cannabinoid

Voacamine (Voacanginine) is an indole alkaloid. Voacamine exhibits potent cannabinoid CB1 receptor antagonistic activity. Voacamine also inhibits P-glycoprotein (P-gp) action in multidrug-resistant tumor cells.Voacanginine may have rhythmic effects.

Pregnenolone acetate is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. It acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. It can protect the brain from cannabis intoxication

β-Caryophyllene ((-)-(E)-Caryophyllene) acts as an CB2 receptor agonist.

2,3-Butanediol, derived from the bioconversion of natural resources, holds significant potential for various industries, including chemical, cosmetics, agriculture, and pharmaceutical sectors.

Pregnenolone (Arthenolone) is an endogenous steroid hormone synthesized from cholesterol, used in the treatment of Alzheimer's disease.

(-)-Gallocatechin ((−)-GC) has free radical scavenging ability and moderate affinity to the human cannabinoid receptor.

Cannabigerol is a high affinity α±2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist ; also binds to the CB2 receptor; it can relieve interocular pressure, which may be of benefit in the treatment of glaucoma.

(+)-Gallocatechin (Gallocatechol) possesses free radical scavenging ability. (+)-Gallocatechin has moderate affinity to the human cannabinoid receptor.

(±)-Cannabichromene is a major non-psychotropic phytocannabinoid that inhibits endocannabinoid inactivation and activates the transient receptor potential ankyrin-1 (TRPA1), it selectively reduces inflammation-induced hypermotility in vivo in a manner that is not dependent on cannabinoid receptors or TRPA1.

Yangonin (Y100550) is a novel CB receptor ligand, it exhibits affinity for the human recombinant CB receptor. Yangonin (Y100550) could be a valuable candidate for the intervention of NF-κB-dependent pathological conditions such as inflammation.

Tetrahydromagnolol can activate cannabinoid (CB) receptors.

2'-Hydroxydaidzein is an isoflavonoid phytonutrient found in plant species, when a natural compound. 2'-Hydroxydaidzein has antioxidant activity, driven mainly by o-hydrogen bond dissociation enthalpy (BDE) and hydrogen atom transfer (HAT) mechanisms. 2'-Hydroxydaidzein inhibits chemical mediators in inflammatory cells and may be of value in the treatment and prevention of inflammatory diseases associated with excessive chemical mediator production. It may have a role in the treatment and prevention of central and peripheral inflammatory diseases associated with excessive chemical mediator production. 2'-Hydroxydaidzein inhibited the release of neutrophils and formyl-Met-Leu-Phe cytochalasin B (fMLP CB) in rats, with IC(50) values of 2.8+ -0.1 and 5.9+ -1.4 microM, respectively.

(±)-cis-Δ9-THC, a racemic mixture of the phytocannabinoid (–)-cis-Δ9-THC and synthetic cannabinoid (+)-cis-Δ9-THC, serves as an analytical reference standard. It is classified as a Schedule I compound in the United States, denoting regulation due to its notable potential for abuse. This compound is specifically designed for use in research and forensic applications.

Nervonoyl ethanolamide (NEA), an endogenous cannabinoid, functions as both a presynaptic and postsynaptic neuromodulator. Additionally, it is utilized in inflammation research [1].

Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannabinoid receptors. Flavoglaucin appears to be an antitumor promoter, it also has anti-inflammato

Hemopressin (human, mouse) acetate is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin is orally active, selective and inverse agonist of CB1 cannabinoid receptors. Hemopressin exerts an

Cannabielsoin, a phytocannabinoid metabolite, is an analytical reference standard primarily classified for its role as a metabolite of cannabidiol (CBD). Designed for research and forensic applications, it serves as a crucial compound in the study of cannabinoid substances.

Leelamine hydrochloride, a tricyclic diterpene extracted from pine tree bark, inhibits the transcriptional activity of the androgen receptor, known to regulate fatty acid synthesis [2,3]. This compound acts as a cannabinoid receptor type 1 (CB1) agonist and suppresses SREBP1-regulated fatty acid lipid synthesis in prostate cancer cells, irrespective of androgen receptor status.

Olivetol (5-n-Amylresorcinol) (5-pentylresorcinol, 5-pentyl-1,3-benzenediol) is an organic compound found in certain species of lichen; it is also a precursor in various syntheses of tetrahydrocannabinol. Olivetol has an antioxidant effect.

(-)-7-nor-7-carboxy Cannabidiol (CRM) is a plant-derived cannabinoid metabolite.

Falcarinol (Panaxynol) is an Hsp90 inhibitor and CB1 receptor antagonist that inhibits the action of amphetamine on TNF-α-stimulated keratinocytes.

In the central nervous system, 2-Arachidonoylglycerol is a second endogenous cannabinoid ligand

Stearoylethanolamide(N-(2-Hydroxyethyl)octadecanamide) is a cannabinoid compound present in the brains of humans, rats, and mice with pro-apoptotic activity.

Δ8-THCO (delta 8-tetrahydrocannabinol) is a cannabinoid compound that can be isolated from medicinal cannabis (sp. Sativa).