a polyethylene glycol (PEG)-derived linker, is utilized in the synthesis of proteolysis-targeting chimeric molecules (PROTACs)[1].

Tri(Amino-PEG4-amide)-amine is a polyethylene glycol (PEG)-based linker compound used in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

Tri(Mal-PEG2-amide)-amine, a polyethylene glycol (PEG)-derived linker, is commonly used for synthesizing proteolysis-targeting chimeras (PROTACs)[1].

Tri-(PEG1-C2-acid) is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules, and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

2-[2-(2-ethoxyethoxy)ethoxy]ethan-1-ol (Tri(ethylene glycol) monoethyl ether) is an organic solvent with high solubility and coupling properties, which can be used as a chemical synthesis intermediate for the preparation of ester derivatives, and is mainly used as a high-boiling solvent for paints, inks, dyes and resins.

Chlorotrianisene (tri-p-anisylchloroethylene) is an orally bioavailable, highly lipophilic, synthetic triphenylethylene (TPE) derivative and selective estrogen receptor modulator (SERM), with predominantly estrogenic but also antiestrogenic activities.

3-Acetyldeoxy nivalenol-13C17is intended for use as an internal standard for the quantification of 3-acetyldeoxy nivalenol by GC- or LC-MS. 3-Acetyldeoxy nivalenol is a mycotoxin that has been found inF. graminearum.1In vivo, 3-acetyldeoxy nivalenol (40 mg/kg) induces duodenal and splenic cell necrosis, as well as lethality (LD50= 70 mg/kg) in mice.2 1.Jiao, F., Kawakami, A., and Nakajima, T.Effects of different carbon sources on trichothecene production and Tri gene expression by Fusarium graminearum in liquid cultureFEMS Microbiol.Lett.285(2)212-219(2008) 2.Schiefer, H.B., Nicholson, S., Kasali, O.B., et al.Pathology of acute 3-acetyldeoxynivalenol toxicity in miceCan. J. Comp. Med.49(3)315-318(1985)

2,3,4-Tri-O-acetyl-β-D-glucuronide methyl ester is a synthetic intermediate in the synthesis of prodrug forms of the antitumor antibiotic daunomycin .1 1.Leenders, R.G.G., and Scheeren, H.W.Synthesis and evaluation of novel daunomycin-phosphate-sulfate-β-glucuronide and -β-glucoside prodrugs for application in ADEPTBioorg. Med. Chem. Lett.5(24)2975-2980(1995)

Methanesulfonato(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium(II) is a useful organic compound for research related to life sciences. The catalog number is T64630 and the CAS number is 1445085-55-1.