dms

N,N-Dimethylsphingosine, an endogenous metabolite, is a potent competitive sphingosine kinase (SphK) inhibitor that selectively inhibits sphingosine phosphorylation without affecting its N-acylation.DMS is elevated in models of neuropathic pain, and may mediate mechanical nociception by increasing the release of IL-1β and MCP-1.

Lotilaner is a parasiticide. It is used as a potent non-competitive antagonist of insects GABACl receptors (IC50 of 23.84 nM for Drosophila melanogaster GABA receptor). It also has no effect on a dog GABAA receptor.

Remacemide is a low-affinity NMDA antagonist with sodium channel blocking properties. It has been studied for the treatment of acute ischemic stroke, epilepsy, Huntington's disease, and Parkinson's disease.

DMS-612 (NSC-281612), an alkylating agent, exhibits activity against renal cell carcinoma. It is applicable in cancer research.

DMS(O)MT aminolink C6 is utilized in oligonucleotide synthesis. DMS(O)MT serves as a distinct protective group akin to the conventional MMT, but it is engineered as an enhanced alternative.

Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate)) is a highly potent and selective MEK inhibitor that specifically inhibits MEK1/2 (IC50: 2 nM).

TBDMS-PEG4-OH is a PEG-based linker for PROTACs (Proteolysis Targeting Chimeras) that joins two essential ligands, facilitating the selective degradation of proteins by utilizing the ubiquitin-proteasome system within cells.

MiADMSA (Monoisoamyl DMSA) is a lipophilic chelating agent that has shown potential as a chelator/detoxifier for arsenic and several heavy metals, including lead, mercury, cadmium, and gallium arsenide. It mitigates oxidative stress induced by sodium tungstate and improves liver and immune system alterations caused by chronic copper poisoning in Sprague Dawley rats. Additionally, MiADMSA protects human keratinocytes ['HaCaT'] from arsenic-induced oxidative stress.

4-oxo-27-TBDMS Withaferin A is a derivative of the steroidal lactone withaferin A that has anticancer activity.1 It is cytotoxic to A2780 ovarian cancer cells (IC50 = 17 μM) but not to carboplatin-resistant A2780 (A2780/CP70) cells (IC50 = >100 μM). It is selective for A2780 cells over non-cancerous ARPE19 cells (IC50 = 1,660 μM). 4-oxo-27-TBDMS Withaferin A induces DNA fragmentation in A2780 cells.References1. Perestelo, N.R., Llanos, G.G., Reyes, C.P., et al. Expanding the chemical space of withaferin A by incorporating silicon to improve its clinical potential on human ovarian carcinoma cells. J. Med. Chem. 62(9), 4571-4585 (2019). 4-oxo-27-TBDMS Withaferin A is a derivative of the steroidal lactone withaferin A that has anticancer activity.1 It is cytotoxic to A2780 ovarian cancer cells (IC50 = 17 μM) but not to carboplatin-resistant A2780 (A2780/CP70) cells (IC50 = >100 μM). It is selective for A2780 cells over non-cancerous ARPE19 cells (IC50 = 1,660 μM). 4-oxo-27-TBDMS Withaferin A induces DNA fragmentation in A2780 cells. References1. Perestelo, N.R., Llanos, G.G., Reyes, C.P., et al. Expanding the chemical space of withaferin A by incorporating silicon to improve its clinical potential on human ovarian carcinoma cells. J. Med. Chem. 62(9), 4571-4585 (2019).

5-O-TBDMS-N4-Benzoyl-2-deoxycytidine is a modified nucleoside used in the synthesis of deoxyribonucleic acid (DNA) or nucleic acid.

5'-O-DMT-2'-O-TBDMS-Ac-rC is a modified nucleoside used in the synthesis of DNA or RNA.

5'-O-DMT-2'-TBDMS-Uridine is a deoxyribonucleoside used for the oligonucleotide synthesis.

5'-O-DMT-3'-O-TBDMS-Ac-rC is a modified nucleoside used for synthesizing DNA or RNA.

5'-O-TBDMS-Bz-dA is a nucleoside known for its protective and modification effects.

5'-O-TBDMS-dA is a modified nucleoside utilized in the synthesis of DNA or RNA.

5'-O-TBDMS-dG is a modified nucleoside, while 5'-O-DMT-2'-O-TBDMS-rI can be used in the synthesis of deoxyribonucleic acid (DNA) or nucleic acid.

5'-O-TBDMS-dT is a nucleoside characterized by its protective and modification effects.

5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine, an adenosine derivative, functions as an intermediate in oligonucleotide synthesis.

5'-O-DMT-2'-O-TBDMS-rI is a modified nucleoside used in the synthesis of deoxyribonucleic acid (DNA) or nucleic acid.

5'-O-TBDMS-dU is used in the synthesis of oligoribonucleotides.

5'-O-DMT-2'-O-TBDMS-Bz-rC, a modified nucleoside, is used in DNA or RNA synthesis.

5'-DMT-3'-TBDMS-Bz-rA is a nucleoside possessing protective and modification effects.

5'-DMT-3'-TBDMS-ibu-rG is a modified nucleoside employed in deoxyribonucleic acid (DNA) synthesis.

5'-O-TBDMS-N2-ibu-dG is a nucleoside derivative with potent anti-bovine viral diarrhea virus activity and is valuable for the synthesis of lead compounds exhibiting this activity.