staphylococci

Ceftobiprole medocaril (BAL5788), the parenteral prodrug of Ceftobiprole, is a broad-spectrum cephalosporin effective against Methicillin-resistant Staphylococcus aureus (MRSA).

Antibacterial compound 2 is a potent antimicrobial agent effective against many human veterinary pathogens, inhibiting multi-drug resistant staphylococci, enterococci and streptococci, as well as anaerobic bacteria.

Mupirocin calcium hydrate is an antibiotic produced by Pseudomonas fluorescens, showed a high level of activity against staphylococci and streptococci and against certain gram-negative bacteria

Spiramycin (Rovamycin) is a macrolide antibiotic produced by Streptomyces ambofaciens, effective against gram-positive aerobic pathogens, N. gonorrhoeae, and staphylococci, and is used to treat infections caused by bacteria and Toxoplasma gondii.

Oxacillin sodium salt (Oxabel) is an antibiotic similar to FLUCLOXACILLIN used in resistant staphylococci infections.

Mupirocin (BRL-4910A) is a RNA synthetase inhibitor antibacterial. It has shown excellent activity against gram-positive staphylococci and streptococci.

Nafcillin sodium monohydrate (CL 8491) is the sodium salt form of nafcillin, a semi-synthetic naphthalene, penicillin-related Nafcillin inhibits bacterial wall synthesis by a mechanism of action similar to penicillin. Penicillinase-resistant Nafcillin is used to treat infections caused by penicillin-resistant strains of Staphylococci.

Nafcillin sodium, a narrow-spectrum beta-lactam antibiotic of the penicillin class, is used to treat infections caused by Gram-positive bacteria, in particular, species of staphylococci that are resistant to other penicillins.

Vulpinic Acid (Pulvinic acid methyl ester) is a lichen metabolite with anti-inflammatory, antibacteria, properties, plant growth inhibitor.

Levonadifloxacin, a broad-spectrum fluoroquinolone antibiotic, is used potentially for the treatment of staphylococci.

Cetocycline hydrochloride is an antibacterial biochemical. It is active against many clinical isolates of aerobic gram-negative bacilli, but is less active against staphylococci, and has no activity against Pseudomonas.

BO3482 is an antimicrobial compound and can inhibit the growth of methicillin-resistant Staphylococci (MIC90: 6.25 mg mL).

Nemonoxacin (TG-873870) is an orally available non-fluorinated quinolone antibiotic with broad-spectrum antimicrobial activity against staphylococci, streptococci, and enterococci, as well as against Neisseria gonorrhoeae and Haemophilus influenzae.Nemonoxacin is used in the study of bacterial infections and community-acquired pneumonia.

Cloxacillin Sodium, a chlorinated derivative of Oxacillin, is a semi-synthetic antibiotic. Cloxacillin is used for the treatment of infections caused by species of staphylococci which produce beta-lactamase.

PD 117588 is a quinolone against bacterial isolates from cancer patients. PD 117558 has a broad antimicrobial spectrum with excellent activity against all Gram-positive isolates (including methicillin-resistant Staphylococcus aureus, coagulase-negative st

Cefalonium hydrate is a first-generation β-lactam cephalosporin antibiotic commonly employed in the study of bovine mastitis induced by Gram-positive bacteria, particularly staphylococci. It demonstrates significant effectiveness in this research area.

Piromidic acid is an antibacterial agent active against gram-negative bacteria and staphylococci, used for urinary tract and intestinal infections (Piromidic acid) [USP].

Ceftobiprole medocaril sodium (BAL5788) is a parenteral prodrug of Ceftobiprole, a pyrrolidinone cephalosporin administered intravenously. As a broad-spectrum cephalosporin, Ceftobiprole exhibits high in vitro activity against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Staphylococci (VRSA), and penicillin-resistant Streptococci. Additionally, it is effective in inhibiting both gram-positive and gram-negative pathogens.

Ticarcillin monosodium, a semisynthetic carboxypenicillin antibacterial agent, exhibits broad-spectrum activity against gram-positive cocci such as streptococci and staphylococci. It is also effective against most gram-negative organisms, notably Pseudomonas aeruginosa. The compound is utilized in the treatment of various infections, including those of the lower respiratory tract, skin and skin structures, urinary tract, and intraabdominal infections, according to research [1] [2] [3].

Afabicin is the prodrug of Debio1452. Debio1452 is an inhibitor FabI, an enzyme critical to fatty acid biosynthesis in staphylococci.

Eperezolid (PNU-100592) is an oxazolidinone antibacterial agent. Eperezolid showed well in vitro inhibitory activity, regardless of methicillin susceptibility for staphylococci(MIC90= 1-4 mg ml).

Balhimycin, a glycopeptide antibiotic produced through the fermentation broth of Amycolatopsis sp., exhibits anti-bacterial effects against staphylococci and anaerobes [1].

Afabicin (Debio 1450) is a precursor drug to Debio1452 that is resistant to Staphylococcus staphylococci and has no significant effect on other Gram-positive and negative bacteria. Debio1452 is a FabI inhibitor that inhibits lipid synthesis in staphylococci.

AVX 13616, Avexa's leading antibacterial candidate, demonstrates significant in vivo antibacterial efficacy, especially against drug-resistant Staphylococcus pathogens, with an IC50 value of 2-4 µg/ml (MICs) and is targeted as an antibacterial agent. Comparable in activity to mupirocin within a nasal decolonization model, AVX13616 necessitated only a single application for effectiveness. This compound, alongside others, exhibited broad-spectrum antibacterial action, achieving MICs of 2-4 micrograms per milliliter against various isolates, including S. aureus, coagulase-negative staphylococci, enterococci, MRSA, VISA, and VRSA. Aimed for topical use and the treatment of wound infection or catheter-related infections, a solitary 5% (w/w) AVX13616 application (roughly equivalent to 2% mupirocin) proved as efficacious as twice-daily 2% mupirocin over five days in decolonizing MRSA in mice.