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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T80973 | TNF-α-IN-8 | ||
TNF-α-IN-8 (compound I-42) is an isoindole-imide-based inhibitor of tumor necrosis factor-alpha (TNF-α) with applications in researching various diseases including cancer, heart disease, osteoporosis, and autoimmune diso... | |||
TN1520 | Isoforskolin | Coleonol B | IL Receptor , TNF |
Isoforskolin is derived from Coleus forskohlii and reduces the secretion of TNF-α, IL-1β, IL-6 and IL-8 in human mononuclear leukocytes. Isoforskolin can be used in studies about the treatment of Lyme arthritis. | |||
T24816 | SP-100030 | SP100030,SP 100030 | NF-κB |
SP-100030 is a dual inhibitor of NF-κB and activator protein-1 (AP-1), demonstrating potent inhibition with IC50 values of 50 nM for both. It effectively reduces the production of IL-2, IL-8, and TNF-alpha in Jurkat and ... | |||
T3240 | Citronellol | dihydrogeraniol,(±)-β-Citronellol | Reactive Oxygen Species |
Citronellol ((±)-β-Citronellol) is used in insect repellents and perfumes and as a mite attractant. | |||
T27695 | JTE-607 | JTE-607 dihydrochloride,JTE-607 HCl | Cysteine Protease |
JTE-607 is a cytokine production inhibitor. JTE-607 induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells. | |||
T81159 | Sibiricine | ||
Sibiricine (Compound 8), an isoquinoline alkaloid extracted from the medicinal plant Corydalis crispa, exhibits substantial anti-inflammatory effects by inhibiting TNF-α production in LPS-activated THP-1 cells [1]. | |||
T75694 | Lacto-N-neotetraose | ||
Lacto-N-neotetraose (LNnT), an endogenous metabolite, inhibits TNF-α-induced IL-8 secretion in immature epithelial cells, exhibits anti-inflammatory activity, and enhances wound closure [1] [2] [4]. | |||
TP2035 | FSL-1 | FSL 1 | |
TLR2/6 agonist (also a putative TLR10 ligand). Activates NF-κB. Induces pro-inflammatory cytokines including IL-8, IL-1β, CCL20 and TNF-α in vitro. Synergizes with IFNγ to induce CXCL10 release from melanoma cells. | |||
T63088 | NOD2 antagonist 1 | ||
NOD2 antagonist 1 (compound 32) is an effective and selective NOD2 antagonist (IC50: 5.23μM). NOD2 antagonist 1 in THP-1 cells repress Muramyl DiDP (MDP) -induced IL-8 secretion. NOD2 antagonist 1 in PBMCs cells inhibits... | |||
T37751 | Streptazolin | ||
Streptazolin is a fungal metabolite originally isolated from S. viridochromogenes. It increases NF-κB activity when used at concentrations ranging from 60 to 130 μg/ml, at least in part, via PI3K signaling. Streptazolin ... | |||
T79256 | DPP-4-IN-8 | ||
DPP-4-IN-8 (compound 27) is a potent and selective inhibitor of dipeptidyl peptidase 4 (DPP4), with an inhibition constant (Ki) of 0.96 μM. It inhibits the dipeptidase activity of DPP4 in both Caco-2 and HepG-2 cells and... | |||
T83798 | 8-bromo NAD+ sodium | 8-bromo Nicotinamide adenine dinucleotide,N(8-bromo-A)D+ | |
8-Bromo NAD+ serves as a prodrug for the cyclic ADP-ribose (cADPR) inhibitor, 8-bromo cADPR, undergoing conversion to its active form by the enzyme CD38. At a concentration of 1 mM, it effectively inhibits the rise in in... | |||
T35864 | T-5342126 | ||
T-5342126 is a toll-like receptor 4 (TLR4) antagonist.1It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50= 27.8 μM), as well as decreases LPS-induced IL-8, TNF-α, and IL-6 production in isola... | |||
T83698 | Cathelicidin-2 (128-153) (chicken) TFA | Fowlicidin-2 (128-153),CATH-2 (128-153),Myeloid Antimicrobial Peptide 27 (128-153) | |
Cathelicidin-2 (CATH-2) (128-153) is a synthetic antimicrobial peptide derived from amino acids 128-153 of chicken CATH-2, demonstrating activity against pathogens such as E. coli, S. aureus, S. enteritidis, and B. globi... | |||
T35406 | α-MSH TFA | ||
α-Melanocyte-stimulating hormone (α-MSH) is a 13-amino acid peptide hormone produced by post-translational processing of proopiomelanocortin (POMC) in the pituitary gland, as well as in keratinocytes, astrocytes, monocyt... | |||
T83895 | NCI 126224 | NSC 126224 | |
NCI 126224, a toll-like receptor 4 (TLR4) antagonist, demonstrates selective inhibition of nitric oxide (NO) production in RAW 264.7 macrophages, triggered by the TLR4 agonist LPS (IC50 = 0.31 µM), as opposed to minimal ... | |||
T38002 | LEO 39652 | ||
LEO 39652, a dual-soft PDE4 inhibitor, demonstrates potent inhibition of PDE4 subtypes A, B, C, and D with respective IC50 values of 1.2 nM, 1.2 nM, 3.0 nM, and 3.8 nM. Additionally, it inhibits TNF-α with an IC50 of 6.0... | |||
T83866 | LCC-12 formate | ||
LCC-12, a derivative of the biguanide metformin, acts as a copper (II) chelator. It efficiently forms a monomeric bond with copper (II) and at 20 µM, it mitigates hydrogen peroxide-induced oxidation from NADH to NAD+. At... | |||
T35672 | SMU127 | ||
SMU127 is an agonist of the toll-like receptor 1/2 (TLR1/2) heterodimer.1It induces NF-κB signaling in cells expressing human TLR2 (EC50= 0.55 μM) but not cells expressing human TLR3, -4, -5, -7, or -8 when used at conce... | |||
T83735 | Pap12-6 TFA | ||
Pap12-6, an antibacterial peptide originating from the first twelve N-terminal amino acids of papiliocin found in P. xuthus larvae, exhibits activity against a range of eight Gram-negative bacteria (e.g., E. coli, P. aer... |