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Search Result

Search Results for " multi-drug "

Targets

Apoptosis S1P Receptor

29

Compounds

6

Natural Products

3

Recombinant Proteins

2

Libraries

Cat No. Product Name Synonyms Targets
T9014 SKI-178 Apoptosis , S1P Receptor
SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during ...
T15168 DRF-1042 Others
DRF-1042 acts to inhibit DNA topoisomerase I. DRF-1042 displays perfect anticancer activity against a panel of human cancer cell lines including multi-drug resistance (MDR) phenotype.
T6018 Zosuquidar trihydrochloride Zosuquidar (LY335979) 3HCl,RS 33295-198 trihydrochloride,RS 33295-198 (D06387) 3HCl,Zosuquidar 3HCl,LY-335979 trihydrochloride P-gp
Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3.
T14081 Enmetazobactam AAI101 Antibacterial
Enmetazobactam (AAI101) is an extended-spectrum β-lactamase inhibitor for the treatment of multi-drug resistant gram-negative bacterial infections.
T11427 Antibacterial compound 2 Antifungal
Antibacterial compound 2 is a potent antimicrobial agent effective against many human veterinary pathogens, inhibiting multi-drug resistant staphylococci, enterococci and streptococci, as well as anaerobic bacteria.
T0331L Moxifloxacin Avelox,Moxeza Others , Antibacterial , Antibiotic
Moxifloxacin (Avelox) is a fourth-generation fluoroquinolone that has been shown to be effective against Gram-positive, Gram-negative, and atypical strains, as well as multi-drug resistant Streptococcus pneumoniae.
T9830 GSK2556286 GSK286 Antibacterial
GSK2556286 (GSK286) is an orally active inhibitor of Mycobacterium tuberculosis (M. tuberculosis).GSK2556286 inhibits the growth of human macrophages with an IC50 value of 0.07 μM.GSK2556286 is effective against both mul...
T0391 Linezolid PNU-100766 MAO , Antibacterial , Antibiotic
Linezolid (PNU-100766), the first of the oxazolidinone class, is a synthetic antibiotic used for the therapy of infections resulted from multi-resistant bacteria including methicillin-resistant Staphylococcus aureus (MRS...
T1146 Nifedipine BAY-a-1040,Procardia XL,Procardia,Adalat CaMK , Potassium Channel , Calcium Channel , Autophagy
Nifedipine (Procardia) is a dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation ...
T31019 CP 117227 CP117227,CP-117227
CP 117227 is a multi-drug resistance regulator.
T11116 Duocarmycin MA Others
Duocarmycin MA can be used against multi-drug resistant cell lines.Duocarmycin MA is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove.
T11117 Duocarmycin MB Others
Duocarmycin MB can be used against multi-drug resistant cell lines. Duocarmycin MB is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove.
T26990 CGI-17341 CGI17341
CGI-17341 is an orally active representative of the 5-nitroimidazole series of antimicrobial agents. CGI 17341 inhibits the drug-susceptible and multi-drug-resistant strains of Mycobacterium tuberculosis at concentration...
T26733 B 746 B-746,B746
B 746 is an antibacterial agent primarily. B 746 is used in therapy for leprosy and Mycobacterium avium infections as well as against Mycobacterium tuberculosis, including those with multi-drug resistance.
T11115 Duocarmycin GA Others
Duocarmycin GA, an antibody drug conjugate (ADC) toxin and a DNA alkylating agent, effectively targets and binds in the minor groove of DNA. It is particularly potent against multi-drug resistant cell lines, offering a s...
T71593 AVN-101 free base
AVN-101 is a very potent 5-HT7 receptor antagonist, with slightly lesser potency toward 5-HT6, 5-HT2A, and 5HT-2C receptors. It is a multi-target drug candidate for the treatment of CNS disorders.
T4047L Bisantrene HCl CL216942,CL-216942,NSC-337766,CL 216942
Bisantrene (CL-216942; NSC 337766) is a topoisomerase II poison and DNA intercalator. It can be used as a Rac1 inhibitor or model compound to study P-glycoprotein-mediated multi-drug resistance (MDR1). Bisantrene inserts...
T61624 Antibacterial agent 106
Antibacterial agent 106 (compound 8) is a highly effective orally active antibacterial compound with antibiofilm activity. It demonstrates potent antibacterial effects against multi-drug resistant (MDR)-Gram-positive pat...
T74775 Antibacterial agent 138
Antibacterial agent 138 exhibits superior efficacy against multi-drug resistant bacteria by inhibiting their protein synthesis and affecting bacterial cell walls [1].
T64135 Antibacterial agent 68
Antibacterial agent 68 is an antimicrobial agent against drug-resistant Escherichia coli with low cytotoxicity. antibacterial agent 68 strongly inhibits the activity of multi-drug resistant Escherichia coli at a low conc...
T68480 4SC-207
4SC-207 is a novel microtubule inhibitor , which shows strong anti-proliferative activity in a large panel of tumor cell lines with an average GI50 of 11 nM. In particular, 4SC-207 is active in multi-drug resistant cell ...
T35851 Etzadroxil Ethyl 2-Ethylbutyrate Antibacterial
Etzadroxil (Ethyl 2-Ethylbutyrate) is an orally available and volatile esterification.Etzadroxil has broad-spectrum antimicrobial activity for the treatment of urinary tract infections caused by multi-drug resistant bact...
T68866 Ceftolozane
Ceftolozane, also known as FR-264,205 and CXA-101; is an antibiotic drug from the cephalosporin family, approved for the treatment of infections with gram-negative bacteria, or gram-positive bacteria. Ceftolozane is of g...
T80276 Lynronne-3
Lynronne-3, an antimicrobial peptide, demonstrates activity against Gram-positive bacteria, including multi-drug resistant (MDR) strains, with a minimum inhibitory concentration (MIC) ranging from 32-128 μg/mL for methic...
T60726 OYYF-175
OYYF-175 is an antimicrobial antifolate. OYYF-175 exhibits potent broad-spectrum antibacterial activities, especially against multi-drug resistant Gram-Negative-strains. OYYF-175 is an inhibitor of dihydrofolate reductas...
T79467 Antifungal agent 60
Antifungal agent 60 (compound 16), a broad-spectrum ergosterol biosynthesis inhibitor, demonstrates potent activity against seven human pathogenic fungal species, including two fluconazole-resistant C. albicans isolates ...
T80274 Lynronne-1
Lynronne-1, an antimicrobial peptide, exhibits activity against Gram-positive bacteria, including multi-drug resistant (MDR) strains, with a minimal inhibitory concentration (MIC) of 8-32 μg/mL for methicillin-resistant ...
T38073 Thiocarlide Isoxyl
Thiocarlide (isoxyl) is a thiourea derivative that was used in the 1960s to successfully treat tuberculosis (TB). It has considerable antimycobacterial activity in vitro and is effective against multi-drug resistant stra...
T35739 Evoxanthine
Evoxanthine is an alkaloid that has been found in O. renieri and has antimalarial and anticancer activities.1,2 It is active against P. falciparum with an IC50 value of 67.6 μg/ml.1 Evoxanthine decreases proliferation of...

Compounds

SKI-178
T9014
Synonym:
Target: Apoptosis, S1P Receptor
DRF-1042
T15168
Synonym:
Target: Others
Zosuquidar trihydrochloride
T6018
Synonym: Zosuquidar (LY335979) 3HCl,RS 33295-198 trihydrochloride,RS 33295-198 (D06387) 3HCl,Zosuquidar 3HCl,LY-335979 trihydrochloride
Target: P-gp
Enmetazobactam
T14081
Synonym: AAI101
Target: Antibacterial
Antibacterial compound 2
T11427
Synonym:
Target: Antifungal
Moxifloxacin
T0331L
Synonym: Avelox,Moxeza
Target: Others, Antibacterial, Antibiotic
GSK2556286
T9830
Synonym: GSK286
Target: Antibacterial
Linezolid
T0391
Synonym: PNU-100766
Target: MAO, Antibacterial, Antibiotic
Nifedipine
T1146
Synonym: BAY-a-1040,Procardia XL,Procardia,Adalat
Target: CaMK, Potassium Channel, Calcium Channel, Autophagy
CP 117227
T31019
Synonym: CP117227,CP-117227
Target:
Duocarmycin MA
T11116
Synonym:
Target: Others
Duocarmycin MB
T11117
Synonym:
Target: Others
CGI-17341
T26990
Synonym: CGI17341
Target:
B 746
T26733
Synonym: B-746,B746
Target:
Duocarmycin GA
T11115
Synonym:
Target: Others
AVN-101 free base
T71593
Synonym:
Target:
Bisantrene HCl
T4047L
Synonym: CL216942,CL-216942,NSC-337766,CL 216942
Target:
Antibacterial agent 106
T61624
Synonym:
Target:
Antibacterial agent 138
T74775
Synonym:
Target:
Antibacterial agent 68
T64135
Synonym:
Target:
4SC-207
T68480
Synonym:
Target:
Etzadroxil
T35851
Synonym: Ethyl 2-Ethylbutyrate
Target: Antibacterial
Ceftolozane
T68866
Synonym:
Target:
Lynronne-3
T80276
Synonym:
Target:
OYYF-175
T60726
Synonym:
Target:
Antifungal agent 60
T79467
Synonym:
Target:
Lynronne-1
T80274
Synonym:
Target:
Thiocarlide
T38073
Synonym: Isoxyl
Target:
Evoxanthine
T35739
Synonym:
Target:
Cat No. Product Name Synonyms Targets
TQ0152 Dalfopristin RP54476 Antibacterial , Antibiotic
Dalfopristin (RP54476) is a semi-synthetic streptogramin antibiotic. Quinupristin/Dalfopristin (Q/D) is used for the treatment of multi-drug resistant Enterococcus faecium infections.
TN2213 Imperialine 3-β-D-glucoside Sipeimine-3-beta-D-glucoside Others
Imperialine 3-β-D-glucoside (Sipeimine-3-beta-D-glucoside) is a natural product. Imperialine 3-β-D-glucoside may exhibit anti-tumor properties against multi-drug resistant tumor cells.
TN1397 Ardisiacrispin B Others
Ardisiacrispin B displays cytotoxic effects in multi-factorial drug resistant cancer cells via ferroptotic and apoptotic cell death.
TN2726 Jatrophane 5 P-gp
Jatrophane 5 demonstrates the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR).
TN3911 Ecdysterone 2,3:20,22-diacetonide Others
Due to the multi-drug resistance reversal activity of the less polar ecdysteroids, several new products( including 20-hydroxyecdysone,20-hydroxyecdysone 2,3;20,22-diacetonide) are promising for being tested against vario...
TN2727 Jatrophane 2 P-gp , Antifection
2,5,7,8,9,14-Hexaacetoxy-3-benzoyloxy-15-hydroxyjatropha-6(17),11E-diene (Jatrophane 2 ) exhibits significant antifeedant activity against a generalist plant-feeding insect, the cotton bollworm (Helicoverpa armigera). Ja...

Natural Products

Dalfopristin
TQ0152
Synonym: RP54476
Target: Antibacterial, Antibiotic
Imperialine 3-β-D-glucoside
TN2213
Synonym: Sipeimine-3-beta-D-glucoside
Target: Others
Ardisiacrispin B
TN1397
Synonym:
Target: Others
Jatrophane 5
TN2726
Synonym:
Target: P-gp
Ecdysterone 2,3:20,22-diacetonide
TN3911
Synonym:
Target: Others
Jatrophane 2
TN2727
Synonym:
Target: P-gp, Antifection

Recombinant Proteins

Species：
Human (2)
Mouse (1)
Expression System：
Baculovirus-Insect Cells (2)
HEK293 (1)
Tag：
His,GST (1)
Tag Free (1)
hFc (1)
Cat No. Product Name Species Expression System
TMPY-03458 Sorcin/SRI Protein, Human, Recombinant Human Baculovirus-Insect Cells
Sorcin was originally identified in multidrug-resistant cells. It is a calcium-binding protein. Sorcin modulates excitation-contraction coupling in the heart, contributes to calcium homeostasis in the heart sarcoplasmic ...
TMPY-03267 Sorcin/SRI Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
Sorcin was originally identified in multidrug-resistant cells. It is a calcium-binding protein. Sorcin modulates excitation-contraction coupling in the heart, contributes to calcium homeostasis in the heart sarcoplasmic ...
TMPY-01576 Artemin Protein, Mouse, Recombinant (hFc) Mouse HEK293
Artemin (ARTN) is a member of glial cell line-derived neurotrophic factor (GDNF) family of ligands, and its signaling is mediated via a multi-component receptor complex including the glycosylphosphatidylinositol-anchored...
Cat No. Product Name
L6720 Anti-COVID-19 Traditional Chinese Medicine Compound Library

1162 compounds
A unique collection of 1162 monomers from 60 TCM plants, a powerful tool for anti-COVID-19 drug discovery, can be used for HTS and HCS screening；
L7100 Anti-Obesity Compound Library

2286 compounds
A unique collection of 2286 anti-obesity compounds for high throughput and high content screening;

Libraries

Anti-COVID-19 Traditional Chinese Medicine Compound Library
L6720
Compounds: 1162
Anti-Obesity Compound Library
L7100
Compounds: 2286
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