Search Result

Search Results for " antiproliferative "

Targets

402

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T64348	Antiproliferative agent-16	Antiproliferative agent-16	Others
	Antiproliferative agent-16 (Antiproliferative agent-16) is an indolyl hydrazide-hydrazone compound with anticancer activity. Antiproliferative agent-16 exhibits specificity toward breast cancer cells (IC50 of 6.94 μM for...		Others
T9974	Antiproliferative agent-13		Dehydrogenase
	Antiproliferative agent-13 is a compound with antiproliferative activity.		Dehydrogenase
T64391	Antiproliferative agent-15		Others
	Antiproliferative agent-15 is a reagent with anticancer activity. Antiproliferative agent-15 showed antiproliferative activity against human colon cancer (HCT116 and HCT15) and brain cancer (LN-229 and GBM-10).		Others
T60129	MT189	Antiproliferative agent-14	Microtubule Associated
	MT189 (Antiproliferative agent-14) is a potent tubulin polymerization inhibitor, with an IC50 of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferative activity. Antiproliferative agent-14 possess the abilit...		Microtubule Associated
T83021	Antiproliferative agent-36		Others
	Antiproliferative agent-36 is a broad-spectrum anticancer benzothiazolylhydrazone-derived compound that inhibits cell proliferation.		Others
T83015	Antiproliferative agent-42
	Antiproliferative Agent-42 (Compound 7m), a dihydrodipyrrolo compound, exhibits antiproliferative activity against the Panc-1 cell line, with an IC 50 of 12.54 μM [1].
T72200	Antiproliferative agent-11
	Antiproliferative Agent-11, a selective Ruthenium(II)-Tris-pyrazolylmethane complex, exhibits antiproliferative effects on MCF-7, HeLa, 518A2, HCT116, and RD cancer cell lines with IC50 values of 6, 10, 6.8, 6.7, and 6 μ...
T83019	Antiproliferative agent-38
	Antiproliferative Agent-38 (COM 18), a tetracyclic compound, features a reactive ring nitrogen (likely the quinoline moiety) that resists N-alkylation. Despite its classification, it neither exhibits anti-malarial proper...
T79332	Antiproliferative agent-32		Apoptosis
	Antiproliferative agent-32 (Compound 1c) impedes phosphorylation within the PI3K/Akt/mTOR signaling pathway, restrains proliferation of Huh7 and SK-Hep-1 cells, induces apoptosis, and inflicts mitochondrial damage, rende...		Apoptosis
T83022	Antiproliferative agent-33
	Antiproliferative Agent-33 (Compound 2g) serves as an anti-proliferative, antifungal, and antibacterial agent, effectively inhibiting the proliferation of MDA-MB-231 cells (IC50: 16.38 μM), impairing the growth of gram-n...
T79368	Antiproliferative agent-34		EGFR
	Antiproliferative Agent-34 (Compound A14), a multitarget kinase inhibitor, demonstrates IC50 values of 177 nM for EGFR L858R/T790M and 1567 nM for EGFR WT. Additionally, it inhibits JAK2, ROS1, FLT3, FLT4, and PDGFRα wit...		EGFR
T63864	Antiproliferative agent-4
	Antiproliferative agent-4 showed good anti-proliferative effects on some cancer cells. antiproliferative agent-4 inhibited tumour growth in nude mice and showed low toxicity. antiproliferative agent-4 reduced the mitocho...
T75014	Antiproliferative agent-18
	Compound 5k (Antiproliferative Agent-18) is an antiproliferative agent that exhibits moderate antibacterial and antifungal activities [1].
T60555	Antiproliferative agent-3
	Antiproliferative agent-3 (comp 4) exhibits potent growth inhibitory effects against MCF-7 cells with IC 50 of 0.19 nM [1].
T83020	Antiproliferative agent-37
	Antiproliferative agent-37 (compound 10J) inhibits cell proliferation by arresting cells at the G2/M phase of the cell cycle [1].
T79322	Antiproliferative agent-30
	Antiproliferative agent-30 (Compound 8g) demonstrates broad-spectrum antiproliferative activity, with IC50 values of 0.054 nM, 0.008 nM, and 0.144 nM against HCT-116, K562, and MV-4-11 cancer cell lines, respectively. It...
T74921	Antiproliferative agent-12
	Antiproliferative Agent-10 (Compound 1), a ruthenium(II)-tris-pyrazolylmethane complex, functions as an anti-tumor agent by impeding cancer cell proliferation through the inhibition of mitochondrial calcium uptake [1].
T83023	Antiproliferative agent-26
	Antiproliferative agent-26 (compound 4g) exhibits a broad spectrum of activity against leukemia, CNS cancers, melanoma, renal, and breast cancers at a concentration of 10 μM. It hinders colony formation and induces cell ...
T74844	Antiproliferative agent-23
	Antiproliferative agent-23, a microtubule-destabilizing agent (MDA), disrupts the tubulin-microtubule system, leading to apoptosis through a mitochondrion-dependent pathway. This involves downregulation of Bcl-2 protein,...
T62012	Antiproliferative agent-8
	Antiproliferative agent-8 (Compound 5a) is an anti-cancer compoundwith antiproliferative activity. Antiproliferative agent-8 can significantly increase the P53 levels.
T83016	Antiproliferative agent-41
	Antiproliferative Agent-41 (Compound 14), classified as indanorine [1], functions as an antiproliferative compound.
T61996	Antiproliferative agent-6
	Antiproliferative agent-6 (compound 8a) is a potent antitumor compound. Antiproliferative agent-6 shows antiproliferative activity. Antiproliferative agent-6 inhibits cancer cell lines HCT116, MCF-7, H460 and non-tumor a...
T64212	Antiproliferative agent-5
	Antiproliferative agent-5 (compound 4o) irreversibly and significantly inhibits the proliferation of gastric cancer cells. antiproliferative agent-5 blocks the cell cycle in G2/M phase, induces ROS accumulation and activ...
T72191	Antiproliferative agent-20
	Antiproliferative Agent-20 is a potent, orally active anticancer compound exhibiting both antiproliferative and anti-angiogenic activities.
T62549	Antiproliferative agent-7
	Antiproliferative agent-7 (compound 8f) is a potent anti-proliferative agent. Antiproliferative agent-7 can promote ROS production and induce apoptosis.
T72205	Antiproliferative agent-19
	Antiproliferative Agent-19, an anti-cancer compound, demonstrates antiproliferative effects by inducing apoptosis in lung cancer cells and causing cell cycle arrest in the G2/M phase.
T79289	Antiproliferative agent-27		Apoptosis
	Antiproliferative Agent-27 (Compound 11) is a notable antiproliferative agent that markedly diminishes tumor cell colony formation and induces apoptosis, demonstrating potential for utilization in cancer research [1].		Apoptosis
T72204	Antiproliferative agent-17
	Antiproliferative Agent-17 exhibits both antimicrobial properties against Gram-positive bacteria and anticancer activity [1].
T72199	Antiproliferative agent-10
	Antiproliferative Agent-10, a ruthenium(II)-tris-pyrazolylmethane complex, functions as an anti-tumor compound by impeding cancer cell growth through the inhibition of mitochondrial calcium uptake.
T83018	Antiproliferative agent-39
	Antiproliferative Agent-39 (Compound 12) effectively inhibits the proliferation of various cancer cell lines, including A549, SNU-638, Col2, HT1080, and MCF-7, with respective IC50 values of 11, 25, 14, 11, and 6.3 μM [1...
T79275	Antiproliferative agent-25		Histone Methyltransferase
	Antiproliferative Agent-25 (Compound 3s4) is a selective PRMT5 inhibitor displaying an IC50 of 0.11 μM. It elevates hnRNP E1 protein levels and forms hydrogen bond interactions with SAM and the E444 residue of PRMT5. Thi...		Histone Methyltransferase
T83017	Antiproliferative agent-40
	Antiproliferative agent-40 (Compound 9) effectively inhibits the proliferation of HT1080 and MCF-7 cancer cells, displaying IC50 values of 52 μM and 8.2 μM, respectively [1].
T1892	Kobe2602		Raf , Ras
	Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities.		Raf , Ras
T7969	Dipyrithione		Others
	Dipyrithione appears to have novel cytotoxicity and potent broad-spectrum antitumor activity		Others
T7538	Tetraethylammonium chloride		Potassium Channel
	Tetraethylammonium chloride is a quaternary ammonium compound. It is a non-selective potassium channel blocker. It is a good substrate for organic cation transporter proteins and has antitumor properties.		Potassium Channel
T40168	DHODH-IN-16		Dehydrogenase
	DHODH-IN-16 is an effective inhibitor of dihydroorotate dehydrogenase (DHODH, IC50 = 0.396 nM for human).		Dehydrogenase
T38889	Thailanstatin A
	Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50 =650 nM). Thailanstatin A inhibits multiple cancer cell lines via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the s...
T1349	5-Fluorouridine		Others , DNA/RNA Synthesis
	5-fluorouridine is also known as FUrd, 5-Fluorouracil 1-beta-D-ribofuranoside, 5-Fur, or 5-Fluoro-uridine. 5-fluorouridine is a solid. This compound belongs to the pyrimidine nucleosides and analogues. These are compound...		Others , DNA/RNA Synthesis
T15648	KDM5-C70		Histone Demethylase
	KDM5-C70 is an ethyl ester derivative of KDM5-C49. KDM5-C70 is an effective, cell-permeable, and pan-KDM5 histone demethylase inhibitor. KDM5-C70 has an antiproliferative effect in myeloma cells, inducing a genome-wide e...		Histone Demethylase
T9117	BSJ-4-116		CDK , Ligand for E3 Ligase
	BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM. It downregulates DDR genes through a premature termination of transcription, primarily through increasing poly(adenylation).		CDK , Ligand for E3 Ligase
T9880	ZINC05007751		MAPK
	ZINC05007751 is an effective inhibitor of NIMA-related kinase NEK6 (IC50 = 3.4 μM). ZINC05007751 is very selective against NEK1 and NEK6 with no significant activity observed against NEK2, NEK7, and NEK9.		MAPK
TP2207	Pasireotide Acetate		Somatostatin
	Pasireotide Acetate is a stable cyclohexapeptide somatostatin mimic		Somatostatin
T21679	4'-bromo-Resveratrol		Sirtuin
	4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3)		Sirtuin
T13336	VTP50469		Apoptosis , Epigenetic Reader Domain , Histone Methyltransferase
	VTP50469 is a highly selective and orally active inhibitor of Menin-MLL interaction( Ki: 104 pM) and has potently anti-leukemia activity.
T9196	IACS-13909	BBP-398	Phosphatase
	IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.		Phosphatase
T1753	D-64131		Microtubule Associated
	D-64131 is a tubulin polymerization inhibitor with an IC50 value of 0.53 μM.		Microtubule Associated
T8478	SC-43		Apoptosis , Phosphatase , STAT
	SC-43 is a potent and orally active agonist of SHP-1 (PTPN6). SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis, and with anti-fibrotic and anticancer effects.		Apoptosis , Phosphatase , STAT
T2451	GlyH-101	GlyH 101	CFTR , Autophagy
	GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.		CFTR , Autophagy
T15012	Crolibulin	EPC2407	Microtubule Associated
	Crolibulin (EPC2407) is an inhibitor of small molecule tubulin polymerization.		Microtubule Associated
T13224	Tubulin inhibitor 6	iHAP1	Microtubule Associated
	Tubulin inhibitor 6 (iHAP1) is an inhibitor of tubulin and a potent inhibitor of multiple cancer cell lines.		Microtubule Associated

Compounds

Antiproliferative agent-16

T64348

Synonym: Antiproliferative agent-16

Target: Others

Antiproliferative agent-13

T9974

Synonym:

Target: Dehydrogenase

Antiproliferative agent-15

Synonym: Antiproliferative agent-14

Target: Microtubule Associated

Antiproliferative agent-36

T83021

Synonym:

Target: Others

Antiproliferative agent-42

T83015

Synonym:

Target:

Antiproliferative agent-11

T72200

Synonym:

Target:

Antiproliferative agent-38

T83019

Synonym:

Target:

Antiproliferative agent-32

T79332

Synonym:

Target: Apoptosis

Antiproliferative agent-33

T83022

Synonym:

Target:

Antiproliferative agent-34

T79368

Synonym:

Target: EGFR

Antiproliferative agent-4

T63864

Synonym:

Target:

Antiproliferative agent-18

T75014

Synonym:

Target:

Antiproliferative agent-3

T60555

Synonym:

Target:

Antiproliferative agent-37

T83020

Synonym:

Target:

Antiproliferative agent-30

T79322

Synonym:

Target:

Antiproliferative agent-12

T74921

Synonym:

Target:

Antiproliferative agent-26

T83023

Synonym:

Target:

Antiproliferative agent-23

T74844

Synonym:

Target:

Antiproliferative agent-8

T62012

Synonym:

Target:

Antiproliferative agent-41

T83016

Synonym:

Target:

Antiproliferative agent-6

T61996

Synonym:

Target:

Antiproliferative agent-5

T64212

Synonym:

Target:

Antiproliferative agent-20

T72191

Synonym:

Target:

Antiproliferative agent-7

T62549

Synonym:

Target:

Antiproliferative agent-19

T72205

Synonym:

Target:

Antiproliferative agent-27

T79289

Synonym:

Target: Apoptosis

Antiproliferative agent-17

T72204

Synonym:

Target:

Antiproliferative agent-10

T72199

Synonym:

Target:

Antiproliferative agent-39

T83018

Synonym:

Target:

Antiproliferative agent-25

T79275

Synonym:

Target: Histone Methyltransferase

Antiproliferative agent-40

Tetraethylammonium chloride

T7538

Synonym:

Target: Potassium Channel

DHODH-IN-16

T40168

Synonym:

Target: Dehydrogenase

Target: Others, DNA/RNA Synthesis

KDM5-C70

T15648

Synonym:

Target: Histone Demethylase

BSJ-4-116

T9117

Synonym:

Target: CDK, Ligand for E3 Ligase

Target: Apoptosis, Epigenetic Reader Domain, Histone Methyltransferase

Target: Microtubule Associated

SC-43

T8478

Synonym:

Target: Apoptosis, Phosphatase, STAT

GlyH-101

T2451

Synonym: GlyH 101

Target: CFTR, Autophagy

Crolibulin

T15012

Synonym: EPC2407

Target: Microtubule Associated

Tubulin inhibitor 6

T13224

Synonym: iHAP1

Target: Microtubule Associated

Cat No.	Product Name	Synonyms	Targets
T10668	Camalexin		Reactive Oxygen Species , ROS , Antibacterial , Antifungal
	Camalexin is a phytoalexin isolated from Camelina sativa. It has antifungal, antibacterial, antiproliferative, and anticancer activities. Camalexin can induce ROS production.		Reactive Oxygen Species , ROS , Antibacterial , Antifungal
TN7041	(-)-Epipodophyllotoxin		Apoptosis
	(-)-Epipodophyllotoxin (2) is an antiproliferative agent against cancer cells with GI50s of 0.36 and 0.24 μM in HeLa cells and MCF-7 cells, respectively. (-)-Epipodophyllotoxin can inhibit mitotic spindle assembly in vit...		Apoptosis
T5808	(-)-Oxypeucedanin hydrate	OXYPEUCEDANIN HYDRATE	Others
	(-)-Oxypeucedanin hydrate is a furanocoumarin. It has a role as a metabolite.		Others
T7052	Gnetol		Tyrosinase , COX , HDAC , AChR
	Gnetol competitivity inhibits butyrylcholinesterase (IC50: 1.3 uM). Gnetol has a strong inhibitory effect on murine tyrosinase activity. Gnetol significantly suppresses melanin biosynthesis in murine B16 melanoma cells. ...		Tyrosinase , COX , HDAC , AChR
TN2069	Picrocrocin		Apoptosis
	Picrocrocin is a natural product		Apoptosis
T6830	Epoxomicin	BU-4061T,BU-4061T,Aids010837	Apoptosis , Proteasome
	Epoxomicin (BU-4061T,Aids010837) is a selective proteasome inhibitor with anti-inflammatory activity, inhibits primarily the CH-L activity of the 20S proteasome, while T-L and PGPH catalytic activities are also inhibited...		Apoptosis , Proteasome
T19676	Tributyrin	NSC661583,NSC 661583,NSC-661583	Apoptosis
	Tributyrin (Glyceryl tributyrate), a neutral short-chain fatty acid triglyceride, is a stable and rapidly absorbed prodrug of Butyric Acid. Tributyrin diffuses through biological membranes and is metabolized by intracell...		Apoptosis
T9605	Sangivamycin	BA-90912,NSC 65346	Nucleoside Antimetabolite/Analog , PKC
	Sangivamycin (NSC-65346) is an effective inhibitor of protein kinase C (PKC, Ki = 10 μM). Sangivamycin exhibits antiproliferative activity against a variety of human cancers.		Nucleoside Antimetabolite/Analog , PKC
T34394	Rotenolone	Rotenolone I,12alpha-HYDROXYROTENONE	Others
	Rotenolone (12alpha-HYDROXYROTENONE) is a metabolite of Rotenone which is a natural compound derived from plants of the genera Derris and Lonchocarpus.		Others
TN4569	Minimolide F		Others
	Minimolide F, isolated from Centipeda minima, shows antiproliferative activity against human nasopharyngeal cancer cells with an IC50 of 17.4 μM.		Others
T7032	Eupatorin		Others , P450
	Eupatorin has antiproliferative and antiangiogenic effects. Eupatorin has antiproliferative and cytostatic effects on MDA-MB-468 human breast cancer cells due to CYP1-mediated metabolism. Eupatorin-induced cell death is ...		Others , P450
T4957	Carnosic acid		Apoptosis , ROS , Antibacterial
	Carnosic acid is a lipid absorption inhibitor, endowed with antioxidative, antimicrobial, photoprotective potential, and antiproliferative properties.		Apoptosis , ROS , Antibacterial
T0036	18β-Glycyrrhetinic acid	Enoxolone,Glycyrrhetin	Dehydrogenase , Endogenous Metabolite
	18β-Glycyrrhetinic acid (Enoxolone) is the major bioactive component of Glycyrrhizae Radix and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.		Dehydrogenase , Endogenous Metabolite
T4373	Brassinin	BSN	Antifungal
	Brassinin (BSN) (BSN) is a phytoalexin isolated from B. campestris that exhibits anticancer, chemopreventative, antiproliferative, and antifungal activities.		Antifungal
TC0039	Vasicinone		Others
	Vasicinone may act as a hepatoprotective agent. (±)-Vasicinone has significant antitussive, expectorant, and bronchodilating activities, which can be used to treat respiratory disease.(S)-Vasicinone exhibits antiprolifer...		Others
TN1260	3-O-beta-D-Glucopyranosylplatycodigenin		Others
	3-O-beta-D-Glucopyranosylplatycodigenin is isolated from the roots of Platycodon grandiflorum.		Others
TN1933	Mitraphylline		IL Receptor , TNF , NF-κB
	Mitraphylline has antiproliferative effects on human glioma and neuroblastoma cell lines. It also has anti-inflammatory activity, it inhibits lipopolysaccharide-mediated activation of primary human neutrophils.		IL Receptor , TNF , NF-κB
T3408	Syringin	Lilacin,Syringoside,eleutheroside-b,Methoxyconiferine	NOS , Autophagy
	Syringin (eleutheroside-b) is a compound with antitumor, antiproliferative, immunomodulatory and platelet aggregation inhibiting effects.		NOS , Autophagy
TN1675	Gardenin B		Apoptosis , ROS , Caspase , NO Synthase
	Gardenin B exhibits superior antiproliferative activity against lung, breast, colon, hepatic and leukaemia cell lines as well as in keratinocytes .		Apoptosis , ROS , Caspase , NO Synthase
T2212	Geniposide		Beta Amyloid , Influenza Virus
	Geniposide is an iridoid glycoside with a variety of biological activities including neuroprotective, anti-diabetic, antiproliferative, and antioxidative activity. Geniposide has been shown to regulate Nrf2 translocation...		Beta Amyloid , Influenza Virus
T7174	Urolithin A		Apoptosis , Reactive Oxygen Species , DNA/RNA Synthesis , Endogenous Metabolite , Autophagy , Drug Metabolite
	Urolithin A is a secondary metabolite of ellagic acid, a polyphenolic antioxidant, that has antiproliferative, anti-inflammatory, and anti-oxidant properties.
T3916	Ginsenoside F2		Apoptosis , Endogenous Metabolite , Autophagy
	Ginsenoside F2 has antiproliferative activity against breast cancer stem cells (CSCs). It induces apoptosis in breast CSCs by activating the intrinsic apoptotic pathway and mitochondrial dysfunction.		Apoptosis , Endogenous Metabolite , Autophagy
T2869	Emodin	Frangula emodin	SARS-CoV , Casein Kinase , Autophagy
	Emodin (Frangula emodin) is a naturally occurring anthraquinone present in the roots and barks of numerous plants; exerts antiproliferative effects in Y cells that are regulated by different signaling pathways.		SARS-CoV , Casein Kinase , Autophagy
T4S2164	Narirutin	Naringenin-7-O-rutinoside,Isonaringin	Others , Antibacterial
	1. Narirutin (Naringenin-7-O-rutinoside) has antiproliferative property. 2. Narirutin has anti-oxidant property. 3. Narirutin has anti-allergic and anti-inflammatory properties , can reduce airway inflammation in ovalbum...		Others , Antibacterial
T3404	Cucurbitacin B	Cuc B,DATISCACIN,Amarine	Apoptosis , PTEN , Integrin , Endogenous Metabolite , HIF , STAT , Autophagy
	Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-regulation of PTEN. Cucurbitacin B is an effective inh...
T0610	Piceatannol	trans-Piceatannol,Astringenin	Apoptosis , Serine/threonin kinase , PKA , Syk , PKC , Autophagy
	Piceatannol (Astringenin) is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activation and gene expression of TNF-induced. It is...
T0795	Rutin	Quercetin 3-O-rutinoside,Rutoside	Beta Amyloid , Prostaglandin Receptor , Autophagy
	Rutin (Quercetin 3-O-rutinoside), a flavonoid, has a variety of biological activities including antiallergic, anti-inflammatory, antiproliferative, and anticarcinogenic properties.		Beta Amyloid , Prostaglandin Receptor , Autophagy
T6102	2'-acetylacteoside		Antioxidant , Reductase
	2'-Acetylacteoside has antioxidative activity. It can significantly attenuate glutamate-induced neurotoxicity at concentrations ranging from 0.1 to 10 μM. 2'-Acetylacteoside shows antiproliferative effects on aortic smoo...		Antioxidant , Reductase
T6S0052	Chelerythrine	Toddalin,Broussonpapyrine,Cheleritrine	Apoptosis , BCL , PKC , Autophagy
	1. Chelerythrine (Broussonpapyrine) may have antimanic effect . 2. Chelerythrine can inhibit telomerase activity. 3. Chelerythrine is a well-known protein kinase C inhibitor . 4. Chelerythrine has potential antiprolifera...		Apoptosis , BCL , PKC , Autophagy
T2821	Ethyl ferulate	Ethyl 4'-hydroxy-3'-methoxycinnamate,Ethyl 3-(4-hydroxy-3-methoxyphenyl)acrylate,Ferulic acid ethyl ester	Reactive Oxygen Species
	Ethyl ferulate (Ethyl 4'-hydroxy-3'-methoxycinnamate) is the alkyl ester derivative of ferulic acid which is a naturally occurring plant product with anti-oxidative, anti-inflammatory, neuroprotective, and antiproliferat...		Reactive Oxygen Species
T14305	Apicidin	OSI 2040	Apoptosis , HDAC , Autophagy
	Apicidin (OSI 2040) is a histone deacetylase (HDAC) inhibitor with antiparasitic activity and antiproliferative activity.Apicidin attenuates memory deficits, inhibits cell growth and proliferation, and induces apoptosis ...		Apoptosis , HDAC , Autophagy
T3S1967	(S)-Indoximod	N-ME-Tryptophan,Abrine,L-Abrine	Others , Indoleamine 2,3-Dioxygenase (IDO)
	(S)-Indoximod (L-Abrine) exhibits inhibition of rabbit small intestine indoleamine 2, 3-dioxygenase, competitive inhibition of IDO, reduction of Foxp3 protein expression in tumor of C57BL/6 mouse allografted with mouse L...		Others , Indoleamine 2,3-Dioxygenase (IDO)
T75643	Isoxanthohumol		HSV
	Isoxanthohumol is a prenylated flavonoid derived from hops and beer with antiproliferative activity against several human cancer cell lines.Isoxanthohumol inhibits the metastasis or invasion of lung metastases of tumor c...		HSV
T2P2806	Hederacolchiside A1	Raddeanoside R13	Apoptosis , ERK , MEK , Akt , PI3K , Parasite , mTOR
	Hederacolchiside A1 (Raddeanoside R13) shows anti-leishmanial activity, it exhibits a strong antiproliferative activity on all stages of development of the parasite by altering membrane integrity and potential. Hederacol...		Apoptosis , ERK , MEK , Akt , PI3K , Parasite , mTOR
T4S1637	Gamma-Mangostin	Normangostin	Others , 5-HT Receptor
	1. gamma-Mangostin (Normangostin) as a preventive agent of the metabolic syndrome. 2. Gamma-Mangostin has free radical scavenging activity, and antiproliferative and apoptotic activity in HepG2 cells. 3. Gamma-Mangostin ...		Others , 5-HT Receptor
TMS0418	Dihydroergotoxine mesylate	Ergoloid mesylates	GABA Receptor
	Dihydroergotoxine mesylate (Ergoloid mesylates) is mainly used to improve symptoms and physical symptoms of mental degeneration related to aging.		GABA Receptor
TN6637	Gardenin D
	Gardenin D has antioxidant, and antiproliferative activities.
TN3247	7-O-Prenylscopoletin		PLK , CDK
	7-O-Prenylscopoletin and cedrelopsin show high antiproliferative activities against cancer cell lines.		PLK , CDK
T81794	Micromonosporamide A
	Micromonosporamide A demonstrates antiproliferative activity contingent upon glutamine presence.
T12403	Penitrem A		Others
	Penitrem A is a selective antagonist of BK channel with antiproliferative and anti-invasive activities against multiple malignancies.		Others
T38890	Thailanstatin C
	Thailanstatin C, an antiproliferative agent derived from Burkholderia thailandensis MSMB43, functions as a potent inhibitor of pre-mRNA splicing (IC50 = 6.84 μM).
T17270	Yatein		Others
	Yatein inhibits herpes simplex virus type 1 replication by interruption the immediate-early gene expression. Yatein is a lignan isolated from A. chilensis. It also has antiproliferative activity.		Others
T81996	Kadsuphilin A
	Kadsuphilin A, extracted from Kadsura coccinea (Lem.), exhibits weak antiproliferative activity [1].
TN4629	Nemoralisin C		Others
	Nemoralisin C shows antiproliferative activity against HepG2, AGS, MCF-7, and A-549 cancer cell lines.		Others
TN1942	Momordicoside F1		Others
	Momordicoside F1 may have antiproliferative activities against MCF-7, WiDr, HEp-2, and Doay human tumor cell lines.		Others
T38891	Valeriandoid F
	Valeriandoid F, an iridoid, exhibits potent inhibition of nitric oxide (NO) production with an IC50 value of 0.88 μM. Additionally, Valeriandoid F possesses anti-inflammatory and antiproliferative properties.
TN1810	Jatropholone B		Others
	Jatropholone B shows antiproliferative activity against cancer cell lines. It also has gastroprotective activity in preventing the gastric lesions in mice.		Others
TN3605	Casegravol		Others
	Casegravol shows antiproliferative activity against human gastric adenocarcinoma (MK-1), human uterus carcinoma (HeLa), and murine melanoma (B16F10) cells.		Others
TN1988	Nephthenol		Others
	Nephthenol shows antiproliferative activity against the cell lines HUVEC and K-562 and for cytotoxicity against the cell line HeLa.		Others
TN6591	Cannabisin B
	Cannabisin B possesses considerable antiproliferative activity and that it may be utilised as a promising chemopreventive agent against hepatoblastoma disease. It induces autophagic cell death by inhibiting the AKT/mTOR ...
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Natural Products

Camalexin

T10668

Synonym:

Target: Reactive Oxygen Species, ROS, Antibacterial, Antifungal

(-)-Epipodophyllotoxin

TN7041

Synonym:

Target: Apoptosis

(-)-Oxypeucedanin hydrate

T5808

Synonym: OXYPEUCEDANIN HYDRATE

Target: Tyrosinase, COX, HDAC, AChR

Synonym: BU-4061T,BU-4061T,Aids010837

Target: Apoptosis, Proteasome

Tributyrin

T19676

Synonym: NSC661583,NSC 661583,NSC-661583

Target: Apoptosis

Sangivamycin

T9605

Synonym: BA-90912,NSC 65346

Target: Nucleoside Antimetabolite/Analog, PKC

Rotenolone

T34394

Synonym: Rotenolone I,12alpha-HYDROXYROTENONE

Target: Apoptosis, ROS, Antibacterial

18β-Glycyrrhetinic acid

T0036

Synonym: Enoxolone,Glycyrrhetin

Target: Dehydrogenase, Endogenous Metabolite

3-O-beta-D-Glucopyranosylplatycodigenin

Target: IL Receptor, TNF, NF-κB

Syringin

T3408

Synonym: Lilacin,Syringoside,eleutheroside-b,Methoxyconiferine

Target: NOS, Autophagy

Gardenin B

TN1675

Synonym:

Target: Apoptosis, ROS, Caspase, NO Synthase

Geniposide

T2212

Synonym:

Target: Beta Amyloid, Influenza Virus

Urolithin A

T7174

Synonym:

Target: Apoptosis, Reactive Oxygen Species, DNA/RNA Synthesis, Endogenous Metabolite, Autophagy, Drug Metabolite

Ginsenoside F2

T3916

Synonym:

Target: Apoptosis, Endogenous Metabolite, Autophagy

Emodin

T2869

Synonym: Frangula emodin

Target: SARS-CoV, Casein Kinase, Autophagy

Narirutin

T4S2164

Synonym: Naringenin-7-O-rutinoside,Isonaringin

Target: Others, Antibacterial

Cucurbitacin B

T3404

Synonym: Cuc B,DATISCACIN,Amarine

Target: Apoptosis, PTEN, Integrin, Endogenous Metabolite, HIF, STAT, Autophagy

Piceatannol

T0610

Synonym: trans-Piceatannol,Astringenin

Target: Apoptosis, Serine/threonin kinase, PKA, Syk, PKC, Autophagy

Rutin

T0795

Synonym: Quercetin 3-O-rutinoside,Rutoside

Target: Beta Amyloid, Prostaglandin Receptor, Autophagy

2'-acetylacteoside

T6102

Synonym:

Target: Antioxidant, Reductase

Chelerythrine

T6S0052

Synonym: Toddalin,Broussonpapyrine,Cheleritrine

Target: Apoptosis, BCL, PKC, Autophagy

Ethyl ferulate

T2821

Synonym: Ethyl 4'-hydroxy-3'-methoxycinnamate,Ethyl 3-(4-hydroxy-3-methoxyphenyl)acrylate,Ferulic acid ethyl ester

Target: Reactive Oxygen Species

Apicidin

T14305

Synonym: OSI 2040

Target: Apoptosis, HDAC, Autophagy

(S)-Indoximod

T3S1967

Synonym: N-ME-Tryptophan,Abrine,L-Abrine

Target: Others, Indoleamine 2,3-Dioxygenase (IDO)

Synonym: Raddeanoside R13

Target: Apoptosis, ERK, MEK, Akt, PI3K, Parasite, mTOR

gamma-Mangostin

T4S1637

Synonym: Normangostin

Target: Others, 5-HT Receptor

Dihydroergotoxine mesylate

TMS0418

Synonym: Ergoloid mesylates

Target: GABA Receptor

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Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-01073	CD81 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalizati...
TMPY-03142	IL-27 Protein, Human, Recombinant (His)	Human	CHO
	IL-27 protein is a member of the IL-6 superfamily, which is expressed on monocytes, endothelial cells, and dendritic cells. IL-27 protein is also referred to as the IL-12 p35-related protein, p28, is one subunit of a het...
TMPY-03153	IL-27 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	IL-27 protein is a member of the IL-6 superfamily, which is expressed on monocytes, endothelial cells, and dendritic cells. IL-27 protein is also referred to as the IL-12 p35-related protein, p28, is one subunit of a het...
TMPY-03072	IFN-omega Protein, Human, Recombinant (His)	Human	HEK293
	IFNs are a large family of proteins having antiviral, antiproliferative, and immunomodulatory effects, and are divided into two major classes, type I and type II, based on differences in receptor binding and nucleotide s...
TMPY-03356	IFN gamma Protein, Mouse, Recombinant	Mouse	HEK293
	IFN gamma, also known as IFNG, is a secreted protein that belongs to the type II interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, ...
TMPY-01714	IFN gamma Protein, Human, Recombinant	Human	CHO
	IFN gamma, also known as IFNG, is a secreted protein that belongs to the type II interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, ...
TMPY-06983	IFN gamma Protein, Human, Recombinant (E. coli)	Human	E. coli
	IFN gamma, also known as IFNG, is a secreted protein that belongs to the type II interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, ...
TMPY-02827	IFN gamma Protein, Rat, Recombinant (hFc)	Rat	HEK293
	IFN gamma, also known as IFNG, is a secreted protein that belongs to the type II interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, ...
TMPY-00835	IGFBP-3 Protein, Human, Recombinant (His)	Human	HEK293
	The Insulin-like Growth Factor (IGF) signaling system plays a central role in cellular growth, differentiation, and proliferation. IGFBP3 is the most abundant IGF binding protein in human serum and is a growth inhibitory...
TMPY-03467	IFN-beta Protein, Mouse, Recombinant	Mouse	HEK293
	Interferons (IFNs) are natural glycoproteins belonging to the cytokine superfamily and are produced by the cells of the immune system of most vertebrates in response to challenges by foreign agents such as viruses, paras...
TMPY-00831	IFN-beta Protein, Human, Recombinant (hFc)	Human	HEK293
	Interferons (IFNs) are natural glycoproteins belonging to the cytokine superfamily and are produced by the cells of the immune system of most vertebrates in response to challenges by foreign agents such as viruses, paras...
TMPY-03145	IFN-beta Protein, Human, Recombinant	Human	CHO
	Interferons (IFNs) are natural glycoproteins belonging to the cytokine superfamily and are produced by the cells of the immune system of most vertebrates in response to challenges by foreign agents such as viruses, paras...
TMPH-02451	IFN gamma Protein, Marmota monax, Recombinant (His)	Marmota monax	Yeast
	Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproli...
TMPH-00373	IFN gamma Protein, Chicken, Recombinant (GST)	Chicken	E. coli
	Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproli...
TMPK-00889	IFNAR2 Protein, Human, Recombinant (aa 27-243, His)	Human	HEK293
	Although interferon (IFN)-α is known to exert immunomodulatory and antiproliferative effects on dendritic cells (DCs) through induction of protein-coding IFN-stimulated genes (ISGs), little is known about IFN-α-regulated...
TMPK-00637	IFNAR2 Protein, Cynomolgus, Recombinant (aa 27-243, His)	Cynomolgus	HEK293
	Although interferon (IFN)-α is known to exert immunomodulatory and antiproliferative effects on dendritic cells (DCs) through induction of protein-coding IFN-stimulated genes (ISGs), little is known about IFN-α-regulated...
TMPJ-01371	Limitin Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	Limitin, also called IFN-ζ, is a secreted interferon (IFN)-like glycoprotein. Limitin has approximately 30% sequence homology with IFN-α, IFN-β, and IFN-ω and binds to the IFN-α/β receptors. Like IFN-α and IFN-β, limitin...
TMPH-00278	Interferon tau-1/IFNT1 Protein, Bovine, Recombinant (E. coli, His)	Bovine	E. coli
	Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-...
TMPH-01836	Human Papilloma Virus type 18 (HPV 18) Protein E7 (E. coli, His)	HPV 18	E. coli
	Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery t...
TMPH-01838	Human Papilloma Virus type 52 (HPV 52) Protein E7 (His & SUMO)	HPV 52	E. coli
	Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery t...
TMPH-01837	Human Papilloma Virus type 18 (HPV 18) Protein E7 (His)	HPV 18	Yeast
	Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery t...
TMPH-01834	Human Papilloma Virus type 16 (HPV 16) Protein E7 (His)	HPV 16	E. coli
	Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery t...
TMPY-01663	PPM1A Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Protein phosphatase 1A (PPM1A / PP2CA) is an enzyme belonging to the PP2C family of Ser / Thr protein phosphatases. Members of PP2C family are negative regulators of cell stress response pathways and the MAP kinases and ...
TMPY-02567	PPM1A Protein, Human, Recombinant (His)	Human	E. coli
	Protein phosphatase 1A (PPM1A / PP2CA) is an enzyme belonging to the PP2C family of Ser / Thr protein phosphatases. Members of PP2C family are negative regulators of cell stress response pathways and the MAP kinases and ...
TMPH-01827	Human Papilloma Virus type 11 (HPV 11) Protein E7 (His & Myc)	HPV 11	E. coli
	Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery t...
TMPH-00279	Interferon tau-1/IFNT1 Protein, Bovine, Recombinant (His)	Bovine	Yeast
	Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-...
TMPY-00833	IFN-omega Protein, Human, Recombinant (hFc)	Human	HEK293
	IFNs are a large family of proteins having antiviral, antiproliferative, and immunomodulatory effects, and are divided into two major classes, type I and type II, based on differences in receptor binding and nucleotide s...
TMPY-02122	IFNGR2 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Interferon-gamma receptor beta chain (IFNgammaR2), also known as IFNGR2, belongs to the type II cytokine receptor family, whose deficiency is a cause of autosomal recessive mendelian susceptibility to mycobacterial disea...
TMPY-03664	IFN gamma Protein, Ferret, Recombinant (His)	Ferret	HEK293
	IFN gamma, also known as IFNG, is a secreted protein that belongs to the type II interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, ...
TMPY-04191	IFN gamma Protein, Rhesus, Recombinant (His)	Rhesus	HEK293
	IFN gamma, also known as IFNG, is a secreted protein that belongs to the type II interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, ...
TMPY-02323	IFN gamma Protein, Mouse, Recombinant (His)	Mouse	HEK293
	IFN gamma, also known as IFNG, is a secreted protein that belongs to the type II interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, ...
TMPY-00527	IFN gamma Protein, Rhesus, Recombinant	Rhesus	E. coli
	IFN gamma, also known as IFNG, is a secreted protein that belongs to the type II interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, ...
TMPY-02322	IFN gamma Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	IFN gamma, also known as IFNG, is a secreted protein that belongs to the type II interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, ...
TMPY-03251	IGFBP-3 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	The Insulin-like Growth Factor (IGF) signaling system plays a central role in cellular growth, differentiation, and proliferation. IGFBP3 is the most abundant IGF binding protein in human serum and is a growth inhibitory...
TMPH-01555	IFITM1 Protein, Human, Recombinant (GST)	Human	E. coli
	IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against ...
TMPY-02456	IFN-beta Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Interferons (IFNs) are natural glycoproteins belonging to the cytokine superfamily and are produced by the cells of the immune system of most vertebrates in response to challenges by foreign agents such as viruses, paras...
TMPY-03828	IFN-beta Protein, Rhesus, Recombinant (mFc)	Rhesus	HEK293
	Interferons (IFNs) are natural glycoproteins belonging to the cytokine superfamily and are produced by the cells of the immune system of most vertebrates in response to challenges by foreign agents such as viruses, paras...