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Search Results for " cxcr3 "

17

Compounds

1

Natural Products

7

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T36982 CXCR3 Antagonist 6c
CXCR3 antagonist 6c is an antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3).1It inhibits calcium mobilization induced by chemokine (C-X-C motif) ligand 11 (CXCL11) in HEK293 cells expressing the human receptor (IC...
T10297L AMG 487 CXCR
AMG 487 is a potent and selective antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively.
T26035 Rac-NBI-74330 rac NBI 74330,racNBI74330 CXCR
rac-NBI-74330 is an effective and selective CXCR3 antagonist.
T7499 TAK-779 Takeda 779 HIV Protease , CXCR , CCR
TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).
T3360 ZK 756326 ZK756326 2HCl CCR
ZK 756326 is a selective, non-peptide CCR8 chemokine receptor agonist (IC50: 1.8 μM, in human; 2.6 μM, in mouse). Displays no activity at CCR4/5 and CXCR3/4 and shows higher 28-fold selectivity over 26 other GPCRs (less ...
T16863 SCH 546738 Others
SCH 546738 is an effective and non-competitive CXCR3 antagonist. SCH 546738 bindings to the human CXCR3 receptor is determined (Ki: 0.4 nM) in multiple experiments.
T24949 VUF10132 VUF-10132,VUF 10132
VUF10132 is a full inverse CXCR3 N3.35A agonist.
T29147 VUF5834 VUF-5834,VUF 5834
VUF5834 is a full inverse agonist of CXCR3 N3.35A.
T12567 PS372424 Others
PS372424 is a specific agonist of human CXCR3, with anti-inflammatory activity.
T10297 AMG 487 (S-enantiomer) Others
AMG 487 S-enantiomer is the S enantiomer of AMG 487. AMG 487 is an CXCR3 antagonist.
T35085 VUF-11222 VUF 11222
VUF-11222 is an agonist of high affinity non-peptide CXCR3 agonist (pKi = 7.2).
T70616 ACT-672125
ACT-672125 is a Potent CXCR3 Antagonist with Therapeutic Potential in Autoimmune Diseases. ACT-672125 showed good physicochemical properties and safety profile. In a proof-of-mechanism model of lung inflammation, ACT-672...
T22477 (±)-AMG 487 Others
AMG 487 is an effective and selective antagonist of chemokine receptor 3. AMG 487 inhibited CXCR3-mediated cell migration induced by three CXCR3 chemokines, IP-10, ITAC and MIG (IC50: 8, 15 and 36 nM, respectively).
T70411 PS372424 HCl
PS372424 is a specific agonist of human CXCR3. It has been shown to induce phosphorylation of ERK and block CXCL11 induced migration of CD45+ cells to air pouches generated on humanized mice.
T23656 VUF11211 VUF-11211,VUF 11211
VUF11211 is an effective antagonist of CXCR3 that acts by extending from the minor pocket into the major pocket of the transmembrane domains.
T73148 ACT-777991
ACT-777991 is an orally active, selective CXCR3 antagonist with demonstrated stability in microsomes and hepatocytes across various animal models. This compound effectively inhibits the migration of activated T cells tow...
T63761 ACT-660602
ACT-660602 is an orally active chemokine receptor CXCR3 antagonist (IC50: 204 nM). ACT-660602 inhibits T cell migration and has shown significant effects in an in vivo model of acute lung injury. ACT-660602 can be used t...
Cat No. Product Name Synonyms Targets
T3765 L-asarinin (-)-Episesamin Others
L-asarinin ((-)-Episesamin) reduces peripheral blood concentration of IL-12 and inhibits the expression of CXCR3 and TLR4, which means Asarinin may have a role on the TLR4 pathway and produce prolongation of allograft he...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPH-01162 CXCR3 Protein, Human, Recombinant (GST & His) Human E. coli
CXCR3 Protein, Human, Recombinant (GST & His) is expressed in E. coli.
TMPH-02612 CXCR3 Protein, Mouse, Recombinant (His & KSI) Mouse E. coli
Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Probably promotes cell c...
TMPY-03274 CXCL11 Protein, Human, Recombinant Human E. coli
I-TAC, also known as CXCL11, is a small cytokine belonging to the CXC chemokine family. It is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low e...
TMPJ-00008 CXCL10 Protein, Human, Recombinant (hFc & His) Human HEK293 Cells
Human C-X-C Motif Chemokine Ligand 10 (CXCL10) is a non-ELR chemokine secreted by various cell types, such as monocytes, endothelial cells and fibroblasts, in response to IFN-γ. CXCL10 functions via chemokine receptor CX...
TMPJ-00884 CXCL9 Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
Chemokine (C-X-C motif) ligand 9 (CXCL9, MIG), is a small cytokine belonging to the CXC chemokine family. CXCL9 functions as one of the three ligands of chemokine receptor CXCR3 which is a G protein-coupled receptor foun...
TMPJ-01084 CXCL9 Protein, Human, Recombinant (His) Human HEK293 Cells
Chemokine (C-X-C Motif) Ligand 9 (CXCL9) belongs to the intercrine alpha (chemokine CXC) family. It is secreted by interferon stimulated monocytes, macrophages and endothelial cells, which elicits chemotactic functions b...
TMPJ-00012 CXCL4 Protein, Human, Recombinant (His) Human HEK293 Cells
Human Chemokine (C-X-C motif) Ligand 4 (CXCL4) is expressed in megakaryocytes and stored in the alpha-granules of platelets. CXCL4 contains several heparin-binding sites at the C-terminal region and binds heparin with hi...
TargetMol