anorexia

Megestrol acetate (BDH1298) is a progestogen with actions and uses similar to those of the progestogens in general. Megestrol acetate also has anti-androgenic properties. It is given by mouth in the palliative treatment or as an adjunct to other therapy in endometrial carcinoma and in breast cancer. Megestrol acetate has been approved to treat anorexia and cachexia.

Ethylmalonic acid is potentially toxic, non-carcinogenic, and has been associated with anorexia nervosa and methoxy decarboxylase deficiency.

JNJ-31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity(pIC50=8.07, human; pIC50=8.22, rat); it exhibits >100-fold selectivity for Y2 versus human Y1 Y4 Y5 receptors.

MCL0020 is a potent and selective melanocortin MC4 receptor antagonist (IC50 values are 11.63, 1115, and >10,000 nM at MC4, MC3, and MC1 receptors, respectively). It significantly reverses stress-induced anorexia without affecting food intake in free-feeding rats and exhibits anxiolytic-like activity in vivo.

AMPD2 inhibitor 1 is an adenosine monophosphate deaminase 2 (AMPD2) inhibitor, useful for studying anorexia in the nervous system.

Bobcat339 hydrochloride is a selective 10 11 translocation (TET) dioxygenase inhibitor that inhibits TET1 and TET2.Bobcat339 hydrochloride induces TET3 protein degradation and also stimulates the expression of AGRP, NPY, and VGAT in a TET3-dependent manner in mouse and human neuronal cells. VGAT expression, which can be used to study transient anorexia nervosa.

Benoxathian hydrochloride is effective α 1 Adrenaline receptor antagonist. Benoxathian hydrochloride has value in the study of anorexia.

Macimorelin Acetate (EP-1572), an orally active growth hormone (GH) secretagogue and a ghrelin receptor (GHSR) agonist, stimulates GH release. It is utilized in research focusing on adult growth hormone deficiency (AGHD) and Cancer Anorexia-Cachexia Syndrome (CACS).

CB1 Inverse Agonist 2, an orally active compound, serves as an inverse agonist for the Cannabinoid Receptor CB1. It effectively counteracts the hypothermia and anorexia induced by CP55940 in mouse models.

Ponsegromab (PF 06946860) is a selective and effective humanized anti-GDF15 antibody inhibitor with anti-cachexic activity. It binds to GDF15, preventing its interaction with GFRAL and disrupting GDF15 GFRAL mediated signaling. Ponsegromab has potential anticancer activity and can be used to treat cancer patients with cancer anorexia cachexia syndrome.

Zymosan A, a polysaccharide from Saccharomyces cerevisiae (brewer's yeast), is a TLR2 agonist that promotes regeneration of ISCs from intestinal stem cells after radiation injury by up-regulating ASCL2 through the TLR2 signaling pathway and the Wnt signaling pathway.Zymosan A stimulates immune responses and induces inflammation , anorexia and elevated body temperature, and also inhibits the gap junction protein connexin 43 in human corneal fibroblasts and causes corneal stromal damage.

PMX-53, a macrocyclic complement 5a (C5a) peptidomimetic and C5a receptor antagonist (IC50 = 0.3 µM), effectively inhibits the C5a-induced secretion of myeloperoxidase (MPO) in isolated human polymorphonuclear leukocytes (PMNs). Administered orally at 10 mg kg, PMX-53 mitigates vascular leakage, PMN infiltration, and the production of TNF-α and IL-6 in a rat peritoneal Arthus reaction model. Additionally, in a 3-nitropropionic acid (3-NP)-induced Huntington's disease rat model, it alleviates body weight loss, anorexia, and striatal degeneration. Furthermore, at a dose of 3 mg kg, PMX-53 decreases atherosclerotic lesion size and lipid content in ApoE- - mice.

α-Cortolone, a metabolite of the glucocorticoid cortisol (hydrocortisone), is produced through the action of 20α-hydroxysteroid dehydrogenase (20α-HSD) via a tetrahydrocortisone (THE) intermediate. Studies indicate that urinary levels of α-cortolone are reduced in patients experiencing severe anorexia nervosa and postmenopausal women diagnosed with endometrial adenocarcinoma, in comparison to postmenopausal women without the condition.

Ethyl-d5-malonic Acid is a deuterated compound of Ethyl-malonic Acid. Ethyl-malonic Acid has a CAS number of 601-75-2. Ethylmalonic acid can be found in blood, cerebrospinal fluid (CSF), and urine, as well as in human fibroblasts, prostate, and skeletal muscle tissues. Moreover, ethylmalonic acid is found to be associated with anorexia nervosa and malonyl-CoA decarboxylase deficiency. Ethylmalonic acid is a non-carcinogenic potentially toxic compound. Chronically high levels of ethylmalonic acid are associated with at least two inborn errors of metabolism, including short chain acyl CoA dehydrogenase deficiency (SCAD deficiency) and ethylmalonic encephalopathy.

Megestrol Acetate-d3 is a deuterated compound of Megestrol Acetate. Megestrol Acetate has a CAS number of 595-33-5. Megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. Megestrol acetate also has anti-androgenic properties. It is given by mouth in the palliative treatment or as an adjunct to other therapy in endometrial carcinoma and in breast cancer. Megestrol acetate has been approved to treat anorexia and cachexia.

Glycyrrhetic acid 3-O-β-D-glucuronide is a potent sweetener (relative sweetness to sucrose: x 941).