nsc 12

NSC 12 is an orally active pan-FGF trap that inhibits FGF-dependent tumor cell proliferation, angiogenesis, and metastasis.NSC 12 binds FGF2 and interferes with its interaction with FGFR1, but does not affect the ability of FGF2 to bind heparin or heparan sulfate proteoglycans (HSPGs), with potential antitumor activity.NSC 12 also organizes several other FGF isoforms to form the HSPG/FGF/FGFR ternary complex.

NSC 122393 is a fluorescent dye that inhibits the interaction between Bax and Bcl-X and induces apoptosis in Bcl-X overexpressing breast cancer cells.

Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity. Decitabine has antitumor activity and antimetabolic activity. Decitabine induces cell cycle arrest and apoptosis.

Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer. Paclitaxel has anti-tumor activity and causes cell death by inducing mitotic arrest, apoptosis, and cell autophagy.

Doxorubicin hydrochloride is an anthracycline antibiotic with cytotoxic and antitumor activity. It is an effective inhibitor of human DNA topoisomerase I and II, with IC50 values of 0.8 μM and 2.67 μM, respectively. In addition to inhibiting DNA topoisomerases, it can reduce the phosphorylation of AMPK and its downstream target, acetyl-CoA carboxylase. Doxorubicin hydrochloride also induces apoptosis and autophagy. In animal studies, it is commonly used to induce models of acute renal failure, chronic kidney injury, and heart failure.

Bleomycin sulfate is a glycopeptide antibiotic with antitumor activity. It is commonly used as a DNA-damaging agent and DNA synthesis inhibitor. It functions by inducing DNA strand breaks without affecting RNA strands. Bleomycin sulfate is widely used in cancer research and for establishing pulmonary fibrosis animal models.

Estriol (Oestriol) is a hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is produced by the PLACENTA.

Dibenzofuran possesses multiple biological activities, including inhibition of the aryl hydrocarbon receptor and bovine viral diarrhoea virus.

4-Chlorophenylurea (NSC-12971) is a novel orally bioavailable inhibitor of factor Xa.

Z-Arg(Z)2-OH can be used in the assay to screen proteolytic activities in mite homogenates.

Teniposide (VM26), a semisynthetic derivative of podophyllotoxin with antitumor activity, inhibits DNA synthesis by forming a complex with topoisomerase II and DNA.

C.I. Pigment Red 60 is a bright, scarlet, semi-transparent red pigment.

Arginine glutamate is an agent of ammonia Detoxicant.

Chloroform has an insecticidal effect.

NSC-12404 is a selective non-lipid LPA2/3 agonist.

Surfen dihydrochloride (Aminoquinuride dihydrochloride) is a potent small molecule antagonist of heparin sulfate with antibacterial and antiviral activity, and inhibits anthrax lethal factor, coagulation factor X, and lethal factor.Surfen inhibits the anticoagulant activity of both normal and low-molecular-weight heparin and inhibits heparin sulfation and heparin cleavage enzyme degradation.Surfen inhibits the blockade of FGF2 binding and signaling mediated by heparin acetylsulfate. Surfen inhibits the blockade of acetylheparin sulfate-mediated FGF2 binding and signaling.Surfen inhibits SEVI and semen-mediated enhancement of HIV type 1 infection.

17-Oxosparteine is a minor urinary metabolite of sparteine in man.

Eupatilin (NSC-122413), a flavone derived from Artemisia princepsPampanini, is a PPARα agonist, with pharmacological activity.

NSC127916 is a bioactive chemical.

Pantoyltaurine is a biochemical.

PEG-9 Laurate is a bioactive chemical.

3-Deazauridine (NSC-126849) is a structural analog of uridine that inhibits the biosynthesis of Cytidine-5'-Triphosphate by competitive inhibition of Cytidine Triphosphate synthetase which is considered to be the primary mode of action of this nucleoside analog.

Geldanamycin, an HSP90 inhibitor (Kd: 1.2 μM), specifically disrupts glucocorticoid receptor (GR)/HSP association.

Cyclamidomycin is an antibiotic. It also functions as an inhibitor of nucleoside diphosphokinase of Escherichia coli.