adducts — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T23046	N-tert-butyl-α-Phenylnitrone	(Z)-N-benzylidene-2-Methylpropan-2-aMine oxide	ROS , COX
	N-tert-butyl-α-Phenylnitrone ((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) inhibits COX2 catalytic activity. N-tert-butyl-α-Phenylnitrone((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) possesses potent reactive oxyge...		ROS , COX
T3903	Angoroside C		Prostaglandin Receptor
	Angoroside C is a Potential anti-inflammatory compound. Inhibitor of prostaglandin E2 release in mouse peritoneal macrophages in vitro. Shows potent antioxidative activity in reducing the oxidized OH adducts of dAMP and ...		Prostaglandin Receptor
T1564	Cisplatin	cis-Diaminodichloroplatinum,CDDP	DNA Alkylator/Crosslinker , Ferroptosis , DNA/RNA Synthesis , Autophagy
	Cisplatin (CDDP) is a DNA cross-linking agent. Cisplatin has antitumor activity and inhibits DNA synthesis by forming DNA adducts in cancer cells. Cisplatin also activates iron death and induces autophagy.
T41358	2-Hydroxybenzylamine		Others
	2-Hydroxybenzylamine, a potent small molecule scavenger of IsoLGs, sequesters the reactive species as inert adducts. 2-Hydroxybenzylamine may be used to decrease early recurrence of atrial fibrillation and other atrial a...		Others
T35366	4-Nitroquinoline 1-oxide	4-Nitroquinoline 1-oxide,4Nqo,NQO,4-NQO,4-Nitroquinoline-N-oxide,NQNO	Others
	4-Nitroquinoline 1-oxide (4-NQO) is a chemical carcinogen that induces mutations in bacteria, fungi, and animals through the formation of large amounts of purine adducts.		Others
T21704	5-fluoro 203	5F-203,NSC-703786	Others
	5-fluoro 203 (NSC-703786) is a cytotoxic molecule leading to cell death by forming DNA adducts. 5-fluoro 203 induces aryl hydrocarbon receptor signaling, and elevates expression of CYP1A1. 5-fluoro 203 treatment of cells...		Others
T16525	PhIP		Others
	PhIP is a heterocyclic aromatic amine (HAA) from cooked meat. It belongs to pyridine heterocyclic amine and is a 2B carcinogen with estrogen activity. PhIP forms adducts with DNA that promote cancer.		Others
T7031	Aristolochic acid B	Aristolochic Acid II	DNA
	Aristolochic acid B (Aristolochic Acid II) is one of the major components of the carcinogenic plant extract aristolochic acid, is known to be mutagenic and to form DNA adducts in vitro and in vivo, Aristolochic acid B sh...		DNA
T18967	Dansyl chloride	DNSCl	Others
	Dansyl chloride (DNSC-l) reacts with primary amino groups in both aliphatic and aromatic amines to produce stable blue- or blue-green-fluorescent sulfonamide adducts. It is widely used to modify amino acids, specifically...		Others
T29689	AFB1-N7-guanine
	In epidemiological studies, Aflatoxin B1-N7-guanine serum albumin adducts have been established as biomarkers of dietary aflatoxin exposure.
T16327	Nitracrine		Others
	Nitracrine is a 1-nitroacridine derivative and is an effective hypoxia-selective agent in vitro and antitumor drugs. Nitracrine suppresses RNA synthesis and covalently, reversibly binds to DNA but also forms covalent add...		Others
T62582	WEHI-150
	WEHI-150 is an analog of mitoxantrone, a DNA interstrand cross-linker (t1/2=12.5 h). WEHI-150 is capable of forming covalent adducts on CpG sequences, with a particular preference for methylated CpG sites. Formaldehyde-a...
TNU1537	O6-Methyldeoxy guanosine
	Nucleoside Derivatives - 6-Modified purine nucleosides; DNA adducts
T40706	Heliotrine N-oxide
	Heliotrine N-oxide is the pyrrolizidine alkaloid (PA) N-oxide counterpart of Heliotrine. It induces the generation of pyrrolic DNA adducts, potentially initiating PA-induced liver tumors in vivo.
T19192	α-Hydroxytamoxifen	α-OHTAM,(E)-α-Hydroxy tamoxifen	Others
	α-Hydroxytamoxifen is a metabolite of tamoxifen. It reacts with DNA and causes the formation of DNA adducts.		Others
T36834	Abacavir Carboxylate
	Abacavir carboxylate is an inactive metabolite of the HIV-1 reverse transcriptase inhibitor abacavir . It is formed from abacavir via reactive aldehyde intermediates that can form adducts with proteins on valine residues...
T32189	Iproplatin	JM-9,CHIP,Code name: JM9,JM 9
	Iproplatin is a synthetic second-generation platinum-containing compound related to cisplatin. Iproplatin binds to and forms DNA crosslinks and platinum-DNA adducts, resulting in DNA replication failure and cell death. A...
T36027	DEPMPO-biotin
	DEPMPO is a nitrone that is used to spin trap reactive O-, N-, S-, and C-centered radicals and allow their characterization when used in association with electron spin resonance. It is noted for the stability of adducts ...
T37612	IBTP (iodide)
	IBTP is a lipophilic cation that is accumulated in mitochondria and forms stable thioether adducts in a thiol-specific manner. As a result, mitochondrial proteins that have changed thiol redox state following oxidative s...
T36708	Monohydroxy Melphalan (hydrochloride)
	Monohydroxy melphalan is a DNA alkylating agent and a degradation product of melphalan . Monohydroxy melphalan is formed by the hydrolysis of melphalan in aqueous solutions, including cell culture medium and human plasma...