Respiratory Distress Syndrome

Aviptadil Acetate (Vasoactive Intestinal Peptide acetate salt) induces pulmonary vasodilation and inhibits the proliferation of vascular SMCs and platelet aggregation. Avitadil acetate can be used for research on pulmonary fibrosis, pulmonary hypertension (PAH), and respiratory failure caused by SARS-CoV-2.

Levocarnitine propionate (L-Propionylcarnitine) is a propionyl-coenzyme A (Pro-CoA) derivative with anti-ischemic effects and high affinity for muscle L-carnitine transferase. Levocarnitine propionate enhances substrate oxidation and mitochondrial respiration in the heart of diabetic rats, reduces gastric ulcer area, induces mucosal recovery, and can be used to study acute respiratory distress syndrome and chronic gastric ulcers in Alzheimer's disease.

SN50 TFA is a cell-permeable inhibitor of NF-κB and attenuates alveolar hypercoagulation and fibrinolysis inhibition in acute respiratory distress syndrome mice through inhibiting NF-κB p65 translocation. SN50 TFA can be used in studies about ARDS.

AMY-101 acetate (Cp40 acetate) is a cyclic peptide, an inhibitor of C3 Complement and an immunomodulator used in the treatment of gingivitis and periodontitis, which significantly reduces inflammation and lowers MMP-8 and MMP-9 levels.AMY-101 acetate also have a palliative effect on covid -19-induced lung inflammation injury and SARS-COV-2-related acute kidney injury in patients with acute respiratory distress syndrome (ARDS).

CNI103 is a potent and metabolically stable inhibitor of the cell-permeable peptide, calcineurin. It selectively inhibits the interaction between calcineurin and NFATc3 (KD=16 nM), thereby preventing the activation of NFATc3 both in vitro and in vivo. CNI103 is applicable for research in acute respiratory distress syndrome (ARDS) and other inflammatory diseases.