impdh

IMPDH2-IN-2 is a potent inhibitor of inosine 5'-monophosphate dehydrogenase (IMPDH) (Ki,app: 14 μM) and a potential anti-tuberculosis agent, exhibiting moderate antibacterial effects with MIC values of 6.3 and 11 μM in minimal GAST Fe and rich 7H9 ADC Tween media, respectively.

Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) , the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways and metabolic in the brain based on the particular disease and clinical condition model. According to the reports, Citric acid trilithium salt tetrahydrate was used as a mood stabilizer when treating bipolar mood disorders (BD) and lower the risk of self-harm in BD patient. In addition,Citric acid trilithium salt tetrahydrate has been the choice drug in the therapy of acute manic episodes.Citric acid trilithium salt tetrahydrate also could dissolve uric acid crystals in urine achieved from patients with gout. Besides,Citric acid trilithium salt tetrahydrate have some dose-dependent side-effects. The the main side-effects of Lithium Citrate is the tendency to inhibit the prostatic acid phosphatase enzyme (PAP), which result in the accumulation of PAP.

Mizoribine (NSC-289637) belongs to the family of 1-Ribosyl-imidazolecarboxamides. Mizoribine has been investigated for the treatment of Rheumatoid Arthritis.

6-Mercaptopurine (6-MP) is an antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.

IMPDH-IN-1 (compound 44) functions as an inhibitor for the bacterial inosine monophosphate dehydrogenase (IMPDH). It specifically binds to the catalytic domain of IMPDH and effectively inhibits the IMPDH activity in organisms such as Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli.

IMPDH2-IN-4 (compound 2d) is a Mycophenolic acid analog and a selective IMPDH2 inhibitor with a Ki of 1.8 μM. It exhibits potent cytotoxic activity against osteosarcoma cancer cell lines. Additionally, IMPDH2-IN-4 demonstrates high affinity for VEGFR-2, CDK2, and IMPDH.

Mycophenolic acid (Mycophenolate) is an inosine monophosphate dehydrogenase(IMPDH) inhibitor with anti-proliferative activity.

RS 61443 (Mycophenolate mofetil) is an immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH)

Mycophenolate Mofetil (TM-MMF), an immunosuppressive agent, is the 2-morpholinoethyl ester of mycophenolic acid (MPA), and an inhibitor of inosine monophosphate dehydrogenase (IMPDH).

Inosinic acid (IMP) is a purine nucleotide which has hypoxanthine as the base and one phosphate group esterified to the sugar moiety. Inosinic acid is a nucleotide present in muscle and other tissues. It is formed by the deamination of AMP and when hydrolysed produces inosine. Inosinic acid is the ribonucleotide of hypoxanthine and is the first compound formed during the synthesis of purine.Inosine 5′-monophosphate (IMP) is used as a substrate to study the distribution, specificity and kinetics of inosine-5′-monophosphate dehydrogenase (IMPDH).

AVN-944 (VX-944)(VX-944) is a selective, noncompetitive inhibitor of human IMPDH with Ki of 6-10 nM for IMPDH1 IMPDH2.

Tiazofurin (NSC-286193) is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), a potent IMP dehydrogenase (IMPDH) inhibitor.

Q151 is an IMPDH inhibitor. It also is a potential antituberculosis agent.

VX-148 is a novel, non-competitive IMPDH inhibitor with a K(i) value of 6 nM for IMPDH Type II enzyme. It is slightly more effective than mycophenolic acid and VX-497 in inhibiting the proliferation of primary human lymphocytes (IC(50) approximately 80 nM). The presence of exogenous guanosine can mitigate VX-148's inhibitory activity. Notably, VX-148 does not impede the proliferation of non-lymphocyte types such as fibroblasts, indicating selective inhibition of IMPDH activity. The compound exhibits oral bioavailability in rats and mice; oral administration of VX-148 inhibits the primary antibody response in mice in a dose-dependent manner, with an ED(50) of 38 mg kg b.i.d. Additionally, in mice, VX-148 at a dosage of 100 mg kg b.i.d. significantly prolongs skin graft survival time.

Nampt-IN-12 (compound 9), a derivative of N-Pyridinylthiophene carboxamid, exhibits activity against peripheral nerve sheath cancer cells. It is metabolized by the enzymes NAMPT and NMNAT1 within the NAD salvage pathway into an adenine dinucleotide (AD) derivative, an analog of NAD that can inhibit inosine monophosphate dehydrogenase (IMPDH), leading to the accumulation of inosine monophosphate (IMP) within the cells. Nampt-IN-12's effective blood-brain barrier permeability makes it suitable for research into cancers of the central and peripheral nervous system.

substrate of IMP dehydrogenase (IMPDH)

Xanthosine 5'-monophosphate is produced from inosine monophosphate (IMP) through the catalytic action of inosine monophosphate dehydrogenase (IMPDH).

DDD00079282 is an inhibitor of IMPDH.

Merimepodib (VX-497) is a novel, noncompetitive inhibitor of inosine monophosphate dehydrogenase (IMPDH).

β-Benzamide adenine dinucleotide is a bioactive metabolite of benzamide ribonucleoside and functions as an effective inhibitor of inosine monophosphate dehydrogenase (IMPDH). It also acts as a potent, competitive inhibitor of human NAD kinase with a Ki value of 90 µM.

T-705RMP (ammonium), the ammonium form of T-705RMP, exhibits weak inhibition of IMP dehydrogenase (IMPDH) activity [1].

Mycophenolic acid sodium is a potent uncompetitive inhibitor of inosine monophosphate dehydrogenase (IMPDH) with an EC50 of 0.24 μM, exhibiting broad antiviral activity against RNA viruses, including influenza, along with immunosuppressive properties and antiangiogenic and antitumor effects [1][2].

BMS-337197 is an IMPDH inhibitor.

Mycophenolic acid-13C-d3 the 13C and deuterated compound of Mycophenolic acid. Mycophenolic acid has a CAS number of 24280-93-1. Mycophenolic acid is an inosine monophosphate dehydrogenase(IMPDH) inhibitor with anti-proliferative activity.