SM-4

SM4 is a SOX18 small molecule inhibitor of HemSC vessel formation in vivo.

SM-433 is a Smac mimetic and inhibitor of inhibitors of apoptosis (IAPs). SM-433 has a strong affinity for XIAP BIR3 protein (IC50 <1 μM).

SM-433 hydrochlorid is a Smac mimetic, an inhibitor of inhibitory apoptosis proteins (IAPs). SM-433 hydrochlorid is able to bind XIAP BIR3 protein with a potent IC50 <1 μM.

Eudesm-4(15)-ene-3alpha,11-diol is a compound derived from Eudesm-4(15)-ene-3alpha,11-diol.

DSM421 (DSM-421) is a dihydrodehydrogenase inhibitor (DHODH) that is in preclinical development as a potential treatment option for malaria and has shown activity against field isolates of both P. falciparum and P. vivax.

NCATS-SM4420 (Compound A35) is an orally effective ligand for the thyroid-stimulating hormone receptor (TSHR) that inhibits the proliferation of MDA-T32 and MDA-T85 cells both in vitro and in vivo, with IC50 values of 0.71 μM and 0.38 μM, respectively. Additionally, it suppresses the metastasis of MDA-T85F1 in mice. NCATS-SM4420 holds potential for research in the field of thyroid cancer.

SM 4470 is an imidazole derivative with antifungal properties.

Xevinapant hydrochloride (AT-406 HCl) , an orally active antagonist of multiple inhibitor of apoptosis proteins(IAP), inhibits progression of human ovarian Y binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide.

NCATS-SM4487 is a highly selective inhibitor of GALK1 with an IC50 of 0.05 μM.

Xevinapant (Debio-1143) is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide. Phase 1.

DSM43 is a dihydroorotate dehydrogenase (DHODH) inhibitor. Malaria puts at risk nearly half the world's population and causes high mortality in sub-Saharan Africa, while drug resistance threatens current therapies. The pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase (DHODH) is a validated target for malaria treatmen

3β-Cholic Acid (Standard) is a reference standard of 3β-Cholic Acid intended for quantitative analysis, quality control, and related biochemical research applications.

Deoxycholic Acid 3-O-β-D-Glucuronide Disodium Salt (Standard) is a reference standard of Deoxycholic Acid 3-O-β-D-Glucuronide Disodium Salt intended for quantitative analysis, quality control, and related biochemical research applications.

3-Oxodeoxycholic Acid (Standard) is the standard of 3-Oxodeoxycholic Acid, suitable for research related to quantitative analysis, quality control, and biochemical experiments. 3-Oxodeoxycholic Acid is a bile acid derivative formed by the oxidation of the 3-hydroxyl group of deoxycholic acid, participating in bile acid metabolism and the enterohepatic circulation. It is commonly used to study bile acid signaling pathways and their effects on lipid metabolism and liver function regulation.

Tauro-ω-Muricholic Acid Sodium Salt (Standard) is a reference standard of Tauro-ω-Muricholic Acid Sodium Salt intended for quantitative analysis, quality control, and related biochemical research applications.

4-CHOLENIC ACID-3-ONE (Standard) is a reference standard of 4-CHOLENIC ACID-3-ONE intended for quantitative analysis, quality control, and related biochemical research applications.

7α-Hydroxy-3-oxochol-4-en-24-oic Acid-[13C3] in Methanol (Standard) is a reference standard of 7α-Hydroxy-3-oxochol-4-en-24-oic Acid-[13C3] in Methanol intended for quantitative analysis, quality control, and related biochemical research applications.

L-3,3`-Diiodothyronine (T2) (Standard) is a reference standard of L-3,3`-Diiodothyronine (T2) intended for quantitative analysis, quality control, and related biochemical research applications.

18-Hydroxycortisone in Methanol (Standard) is a reference standard of 18-Hydroxycortisone in Methanol intended for quantitative analysis, quality control, and related biochemical research applications.

Dehydroepiandrosterone Glucuronide (Standard) is a reference standard of Dehydroepiandrosterone Glucuronide intended for quantitative analysis, quality control, and related biochemical research applications.

5α-Dihydrocorticosterone in Methanol (Standard) is a reference standard of 5α-Dihydrocorticosterone in Methanol intended for quantitative analysis, quality control, and related biochemical research applications.

5α-Dihydrocortisone (Standard) is a reference standard of 5α-Dihydrocortisone intended for quantitative analysis, quality control, and related biochemical research applications.

Prostaglandin A2-[d4] in Ethyl acetate (Standard) is a reference standard of Prostaglandin A2-[d4] in Ethyl acetate intended for quantitative analysis, quality control, and related biochemical research applications.

N-Acetyl-S-(2-carbamoylethyl)-L-cysteine (unlabelled) (Standard) is a reference standard of N-Acetyl-S-(2-carbamoylethyl)-L-cysteine (unlabelled) intended for quantitative analysis, quality control, and related biochemical research applications.