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N-Acetylneuraminic acid (Standard) is a reference grade N-Acetylneuraminic acid suitable for quantitative analysis, quality control, and biochemical research. N-Acetylneuraminic acid is a naturally occurring nine-carbon sialic acid monosaccharide involved in neurotransmission, leukocyte extravasation, viral or bacterial infection, and carbohydrate-protein recognition.

Sialic acid aldolase (Pm NaNa) (EC 4.1.3.3) is a type I aldolase that catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (Neu5Ac) to produce pyruvate and N-acetyl-D-mannosamine (ManNAc), with the equilibrium favoring the cleavage of Neu5Ac.

N-Acetylneuraminic acid (Acide aceneuramique) is a nine-carbon sialic acid monosaccharide commonly found in glycoproteins on cell membranes and in glycolipids such as gangliosides in mammalian cells. Studies have shown that N-Acetylneuraminic acid is biologically useful for neurotransmission, leukocyte extravasation, viral or bacterial infections, and carbohydrate-protein recognition.

Nonanal is a growth factor for wood-rotting fungi. Nonanal is a potential attractant for the pine shoot beetle.

Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A is a selective inhibitor of DNMT3B (IC50 = 500 nM).

Nanatinostat (CHR-3996) is an HDAC inhibitor with selectivity and oral bioavailability, with IC50 values of 3-7 nM for HDAC1/2/3 and >200 nM for other subtypes. Nanatinostat also inhibits tumour cell proliferation and induces apoptosis, for studying neurodegenerative diseases and cancer.

(Rac)-Nanatinostat ((Rac)-CHR-3996, example 44) is a potent HDAC inhibitor with an IC50 of less than 330 nM. It exhibits anticancer properties, effectively inhibiting the growth of HeLa, U937, and HUT cells.

2-Norbornanamine, 2,3-dimethyl- is a Drug / Therapeutic Agent.

2-Norbornanamine, 2-ethyl-N-methyl- is a Drug / Therapeutic Agent.

2-Norbornanamine, N,2,3-trimethyl- is a Drug / Therapeutic Agent.

2-Norbornanamine, N,2-dimethyl- is a Drug / Therapeutic Agent.

2-Norbornanamine, N,3,3-trimethyl- is a Drug / Therapeutic Agent.

2-Norbornanamine, N,N,2,3-tetramethyl- is a Drug / Therapeutic Agent.

Nanangenine B is a drimane sesquiterpene that has been found inAspergillus.1It is active againstB. subtilis(IC50= 62 μg/ml) and cytotoxic to NS-1 mouse myeloma cells (IC50= 38 μg/ml). 1.Lacey, H.J., Gilchrist, C.L.M., Crombie, A., et al.Nanangenines: Drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, Aspergillus nanangensisBeilstein J. Org. Chem.152631-2643(2019)

Nanangenine F is a drimane sesquiterpene fungal metabolite that has been found inA. nanangensis.1It is active againstB. subtilis(IC50= 78 μg/ml) and cytotoxic to NS-1, DU145, and MCF-7 cancer and NFF non-cancerous cells (IC50s = 49, 95, 49, and 84 μg/ml, respectively). 1.Lacey, H.J., Gilchrist, C.L.M., Crombie, A., et al.Nanangenines: Drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, Aspergillus nanangensisBeilstein J. Org. Chem.152631-2643(2019)

Nanangenine G is a drimane sesquiterpene that has been found inAspergillus.1It is cytotoxic to NS-1 mouse myeloma cells (IC50= 47 μg/ml). 1.Lacey, H.J., Gilchrist, C.L.M., Crombie, A., et al.Nanangenines: Drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, Aspergillus nanangensisBeilstein J. Org. Chem.152631-2643(2019)

Nanatinostat, also known as Tractinostat, CHR-3996 and VRx-3996, is an orally bioavailable, second-generation hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inhibitor CHR-3996 inhibits HDAC, resulting in an accumulation of highly acetylated histones, the induction of chromatin remodeling, and the selective transcription of tumor suppressor genes; these events may result in the inhibition of tumor cell division and the induction of tumor cell apoptosis. This agent may upregulate HSP70 and downregulate anti-apoptotic Bcl-2 proteins more substantially than some first-generation HDAC inhibitors. HDACs, upregulated in many tumor cell types, are a family of metalloenzymes responsible for the deacetylation of chromatin histone proteins.

Isonanangenine B is a drimane sesquiterpene lactone that has been found in Aspergillus. It decreases survivin mRNA expression in a reporter assay when used at concentrations of 13.6, 18.42, and 26.31 µM. Isonanagenine B (18.42 µM) inhibits STAT3 and NF-κB binding to the survivin promoter in chromatin immunoprecipitation (ChIP) assays. It also induces apoptosis in COLO 320DM cells.

Nonanal (Standard) is the standard substance of Nonanal, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Nonanal is a growth factor for wood-rotting fungi. Nonanal is a potential attractant for the pine shoot beetle.

Nanaomycin D is an antibiotic with antibacterial properties.

Nanaomycin B is an antibiotic with activity against Gram-positive bacteria, mycobacteria, mycoplasma, and fungi.

Nanaomycin E is an antibiotic with activity against Gram-positive bacteria and fungi.

Nanangenine H is a diterpenoid compound found in Aspergillus spp.

Nanangenine D is a diterpenoid compound found in Aspergillus species.