glutaric acid

Glutaric acid is a simple five-carbon linear dicarboxylic acid. Glutaric acid is naturally produced in the body during the metabolism of some amino acids, including lysine and tryptophan

α-Hydroxyglutaric Acid is a natural product for research related to life sciences. The catalog number is T36624 and the CAS number is 2889-31-8.This compound is unstable in powder form and other related salt forms are recommended.

Methylglutaric acid is a leucine metabolite. A large amount of methylglutaric acid is identified in urine of patients with deficiency of 3-methylglutaconyl coenzyme A hydratase (PMID 6181239 ). Methylglutaric acid is also found to be associated with 3-hyd

2-Ketoglutaric acid Sodium (AKG) is a key molecule in the TCA cycle. It can be produced from glutamate by oxidative deamination via glutamate dehydrogenase and as a product of pyridoxal phosphate-dependent transamination reactions (mediated by branched-chain amino acid transaminases) in which glutamate is a common amino donor.

2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM). 2-Ketoglutaric acid is an intermediate of the Krebs cycle and can produce either ATP or GTP. 2-Ketoglutaric acid also acts as a major carbon backbone for the nitrogen assimilation reaction.

3,3-Dimethylglutaric acid (3,3-Dimethylpentanedioate) is a compound found in human urine.

L-2-Hydroxyglutaric acid (L-2-HG) is a compartmentalized metabolite and a substrate for L-2-hydroxyglutarate dehydrogenase (L2HGDH). It inhibits histone demethylases and increases the expression of ATF4 and its target genes by activating the mTOR pathway. L-2-Hydroxyglutaric acid mediates the mTOR-ATF4 signaling pathway and can be used in biosensor research.

DL-alpha-Hydroxyglutaric acid disodium salt is an alpha-ketoglutarate (α-KG) antagonist that inhibits a variety of α-KG-dependent dioxygenases.

D-α-Hydroxyglutaric acid is a natural product for research related to life sciences. The catalog number is T41318 and the CAS number is 13095-47-1.

3-Hydroxy-2-methylglutaric acid is a carboxylic acid metabolite that can be isolated from the plant Veronica incanaL. It is utilized in research related to upper respiratory tract diseases, malignancies, gastrointestinal and urogenital system disorders, as well as diabetes.

3-Hydroxyglutaric acid is one of several metabolites produced when insufficient levels of GCDH are available. It is used as a biomarker of GCDH deficiency.

2-Methylpentanedioic acid (alpha-Methylglutarate) is an organic acid normally found in human urine, in healthy adults and children. 2-Methylpentanedioic acid (alpha-Methylglutarate) is a metabolite of succinic acid, a citric acid cycle intermediate.

Tricarballylic acid (Carballylic acid) is an inhibitor of aconitase.

Meglutol (3-Hydroxy-3-methylglutaric acid) is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethyl glutaryl coenzyme A as well as inhibiting the activity of HYDROXYMETHYLGLUTARYL COA REDUCTASES which is the rate-limiting enzyme in the biosynthesis of cholesterol.

3-Oxopentanedioic acid (1,3-Acetonedicarboxylic acid) is a simple carboxylic acid, which may be used as a building block in organic chemistry. It has been found to be a microbial metabolite.

Oganomycin GA is a fermentation product from the bacterium Streptomyces (Streptomyces str. oganonensis YG 19Z). By introducing sodium p-hydroxycinnamate into the fermentation medium, Oganomycin A is produced. Under the influence of D-amino acid oxidase, Oganomycin A is converted into the glutaric acid derivative Oganomycin GA, which exhibits greater efficacy against Gram-negative bacteria than against Gram-positive bacteria.

Oganomycin GB is derived from the bacterium Streptomyces (Streptomyces str. oganonensis YG 19Z). When sodium para-hydroxycinnamate is added to the fermentation medium, Oganomycin A is produced. This compound is converted into its glutaric acid derivative, Oganomycin GA, via the action of D-amino acid oxidase. After the removal of sulfate ester through acidic hydrolysis, both A and GA yield Oganomycin B and Oganomycin GB. The effectiveness of Oganomycin GB is greater against Gram-negative bacteria compared to Gram-positive bacteria.

D-Glyceric acid calcium hydrate is an endogenous metabolite found in urine, useful for studying primary hyperoxaluria type I and glutaric aciduria type 2.