siRNA

DOPE (DOPE) is a neutral helper lipid for cationic liposomes.It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery.

D-Lin-MC3-DMA, an ionizable cationic lipid, serves as a potent siRNA delivery vehicle.

DODAP is an ionic cationic lipid with low cytotoxicity and high transfection efficiency that can be used to synthesize liposomes and encapsulate biologically active molecules such as mRNA, siRNA and plasmid DNA.

DLin-KC2-DMA is a cation that can be used for siRNA delivery and is also an ionizable lipid. DLinKC2-DMA can bind to LNP and enable siRNA-mediated GAPDH gene silencing.

DLinDMA, as a benchmark, is a key stable nucleic acid lipid particleslipid component.

DSPE-PEG(2000)-mannose, a pegylated and mannosylated derivative of 1,2-DSPE, has been employed in both in vitro and in vivo studies for delivering peptides, oligodeoxynucleotides, and siRNA via liposomes and lipid nanoparticles (LNPs). Fluorescently labeled LNPs containing DSPE-PEG(2000)-mannose predominantly accumulate in the liver and spleen of mice, significantly more so than in the brain, lungs, heart, kidneys, and pancreas. In immunization studies, liposomes encapsulating Human Papillomavirus type 16 (HPV16) E7 peptides with CpG oligodeoxynucleotides as an adjuvant led to reduced tumor volume and decreased numbers of CD4+ or CD8+ T cells and angiogenesis within tumors in a mouse lung cancer model using TC-1 cells.

PEG(2000)-C-DMG is a polyethylene glycolated derivative of 1,2-Dimyristoyl-sn-glycerol and can be combined with other lipids to form lipid nanoparticles (LNP) for siRNA delivery.

CLinDMA, a cationic lipid, is known to induce an inflammatory response and serves as a precursor in the synthesis of LNP201, a liposome assembly designed for the systemic delivery of siRNA [1].

98N12-5, a novel multi-tail ionizable lipid, demonstrates efficient in vivo siRNA delivery to the liver.

MVL5, a non-degradable multivalent cationic lipid, serves as a highly efficient vector for both DNA and siRNA [1].

503O13 (degradable ionizable lipid) is used for siRNA delivery.

YSK 05, a pH-sensitive cationic lipid, enhances the intracellular trafficking of non-viral vectors, significantly improves gene silencing and hemolytic activities in its modified form YSK 05-MEND, and effectively overcomes the suppression of endosomal escape caused by PEGylation, thereby enhancing siRNA delivery both in vitro and in vivo [1].

Mono-Pal-MTO, a palm oil-derived lipid formed by integrating the anticancer agent mitoxantrone (MTO) with palmitoleic acid, exhibits enhanced anticancer activity and efficient siRNA cell delivery when its nanoparticles are mixed with those of di-Pal-MTO at a molar ratio of 1:1 [1].

Di-Pal-MTO, a lipid derivative synthesized from palm oil by integrating the anticancer agent mitoxantrone (MTO) with palmitoleic acid, exhibits enhanced anticancer activity and efficient siRNA cell delivery when nanoparticles of mono-Pal-MTO and di-Pal-MTO are combined at a molar ratio of 1:1 [1].

NT1-O14B is a novel class of neurotransmitter tryptophan lipids (NT-lipidoids).NT1-O14B can be combined with small molecule drugs (e.g., AmB) and biomolecules (e.g., Tau-ASO) and gene editing proteins (GFP-Cre) to form new neurotransmitter-derived lipid nanoparticles (NT-LNPs) that have blood-brain-barrier (BBB) permeability. Enhanced lipid hydrophobicity and membrane fusion capabilities are commonly used for delivery of nucleic acids such as mRNA, siRNA and DNA.

OF-C4-Deg-Lin, an ionizable lipid featuring variable linker lengths, is employed in the production of lipid nanoparticles (LNPs) for the effective delivery of siRNA and mRNA [1].

50-C2-C9-4tail is a chemical compound utilized in the creation of lipid nanoparticles (LNPs) for the efficient delivery of siRNA and mRNA, both in vitro and in vivo.

DOTMA (N-(1-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium) is a tetra-methylated DOTA analogue. DOTMA is a cationic lipid and can be used as a non-viral vector for gene therapy. It has been used as a component in liposomes that can be used to encapsulate siRNA, microRNAs, and oligonucleotides and for gene transfection in vitro. It exhibits effective in vitro and in vivo gene transfection. DOTMA induces a positive charge on the liposomes and thus promotes efficient liposome- cell membrane interaction.

DMG-PEG 2000 (DMG-PEG2000) is a lipid excipient that has been used in combination with other lipids in the formation of lipid nanoparticles. Formulations containing DMG-PEG 2000 have been used in the development of lipid nanoparticles for the delivery of mRNA-based vaccines.

Tri-N-tridecyl 3-(ethyl(methyl)amino)propanoate is a biodegradable lipid synthesized through the conjugate addition of alkyl amines and acrylate. Tri-N-tridecyl 3-(ethyl(methyl)amino)propanoate can be utilized in various drug delivery systems, including the delivery of polynucleotides such as siRNA.

DSPE-PEG-SH, MW 3400, is a maleimide-reactive PEG lipid. This amphiphilic polymer can form lipid bilayers in water and is utilized in the creation of liposomes. It serves as a drug nanocarrier for delivering mRNA, DNA, or siRNA. Reagent grade, intended for research purposes only.

DSPE-PEG-SPDP, with a molecular weight of 3400, is an amphiphilic polydisperse PEG capable of forming lipid bilayers in water. This compound is useful for encapsulating therapeutic agents, such as hydrophilic nutrients [proteins peptides, mRNA DNA siRNA] or hydrophobic drugs, and is intended for reagent-grade research use only.

DSPE-PEG-SPDP, MW 5000, is an amphiphilic polymer (PEG) capable of forming lipid bilayers in aqueous solutions. It is suitable for encapsulating therapeutic agents. The core can encapsulate hydrophilic substances like proteins peptides and mRNA DNA siRNA, while the lipid bilayer can dissolve hydrophobic drugs such as doxorubicin and curcumin. The SPDP moiety can react with thiol molecules to form disulfide bonds. Reagent grade, for research use only.