Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty
Filter
Applied FilterClear all
TargetMol | Tags By Target
  • Adrenergic Receptor
    (1)
  • Antibiotic
    (1)
  • Myosin
    (1)
  • P2X Receptor
    (1)
  • PARP
    (1)
  • Potassium Channel
    (1)
  • Wnt/beta-catenin
    (1)
  • Others
    (11)
Filter
Search Result
Results for "

atp release

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    25
    TargetMol | Inhibitors_Agonists
  • Peptide Products
    2
    TargetMol | Peptide_Products
  • Natural Products
    1
    TargetMol | Natural_Products
  • Recombinant Protein
    1
    TargetMol | Recombinant_Protein
  • Isotope Products
    3
    TargetMol | Isotope_Products
  • Cell Research
    2
    TargetMol | Inhibitors_Agonists
Aglafoline
Rocaglamide U, Aglafolin, (-)-Methyl rocaglate
T10260143901-35-3In house
Aglafoline inhibits in a concentration-dependent manner the aggregation and ATP release reaction induced in washed rabbit platelets by PAF (platelet-activating factor). The IC50 values of Aglafoline on PAF (3.6 nM)-induced platelet aggregation were about 50 μM.
  • Inquiry Price
3-6 months
Size
QTY
Myosin V-IN-1
T720601259177-59-7In house
Myosin V-IN-1 is a potent and selective inhibitor of Myosin V with a Ki value of 6 μM.Myosin V-IN-1 inhibits actin V and slows down actin-activated myosin V ATPase by selectively inhibiting the release of ADP from the actinoglobulin complex.
  • Inquiry Price
Size
QTY
Salbutamol
Albuterol, AH-3365
T113918559-94-9
Salbutamol (Albuterol) stimulates beta2-adrenergic receptors in the lungs, thereby activating the enzyme adenylate cyclase that catalyzes the conversion of ATP to cyclic-3', 5'-adenosine monophosphate (cAMP). Salbutamol Sulfate is the sulfate salt of the short-acting sympathomimetic agent albuterol, a 1:1 racemic mixture of (R)-albuterol and (S)-albuterol with bronchodilator activity. Increased cAMP concentrations relax the bronchial smooth muscle, relieve bronchospasms, and reduce inflammatory cell mediator release, especially from mast cells. To a lesser extent, Salbutamol stimulates beta1-adrenergic receptors, thereby increasing the force and rate of myocardial contraction.
  • Inquiry Price
Size
QTY
Dibutyryl-cGMP sodium
Bt2cGMP sodium
T1103851116-00-8In house
Dibutyryl-cGMP sodium (Bt2cGMP sodium) is a cell-permeable cGMP analog that preferentially activates cGMP-dependent protein kinase (PKG). It inhibits [3H]-arachidonic acid release in human platelets stimulated by gamma thrombin and can induce peripheral analgesia by activating ATP-sensitive K+ channels.
  • Inquiry Price
8-10 weeks
Size
QTY
TNKS-2-IN-1
T776754765-59-7
TNKS-2-IN-1 is a TNKS-2 inhibitor.TNKS-2-IN-1 inhibits TNKS-1 and TNKS-2 with IC50s of 259 nM and 1100 nM, respectively.TNKS-2-IN-1 has antimicrobial activity against E. coli and S. aureus.TNKS-2-IN-1 inhibits the release of IL-1β from the NLRP3 inflammasome (IC50: 5 μM) by inhibiting IL-1β release from ATP-stimulated J1A.774 cells.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Sale
Gliclazide
S1702, SE1702
T152721187-98-4
Gliclazide (SE1702), an oral antihyperglycemic agent, belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating beta-cells of the pancreas to release insulin.
  • Inquiry Price
Size
QTY
P2X4 antagonist-4
T204441
P2X4 antagonist-4 (compound 64) is a potent P2X4R antagonist with an IC50 value of 8 µM. It can inhibit ATP-induced activation of the NLRP3 inflammasome and the subsequent release of IL-1β.
  • Inquiry Price
Size
QTY
Ganglioside GM1 Asialo Mixture
T3729571012-19-6
Ganglioside GM1 asialo is a component of cellular lipid rafts and can be formed by the cleavage of the sialic acid residue from ganglioside GM1 by neuraminidase. Ganglioside GM1 asialo is a glycolipid receptor for P. aeruginosa flagellin and stimulates defensive responses in host cells, including extracellular ATP release, calcium mobilization, and ERK1/2 phosphorylation when stimulated by flagellin and an anti-ganglioside GM1 asialo antibody. The percentage of ganglioside GM1 asialo-positive natural killer (NK) and CD8+ T cells in lung is increased in a mouse model of respiratory syncytial virus (RSV) infection compared with healthy animals. Depletion of ganglioside GM1 asialo-positive NK and T cells reduces IFN-γ levels in the lung, reduces weight loss, and increases lung viral load in RSV-infected mice. Ganglioside GM1 asialo mixture contains ganglioside GM1 asialo molecular species with C18:1 and C20:1 sphingoid backbones.
  • Inquiry Price
Size
QTY
ITH15004
T37313
ITH15004 is a non-nucleotide antagonist of the purinergic P2X7receptor (IC50= 9 μM in HEK293 cells expressing the human receptor).1It inhibits ATP-induced currents inX. laevisoocytes expressing the human P2X7receptor when used at a concentration of 100 μM. ITH15004 (1 μM) decreases IL-1β release from LPS-primed, ATP-stimulated isolated mouse peritoneal macrophages. It has high permeability in a parallel artificial membrane permeability assay (PAMPA). 1.Calzaferri, F., Narros-Fernández, P., de Pascual, R., et al.Synthesis and pharmacological evaluation of novel non-nucleotide purine derivatives as P2X7 antagonists for the treatment of neuroinflammationJ. Med. Chem.64(4)2272-2290(2021)
  • Inquiry Price
Size
QTY
JC-171
T381062112809-98-8
JC-171, a selective inhibitor of the NLRP3 inflammasome, effectively inhibits LPS ATP-induced interleukin-1β (IL-1β) release from J774A.1 macrophages with an IC50 of 8.45 μM[1].
  • Inquiry Price
7-10 days
Size
QTY
NBC 19
T383602068818-75-5
Potent NLRP3 inflammasome inhibitor (IC50 = 60-80 nM). Inhibits nigericin- and ATP-induced IL-1β release. Baldwin et al (2017) Boron-Based Inhibitors of the NLRP3 Inflammasome. Cell Chem.Biol. 24 1321 PMID:28943355 |Redondo-Castro et al (2018) Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses. Sci.Rep. 8 5667 PMID:29618797
  • Inquiry Price
6-8 weeks
Size
QTY
TAT-Gap19(I130A)
TAT-Gap19(I130A)
T41204
TAT-Gap19(I130A) is a control peptide for TAT-Gap19, a Cx43 hemichannel blocker. TAT-Gap19(I130A) consists of TAT-GAP19 with a I130A amino acid residue change at a key residue for GAP19 activity. In C6 glioma cells expression Cx43, TAT-GAP19(1130A) does not inhibit [Ca2+]i-triggered ATP release at 200 μM. TAT-Gap19(I130A) is cell permeable.
  • Inquiry Price
Size
QTY
AZ-DF 265
T6860283901-40-0
AZ-DF 265 is a hypoglycaemic drug which stimulates insulin release. AZ-DF-265 inhibits ATP-sensitive potassium channels and displaces [3H]-glibenclamide from the sulphonylurea receptor.
  • Inquiry Price
6-8 weeks
Size
QTY
GSK1370319A
T716511001389-31-6
GSK1370319A is a potent P2X7 antagonist (IC50 = 3.2 nM). GSK1370319A inhibits ATP-induced increase in IL-1β release and caspase 1 activation in lipopolysaccharide (LPS)-primed mixed glia by blocking assembly of the inflammasome in a pannexin 1-dependent manner. GSK1370319A also inhibits ATP-induced subregion-specific neuronal loss in hippocampal organotypic slice cultures, which is dependent on its ability to prevent inflammasome assembly in glia. Significantly, GSK1370319A attenuates age-related deficits in long-term potentiation (LTP) and inhibits the accompanying age-related caspase 1 activity. We conclude that inhibiting P2X(7) receptor-activated NLRP3 inflammasome formation and the consequent IL-1β release from glia preserve neuronal viability and synaptic activity.
  • Inquiry Price
6-8 weeks
Size
QTY
Dimethyl L-glutamate
Dimethyl glutamate
T724606525-53-7
Dimethyl L-glutamate (Dimethyl glutamate), a membrane-permeable derivative of glutamate, stimulates glucose-induced insulin release, suppresses K_ATP channel activities, inhibits E. gracilis growth, and causes abnormal cell division. This compound is utilized in diabetes research, focusing on glucose transport, phosphorylation, and metabolism.
  • Inquiry Price
6-8 weeks
Size
QTY
Tat-Gap 19 TFA
T83682
Tat-Gap 19, a peptide inhibitor of connexin43 (Cx43) hemichannels, is derived from the HIV-1 Tat protein transduction domain fused with a nine-amino acid sequence from Cx43 residues 128-136. This compound, at a concentration of 10 µM, effectively suppresses glutamate-induced ATP release in primary rat hepatocytes, indicating inhibition of Cx43 hemichannel activity. Furthermore, Tat-Gap 19 demonstrates therapeutic potential by significantly reducing infarct volume in a mouse cerebral ischemia-reperfusion injury model following middle cerebral artery occlusion (MCAO) at a dosage of 25 mg/kg. Moreover, its intraperitoneal administration at 1 mg/kg per day ameliorates fibrosis and decreases the area of hepatic stellate cells, the precursors to myofibroblasts, expressing α-smooth muscle actin (α-SMA), in a model of thioacetamide-induced liver damage. Additionally, it enhances superoxide dismutase (SOD) activity in hepatic cells from the treated mice, indicating its antioxidative benefits.
  • Inquiry Price
Size
QTY
2-MeS-ATP
2-Methylthio-ATP
T8863443170-89-4
2-MeS-ATP (2-Methylthio-ATP) is an analog of adenosine nucleotides, serving specifically as an agonist for P2Y purinergic receptors (P2Y purinergic receptor). This compound also inhibits the release of toxic mediators by macrophages stimulated by lipopolysaccharides (LPS). It is utilized in research related to endotoxic shock and inflammatory diseases.
  • Inquiry Price
10-14 weeks
Size
QTY
CS-6253 TFA
T89173
CS-6253TFA is the TFA salt form of CS-6253. This compound serves as an activator for the ATP Binding Cassette 1 (ABCA1). It effectively modulates the amyloid-beta Aβ42 40 ratio and influences the metabolism of lipoproteins in plasma. Additionally, CS-6253TFA facilitates the production of cholesterol-rich high-density lipoprotein (HDL) particles and induces the release of microparticles.
  • Inquiry Price
Size
QTY
CS-6253
T895441627911-44-7
CS-6253 is an agonist of ATP Binding Cassette 1 (ABCA 1). It modulates the amyloid beta Aβ42 40 ratio, influencing lipoprotein metabolism in the plasma. Additionally, CS-6253 promotes the production of cholesterol-rich high-density lipoprotein (HDL) particles and induces the release of microparticles.
  • Inquiry Price
Size
QTY
Salbutamol-d9
TMID-02331173021-73-2
Salbutamol-d9 is a deuterated compound of Salbutamol. Salbutamol has a CAS number of 18559-94-9. Albuterol stimulates beta2-adrenergic receptors in the lungs, thereby activating the enzyme adenylate cyclase that catalyzes the conversion of ATP to cyclic-3', 5'-adenosine monophosphate (cAMP). Albuterol Sulfate is the sulfate salt of the short-acting sympathomimetic agent albuterol, a 1:1 racemic mixture of (R)-albuterol and (S)-albuterol with bronchodilator activity. Increased cAMP concentrations relax the bronchial smooth muscle, relieve bronchospasms, and reduce inflammatory cell mediator release, especially from mast cells. To a lesser extent, albuterol stimulates beta1-adrenergic receptors, thereby increasing the force and rate of myocardial contraction.
  • Inquiry Price
35 days
Size
QTY
Gliclazide-d7
TMIH-0253
Gliclazide-d7 is a deuterated compound of Gliclazide. Gliclazide has a CAS number of 21187-98-4. Gliclazide, an oral antihyperglycemic agent, belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating beta-cells of the pancreas to release insulin.
  • Inquiry Price
7-10 days
Size
QTY
Salbutamol-d3
TMIH-05121219798-60-3
Salbutamol-d3 is a deuterated compound of Salbutamol. Salbutamol has a CAS number of 18559-94-9. Albuterol stimulates beta2-adrenergic receptors in the lungs, thereby activating the enzyme adenylate cyclase that catalyzes the conversion of ATP to cyclic-3', 5'-adenosine monophosphate (cAMP). Albuterol Sulfate is the sulfate salt of the short-acting sympathomimetic agent albuterol, a 1:1 racemic mixture of (R)-albuterol and (S)-albuterol with bronchodilator activity. Increased cAMP concentrations relax the bronchial smooth muscle, relieve bronchospasms, and reduce inflammatory cell mediator release, especially from mast cells. To a lesser extent, albuterol stimulates beta1-adrenergic receptors, thereby increasing the force and rate of myocardial contraction.
  • Inquiry Price
7-10 days
Size
QTY
Sambutoxin
TN4937160047-56-3
Sambutoxin, a new mycotoxin produced by toxic Fusarium isolates obtained from rotted potato tubers, it can cause toxic effects in rats, including body weight loss, feed refusal, hemorrhage in the stomach and intestines, and, finally, death when rats were
  • Inquiry Price
Size
QTY
N,N-Dimethyl-ATP sodium
TSW-00874
N,N-Dimethyl-ATP sodium is a labeled and modified deoxyoligonucleotide (dNTP) that can release pyrophosphate and generate fluorescence during gene synthesis and sequencing, so it has special application value.
  • Inquiry Price
Inquiry
Size
QTY