fkbp12 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T71840	FKBP12-IN-Q2
	FKBP12-IN-Q2 is an inhibitor of FKBP12.
T13694	FKBP12 PROTAC RC32	RC32	Others
	FKBP12 PROTAC RC32 contains conjugation of Rapamycin and a ligand for an E3 ubiquitin ligase.FKBP12 PROTAC RC32 (RC32) is a potent FKBP12 degrader based on PROTAC technology.		Others
T11291	FKBP12 PROTAC dTAG-13	dTAG-13	Epigenetic Reader Domain
	FKBP12 PROTAC dTAG-13 (dTAG-13) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-13 (dTAG-13) also is a selective degrader of BET bromodomain transcription...		Epigenetic Reader Domain
T11292	FKBP12 PROTAC dTAG-7	dTAG-7	Epigenetic Reader Domain
	FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional compound that selectively degrades the BET bromodomain transcriptional co-activator BRD4 by connecting BET bromodomains to the E3 ubiquitin ligase CRBN. Additionally,...		Epigenetic Reader Domain
T13914	SLF-amido-C2-COOH	PROTAC FKBP12-binding moiety 1	Others
	SLF-amido-C2-COOH is a synthetic ligand for FKBP (SLF), and can be used in the synthesis of PROTACs.		Others
T18611	AP1867-2-(carboxymethoxy)	PROTAC FKBP12-binding moiety 2	Others
	AP1867-2-(carboxymethoxy), a moiety based on the synthetic FKBP12F36V-directed ligand AP1867, connects to the CRBN ligand through a linker to generate dTAG molecules[1].		Others
T2481	Ascomycin	FK520,Immunomycin,FR-900520	Phosphatase , Others , Antibiotic , Parasite , Antifungal
	Ascomycin (Immunomycin)(Immunomycin, FR-900520, FK520) is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties.		Phosphatase , Others , Antibiotic , Parasite , Antifungal
T1537	Rapamycin	Sirolimus,AY 22989,NSC-2260804	Others , Endogenous Metabolite , Antibiotic , mTOR , Autophagy , Antifungal
	Rapamycin (AY 22989) is a natural product of macrolides, an mTOR inhibitor with specificity (HEK293 cells: IC50=0.1 nM). Rapamycin has immunosuppressive activity and induces autophagy.
T40031	Thalidomide-O-C6-NH2 hydrochloride	4-((6-aminohexyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride	E3 Ligase Ligand-Linker Conjugate
	Thalidomide-O-C6-NH2 hydrochloride (4-((6-aminohexyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride) is a synthesized E3 ligase ligand-linker conjugate.		E3 Ligase Ligand-Linker Conjugate
T2144	Tacrolimus	Fujimycin,FK506,FR900506	Phosphatase , Others , Antibacterial , Antibiotic , mTOR , Autophagy
	Tacrolimus (Fujimycin) can bind FKBP12 to form a high-affinity complex (Ki: 0.2 nM) which inhibits the activity of the calcium/calmodulin-dependent protein phosphatase.
T9950	ElteN378		mTOR
	ElteN378 is a highly potent synthetic inhibitor of FKBP12 with Ki of 0.5 nM, a low atomic weight ligand with affinity comparable to that of the macrolide Rapamycin.		mTOR
T74025	AUTAC1		AUTACs
	AUTAC1 is a MetAP2-targeted autophagy-mediated degrader (AUTAC) with potential anticancer activity that degrades MetAP2 and FKBP12 proteins and can be used to synthesize PROTAC.		AUTACs
T14298	Rimiducid		Apoptosis , Others , Fatty Acid Synthase
	Rimiducid is a lipid-permeable tacrolimus analogue, homodimerizing an analogue of human protein fkbp12 and binding to wild-type fkbp12 with 1000-fold lower affinity. Rimiducid is a dimerizer agent that acts by cross-link...		Apoptosis , Others , Fatty Acid Synthase
T6033	Zotarolimus	ABT-578,A 179578	mTOR
	Zotarolimus (ABT-578), an analogue of rapamycin, inhibits FKBP-12 (IC50= 2.8 nM).		mTOR
T1784	Everolimus	RAD001,SDZ-RAD	Apoptosis , Others , mTOR , Autophagy
	Everolimus (SDZ-RAD) is a potent mTOR inhibitor that binds to FKBP-12. It is used alone or in combination with calcineurin inhibitors.		Apoptosis , Others , mTOR , Autophagy
T18597	DFKBP-1		Others
	dFKBP-1 is a potent and PROTAC-based FKBP12 degrader. dFKBP-1 incorporates the ligand SLF of FKBP12, the Thalidomide based cereblon ligand and a linker[1].		Others
T74026	AUTAC2
	AUTAC2, an autophagy-mediated degrader (AUTAC) targeting FKBP12, comprises an FBnG (p-Fluorobenzyl Guanine) and an SLF (c ligand of FKBP) moiety. The SLF component binds non-covalently to FKBP12 [1].
T40251	DTAGV-1 TFA
	dTAGV-1 TFA is a highly effective and specific compound that targets mutant FKBP12 F36V fusion proteins for degradation. It possesses potent activity in inducing the degradation of the FKBP12 F36V -Nluc protein in living...
T18061	KB02-SLF		Others
	KB02-SLF is a PROTAC-based nuclear FKBP12 degrader, known as a molecular glue. It facilitates the degradation of nuclear FKBP12 by covalently modifying DCAF16, an E3 ligase. Moreover, KB02-SLF enhances the longevity of p...		Others
T74556	DTAG-47
	dTAG-47, a heterobifunctional molecule, specifically targets the mutant FKBP12 (FKBP12 F36V), which functions as a degradation tag (dTAG) when fused to a protein of interest. This compound is utilized in the study of bas...