acetyl coenzyme a

Acetyl coenzyme A (Acetyl-CoA) is a pivotal molecule connecting multiple cellular metabolic pathways, participating in the tricarboxylic acid cycle, fatty acid synthesis, and oxidative phosphorylation metabolism, among others, regulating various cellular metabolic mechanisms and reflecting cellular energy status.

Acetyl-coenzyme A (Acetyl-CoA) lithium, a membrane-impermeant central metabolic intermediate, is integral to the TCA cycle and oxidative phosphorylation, regulates cellular mechanisms by serving as the sole donor of acetyl groups for post-translational acetylation of proteins, and is a critical precursor in lipid synthesis [1] [2] [3] [4].

Acetyl Coenzyme A trisodium (Acetyl-CoA trisodium) is an important compound in glucose metabolism and lipid metabolism and is involved in the tricarboxylic acid cycle.

Acetoacetyl Coenzyme A sodium hydrate is a precursor of poly-β-hydroxybutyrate, which is closely related to the body's energy metabolism.

Acetoacetyl coenzyme A sodium, a pivotal endogenous metabolite, exhibits a K m of 1.10 mM at pH 7.5 and plays a crucial role in the synthesis of phosphotransbutyrylase (PTB) and poly-3-hydroxybutyrate (PHB) [1] [2].

CMS-121, a quinolone derivative, is an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage (EC50: 7 nM and 200 nM). CMS-121 shows strong neuroprotective, antioxidative, anti-inflammatory, and renoprotective activities.

CP-640186 is an isozyme-nonselective Acetyl-CoA carboxylase (ACCase) inhibitor. The IC50s of CP-640186(CP 640186) is 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively.

Olumacostat glasaretil is a small molecule inhibitor of acetyl coenzyme A carboxylase (ACC). It has been used in trials studying the treatment of Acne Vulgaris.

CP-640186 hydrochloride (CP 640186 HCl) is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor, including rat liver ACC1 (IC50: 53 nM) and rat skeletal muscle ACC2 (IC50: 61 nM); with higher metabolic stability than CP-610431.

TOFA (MDL14514) is an allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA).

(±)-Haloxyfop (Haloxyfop Acid) is a herbicide.

PF 05175157 is an inhibitor of acetyl-CoA carboxylase 1 (ACC1) and ACC2 (IC50s = 27, 33, 23.5, and 50.4 nM for human ACC1, human ACC2, rat ACC1, and rat ACC2, respectively

Firsocostat (GS-0976) is an inhibitor of acetyl-CoA carboxylase (ACC) dimerization that inhibits human ACC1 and ACC2 activity (IC50s of 2.1 and 6.1 nM, respectively)

ND-646 is an orally bioavailable and allosteric inhibitor of the ACC enzymes ACC1 and ACC2, with IC50 values of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively.

2-(1,2-Epoxy-1,2-dihydrophenyl)acetyl-CoA (2-(1,2-Epoxy-1,2-dihydrophenyl)acetyl-coenzyme A) is a type of acyl coenzyme A.

Benzoyl-acetyl-CoA (Benzoyl acetyl-coenzyme A) is a derivative of coenzyme A.

5-Oxo-furan-2-acetyl-CoA (5-Oxo-furan-2-acetyl-coenzyme A) is a derivative of coenzyme A.

Di(acetyl-CoA) (Acetyl coenzyme A (Acetyl-coenzyme A)) is a derivative of coenzyme A.

[(2R)-3,3,4-Trimethyl-6-oxo-3,6-dihydro-1H-pyran-2-yl]acetyl-CoA, also known as [(2R)-3,3,4-Trimethyl-6-oxo-3,6-dihydro-1H-pyran-2-yl]acetyl-coenzyme A, is a derivative of coenzyme A.

S-2-(Indol-3-yl)acetyl-CoA (S-2-(Indol-3-yl)acetyl-coenzyme A) is a derivative of coenzyme A.

[(1R)-2,2,3-Trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA (2-Oxo-delta(3)-4,5,5-trimethylcyclopentenylacetyl-coenzyme A) is a derivative of coenzyme A.

Phenylacetyl Coenzyme A (Phenylacetyl Coenzyme A) tetrasodium serves as an effector molecule for the TetR family transcription repressor protein PaaR. It alters the conformation of PaaR, facilitating its dissociation from DNA and initiating transcription. This compound holds potential for use in the study of microbial metabolism.

Phenylacetyl-coenzyme A (CoA) is a key intermediate in aerobic catabolism of phenylacetate in bacteria such asPseudomonas, when cultured in minimal media using phenylacetate as the sole carbon source.1It is a precursor in the synthesis of the antibiotic penicillin G found in industrial strains ofP. chrysogenum. Phenylacetyl-CoA also acts as an effector molecule of the TetR family transcriptional repressor PaaR inT. thermophilusand the GntR family transcriptional regulator PaaX inE. coliandPseudomonas, binding to each protein to induce derepression of various genes.2

2-Tolylacetyl-CoA (2-Tolylacetyl-coenzyme A) is a derivative of coenzyme A.