orexin a

Orexin A (human, rat, mouse) acetate (Hypocretin-1) is an excitatory neuropeptide with analgesic properties. It activates Orexin-1 (OX1R) and Orexin-2 (OX2R) receptors, used for studying neurodegenerative diseases.

Orexin A human, rat, mouse, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A human, rat, mouse has been used to study its effect on the functioning of porcine pancreatic islets. It has also been used as an orexin receptor 1 (OX1R) agonist to study the effect of orexin systems in the effect of etonogestrel on respiratory response to prolonged metabolic acidosis.

Endogenous agonist at orexin receptors (Ki values are 20 and 38 nM for OX1 and OX2 receptors respectively). Stimulates feeding following central administration and may be involved in the control of sleep-wake cycle and other hypothalamic functions.

Potent and selective peptide orexin OX1 receptor agonist (EC50 values are 8.29 and 187 nM for OX1 and OX2 receptors respectively). Truncated form of orexin A.

OXA (17-33) acetate is a more potent agonist of orexin-1 receptor (OX1, EC50 = 8.29 nM)) over OX2 (EC50 = 187 nM).

[Ala11,D-Leu15]-Orexin B(human) TFA is a potent, selective agonist for the orexin-2 receptor (OX2), demonstrating 400-fold higher selectivity for OX2 (EC50=0.13 nM) compared to the orexin-1 receptor (OX1) with an EC50 of 52 nM.

OXA(17-33) TFA is a potent and selective agonist for the orexin-1 receptor (OX1), with approximately 23-fold higher affinity for OX1 (EC50 = 8.29 nM) compared to the orexin-2 receptor (OX2) (187 nM) [1].

Orexin B, rat, mouse (Rat orexin B) TFA, an endogenous agonist for orexin receptors, binds to and activates the orphan G protein-coupled receptors OX1-R and OX2-R, playing a crucial role in stimulating food intake, increasing energy expenditure, and regulating sleep-wake cycles [1] [2] [3].

Hypocretin (70-98), human, is a polypeptide that binds to the orexin receptor OX1R and facilitates apoptosis [1].

Orexin B, human, is an endogenous agonist at Orexin receptors with Ki values of 420 nM for OX1 and 36 nM for OX2, respectively. Orexin B is a hypothalamic neuropeptide that stimulates food intake in rats.

[Ala11,D-Leu15]-Orexin B acetate is a selective agonist of orexin-2 receptor (OX2) with an EC50 of 0.13 nM, showing 400-fold selectivity over OX1 (52 nM).

Orexin B, human acetate is the acetate form of Orexin B, human. It acts as an agonist for the orexin receptors (Orexin Receptor, OX Receptor), with a Ki of 420 nM for OXR1 and 36 nM for OXR2. Orexin B, human acetate plays a role in modulating appetite, wakefulness, cardiovascular function, and neuroendocrine activity.

Orexin B, canine is a polypeptide molecule with the sequence RPGPPGLQGRLQRLLQASGNHAAGILTM-NH2.