Search Result

Search Results for " acetylcholine "

Targets

381

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T20344	Acetylcholine bromide		Others
	Acetylcholine bromide is the bromide salt of acetylcholine. It is an neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, a...		Others
T20522	Acetylcholine perchlorate	AI351678,AI3-51678,AI3 51678
	Acetylcholine perchlorate is the perchlorate salt of acetylcholine. Acetylcholine, an endogenous neurotransmitter at cholinergic synapses, could amplify the action potential of the sarcolemma following by inducing muscle...
T9787	Suvn-911		AChR
	suvn-911 is a potent and selective antagonist of neuronal nicotinic acetylcholine α4β2 receptor (Ki = 1.5 nM) with antidepressant activity.		AChR
T1760	TBPB		AChR
	TBPB is an allosteric M1 mAChR agonist.		AChR
T29123	VU0152099	VU 0152099,VU-0152099	AChR
	VU0152099 is a potent and selective M4 mAChR allosteric potentiator(EC50 = 380 ± 93 nM).		AChR
T23513	VU10010	VU 10010	AChR
	VU10010 (VU 10010) is allosteric potentiator of M4 acetylcholine receptors.		AChR
T23116	Oxotremorine sesquifumarate		AChR
	Oxotremorine sesquifumarate is a muscarinic agonist.		AChR
T11095L	DREADD agonist 21		5-HT Receptor , Adrenergic Receptor , AChR , Histamine Receptor
	DREADD agonist 21 is a potent agonist of human muscarinic acetylcholine M3 receptors (EC50=1.7 nM).
T1281	Tropicamide	Ro 1-7683	AChR
	Tropicamide (Ro 1-7683) is a synthetic muscarinic antagonist with actions similar to atropine and with an anticholinergic property. Upon ocular administration, tropicamide binds to and blocks the muscarinic receptors in ...		AChR
T7555	Piperidolate hydrochloride		AChR
	Piperidolate hydrochloride is an antimuscarinic, could restrain the abnormal activity caused by acetylcholine. inhibits intestinal cramp induced by acetylcholine (rats and dogs).		AChR
T14094	Acetamiprid		AChR
	Acetamiprid is a nicotinic acetylcholine receptor (nAChR) agonist. Acetamiprid is a neonicotinoid insecticide used worldwide. It is shown to be associated with neuromuscular and reproductive disorders.		AChR
T11078	Deschloroclozapine		Serotonin Transporter
	Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs agonist. Deschloroclozapine binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively.		Serotonin Transporter
T17300	(-)-(S)-B-973B		AChR
	(-)-(S)-B-973B is an effective allosteric agonist and a positive allosteric modulator of α7 nAChR.		AChR
T6575	LY2119620		AChR
	LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors.		AChR
T6548	Irsogladine	Dicloguamine	PDE , AChR
	Irsogladine (Dicloguamine) is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding.		PDE , AChR
T37906	Dibenamine hydrochloride		Adrenergic Receptor
	Dibenamine hydrochloride is a competitive and irreversible blocking agent of the β-adrenergic receptor.		Adrenergic Receptor
T2422	PNU-282987		AChR
	PNU-282987 is a selective α7 nicotinic acetylcholine receptor(α7 nAChR) agonist with Ki of 26 nM; no affinity for α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM).		AChR
T0072	Adiphenine hydrochloride	Adiphenine HCl,Spasnil,Patrovina,Sentiv	AChR
	Adiphenine hydrochloride (Patrovina), a nicotinic receptor inhibitor, can be used as an antispasmodic drug.		AChR
T7405	Piperidolate		AChR
	Piperidolate inhibits intestinal cramp induced by acetylcholine		AChR
T8219	VU0238441		AChR
	VU0238441 is agonist of Muscarinic acetylcholine receptor M5 (human) with EC50 of 2.1μM.		AChR
T13066	TAK-071		AChR
	TAK-071 is a potent, novel and highly selective modulator of muscarinic acetylcholine receptor 1 (M1R) positive allosteric(EC50 : 520 nM).		AChR
T17244	VU0467154		AChR
	VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor. The response to ACh with pEC50s of 7.75, 6.2, and 6 for a rat, human, and cynomolgus monkey M4 receptor, respectively.		AChR
T5655	MAChR-IN-1 hydrochloride		AChR
	mAChR-IN-1 hydrochloride is a potent muscarinic cholinergic receptor (mAChR) antagonist, with an IC50 of 17 Nm.		AChR
T13325	VU 0365114		AChR
	VU 0365114 is a positive allosteric modulator of mAChR M5 (EC50: 2.7 μM).		AChR
T9420	Prifinium bromide		Others
	Prifinium bromide is a quaternary ammon antimuscarinic. It inhibits hyperkinesia of the digestive organs and urinary tract and has a spasmolytic action.		Others
T23524	W-84 dibromide	HDMPPA	AChR
	W-84 dibromide (HDMPPA) is a M2-receptor selective modulator.		AChR
T8868	4BP-TQS		AChR
	4BP-TQS is an allosteric agonist of α7 nAChRs.		AChR
TQ0117	A-867744		AChR , Autophagy
	A-867744 is an effective and selective type II positive allosteric modulator of the α7 nAChR (EC50: 1.0 μM).		AChR , Autophagy
T23469	TQS	4-Naphthalen-1-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide	AChR
	TQS (4-Naphthalen-1-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide) is a positive allosteric modulator of α7 nACh receptors.		AChR
T3993	BQCA	benzylquinolone carboxylic acid	AChR
	BQCA (benzylquinolone carboxylic acid) a highly selective allosteric M1 mAChR modulator.		AChR
T4997	Umeclidinium bromide	GSK573719A	AChR
	Umeclidinium bromide (GSK573719A) is a novel mAChR antagonist.		AChR
T8383	Cyclopentolate Hydrochloride		AChR
	Cyclopentolate Hydrochloride is a muscarinic acetylcholine receptors antagonist with Kis of 1.62, 27.5, and 2.63 nM for M1, M2, and M3 receptors, respectively.		AChR
T4981	Anisotropine Methylbromide		Prostaglandin Receptor , AChR
	Anisotropine Methylbromide is an anticholinergic agent and has been used for relief of gastrointestinal spasm and for the suppression of gastric acid secretion.		Prostaglandin Receptor , AChR
T8224	VU0119498		AChR
	VU0119498 is a M1 muscarinic receptor agonist (EC50 = 3.1 μM) and pan mAChR M3, M5 positive allosteric modulator (PAM),and is a neuroprotective agent.		AChR
T37196	5-AAM-2-CP		AChR
	5-AAM-2-CP is one of the major metabolites of Acetamiprid. Acetamiprid, a nAChR agonist, is a neonicotinoid insecticide used worldwide.		AChR
T27624	Iptakalim Hydrochloride		Potassium Channel , AChR
	Iptakalim, a lipophilic para-amino compound, is a novel ATP-sensitive potassium channel (KATP) opener, as well as an α4β2-containing nicotinic acetylcholine receptor (nAChR) antagonist. Iptakalim is also a K(ir) 6.1/SUR2...		Potassium Channel , AChR
T23146	PHA 568487 free base	PHA 568487	AChR
	The quinuclidine PHA 568487 free base is an agonist of the alpha 7 nicotinic acetylcholine receptor that was designed to mitigate the bioactivation associated with the core scaffold and subsequently remove associated lia...		AChR
T8552	PSEM 89S TFA		AChR
	PSEM 89S TFA is a brain-penetrant and selective ion channels agonist, and is orthogonally selective for Q79G and L141F, respectively.		AChR
T8007	VU 0238429	SCR-1481B1,VU0238429	AChR
	VU 0238429 (SCR-1481B1) is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5)( EC50 : 1.16 μM).		AChR
T7193	Encenicline	EVP-6124	AChR
	Encenicline (EVP-6124) is a selective α7 nicotinic acetylcholine receptor (nAChRs) agonist in development for treating cognitive impairment in schizophrenia and Alzheimer's disease.		AChR
T28199	NS9283	NS 9283,NS-9283	AChR
	NS9283 is a positive allosteric modulator of α4β2 receptor.		AChR
T0427	Homatropine Methylbromide	Homatropine methobromide	AChR
	Homatropine Methylbromide is the methyl bromide salt of homatropine, a synthetic tertiary amine alkaloid with antimuscarinic properties.		AChR
T1460	Dicyclomine hydrochloride		AChR
	Dicyclomine hydrochloride is a muscarinic antagonist used as an antispasmodic and in urinary incontinence.		AChR
T4246	Varenicline dihydrochloride		AChR
	Varenicline dihydrochloride is a Selective α4β2 nicotinic acetylcholine receptor partial agonist.		AChR
T9019	JHU37152	JHU 37152	AChR
	JHU37152 (JHU 37152) is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.8 nM and 8.7 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. ...		AChR
T23508	VU 0255035		AChR
	muscarinic M1 antagonist		AChR
T9018	JHU37160	JHU 37160	AChR
	JHU37160 (JHU 37160) is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.9 nM and 3.6 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. ...		AChR
T9542	NS3861		AChR
	NS3861 is an agonist of nicotinic acetylcholine receptors (nAChRs) and bind with high affinity to heteromeric α3β4 and α4β2 nAChRs. NS3861 displays the β-subunit preference and a complete lack of activation at α4-contain...		AChR
TP2063	α-Conotoxin MII		AChR
	α-Conotoxin MII is a highly potent and selective competitive antagonist for α3β2 subunit-containing nicotinic receptors (IC50 = 0.5 - 3.5 nM at α3β2 expressed in Xenopus oocytes). Also potently blocks β3-containing neuro...		AChR
T8236	RHC 80267	U-57908	Others , Phospholipase , COX , Acyltransferase , AChR
	RHC 80267 (U-57908) is a selective inhibitor of DAGL (IC50 : 4 μM in canine platelets)		Others , Phospholipase , COX , Acyltransferase , AChR

Compounds

Acetylcholine bromide

T20344

Synonym:

Target: Others

Acetylcholine perchlorate

T20522

Synonym: AI351678,AI3-51678,AI3 51678

Synonym: VU 0152099,VU-0152099

Oxotremorine sesquifumarate

Target: 5-HT Receptor, Adrenergic Receptor, AChR, Histamine Receptor

Piperidolate hydrochloride

Target: Serotonin Transporter

Synonym: Dicloguamine

Target: PDE, AChR

Dibenamine hydrochloride

T37906

Synonym:

Target: Adrenergic Receptor

Adiphenine hydrochloride

T0072

Synonym: Adiphenine HCl,Spasnil,Patrovina,Sentiv

mAChR-IN-1 hydrochloride

Target: AChR, Autophagy

TQS

T23469

Synonym: 4-Naphthalen-1-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide

Target: AChR

BQCA

T3993

Synonym: benzylquinolone carboxylic acid

Cyclopentolate Hydrochloride

T8383

Synonym:

Target: AChR

Anisotropine Methylbromide

T4981

Synonym:

Target: Prostaglandin Receptor, AChR

Iptakalim Hydrochloride

T27624

Synonym:

Target: Potassium Channel, AChR

Synonym: SCR-1481B1,VU0238429

Synonym: NS 9283,NS-9283

Target: AChR

Homatropine Methylbromide

T0427

Synonym: Homatropine methobromide

Target: AChR

Dicyclomine hydrochloride

T1460

Synonym:

Target: AChR

Varenicline dihydrochloride

Target: Others, Phospholipase, COX, Acyltransferase, AChR

Cat No.	Product Name	Synonyms	Targets
T6751	Acetylcholine iodide	Acetylcolina	Others
	Acetylcholine iodide (Acetylcolina) is a neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the cent...		Others
T1221	Acetylcholine chloride	ACh chloride,Pilofrin	Calcium Channel , Endogenous Metabolite , AChR
	Acetylcholine Chloride is the chloride salt form of acetylcholine, a synthetic, quaternary amino alcohol with cholinergic properties. Acetylcholine chloride (Pilofrin) mimics the parasympathomimetic effect of the endogen...		Calcium Channel , Endogenous Metabolite , AChR
T2198	Arecoline hydrobromide	Arecoline HBr,Arecoline bromide	AChR
	Arecoline hydrobromide (Arecoline HBr) is a muscarinic acetylcholine receptor agonist.		AChR
T8304	Anisodamine Hydrobromide	6-Hydroxyhyoscyamine	Adrenergic Receptor , AChR
	Anisodamine Hydrobromide (6-Hydroxyhyoscyamine) is an anticholinergic and α1-adrenergic receptor antagonist used in the treatment of acute circulatory shock.		Adrenergic Receptor , AChR
T8196	Arborine	Arborin	Others , AChR
	Arborine (Arborin) is a larval growth inhibitor from glycoslnis pentaphylla.		Others , AChR
T9076	Spinosad		Others
	Spinosad is a naturally-occurring insecticide found in the the soil bacterium S. spinosa. It is a mixture of the macrocyclic lactones spinosyn A and spinosyn D, which act as agonists of insect nicotinic acetylcholinester...		Others
T7671	Myosmine		Others , AChR
	Myosmine is a minor tobacco alkaloid that is structurally related to nicotine.		Others , AChR
T7853	(+)-Sparteine	Pachycarpine	AChR
	(+)-Sparteine (Pachycarpine) is a natural product extracted from scotch broom, is a sodium channel blocker and a class 1a antiarrhythmic agent		AChR
T5S0994	N-Methylcytisine	Caulophylline	Others , AChR
	1. N-Methylcytisine (Caulophylline)'s nicotinic receptors have high affinity (KD = 5 nM)to nAChR from squid optical ganglia. 2. N-Methylcytisine and N, N-dimethylcytisine did not displace 14C-tubocurarine at a concentrat...		Others , AChR
T1285	Anethole trithione	Anetholtrithion	Others , AChR
	Anethole trithione (Anetholtrithion) is a bile secretion-stimulating drug that restores salivation and relieves the discomfort of dry mouth in chemotherapy-induced xerostomia.		Others , AChR
T0479	Cytisinicline	Baptitoxine,Cytisine,Baphitoxine,Sophorine	AChR
	Cytisinicline (Sophorine), an alkaloid, is found naturally in several plants.		AChR
TN1643	Ferulamide	4-Hydroxy-3-methoxycinnamide	PAFR , AChR
	Ferulamide (4-Hydroxy-3-methoxycinnamide), a Ferulic acid derivative, shows potent inhibitory activity against arachidonic acid-induced platelet aggregation.		PAFR , AChR
T1231	Pilocarpine nitrate	Pilagan,Pilofrin	AChR
	Pilocarpine nitrate (Pilagan) is a slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.		AChR
T0970	Racanisodamine	Anisodamine,7β-Hydroxyhyoscyamine,Raceanisodamine	Adrenergic Receptor , AChR
	Racanisodamine (7β-Hydroxyhyoscyamine) is an anticholinergic and α1-adrenergic receptor antagonist used in the treatment of acute circulatory shock.		Adrenergic Receptor , AChR
T0962	L-Hyoscyamine	Daturine,Hyoscyamine	AChR
	L-Hyoscyamine (Daturine) functions as a non-selective, competitive antagonist of muscarinic receptors, thereby inhibiting the parasympathetic activities of acetylcholine on the salivary, bronchial, and sweat glands, as w...		AChR
T1039	Choline chloride	Biocolina,Biocoline,Hepacholine	AChR
	Choline chloride (Biocoline) is a basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in li...		AChR
T5805	Guvacoline hydrochloride	Norarecoline hydrochloride	AChR
	Guvacoline hydrochloride (Norarecoline hydrochloride) is a muscarinic agonist.		AChR
T0804	Pilocarpine Hydrochloride	NSC 5746 HCl,Pilocarpine HCl,(+)-Pilocarpine hydrochloride	AChR
	Pilocarpine Hydrochloride (NSC 5746 HCl) , a nonselective muscarinic acetylcholine receptor agonist, is utilized to produce an experimental model of epilepsy.		AChR
T0086	Galanthamine hydrobromide	Galantamine hydrobromide,Galanthamine HBr	AChR , AChE
	Galanthamine hydrobromide (Galantamine hydrobromide), a long-acting and centrally active AChE inhibitor (IC50:410 nM), is an allosteric potentiator at neuronal nicotinic ACh receptors.		AChR , AChE
T6805	Choline bitartrate	2,3,4-trihydroxy-4-oxobutanoate,2-hydroxyethyl(trimethyl)azanium	Others , AChR
	Choline bitartrate (2-hydroxyethyl(trimethyl)azanium) is a form of the nutrient choline which is found in foods. Choline is necessary for normal liver and kidney function and a component of the neurotransmitter acetylcho...		Others , AChR
T5S0106	Peimisine	Ebeiensine	RAAS , AChR
	1. Peimisine (Ebeiensine) can affect M-receptor, excit β-receptor, restrain the release of internal calcium, and promote to releaseing nitrogen monoxidum in order to relax tracheal smooth muscle and relieve asthma. 2. Pe...		RAAS , AChR
T0268	Lobeline hydrochloride	α-Lobeline hydrochloride,L-Lobeline hydrochloride	AChR
	Lobeline hydrochloride (α-Lobeline hydrochloride) is a nicotinic receptor agonist, acting as an effective antagonist at both α4β2 and α3β2 neuronal nicotinic receptor subtypes.		AChR
T7056	Dronedarone	SR 33589	P450 , Potassium Channel , Calcium Channel , Sodium Channel , Adrenergic Receptor , AChR , Autophagy
	Dronedarone (SR 33589) is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.
T8040	Cholesterol myristate	Cholesteryl myristate,Cholesteryl tetradecanoate	Others , Potassium Channel , GABA Receptor , Endogenous Metabolite , AChR
	Cholesterol Myristate (Cholesteryl Myristate) is a natural steroid found in traditional Chinese medicine that interacts with various ion channels, including the GABAA receptor, nicotinic acetylcholine receptor, and the i...
T4S1619	L-Hyoscyamine sulfate	Hyoscyamine sulfate hydrate,Levsin Sulfate,Hyoscyamine Sulphate	AChR
	L-Hyoscyamine sulfate (Levsin Sulfate) is the sulfate salt of a belladonna alkaloid derivative and the levorotatory form of racemic atropine isolated from the plants Hyoscyamus niger or Atropa belladonna, which exhibits ...		AChR
TN1519	(S)-Coclaurine	Coclaurine	AChR
	(S)-Coclaurine (Coclaurine) is an antagonist of nAChR isolated from Sarcopetalum harveyanum.		AChR
TN1653	Fustin		ERK , Beta Amyloid , AChR
	Fustin is the phytogenic flavanol component of the plant Rhus verniciflua Stokes. Fustin shows protective effects on 6-hydroxydopamine-induced neuronal cell death.		ERK , Beta Amyloid , AChR
T4S0111	Hupehenine		AChR
	Hupehenine is a steriodal alkaloid extracted from the bulbs of Fritillaria Hupehensis, with the potential for inhibiting acetylcholine, antagonism for muscarinic receptors and cholinesterase inhibition.		AChR
T7224	Anabasine	(S)-Anabasine,(-)-Anabasine	AChR
	Anabasine ((S)-Anabasine) is an alkaloid extracted from tobacco. Anabasine is a full agonist of nicotinic acetylcholine receptors (nAChRs) with insecticidal activity. Anabasine depolarizes TE671 cells endogenously expres...		AChR
T5855	Edrophonium chloride		AChE
	Edrophonium chloride is an acetylcholinesterase (AChE) inhibitor that is known to prevent the breakdown of the neurotransmitter acetylcholine by binding specifically to its catalytic site.		AChE
T65135	Kynurenic acid	Fibrostop 2,Quinurenic acid	GPR , GluR , NMDAR
	Kynurenic acid (Quinurenic acid) is an endogenous tryptophan active metabolite, a triple antagonist of NMDA, glutamate, α7 nicotinic acetylcholine receptor, and an agonist of GPR35/CXCR8 with neuroprotective and anticonv...		GPR , GluR , NMDAR
T4954	SMILAGENIN ACETATE	Nsc15488	Others
	Smilagenin acetate is a sapogenin derivative that has been shown to upregulate the expression of the acetylcholine M2 receptor in cell assays, making it a candidate for dementia research.		Others
T3865	Beta-Eudesmol	Beta-Selinenol	TRP/TRPV Channel , AChR
	beta-Eudesmol (Beta-Selinenol) is a noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs). It is a sesquiterpene that has been found in a variety of plants, including Cannabis, and has diverse biologica...		TRP/TRPV Channel , AChR
TN3695	Coniine hydrochloride		Others
	Coniine hydrochloride, a polyketide-derived alkaloid, is poisonous to humans and animals. It is a nicotinic acetylcholine receptor antagonist, which leads to inhibition of the nervous system.		Others
T1437	D-Panthenol	D-Pantothenyl alcohol,Ilopan,Dexpanthenol,Pantothenol	Endogenous Metabolite
	D-Panthenol (D-Pantothenyl alcohol) is an alcoholic analogue of D-pantothenic acid and cholinergic agent. D-Panthenol acts as a precursor of coenzyme A necessary for acetylation reactions and is involved in the synthesis...		Endogenous Metabolite
TN1528	Cotoin		AChE
	Cotoin is a natural product isolated from the stem bark of Garcinia virgate.Cotoin has antispasmodic activity and reduces the tone and contraction of isolated rabbit intestine. It partially inhibits the effects of acetyl...		AChE
T0894	Thiamine hydrochloride	Vitamin B1,Vitamin B1 hydrochloride,Thiamine HCl,Thiamine chloride hydrochloride	Apoptosis , HBV , Endogenous Metabolite
	Thiamine hydrochloride (Vitamin B1) is the hydrochloride salt form of thiamine, a vitamin essential for aerobic metabolism, cell growth, transmission of nerve impulses and acetylcholine synthesis. Upon hydrolysis, Thiami...		Apoptosis , HBV , Endogenous Metabolite
T2S1464	Thiocolchicoside	Thiocolchicine 2-glucoside analog,Coltramyl	Others , GABA Receptor
	Thiocolchicoside (Thiocolchicine 2-glucoside analog) (Muscoril, Myoril, Neoflax) is a muscle relaxant with anti-inflammatory and analgesic effects. It acts as a competitive GABAA receptor antagonist and also glycine rece...		Others , GABA Receptor
T68953	Arecoline		Reactive Oxygen Species , AChR
	Arecoline is a natural alkaloid derived from areca nut in the palm family and is a potent nicotine and partial agonist of muscarinic acetylcholine receptors. Arecoline has anti-anxiety and anti-parasitic activity, can in...		Reactive Oxygen Species , AChR
T4S0998	Trifolirhizin		TNF , Tyrosinase
	Trifolirhizin exerts varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, and therefore, are candidates as skin-whitening agents.Trifolirhizin possesses potential anti-inflammatory and anti-cancer ...		TNF , Tyrosinase
T1208	Citicoline sodium	Citicoline sodium salt,CDP-choline	Apoptosis , Others , Endogenous Metabolite
	Citicoline sodium (CDP-choline) is an endogenous intermediate in the synthesis of phosphatidylcholine. It also serves as a choline donor in the biosynthesis of the neurotransmitter acetylcholine. Citicoline sodium demons...		Apoptosis , Others , Endogenous Metabolite
T3767	Polygalacic acid	Virgaureagenin G	MMP , AChR , AChE
	Polygalacic acid (Virgaureagenin G)(PA) significantly improves cholinergic system reactivity, as indicated by decreased acetylcholinesterase (AChE) activity, increases choline acetyltransferase (ChAT) activity, and eleva...		MMP , AChR , AChE
T4439	Sn-Glycero-3-phosphocholine	Choline Alfoscerate,Glycerophosphocholine,Glycerophosphorylcholine,Alpha-GPC,Choline glycerophosphate,L-α-GPC	Endogenous Metabolite , AChE
	sn-Glycero-3-phosphocholine (Choline glycerophosphate) is a natural choline compound found in the brain and in milk. It is also a parasympathomimetic acetylcholine precursor which may have a potential for the treatment o...		Endogenous Metabolite , AChE
T5065	GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD	Monosodium-GMP,cGMP sodium salt,Cyclic GMP	PKA
	GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD (cGMP sodium salt) , also known as cGMP, is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, inc...		PKA
TN4812	Pluviatolide		AChR
	(-)-Pluviatolide can inhibit electrically-induced and acetylcholine-induced contraction in the isolated guinea-pig ileum.		AChR
T11041	Dihydro-β-erythroidine hydrobromide	DHβE hydrobromide	Others
	Dihydro-β-erythroidine hydrobromide(DHβE) is a potent, oral active and competitive antagonist of neuronal nicotinic acetylcholine receptors (nAChRs). Dihydro-β-carotene hydrobromide showed selectivity to α4β4 and α4β2nAC...		Others
T10913	Cyclobuxine D		Others
	Cyclobuxine D is a steroidal alkaloid extracted from Buxus microphylla. Cyclostatin D has obvious bradycardia effect on rat heart, and inhibits acetylcholine and Ba ++ induced longitudinal muscle contraction isolated fro...		Others
T37609	(rel)-Asperparaline A
	Aspergillimide is a fungal metabolite originally isolated from A. japonicus.1 It reduces nicotinic acetylcholine receptor (nAChR) peak and slowly-desensitizing amplitudes induced by acetylcholine in silkworm (B. mori) la...
T62265	(+)-Sparteine sulfate pentahydrate
	(+)-sparteine (sulfate pentahydrate) is a ganglion blocker that competitively blocks nicotinic acetylcholine receptors in neurons.
TN1913	Marmin		Calcium Channel , Antifection , Histamine Receptor
	Marmin have anti-ulcer effects, which are ascribed primarily to the maintenance of the mucosal barrier integrity and inhibition of gastric motor activity and secondarily due to the prevention of the effects of endogenous...		Calcium Channel , Antifection , Histamine Receptor
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Natural Products

Acetylcholine iodide

T6751

Synonym: Acetylcolina

Target: Others

Acetylcholine chloride

T1221

Synonym: ACh chloride,Pilofrin

Target: Calcium Channel, Endogenous Metabolite, AChR

Arecoline hydrobromide

T2198

Synonym: Arecoline HBr,Arecoline bromide

Target: AChR

Anisodamine Hydrobromide

T8304

Synonym: 6-Hydroxyhyoscyamine

Target: Adrenergic Receptor, AChR

Synonym: Pachycarpine

Target: AChR

N-Methylcytisine

T5S0994

Synonym: Caulophylline

Target: Others, AChR

Anethole trithione

T1285

Synonym: Anetholtrithion

Target: Others, AChR

Cytisinicline

T0479

Synonym: Baptitoxine,Cytisine,Baphitoxine,Sophorine

Target: AChR

Ferulamide

TN1643

Synonym: 4-Hydroxy-3-methoxycinnamide

Target: PAFR, AChR

Pilocarpine nitrate

T1231

Synonym: Pilagan,Pilofrin

Target: AChR

Racanisodamine

T0970

Synonym: Anisodamine,7β-Hydroxyhyoscyamine,Raceanisodamine

Target: Adrenergic Receptor, AChR

L-Hyoscyamine

T0962

Synonym: Daturine,Hyoscyamine

Target: AChR

Choline chloride

T1039

Synonym: Biocolina,Biocoline,Hepacholine

Target: AChR

Guvacoline hydrochloride

T5805

Synonym: Norarecoline hydrochloride

Target: AChR

Pilocarpine Hydrochloride

T0804

Synonym: NSC 5746 HCl,Pilocarpine HCl,(+)-Pilocarpine hydrochloride

Target: AChR

Galanthamine hydrobromide

T0086

Synonym: Galantamine hydrobromide,Galanthamine HBr

Target: AChR, AChE

Choline bitartrate

T6805

Synonym: 2,3,4-trihydroxy-4-oxobutanoate,2-hydroxyethyl(trimethyl)azanium

Lobeline hydrochloride

T0268

Synonym: α-Lobeline hydrochloride,L-Lobeline hydrochloride

Target: P450, Potassium Channel, Calcium Channel, Sodium Channel, Adrenergic Receptor, AChR, Autophagy

Cholesterol myristate

T8040

Synonym: Cholesteryl myristate,Cholesteryl tetradecanoate

Target: Others, Potassium Channel, GABA Receptor, Endogenous Metabolite, AChR

L-Hyoscyamine sulfate

T4S1619

Synonym: Hyoscyamine sulfate hydrate,Levsin Sulfate,Hyoscyamine Sulphate

Target: ERK, Beta Amyloid, AChR

Synonym: (S)-Anabasine,(-)-Anabasine

Synonym: Fibrostop 2,Quinurenic acid

Target: GPR, GluR, NMDAR

Synonym: Beta-Selinenol

Target: TRP/TRPV Channel, AChR

Coniine hydrochloride

Synonym: D-Pantothenyl alcohol,Ilopan,Dexpanthenol,Pantothenol

Target: Endogenous Metabolite

Thiamine hydrochloride

T0894

Synonym: Vitamin B1,Vitamin B1 hydrochloride,Thiamine HCl,Thiamine chloride hydrochloride

Target: Apoptosis, HBV, Endogenous Metabolite

Thiocolchicoside

T2S1464

Synonym: Thiocolchicine 2-glucoside analog,Coltramyl

Target: Others, GABA Receptor

Arecoline

T68953

Synonym:

Target: Reactive Oxygen Species, AChR

Trifolirhizin

T4S0998

Synonym:

Target: TNF, Tyrosinase

Citicoline sodium

T1208

Synonym: Citicoline sodium salt,CDP-choline

Target: Apoptosis, Others, Endogenous Metabolite

Polygalacic acid

T3767

Synonym: Virgaureagenin G

Target: MMP, AChR, AChE

sn-Glycero-3-phosphocholine

T4439

Synonym: Choline Alfoscerate,Glycerophosphocholine,Glycerophosphorylcholine,Alpha-GPC,Choline glycerophosphate,L-α-GPC

Target: Endogenous Metabolite, AChE

GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD

T5065

Synonym: Monosodium-GMP,cGMP sodium salt,Cyclic GMP

Dihydro-β-erythroidine hydrobromide

T11041

Synonym: DHβE hydrobromide

(rel)-Asperparaline A

T37609

Synonym:

Target:

(+)-Sparteine sulfate pentahydrate

Target: Calcium Channel, Antifection, Histamine Receptor

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Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-01715	CHRM2 Protein, Human, Recombinant (His)	Human	E. coli
	The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. ...
TMPH-01714	CHRM1 Protein, Human, Recombinant (His)	Human	E. coli
	The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. ...
TMPH-03338	CHRM1 Protein, Rat, Recombinant (His)	Rat	E. coli
	CHRM1 Protein, Rat, Recombinant (His) is expressed in E. coli.
TMPH-01716	CHRM3 Protein, Human, Recombinant (B2M & His)	Human	E. coli
	The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. ...
TMPH-01717	CHRM5 Protein, Human, Recombinant (His)	Human	E. coli
	The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. ...
TMPH-00874	CHRNG Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
TMPH-00873	CHRNG Protein, Human, Recombinant (His)	Human	Yeast
	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
TMPH-00872	CHRNE Protein, Human, Recombinant (His & Myc)	Human	E. coli
	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
TMPH-03620	CHRNA1 Protein, Tetronarce californica, Recombinant (E. coli, His)	Torpedo californica	E. coli
	CHRNA1 Protein, Tetronarce californica, Recombinant (E. coli, His) is expressed in E. coli.
TMPH-03621	CHRNA1 Protein, Tetronarce californica, Recombinant (His)	Tetronarce californica	HEK293
	CHRNA1 Protein, Tetronarce californica, Recombinant (His) is expressed in HEK293.
TMPH-02486	CHRNA1 Protein, Mouse, Recombinant (E. coli, His)	Mouse	E. coli
	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
TMPH-00871	CHRNA1 Protein, Human, Recombinant (His)	Human	E. coli
	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
TMPH-02487	CHRNA1 Protein, Mouse, Recombinant (His)	Mouse	Yeast
	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
TMPH-01763	CHRNB2 Protein, Human, Recombinant (His & V5)	Human	E. coli
	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions.
TMPH-01762	CHRNA3 Protein, Human, Recombinant (His & Myc & SUMO)	Human	E. coli
	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
TMPH-03234	Acetylcholinesterase Protein, Rat, Recombinant (His)	Rat	E. coli
	Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
TMPY-01742	Acetylcholinesterase Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Acetylcholinesterase, also known as ACHE, is an enzyme that degrades (through its hydrolytic activity) the neurotransmitter acetylcholine, producing choline and an acetate group. Acetylcholinesterase plays a crucial role...
TMPY-04195	CHRNB3 Protein, Human, Recombinant (hFc)	Human	HEK293
	Cholinergic nicotinic receptor (CHRN) gene family has been known to mediate the highly additive effects of nicotine in the body, and implicated nicotine dependence (ND) and related phenotypes. Cigarette smoking is protec...
TMPH-01085	CHAT Protein, Human, Recombinant (His)	Human	E. coli
	Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
TMPY-00554	CHRNB3 Protein, Human, Recombinant (His)	Human	HEK293
	Cholinergic nicotinic receptor (CHRN) gene family has been known to mediate the highly additive effects of nicotine in the body, and implicated nicotine dependence (ND) and related phenotypes. Cigarette smoking is protec...
TMPH-03219	Rabies virus (RABV) (strain India) Glycoprotein (His)	RABV	Yeast
	Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell memb...
TMPH-03220	Rabies virus (RABV) (strain India) Glycoprotein (His & SUMO)	RABV	E. coli
	Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell memb...
TMPH-03224	Rabies virus (RABV) (strain HEP-Flury) Glycoprotein (E. coli, His)	RABV	E. coli
	Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell memb...
TMPH-03221	Rabies virus (RABV) (strain CVS-11) Glycoprotein (His & Myc & SUMO)	RABV	E. coli
	Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell memb...
TMPH-03222	Rabies virus (RABV) (strain ERA) Glycoprotein (His)	RABV	E. coli
	Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell memb...
TMPY-04321	CHRNA5 Protein, Human, Recombinant (His)	Human	HEK293
	Genetic variation in the cluster on chromosome 15, encoding the nicotinic acetylcholine receptor subunits (CHRNA5-CHRNA3-CHRNB4), has shown strong associations with tobacco consumption and an additional risk increase in ...
TMPH-03223	Rabies virus (RABV) (strain HEP-Flury) Glycoprotein (His)	RABV	Baculovirus
	Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell memb...
TMPH-02637	Embigin Protein, Mouse, Recombinant (His)	Mouse	in vitro E. coli expression system
	Plays a role in targeting the monocarboxylate transporters SLC16A1 and SLC16A7 to the cell membrane. Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervat...
TMPJ-01197	CRELD2 Protein, Human, Recombinant (His)	Human	Human Cells
	Cysteine-Rich with EGF-Like Domain Protein 2 (CRELD2) is a secreted protein that is a member of the CRELD family. Human CRELD2 is synthesized as a 353 amino acid precursor protein with a signal peptide, a highly conserve...
TMPH-00859	HTR1B Protein, Human, Recombinant (His)	Human	in vitro E. coli expression system
	G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic...
TMPY-00248	Lymphotoxin Beta Protein, Cynomolgus, Recombinant (His)	Cynomolgus	Baculovirus-Insect Cells
	LTB (Lymphotoxin Beta) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surfa...
TMPJ-00448	NRG1 beta 1 Protein, Human, Recombinant (aa 2-246)	Human	E. coli
	Pro-neuregulin-1,Neuregulin-1 beta 1（NRG1） is a single-pass type I membrane protein and belongs to the neuregulin family .It contains 1 EGF-like domain and 1 Ig-like C2-type (immunoglobulin-like) domain. Direct ligand f...
TMPH-01619	LY6E Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane...
TMPH-01718	MUSK Protein, Human, Recombinant (His)	Human	Yeast
	Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to ...
TMPH-03037	Alpha-cobratoxin Protein, Naja kaouthia, Recombinant (GST & His & Myc)	Naja kaouthia	E. coli
	Monomer: binds with high affinity to muscular (alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRNG-CHRND) nAChR (tested on Torpedo californica, Kd=0.2-4.5 nM) and neuronal alpha-7/CHRNA7 nicotinic acetylcholine receptors (Kd=...
TMPY-04414	MUSK Protein, Human, Recombinant (aa 433-783, His & GST)	Human	Baculovirus-Insect Cells
	Muscle, skeletal receptor tyrosine-protein kinase, also known as Muscle-specific tyrosine-protein kinase receptor, Muscle-specific kinase receptor, and MUSK, is a single-pass type I membrane protein that belongs to the p...
TMPH-03741	BoNT/F Protein, Clostridium botulinum, Recombinant (His)	Clostridium botulinum	E. coli
	Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release from the presynaptic membranes of nerve terminals of the eukaryotic host skeletal and autonomic nervous system, with frequen...