secondary bile acid

Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) is a naturally occurring secondary bile acid with anti-inflammatory and cytoprotective activities. Ursodeoxycholic acid sodium acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors,

Ursodeoxycholic acid (UDCA) is a potent inhibitor of liver-specific fatty acid transporter 5 (FATP5). Ursodeoxycholic acid inhibits cholesterol absorption and is used to dissolve gallstones.

Lithocholic acid (3α-Hydroxy-5β-cholanic acid) is a toxic secondary bile acid, They were FXR antagonists (IC50=0.7, 1.4 μM), EphA2 antagonists (IC50=48, 66 μM) and EphB4 antagonists (IC50=141 μM). Lithocholic acid can promote intrahepatic cholestasis and promote tumorigenesis. Lithocholic acid is a cleanser that dissolves fat for absorption and is itself absorbed.

Glycoursodeoxycholic acid (Ursodeoxycholylglycine) is an acyl glycine and a bile acid-glycine conjugate. It is a secondary bile acid produced by the action of enzymes existing in the microbial flora of the colonic environment. In hepatocytes, both primary and secondary bile acids undergo amino acid conjugation at the C-24 carboxylic acid on the side chain, and almost all bile acids in the bile duct, therefore, exist in a glycine conjugated form. Bile acids are steroid acids found predominantly in bile of mammals.

The mechanism by which Glycodeoxycholate Sodium induces apoptosis in hepatocytes is related to DNA cleavage by endonucleases. It is a secondary bile acid produced by the action of enzymes present in the microflora of the colonic environment.

N-butyl Lithocholic acid is a derivative of the secondary bile acid lithocholic acid. Lipid nanoparticles containing N-butyl Lithocholic acid and encapsulating mRNA vaccines that express hemagglutinin show reduced cardiotoxicity, splenic, and hepatic toxicity in mice compared to lipid nanoparticles that contain cholesterol.

6-Ketolithocholic acid is a secondary bile acid formed by further microbial metabolism of primary bile acids in the gut. It is suitable for studying bile acid metabolism and exhibits inhibitory activity against glucosyltransferases.

Hyodeoxycholic acid sodium salt, a natural secondary bile acid, enhances high-density lipoprotein function, reduces farnesoid X receptor antagonist bile acids, and induces potent cytotoxicity, apoptosis, and IL-8 synthesis.

ω-Muricholic acid (ω-MCA) is a murine-specific secondary bile acid.

Glycolithocholic acid sodium salt, the sodium form of Glycolithocholic acid, is a glycine-conjugated secondary bile acid utilized in diagnosing ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH), and primary sclerosing cholangitis (PSC).

glycohyodeoxycholic acid is a major metabolite of the secondary bile acid hyodeoxycholic acid in humans.

Quercetagitrin (Quercetagetin-7-O-glucoside), isolated from the African Marigold (Tagetes erecta), exhibits anti-inflammatory activity.

3-Epideoxycholic Acid is a secondary bile acid, a microbial metabolite of Deoxycholic acid. It targets the FXR receptor on dendritic cells, reducing their immunostimulatory properties, increasing Foxp3 induction, and promoting the generation of regulatory T cells (Tregs), thereby exhibiting anti-inflammatory activity.

Lithocholic acid-d5 is the deuterated form of Lithocholic acid. Lithocholic acid is a toxic secondary bile acid known to induce intrahepatic cholestasis and promote tumor development.

Hyodeoxycholic acid-d5 is the deuterated form of Hyodeoxycholic acid. This compound is a secondary bile acid formed by gut microbiota in the small intestine and acts as an agonist for TGR5 (GPCR19), with an EC50 value of 31.6 µM in CHO cells.

Ursodeoxycholic acid-d5 is the deuterated form of Ursodeoxycholic acid. Ursodeoxycholic acid (Ursodeoxycholate) is a secondary bile acid produced through the transformation of (cheno)deoxycholic acid by intestinal bacteria. It plays a crucial role in maintaining intestinal barrier integrity and is essential for lipid metabolism. As a signaling molecule, Ursodeoxycholic acid functions by interacting with bile acid-activated receptors, including the G protein-coupled bile acid receptor 5 (TGR5, GPCR19) and the Farnesoid X receptor (FXR). It is used in research related to various liver and gastrointestinal disorders and is effective when administered orally.

Glycoursodeoxycholic Acid-d4 is a deuterated compound of Glycoursodeoxycholic Acid. Glycoursodeoxycholic Acid has a CAS number of 64480-66-6. Glycoursodeoxycholic acid is an acyl glycine and a bile acid-glycine conjugate. It is a secondary bile acid produced by the action of enzymes existing in the microbial flora of the colonic environment. In hepatocytes, both primary and secondary bile acids undergo amino acid conjugation at the C-24 carboxylic acid on the side chain, and almost all bile acids in the bile duct, therefore, exist in a glycine conjugated form. Bile acids are steroid acids found predominantly in bile of mammals.

ω-Muricholic Acid (Standard) is a reference standard for research and analysis in studies involving ω-Muricholic Acid. ω-Muricholic acid (ω-MCA) is a murine-specific secondary bile acid.

Lithocholic acid (Standard) is a reference standard for research and analysis in studies involving Lithocholic acid. Lithocholic acid (3α-Hydroxy-5β-cholanic acid) is a toxic secondary bile acid, They were FXR antagonists (IC50=0.7, 1.4 μM), EphA2 antagonists (IC50=48, 66 μM) and EphB4 antagonists (IC50=141 μM). Lithocholic acid can promote intrahepatic cholestasis and promote tumorigenesis. Lithocholic acid is a cleanser that dissolves fat for absorption and is itself absorbed.

Glycodeoxycholate Sodium (Standard) is a reference standard for research and analysis in studies involving Glycodeoxycholate Sodium. The mechanism by which Glycodeoxycholate Sodium induces apoptosis in hepatocytes is related to DNA cleavage by endonucleases. It is a secondary bile acid produced by the action of enzymes present in the microflora of the colonic environment.

Glycoursodeoxycholic acid (Standard) is a reference standard for research and analysis in studies involving Glycoursodeoxycholic acid. Glycoursodeoxycholic acid (Ursodeoxycholylglycine) is an acyl glycine and a bile acid-glycine conjugate. It is a secondary bile acid produced by the action of enzymes existing in the microbial flora of the colonic environment. In hepatocytes, both primary and secondary bile acids undergo amino acid conjugation at the C-24 carboxylic acid on the side chain, and almost all bile acids in the bile duct, therefore, exist in a glycine conjugated form. Bile acids are steroid acids found predominantly in bile of mammals.

glycohyodeoxycholic acid (Standard) is a reference standard for research and analysis in studies involving glycohyodeoxycholic acid. glycohyodeoxycholic acid is a major metabolite of the secondary bile acid hyodeoxycholic acid in humans.

3-Epideoxycholic Acid (Standard) is a reference standard for research and analysis in studies involving 3-Epideoxycholic Acid. 3-Epideoxycholic Acid is a secondary bile acid, a microbial metabolite of Deoxycholic acid. It targets the FXR receptor on dendritic cells, reducing their immunostimulatory properties, increasing Foxp3 induction, and promoting the generation of regulatory T cells (Tregs), thereby exhibiting anti-inflammatory activity.

6-Ketolithocholic acid (Standard) is a reference standard for research and analysis in studies involving 6-Ketolithocholic acid. 6-Ketolithocholic acid is a secondary bile acid formed by further microbial metabolism of primary bile acids in the gut. It is suitable for studying bile acid metabolism and exhibits inhibitory activity against glucosyltransferases.