immunogenicity

PEG300 (Polyethylene glycol 300) is a polymer formed from repeating units of ethylene glycol that is water soluble, low immunogenicity, and biocompatible. PEG300 is a neutral polymer with a molecular weight of 300.

GW280264X (Carbamic acid) is an inhibitor of ADAM17 .

G280-9 acetate is a common melanoma gp100 epitope restricted by MHC-associated HLA-A2. The G280-9 sequence is unique because it could be recognized by cytotoxic T lymphocytes at very low concentrations, however it shows low total immunogenicity that may b

PEG400 (Polyethylene glycol 400) is a polymer formed from repeating units of ethylene glycol that is water soluble, low immunogenicity, and biocompatible. PEG400 is a neutral polymer with a molecular weight of 400.

3D-Monophosphoryl Lipid (14) (3D-Monophosphoryl Lipid (14)) triethylamine is a TLR agonist that serves as an adjuvant in vaccines to enhance their immunogenicity.

3D-Monophosphoryl Lipid (12,16) (triethylamine) serves as a Toll-like Receptor (TLR) agonist and is used as an adjuvant in vaccines to enhance their immunogenicity.

3D-Monophosphoryl Lipid (14) (ammonium) acts as a TLR agonist and serves as an adjuvant for vaccines, enhancing their immunogenicity.

3D-Monophosphoryl Lipid A-5 (free acid) is a TLR agonist used as an adjuvant in vaccines to enhance their immunogenicity.

3D-Monophosphoryl Lipid A-5 (3D-MPLA-5) triethylamine is a TLR agonist that acts as an adjuvant for vaccines, enhancing their immunogenicity.

DHT KLH is a coupling compound for immunological studies, consisting of dihydrotestosterone (DHT) antigen bound to a hemocyanin (KLH) adjuvant, a commonly used carrier protein that enhances the immunogenicity of the antigen. It is widely used to prepare specific antibodies for the study of androgen receptor-associated immune responses.

3D-Monophosphoryl Lipid (12,16) (3D-MPL (12,16)) free acid is a TLR agonist that serves as a vaccine adjuvant to boost the immunogenicity of vaccines.

1,2-Dipalmitoyl-13C-sn-glycero-3-PC is intended for use as an internal standard for the quantification of 1,2-dipalmitoyl-sn-glycero-3-PC by GC- or LC-MS. 1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.1,2,3,4 It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.3 Incorporation of glycosphingolipid antigens into DPPC-containing liposomes increases the immunogenicity of the antigens in mice.4 |1. Ege, C., and Lee, K.Y.C. Insertion of Alzheimer's Aβ40 peptide into lipid monolayers. Biophys. J. 87(3), 1732-1740 (2004).|2. Leekumjorn, S., and Sum, A.K. Molecular simulation study of structural and dynamic properties of mixed DPPC/DPPE bilayers. Biophys. J. 90(11), 3951-3965 (2006).|3. Kalra, V.K., Sikka, S.C., and Sethi, G.S. Transport of amino acids in γ-glutamyl transpeptidase-implanted human erythrocytes. J. Biol. Chem. 256(11), 5567-5571 (1981).|4. Uemura, A., Watarai, S., Iwasaki, T., et al. Induction of immune responses against glycosphingolipid antigens: Comparison of antibody responses in mice immunized with antigen associated with liposomes prepared from various phospholipids. J. Vet. Med. Sci. 67(12), 1197-1201 (2005).

N1-Methylpseudouridine-5'-triphosphate is a modified nucleotide derivative commonly used to explore RNA modification, synthesis, and function, and can replace UTP in synthesis thereby improving RNA stability and reducing immunogenicity.

N1-Methylpseudouridine-5′-triphosphate tetralithium, also known as 1-Methylpseudouridine-5′-triphosphate tetralithium, is a nucleobase-modified nucleotide. It is utilized in the synthesis of mRNA to decrease immunogenicity and enhance stability [1].

Pseudouridine-5'-triphosphate (Pseudo-UTP) is widely known for its role in polymerase-mediated RNA synthesis, frequently surpassing uridine in unmodified mRNAs due to improved nuclease stability, immunogenicity, and translational properties.

Vaxfectin is a lipid adjuvant used in the development of protein and peptide vaccines.Vaxfectin promotes vaccine immunogenicity.

Latikafusp (AMG 256) is a fusion protein that is a PD-1 blocker and IL-21R agonist with antitumor activity.Latikafusp initiates and prolongs cytotoxicity and memory T-cell activity and induces the generation of immunogenicity-mediated responses.

[Leu27]-Melan-A, MART-1 (26-35), is a biologically active peptide modified by substituting leucine for alanine at position 27, which enhances its HLA-A*0201 binding, immunogenicity, and antigenicity compared to the natural peptide. Pyroglutamyl (pGlu) peptides, arising from the spontaneous cyclization of glutamine (Q) or glutamic acid (E) at the N-terminus, are a recognized subset of peptides that may confer increased stability due to the hydrophobic γ-lactam ring of pGlu. These pGlu peptides are typically included during peptide purity assessments in HPLC analysis.

FLAG-Cys is a Flag peptide modified with an additional cysteine (Cys) residue, recognized for its immunogenicity [1].

DYSP-C34, a potent ultrasound (US)-triggered multifunctional molecular machine, exhibits a favorable lipophilic hydrophilic balance, enhanced US-induced reactive oxygen species (ROS) production, and improved cellular permeability. These properties contribute to its superior tumor-targeting efficiency and significant tumor regression when used in sonodynamic therapy (SDT). Additionally, DYSP-C34 demonstrates mild immunogenicity by directly stimulating antigen-presenting cells (APCs) [1].

3D-Monophosphoryl Lipid A-5 (3D-MPLA-5) is a TLR agonist that can serve as an adjuvant in vaccines to enhance their immunogenicity.

Alginate Methacryloyl (AlgMA) (MW 300000) is a methacryloyl-modified alginate known for its potential use in tissue engineering scaffolds and 3D printing inks. This compound exhibits biocompatibility, non-immunogenicity, and low toxicity, and can physically crosslink with divalent cations such as calcium. Under the influence of photoinitiator LAP, AlgMA self-assembles into fibrous hydrogels, targeting bioactive adhesion sites to provide inherent support to tissue cells and facilitate biodegradation. It is applicable in fields such as cell culture, biological 3D printing, and tissue engineering.

m-PEG-NHS ester (MW 3400) can be used to modify active molecules, thereby enhancing their antigenicity and immunogenicity, which is beneficial for the preparation of injectable formulations. Its modification of serine protease lumbrokinase (LK) does not affect the enzyme’s strong fibrinolytic and thrombolytic activities, indicating promising application prospects.

m-PEG-NHS ester (MW 1000) can be used to modify active molecules and enhance their antigenicity and immunogenicity, which is beneficial for the preparation of injectable preparations. m-PEG-NHS ester modification of serine protease lumbrokinase (LK) does not affect its significant fibrinolytic and thrombolytic activities, showing good application prospects.