acetyl coenzyme a

Acetyl Coenzyme A trisodium (Acetyl-CoA trisodium) is an important compound in glucose metabolism and lipid metabolism and is involved in the tricarboxylic acid cycle.

Acetyl coenzyme A (Acetyl-CoA) is a pivotal molecule connecting multiple cellular metabolic pathways, participating in the tricarboxylic acid cycle, fatty acid synthesis, and oxidative phosphorylation metabolism, among others, regulating various cellular metabolic mechanisms and reflecting cellular energy status.

Acetyl-coenzyme A (Acetyl-CoA) lithium, a membrane-impermeant central metabolic intermediate, is integral to the TCA cycle and oxidative phosphorylation, regulates cellular mechanisms by serving as the sole donor of acetyl groups for post-translational acetylation of proteins, and is a critical precursor in lipid synthesis [1] [2] [3] [4].

Acetoacetyl Coenzyme A sodium hydrate is a precursor of poly-β-hydroxybutyrate, which is closely related to the body's energy metabolism.

Acetoacetyl coenzyme A sodium, a pivotal endogenous metabolite, exhibits a K m of 1.10 mM at pH 7.5 and plays a crucial role in the synthesis of phosphotransbutyrylase (PTB) and poly-3-hydroxybutyrate (PHB) [1] [2].

Doxorubicin hydrochloride is an anthracycline antibiotic with cytotoxic and antitumor activity. It is an effective inhibitor of human DNA topoisomerase I and II, with IC50 values of 0.8 μM and 2.67 μM, respectively. In addition to inhibiting DNA topoisomerases, it can reduce the phosphorylation of AMPK and its downstream target, acetyl-CoA carboxylase. Doxorubicin hydrochloride also induces apoptosis and autophagy. In animal studies, it is commonly used to induce models of acute renal failure, chronic kidney injury, and heart failure.

Moiramide B is a potent acetyl coenzyme A carboxylase (ACC) inhibitor (IC50:6 nM) with antimicrobial activity, strongly inhibiting Gram-positive bacteria but weakly inhibiting Gram-negative bacteria.

N-Acetyl-L-aspartic acid is a derivative of aspartic acid, synthesized in neurons from the amino acid aspartic acid and acetyl coenzyme A. N-Acetyl-L-aspartic acid has antioxidant activity.

CMS-121, a quinolone derivative, is an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage (EC50: 7 nM and 200 nM). CMS-121 shows strong neuroprotective, antioxidative, anti-inflammatory, and renoprotective activities.

CP-640186 is an isozyme-nonselective Acetyl-CoA carboxylase (ACCase) inhibitor. The IC50s of CP-640186(CP 640186) is 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively.

N-Methylphthalimide is a phthalimide that inhibits acetyl-coenzyme A synthetase.

Clethodim is a acetyl-coenzyme A carboxylase (ACCase)-inhibiting cyclohexanedione herbicide.

Lauroyl-coenzyme A can function as an acyl group carrier, acetyl-CoA. It can be used as an intermediate in lipid metabolism and is involved in lipid biosynthesis and fatty acid transport.

Olumacostat glasaretil is a small molecule inhibitor of acetyl coenzyme A carboxylase (ACC). It has been used in trials studying the treatment of Acne Vulgaris.

CP-640186 hydrochloride (CP 640186 HCl) is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor, including rat liver ACC1 (IC50: 53 nM) and rat skeletal muscle ACC2 (IC50: 61 nM); with higher metabolic stability than CP-610431.

TOFA (MDL14514) is an allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA).

(±)-Haloxyfop (Haloxyfop Acid) is a herbicide.

hACC2-IN-1 is a potent inhibitor of acetyl coenzyme A carboxylase 2 (ACC2), exhibiting an IC50 of 2.5 μM for hACC2, and holds potential for obesity research.

PF 05175157 is an inhibitor of acetyl-CoA carboxylase 1 (ACC1) and ACC2 (IC50s = 27, 33, 23.5, and 50.4 nM for human ACC1, human ACC2, rat ACC1, and rat ACC2, respectively

Firsocostat (GS-0976) is an inhibitor of acetyl-CoA carboxylase (ACC) dimerization that inhibits human ACC1 and ACC2 activity (IC50s of 2.1 and 6.1 nM, respectively)

Lauroyl coenzyme A lithium salt is a type of coenzyme A that acts as an acyl carrier, specifically acetyl-CoA. Lauryl-CoA (C12-CoA) is a long-chain (C-12) saturated fatty acyl-CoA involved in lipid metabolism, lipid biosynthesis, and fatty acid transport. It serves as a substrate for the FAM34A protein and is a product of firefly luciferase.

Acyl coenzyme A synthetase (ACS), also known as acetyl coenzyme A synthetase, catalyzes the activation of fatty acids via coenzyme A through a two-step thioesterification process, forming acyl coenzyme A. It is crucial in anabolic and catabolic lipid metabolism pathways and contributes to the tricarboxylic acid (TCA) cycle during aerobic respiration [1].

QPP-I-6, an inhibitor of acetyl-coenzyme A carboxylase (ACCase), exhibits herbicidal activity by inducing cell membrane permeability [1].

CPD2028 is an intermediate of ND630, a potent acetyl coenzyme A carboxylase (ACC) inhibitor.