a-186

GCA-186 is an effective non-nucleoside HIV-1 reverse transcriptase inhibitor.

Anti-Mouse CD28 Antibody (PV-1) is an antibody derived from mouse IgG targeting CD28, originally sourced from Armenian hamster. The isotype control for the Anti-Mouse CD28 Antibody (PV-1) is Armenian hamster IgG, Isotype Control.

MINT1526A (RG-7594) is a humanized IgG1 monoclonal antibody inhibitor targeting α5β1 integrin, exhibiting significant anti-angiogenic activity. This compound is applicable in cancer research.

PF-07329640 is a humanized monoclonal antibody inhibitor targeting TNFRSF3. It is used in research on advanced or metastatic solid tumors, such as non-small cell lung cancer (NSCLC) and colorectal cancer (CRC).

AGS-009 is a humanized monoclonal neutralizing antibody that targets IFN-α. It significantly reduces the number of activated lymphocytes (e.g., CD4+ and CD8+ T cells as well as B cells) in a SIV-infected rhesus monkey model. AGS-009 is applicable to research on autoimmune diseases such as systemic lupus erythematosus (SLE) and HIV infection.

HumanIgG1(L234F/L235E/P331S) kappa, Isotype Control, is a human-derived antibody and serves as the isotype control for the HumanIgG1(L234F/L235E/P331S)κ antibody.

Gaspantatug is a humanized IgG1κ antibody that targets CLDN18.2, with the corresponding isotype control being HumanIgG1kappa [Isotype Control].

Gerilimzumab (GB224) is a humanized monoclonal antibody inhibitor targeting interleukin-6 (IL-6). It is being investigated for potential use in autoimmune disease research, such as rheumatoid arthritis.

MEN1112 (OBT357NF) is a humanized monoclonal antibody that selectively targets Bst1/CD157, with an EC50 value of 1 nM. It demonstrates significant antitumor activity against acute myeloid leukemia (AML) cells and holds potential for research into hematologic malignancies, including AML.

Vurolenatide is a long-acting GLP-1 analogue that can be utilized for studying short bowel syndrome.

AMG-172 Antibody is an antibody targeting CD70. It can be used for the synthesis of ADCMG-172.

MEDI7814 is a humanized monoclonal antibody inhibitor targeting C5a and C5adesArg. It has binding affinities of 14 pM for recombinant human C5a and 8 pM for serum-purified human C5a. MEDI7814 shows potential for treating acute inflammatory conditions, including sepsis and renal ischemia-reperfusion injury.

Cortistatin-14 is a neuropeptide have structural similarity to somatostatin-14. It is produced in the cortex and hippocampus of central nervous system.

Edaravone (MCI-186) is a potent new free radical scavenger used for the therapy of patients with acute brain infarction.

diABZI STING agonist-1 (Tautomerism) (diABZI STING agonist (Compound 3)) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.

diABZI STING agonist-1 (trihydrochloride) is a stimulator of interferon genes (STING) receptor agonist.

Emodin (Frangula emodin) is an 11β-HSD1 inhibitor with a selective IC50 of 186 and 86 nM against 11β-HSD1 in humans and mice, respectively. Emodin has antiviral, anti-inflammatory, and anti-cancer effects. Emodin can improve metabolic disorders in diet-induced obese mice.

OUP-186 is a high affinity and human/rat species-selective antagonist of histamine H3 receptor. OUP-186 suppressed the proliferation of breast cancer cells. The IC50 values at 48 hours for OUP-186 was approximately 50 μM. OUP-186 potently induced cell dea

PI3K/mTOR Inhibitor-1 is a potent, orally bioavailable dual inhibitor of PI3K/mTOR (PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ/mTOR with IC50s of 20/376/204/46/186 nM).

PKR-IN-C16 is a specific protein kinase (PKR) inhibitor. PKR-IN-C16 is able to inhibit the autophosphorylation of PKR and unlock the translation blockade induced by PKR in primary neuronal cultures.PKR-IN-C16 binds the ATP-binding site of PKR and blocks autophosphorylation with an IC50 value of 186-210 nM. PKR-IN-C16 protects human neuroblastoma cells against cell damage triggered by tunicamycin-mediated endoplasmic reticulum stress.

PPARγmodulator-3 (Compound 11) is a modulator of the peroxisome proliferator-activated receptor γ (PPARγ) with a KD value of 186 nM. It holds potential for research into insulin resistance (IR)-related conditions, including type 2 diabetes mellitus (T2DM) and metabolic syndrome.

E3LigaseLigand-linker Conjugate 186 is a conjugate comprising a CRBN E3 ubiquitin ligase ligand and a linker (E3ligaseligand-linker conjugate). This compound is utilized in the synthesis of PROTAC SJ10542.

Antibacterialagent 186 (compound 25) is a potent antibacterial agent that demonstrates anti-biofilm formation properties against clinical strains of Staphylococcus epidermidis and has the capability to eradicate existing biofilms. It also holds potential for studying multidrug-resistant strains of Staphylococcus epidermidis.

CRBN ligand-186 is a CRBN-type E3 ubiquitin ligase ligand, suitable for use in the preparation of PROTACs.