glutaric acid

Glutaric acid is a simple five-carbon linear dicarboxylic acid. Glutaric acid is naturally produced in the body during the metabolism of some amino acids, including lysine and tryptophan

DSPE-glutaric acid, a lipid, is utilized in the research of diverse biochemical [1] areas.

α-Hydroxyglutaric Acid is a natural product for research related to life sciences. The catalog number is T36624 and the CAS number is 2889-31-8.This compound is unstable in powder form and other related salt forms are recommended.

α-Hydroxyglutaric Acid Lithium, converted from glutamate in microorganisms and animals, is an inhibitor of α-ketoglutarate-dependent dioxygenase and 5-methylcytosine hydroxylase, and has an inhibitory effect on ATP synthase and mTOR signaling.

Methylglutaric acid is a leucine metabolite. A large amount of methylglutaric acid is identified in urine of patients with deficiency of 3-methylglutaconyl coenzyme A hydratase (PMID 6181239 ). Methylglutaric acid is also found to be associated with 3-hyd

2-Ketoglutaric acid Sodium (AKG) is a key molecule in the TCA cycle. It can be produced from glutamate by oxidative deamination via glutamate dehydrogenase and as a product of pyridoxal phosphate-dependent transamination reactions (mediated by branched-chain amino acid transaminases) in which glutamate is a common amino donor.

2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM) and exhibits antioxidant activity. As an intermediate in the Krebs cycle, 2-Ketoglutaric acid can generate ATP or GTP. 2-Ketoglutaric acid also serves as the primary carbon skeleton for nitrogen assimilation reactions.

D-α-Hydroxyglutaric acid disodium [Disodium (R)-2-Hydroxyglutarate] is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with a Ki of 0.628 mM.

3,3-Dimethylglutaric acid (3,3-Dimethylpentanedioate) is a compound found in human urine.

3-(4-fluorophenyl)glutaric acid, with CAS No. 3449-63-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 3-(4-fluorophenyl)glutaric acid provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

α-Hydroxyglutaric acid-D4 disodium is the deuterated form of α-Hydroxyglutaric acid disodium (T21665). α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium represents the α-hydroxy acid form of glutaric acid. It acts as a competitive inhibitor for several α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methylcytosine (5mC) hydroxylases.

α-Hydroxyglutaric acid-13C5 is the 13C-labeled version of α-Hydroxyglutaric acid (T36624) sodium. This compound, an α-hydroxy acid form of glutaric acid, acts as a competitive inhibitor of various α-ketoglutarate-dependent dioxygenases, including the TET family of enzymes such as histone demethylases and 5-methylcytosine (5mC) hydroxylases.

L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium) is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity(Km and Ki of 2.52 mM and 11.13 mM, respectively).

L-2-Hydroxyglutaric acid (L-2-HG) is a compartmentalized metabolite and a substrate for L-2-hydroxyglutarate dehydrogenase (L2HGDH). It inhibits histone demethylases and increases the expression of ATF4 and its target genes by activating the mTOR pathway. L-2-Hydroxyglutaric acid mediates the mTOR-ATF4 signaling pathway and can be used in biosensor research.

D-α-Hydroxyglutaric acid-D5 disodium isodium (Disodium (R)-2-hydroxyglutarate-D5) is the deuterated version of D-α-Hydroxyglutaric acid disodium. This compound is a major metabolite that accumulates in the neurometabolic disorder D-2-hydroxyglutaric aciduria. As a weak competitive antagonist of α-ketoglutaric acid (α-KG), D-α-Hydroxyglutaric acid disodium (T6820) inhibits various α-KG-dependent dioxygenases with a Ki of 10.87 mM. It also promotes the production of reactive oxygen species (ROS), binds to and inhibits ATP synthase, and suppresses mTOR signaling.

α-Guanidinoglutaric Acid is found in cobalt-induced epileptogenic focus tissue in the cerebral cortex of cats. α-Guanidinoglutaric Acid-induced seizures are associated with abnormal serotonergic function and that they are initiated by a decrease in the 5-HT level.

DL-alpha-Hydroxyglutaric acid disodium salt is an alpha-ketoglutarate (α-KG) antagonist that inhibits a variety of α-KG-dependent dioxygenases.

D-α-Hydroxyglutaric acid is a natural product for research related to life sciences. The catalog number is T41318 and the CAS number is 13095-47-1.

DL-α-Hydroxyglutaric acid-D4 disodium salt is a deuterated compound of DL-α-Hydroxyglutaric acid disodium salt. DL-α-Hydroxyglutaric acid disodium salt (T21665) has a CAS number of 40951-21-1. DL-α-Hydroxyglutaric acid disodium salt (T21665) is an α -hydroxyacid formed from the hydrolysis of (R) -5-oxy-2-tetrahydrofuran carboxylic acid, which is overproduced in human neurometabolic disease D-α -hydroxyglutaric uria.

2-Ketoglutaric acid-D4 is a deuterated form of 2-Ketoglutaric acid. 2-Ketoglutaric acid (T5980) (Alpha-Ketoglutaric acid) functions as an intermediate in the Krebs cycle where ATP or GTP is generated. It also serves as a primary carbon skeleton for nitrogen assimilation reactions. Additionally, 2-Ketoglutaric acid (T5980) acts as a reversible inhibitor of tyrosinase (IC50=15 mM).

2-Ketoglutaric acid-13C5 is the 13C labeled form of 2-Ketoglutaric acid. This compound, also known as Alpha-Ketoglutaric acid, serves as an intermediate in the Krebs cycle for ATP or GTP production. Additionally, it acts as a principal carbon skeleton for nitrogen assimilation reactions. 2-Ketoglutaric acid (T5980) is a reversible inhibitor of tyrosinase (IC50=15 mM).

2-Ketoglutaric acid-D6 is the deuterium-labeled form of 2-Ketoglutaric acid. Also known as Alpha-Ketoglutaric acid, it serves as an intermediate in the Krebs cycle for the production of ATP or GTP. This compound also acts as a primary carbon skeleton in nitrogen assimilation reactions. Furthermore, 2-Ketoglutaric acid (T5980) functions as a reversible inhibitor of tyrosinase with an IC50 of 15 mM.

2-Ketoglutaric acid-13C is a 13C-labeled variant of 2-Ketoglutaric acid. This compound is an intermediate in the Krebs cycle, where it facilitates the production of ATP or GTP. Additionally, 2-Ketoglutaric acid (T5980) serves as the primary carbon framework in nitrogen assimilation reactions and acts as a reversible inhibitor of tyrosinase, with an IC50 of 15 mM.

3-Methylglutaric acid (Standard) is a reference standard for research and analysis in studies involving 3-Methylglutaric acid. Methylglutaric acid is a leucine metabolite. A large amount of methylglutaric acid is identified in urine of patients with deficiency of 3-methylglutaconyl coenzyme A hydratase (PMID 6181239 ). Methylglutaric acid is also found to be associated with 3-hydroxy-3-methylglutaryl-CoA lyase deficiency, another inborn error of metabolism.