sw480 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9151	Teplinovivint		Wnt/beta-catenin
	Teplinovivint is a potent inhibitor of the Wnt/β-catenin signaling pathway, demonstrating anti-inflammatory properties with potential utility in tendinopathy research.		Wnt/beta-catenin
T13224	Tubulin inhibitor 6	iHAP1	Microtubule Associated
	Tubulin inhibitor 6 (iHAP1) is an inhibitor of tubulin and a potent inhibitor of multiple cancer cell lines.		Microtubule Associated
T19147	5-ALA benzyl ester hydrochloride	Benzyl-ALA hydrochloride	Others , Endogenous Metabolite
	5-ALA benzyl ester hydrochloride (Benzyl-ALA hydrochloride) is a protoporphyrin precursor. 5-ALA benzyl ester hydrochloride is used as a photodetection agent. 5-ALA benzyl ester hydrochloride could induce protoporphyrin ...		Others , Endogenous Metabolite
T4459	PK11000		DNA Alkylator/Crosslinker
	PK11000 is a p53 targeting compound, has anti-tumor activities through activation of unstable p53.		DNA Alkylator/Crosslinker
T6583	MG-101	ALLN,Ac-LLnL-CHO,Calpain inhibitor I,Calpain inhibitor-1,MG101	Cysteine Protease , Proteasome
	MG-101 (Calpain inhibitor I) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.		Cysteine Protease , Proteasome
T5858	Sertindole	Lu 23-174	Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , Autophagy
	Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, respectively)
T5636	Adavivint	Adavivint (SM04690)	Wnt/beta-catenin
	Adavivint (Adavivint (SM04690)) (SM04690) is a Wnt pathway inhibitor.		Wnt/beta-catenin
T5750	Oxyberberine	Ketoberberine,Berlambine,8-Oxoberberine	Others
	Oxyberberine (8-Oxoberberine) is isolated from the methanol extract of A. mexicana. It has been used to study the SW480 human colon cancer cell line.		Others
T69625	Benitrobenrazide	Hexokinase 2 inhibitor 1	Hexokinase
	Benitrobenrazide (Hexokinase 2 inhibitor 1) is a hexokinase 2 inhibitor with anticancer and antitumor activity.Benitrobenrazide inhibits the growth of tumors and can be used in cancer research.		Hexokinase
T13807	OSIP-486823	CP248	Microtubule Associated , PKA
	OSIP-486823（CP248） is a novel and potent microtubule disruptor with affinity for both protein kinase G (PKG) and microtubules.		Microtubule Associated , PKA
T71862	GPR120-IN-1
	GPR120-IN-1 is a novel GPR120 inhibitor, showing ~90% inhibitory effects on cell growth with micromolar affinities against SW480.
T78701	Tubulin inhibitor 32		Apoptosis
	Tubulin inhibitor 32 is an orally active novel microtubule inhibitor with antiproliferative and antitumor activity, inhibits microtubule polymerization, induces apoptosis and cell cycle arrest in G2/M phase.		Apoptosis
TN5422	Ciwujiatone
	Ciwujiatone exhibits significant activities against colon cancer cell lines SW480 and SW620.
T72548	IGUANA-1 free base	STL5-T-0057
	IGUANA-1 free base (STL5-T-0057) acts as a selective ALDH1 B1 inhibitor, demonstrating an IC50 value of 30 nM. It efficaciously inhibits the growth of SW480 cells under both adherent and spheroid conditions, yielding IC5...
TN5676	Musellarin B
	Musellarin B is cytotoxic toward several of the human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480).
T34120	PQ1	PQ-1,PQ 1
	PQ1, as an enhancer of gap junction in SW480 human colorectal cancer cells can act by restoring GJIC and increasing connexin expression in breast cancer cell lines while not affecting normal mammary cells.
TN3925	Eichlerianic acid		HSV
	Eichlerianic acid is a trypanocidal compound with an IC50 value of 10 mg/mL. Eichlerianic acid may have antiviral activity against Herpes simplex virus types I and II in vitro. Eichlerianic acid shows weak cytotoxicity (...		HSV
TN3250	7-Prenyljacareubin		Others
	7-Prenyljacareubin shows moderate cytotoxic activity against HL-60, SMMC-7721, A549, MCF-7, and SW480 cell lines.		Others
T73832	Tubulin inhibitor 21
	Tubulin Inhibitor 21 (compound 6f), a hybrid based on chalcone and melatonin, exhibits potent tubulin inhibition properties. It demonstrates significant cytotoxic activity against SW480 cells (IC 50 =0.26 μM) while showi...
T61946	IMP2-IN-1
	IMP2-IN-1 (compound 4) is an effective IMP2 inhibitor with an IC50 of 81.3-127.5 μM for IMP2 RNA . IMP2-IN-1 decreased the level of IMP2 in SW480 cells. IMP2-IN-1 significantly inhibited the activity of differentiated an...