hepatotoxic

Retrorsine selectively inhibits hepatocyte proliferation and following liver injury evokes small hepatocyte-like progenitor cells. Retrorsine can be used for the research of hepatocellular injury.

Tacrine (CS 12602) is an indirect cholinergic agonist and centrally acting anticholinesterase. It is approved for the treatment of Alzheimer's disease.

Gnetol competitivity inhibits butyrylcholinesterase (IC50: 1.3 uM). Gnetol has a strong inhibitory effect on murine tyrosinase activity. Gnetol significantly suppresses melanin biosynthesis in murine B16 melanoma cells. It is active in the inhibition of a

Punicalin exerts anti-inflammatory, antioxidative, and anti-hepatotoxic activities, it shows inhibitory activity on HIV-1 reverse transcriptase in a dose-dependent manner, with an IC50 of 0.11 microg/ml (0.14 microM).

Ligularine is a hepatotoxic otonecine-type pyrrolizidine alkaloid isolated from Ligularia hodgsonii, a Chinese traditional antitussive medicine.

1. 4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) has antiviral activity, including anti-HIV-1 integrase activity. 2. 4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) shows anti-hepatotoxic activity.

Plantamajoside (Y0160) has anti-hepatotoxic, anti-inflammatory, antinociceptive activities, improving sexual function and antioxidant activity.

Silychristin (Silicristin) is a plant growth regulator. Silychristin is an anti-hepatotoxic agent. Silychristin is the inhibitor of horseradish peroxidases and lipoxygenase.

Trichodesmine, a dehydropyrrolizidine alkaloid, exhibits hepatotoxic, pneumotoxic, and neurotoxic effects in vivo.

7-Acetylintermedine is a hepatotoxic botanical pyrrolizidine alkaloid.

1. Flavokawain B (Flavokavain B) has potent anti-inflammatory activity, can significantly inhibit production of NO and PGE2 in LPS-induced RAW 264.7 cells. 2. Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-κB and MAPK signaling pathways. 3. Flavokawain B induces apoptosis, has the potential usefulness of FKB for prevention and treatment of hormone-refractory prostate cancer in an adjuvant setting. 4. Flavokawain B acts through ROS generation and GADD153 up-regulation to regulate the expression of Bcl-2 family members, thereby inducing mitochondrial dysfunction and apoptosis in HCT116 cells.

1. Brazilin (Braziletto) exhibits anti-hepatotoxic, antiplatelet effects. 2. Brazilin has cancer preventive effect, may inhibit T24 cell growth and trigger cell death through a c-Fos-mediated and tumor cell specific signaling pathway. 3. Brazilin has anti-inflammatory property, can suppress mastitis and high glucose-induced vascular inflammatory process related with the inhibition of oxidative stress, CAMs expression, and NF-κB activation in HUVEC; may be useful to treat chronic inflammatory disorders including rheumatoid arthritis.

Microcystin-WR, a hepatotoxic metabolite derived from cyanobacteria, has been demonstrated to induce hepatotoxicity in mice [1].

Adonifoline is a hepatotoxic pyrrolizidine alkaloid.

4,5-Dicaffeoylquinic acid (Standard) is a reference standard for research and analysis in studies involving 4,5-Dicaffeoylquinic acid. 1. 4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) has antiviral activity, including anti-HIV-1 integrase activity. 2. 4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) shows anti-hepatotoxic activity.

7-Acetylintermedine (Standard) is a reference standard for research and analysis in studies involving 7-Acetylintermedine. 7-Acetylintermedine is a hepatotoxic botanical pyrrolizidine alkaloid.

Brazilin (Standard) is a reference standard for research and analysis in studies involving Brazilin. 1. Brazilin (Braziletto) exhibits anti-hepatotoxic, antiplatelet effects. 2. Brazilin has cancer preventive effect, may inhibit T24 cell growth and trigger cell death through a c-Fos-mediated and tumor cell specific signaling pathway. 3. Brazilin has anti-inflammatory property, can suppress mastitis and high glucose-induced vascular inflammatory process related with the inhibition of oxidative stress, CAMs expression, and NF-κB activation in HUVEC; may be useful to treat chronic inflammatory disorders including rheumatoid arthritis.

Plantamajoside (Standard) is a reference standard for research and analysis in studies involving Plantamajoside. Plantamajoside (Y0160) has anti-hepatotoxic, anti-inflammatory, antinociceptive activities, improving sexual function and antioxidant activity.

Flavokawain B (Standard) is a reference standard for research and analysis in studies involving Flavokawain B. 1. Flavokawain B (Flavokavain B) has potent anti-inflammatory activity, can significantly inhibit production of NO and PGE2 in LPS-induced RAW 264.7 cells. 2. Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-κB and MAPK signaling pathways. 3. Flavokawain B induces apoptosis, has the potential usefulness of FKB for prevention and treatment of hormone-refractory prostate cancer in an adjuvant setting. 4. Flavokawain B acts through ROS generation and GADD153 up-regulation to regulate the expression of Bcl-2 family members, thereby inducing mitochondrial dysfunction and apoptosis in HCT116 cells.

Trichodesmine (Standard) is a reference standard for research and analysis in studies involving Trichodesmine. Trichodesmine, a dehydropyrrolizidine alkaloid, exhibits hepatotoxic, pneumotoxic, and neurotoxic effects in vivo.

Seneciphylline (Standard) is a reference standard for research and analysis in studies involving Seneciphylline. Seneciphylline, one of the hepatotoxic pyrolizidine alkaloids, has mutagenic activity in Drosophila and their transfer into rat milk.Seneciphylline can significantly increased the activities of epoxide hydrase and glutathione-S-transferase but cause reduction of cytochrome P-450 and related monooxygenase activities.

Silychristin (Standard) is a reference standard for research and analysis in studies involving Silychristin. Silychristin (Silicristin) is a plant growth regulator. Silychristin is an anti-hepatotoxic agent. Silychristin is the inhibitor of horseradish peroxidases and lipoxygenase.

Erucifoline N-oxide (Standard) is a reference standard for research and analysis in studies involving Erucifoline N-oxide. Erucifoline N-oxide, isolated from Senecio persoonia, exhibits hepatotoxic activity [1].

Seneciphylline, one of the hepatotoxic pyrolizidine alkaloids, has mutagenic activity in Drosophila and their transfer into rat milk.Seneciphylline can significantly increased the activities of epoxide hydrase and glutathione-S-transferase but cause reduc