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Search Results for " molecular glues "

7

Compounds

Cat No. Product Name Synonyms Targets
T9849 HQ461 CDK , Molecular Glues
HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death.
T0213 Thalidomide Thalomid,Sedoval Apoptosis , TNF , Autophagy , Ligand for E3 Ligase , Molecular Glues
Thalidomide (Thalomid) is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic properties.
T2384 Pomalidomide CC-4047 Apoptosis , TNF , Ligand for E3 Ligase , Molecular Glues
Pomalidomide (CC-4047) inhibits TNF-α release in LPS stimulated human PBMCs (IC50: 13 nM). It is an anti-angiogenic agent and an immunomodulator.
T22922 Lenalidomide hemihydrate TNF , Ligand for E3 Ligase , Molecular Glues
Lenalidomide hemihydrate is a TNF-α secretion inhibitor (IC50 = 13 nM). Lenalidomide hemihydrate could bound endogenous CRBN and recombinant CRBN-DNA damage binding protein-1 (DDB1) complexes.
T10703 Mezigdomide CC-92480 Apoptosis , E1/E2/E3 Enzyme , Molecular Glues
Mezigdomide (CC-92480) is a potent, novel, selective and active cereblon E3 ubiquitin ligase modulator (CELMoD) that often acts as a molecular glue. Mezigdomide has antimyeloma activity.
T10765 Eragidomide CC-90009,Cereblon modulator 1 Apoptosis , Ligand for E3 Ligase , Molecular Glues
Eragidomide (CC-90009; Cereblon modulator 1) is a cereblon (CRBN) E3 ligase modulator. Eragidomide specifically binds to CRBN, thereby affecting the activity of the ubiquitin E3 ligase complex.
T1642 Lenalidomide CC-5013 Apoptosis , TNF , Ligand for E3 Ligase , Molecular Glues
Lenalidomide (CC-5013) is a potent inhibitor of TNF-α that, at 10 μM, alters gene expression and cell viability in a range of cancer cell lines.
TargetMol