metal ion

Ethylenediaminetetraacetic acid trisodium salt (EDTA Trisodium) used to bind metal ions in the chelation therapy.

BChE/HDAC6-IN-2 is a selective and potent dual inhibitor of BChE and HDAC6 with neuroprotective and reactive oxygen species (ROS) scavenging activity. BChE/HDAC6-IN-2 is a metal ion co-agonist that inhibits tau phosphorylation and can be used in the study of immune and neurological diseases.

Framycetin sulfate (Neomycin Sulphate B) belongs to aminoglycoside class of antibiotics that contain two or more aminosugars connected by glycosidic bonds.

D-(-)-Quinic acid (Kinic acid) is a cellular metal ion chelator, capable of promoting reactions with metal M(II,III) ions under pH-specific conditions. It may possess potent inhibition against alpha-mannosidase and alpha-fucosidase.

EDTA, Disodium Salt, Dihydrate (Ethylenediaminetetraacetic acid disodium dihydrate) is a metal ion chelator used as a protease inhibitor.EDTA, Disodium Salt, Dihydrate is a molecule that is ineffective against cellulase activity and is widely used in protein purification.EDTA, Disodium Salt, Dihydrate promotes the excretion of cellulase by binding to the metals and promotes their excretion.

1-Thioglycerol (alpha-Thioglycerol) is an antioxidant thioglycerol that scavenges free radicals and reduces oxidative stress as a media component, and is used as a matrix in fast atom bombardment mass spectrometry (FAB-MS) and liquid secondary ion mass spectrometry (LSIMS).

Trans-1,2-Cyclohexanediaminetetraacetic acid (CDTA) is a cyclohexane derivative and a multidentate chelating agent with strong chelating ability towards divalent and trivalent metal ions, comparable to EDTA. It is commonly used as a metal ion chelating agent, titrant, and radiopharmaceutical ligand.

Tropolone, a metal chelator, possesses weak antioxidative and radical-scavenging properties and shows a strong affinity for ferric ion

Photosensitizer-6 (Compound 4) is a metal ion complex that inhibits TrxR. It induces apoptosis in 4T1 cells, targeting cancer cells and eliminating tumors through chemophototherapy and immunogenic cell death under illumination. Additionally, Photosensitizer-6 can be utilized for tumor imaging.

Lead Ionophore IV, an ion carrier, actively facilitates the transport of metal ions. It is commonly utilized in biological research to investigate the biological effects of lead ions and their impact on cellular functions. Additionally, Lead Ionophore IV is employed in developing drug delivery systems to enhance the bioavailability of compounds.

EDTA tetrasodium tetrahydrate is a metal chelator known for its ability to bind with divalent and trivalent metal cations, including calcium. It exhibits antihypercalcemic and anticoagulant properties. This compound reduces metal ion-catalyzed oxidative damage to proteins and maintains a reducing environment during protein purification processes, making it commonly used for protein purification and storage. Additionally, it helps in minimizing the formation of disulfide bonds.

Aβ1–42 aggregation inhibitor 2 (compound 7c) is a potent inhibitor of Aβ1-42 aggregation, playing a significant role in Alzheimer's disease research. It exhibits excellent antioxidant properties, metal ion chelation ability, reduces oxidative stress, and demonstrates neuroprotective and anti-neuroinflammatory activities.

ZIP14-IN-1 is a selective inhibitor of ZIP14. It can significantly inhibit the activity of ZIP14, but has no significant effect on ZIP8 (SLC39A8). ZIP14-IN-1 can effectively block the uptake of various divalent metal ions including zinc, iron, manganese and cadmium mediated by ZIP14. Its mechanism of action is to bind to the binding pocket formed at the dimer interface of ZIP14, thereby interfering with the metal ion transport pathway. In addition, ZIP14-IN-1 can reduce the levels of reactive oxygen species (ROS) and lipid peroxidation, alleviate metal-induced cytotoxicity, and can be used in related research on cancer cachexia .

Bis(2-benzothiazolyl)methane is a versatile bidentate ligand and synthetic intermediate containing a bis-benzothiazole scaffold. Its active methylene and heterocyclic nature endow it with strong metal ion chelating abilities, widely used in designing specific fluorescent sensors and constructing metallo-heterocyclic antineoplastic libraries.

p-SCN-Bn-TCMC is a bifunctional chelator, it contains a powerful chelator TCMC and reactive tioisocyante linker. TCMC is a powerful chelator with capability to strongly bind radio-isotopic heavy metal ion, which are widely used for radio-diagnostic/imagin

Sonoflora 1, also known as SF1, a PDT photosensitivizer. Chemically, SF1 is an analog of chlorophyll in that its macrocycle backbone is porphyrin-based and the center of the porphyrin ring consists of a metal ion. Preclinical studies showed that SF1 had v

Graphislactone A is an antioxidant produced by Cephalosporium IFB-E001 and M. olivacea. It exhibits dose-dependent scavenging activity against DPPH radicals and metal ion-dependent hydroxyl radicals in vitro. Graphislactone A reduces peroxidation of human LDL and slows peroxidation of linoleic acid by 4.4-fold. It also inhibits acetylcholinesterase (AChE) with an IC50 value of 27 μM.

Antioxidant agent-2 (comp 3c), a BBB-penetrating and selective metal ion chelator, exhibits significant neuroprotective and hepatoprotective effects, making it beneficial for Alzheimer's disease research.

MAO-B-IN-21 is an MAO-B inhibitor characterized by superior antioxidant and anti-Aβ aggregation activities, metal-ion chelating capabilities, and mitigation of neuroinflammation (NO, TNF-α). It demonstrates neuroprotective effects with notable BBB permeability and, in an Aβ1-42 induced Alzheimer's disease mouse model, significantly enhances memory and cognitive functions [1].

Ethylenediaminetetraacetic acid-d12 is the deuterated form of Ethylenediaminetetraacetic acid. Ethylenediaminetetraacetic acid (EDTA) serves as a metal chelator, binding with divalent and trivalent metal cations, including calcium. It exhibits antihypercalcemic and anticoagulant properties, reduces metal ion-catalyzed oxidative damage to proteins, and maintains a reducing environment during protein purification. EDTA is commonly used in protein purification and storage and helps minimize the formation of disulfide bonds.

EDTA, Disodium Salt, Dihydrate (Standard) is the standard substance of EDTA, Disodium Salt, Dihydrate, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. EDTA, Disodium Salt, Dihydrate (Ethylenediaminetetraacetic acid disodium dihydrate) is a metal ion chelator used as a protease inhibitor.EDTA, Disodium Salt, Dihydrate is a molecule that is ineffective against cellulase activity and is widely used in protein purification.EDTA, Disodium Salt, Dihydrate promotes the excretion of cellulase by binding to the metals and promotes their excretion.

β-Amyloid (1-16) acetate (131580-10-4 Free base) is a fragment derived from β-Amyloid amyloid protein, where its N-terminal amino group participates in metal ion coordination (e.g., copper and zinc), making it useful for Alzheimer's disease research.

Exo-β-1,4-xylosidase, Bacteroides ovatus (EC.3.2.1.37), is a specialized exonuclease that targets the non-reducing end β-1,4 glycosidic bonds of xylan and xylooligosaccharides. This enzyme is Ca2+-dependent and facilitates the hydrolysis of β-1,4 glycosidic bonds through reversible metal ion binding, thereby degrading xylan to produce xylose. It is applicable in research areas such as lignocellulose bioconversion, bioethanol production, and optimization of xylan saccharification processes.

Exo-β-1,4-xylosidase, derived from Clostridium stercorarium (EC.3.2.1.37), is an exonuclease that specifically targets the β-1,4 glycosidic bonds at the non-reducing ends of xylan and xylooligosaccharides. This enzyme requires Ca2+ ions, facilitating the hydrolysis of β-1,4 glycosidic bonds through reversible metal ion binding, consequently breaking down xylan into xylose. It is utilized in fields such as lignocellulosic bioconversion, bioethanol production, and the optimization of xylan saccharification processes.